Uchl5 (ubiquitin C-terminal hydrolase L5) - Rat Genome Database

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Gene: Uchl5 (ubiquitin C-terminal hydrolase L5) Rattus norvegicus
Analyze
Symbol: Uchl5
Name: ubiquitin C-terminal hydrolase L5
RGD ID: 1305414
Description: Predicted to enable cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Predicted to be involved in several processes, including brain development; positive regulation of smoothened signaling pathway; and regulation of nucleobase-containing compound metabolic process. Part of cytosolic proteasome complex. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360853; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,070,947 - 58,106,825 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1358,042,029 - 58,107,441 (+)EnsemblGRCr8
mRatBN7.21355,520,722 - 55,556,503 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,520,729 - 55,556,502 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1358,089,283 - 58,125,040 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,356,425 - 59,392,187 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,641,812 - 56,677,555 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,568,102 - 60,603,812 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,545,635 - 60,603,811 (+)Ensemblrn6Rnor6.0
Rnor_5.01365,556,665 - 65,592,649 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41357,605,912 - 57,643,050 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1355,608,483 - 55,644,135 (+)NCBICelera
RGSC_v3.11357,619,991 - 57,908,156 (+)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
maneb  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paraquat  (ISO)
phlorizin  (ISO)
piroxicam  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Chronic ethanol feeding affects proteasome-interacting proteins. Bousquet-Dubouch MP, etal., Proteomics. 2009 Jul;9(13):3609-22. doi: 10.1002/pmic.200800959.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-beta receptor I expression and hypertrophy in mesangial cells. Ko YM, etal., Arch Biochem Biophys. 2013 Jul 15;535(2):177-86. doi: 10.1016/j.abb.2013.03.003. Epub 2013 Mar 13.
5. Proteomic analysis of testicular ischemia-reperfusion injury in rats. Ouh IO, etal., J Vet Med Sci. 2014 Mar;76(3):313-21. Epub 2013 Nov 1.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses. Sun C, etal., Science. 2023 May 26;380(6647):eadf2018. doi: 10.1126/science.adf2018. Epub 2023 May 26.
10. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.
Additional References at PubMed
PMID:12477932   PMID:18162577   PMID:18922472   PMID:19182904   PMID:21048919   PMID:21303910   PMID:22658674   PMID:23770237   PMID:28992318  


Genomics

Comparative Map Data
Uchl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,070,947 - 58,106,825 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1358,042,029 - 58,107,441 (+)EnsemblGRCr8
mRatBN7.21355,520,722 - 55,556,503 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,520,729 - 55,556,502 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1358,089,283 - 58,125,040 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,356,425 - 59,392,187 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,641,812 - 56,677,555 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,568,102 - 60,603,812 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,545,635 - 60,603,811 (+)Ensemblrn6Rnor6.0
Rnor_5.01365,556,665 - 65,592,649 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41357,605,912 - 57,643,050 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1355,608,483 - 55,644,135 (+)NCBICelera
RGSC_v3.11357,619,991 - 57,908,156 (+)NCBI
Cytogenetic Map13q21NCBI
UCHL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381193,012,254 - 193,060,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1193,012,246 - 193,060,080 (-)Ensemblhg38GRCh38
GRCh371192,981,384 - 193,029,206 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,251,522 - 191,295,144 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341189,716,556 - 189,760,178NCBI
Celera1166,094,514 - 166,138,132 (-)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1164,217,286 - 164,265,038 (-)NCBIHuRef
CHM1_11194,403,215 - 194,450,956 (-)NCBICHM1_1
T2T-CHM13v2.01192,359,462 - 192,407,284 (-)NCBIT2T-CHM13v2.0
Uchl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,652,993 - 143,683,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,653,010 - 143,683,204 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381143,777,234 - 143,807,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,777,272 - 143,807,466 (+)Ensemblmm10GRCm38
MGSCv371145,624,408 - 145,654,596 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361145,539,553 - 145,569,033 (+)NCBIMGSCv36mm8
Celera1146,352,307 - 146,382,478 (+)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.54NCBI
Uchl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,432,652 - 30,468,741 (-)Ensembl
ChiLan1.0NW_00495540630,432,652 - 30,468,741 (-)NCBIChiLan1.0ChiLan1.0
UCHL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2156,732,736 - 56,780,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1156,396,699 - 56,444,658 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,471,501 - 168,519,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,764,606 - 172,812,502 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,764,606 - 172,811,880 (-)EnsemblpanPan2panpan1.1
UCHL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1386,004,595 - 6,045,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,004,659 - 6,113,714 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha386,102,225 - 6,143,345 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0386,021,866 - 6,063,304 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,021,819 - 6,125,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,021,177 - 6,062,576 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,386,756 - 6,427,852 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,615,571 - 6,657,212 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Uchl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934480,855,144 - 80,907,329 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366381,242,893 - 1,290,512 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366381,242,950 - 1,289,376 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCHL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl10725,561 - 763,985 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.110725,688 - 761,633 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,258,893 - 2,274,919 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UCHL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,362,340 - 36,415,550 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,364,027 - 36,414,762 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605537,311,867 - 37,365,433 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uchl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624814529,084 - 567,666 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624814529,100 - 568,387 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Uchl5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11023,696,673 - 23,738,834 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Uchl5
407 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000004881
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC088841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004881   ⟹   ENSRNOP00000004881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1358,071,092 - 58,106,824 (+)Ensembl
mRatBN7.2 Ensembl1355,520,768 - 55,556,502 (+)Ensembl
Rnor_6.0 Ensembl1360,568,146 - 60,603,811 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077153   ⟹   ENSRNOP00000072164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1358,077,215 - 58,106,323 (+)Ensembl
mRatBN7.2 Ensembl1355,527,046 - 55,556,133 (+)Ensembl
Rnor_6.0 Ensembl1360,545,635 - 60,603,438 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098889   ⟹   ENSRNOP00000094138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1358,071,076 - 58,106,825 (+)Ensembl
mRatBN7.2 Ensembl1355,520,729 - 55,556,133 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000140387   ⟹   ENSRNOP00000102415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1358,071,062 - 58,107,441 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150460   ⟹   ENSRNOP00000100152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1358,077,171 - 58,106,825 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159999   ⟹   ENSRNOP00000100228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1358,042,029 - 58,106,323 (+)Ensembl
RefSeq Acc Id: NM_001393849   ⟹   NP_001380778
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,076 - 58,106,825 (+)NCBI
mRatBN7.21355,520,752 - 55,556,503 (+)NCBI
RefSeq Acc Id: NM_001393850   ⟹   NP_001380779
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,076 - 58,106,825 (+)NCBI
mRatBN7.21355,520,752 - 55,556,503 (+)NCBI
RefSeq Acc Id: NM_001393851   ⟹   NP_001380780
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,076 - 58,106,825 (+)NCBI
mRatBN7.21355,520,752 - 55,556,503 (+)NCBI
RefSeq Acc Id: NR_172020
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,076 - 58,106,825 (+)NCBI
mRatBN7.21355,520,752 - 55,556,503 (+)NCBI
RefSeq Acc Id: XM_039090901   ⟹   XP_038946829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,002 - 58,106,451 (+)NCBI
mRatBN7.21355,520,723 - 55,552,368 (+)NCBI
RefSeq Acc Id: XM_063272472   ⟹   XP_063128542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,070,947 - 58,106,451 (+)NCBI
Ensembl Acc Id: ENSRNOP00000072164   ⟸   ENSRNOT00000077153
Ensembl Acc Id: ENSRNOP00000004881   ⟸   ENSRNOT00000004881
RefSeq Acc Id: XP_038946829   ⟸   XM_039090901
- Peptide Label: isoform X1
- UniProtKB: Q5HZY3 (UniProtKB/TrEMBL),   A0A0G2K2A5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094138   ⟸   ENSRNOT00000098889
RefSeq Acc Id: NP_001380778   ⟸   NM_001393849
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GL10 (UniProtKB/TrEMBL),   A6ICP4 (UniProtKB/TrEMBL),   A0A0G2K2A5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380779   ⟸   NM_001393850
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K2A5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380780   ⟸   NM_001393851
- Peptide Label: isoform 3
- UniProtKB: A0A0G2K2A5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128542   ⟸   XM_063272472
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100152   ⟸   ENSRNOT00000150460
Ensembl Acc Id: ENSRNOP00000102415   ⟸   ENSRNOT00000140387
Ensembl Acc Id: ENSRNOP00000100228   ⟸   ENSRNOT00000159999
Protein Domains
UCH catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2A5-F1-model_v2 AlphaFold A0A0G2K2A5 1-340 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698874
Promoter ID:EPDNEW_R9399
Type:initiation region
Name:Uchl5_1
Description:ubiquitin C-terminal hydrolase L5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01360,568,147 - 60,568,207EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305414 AgrOrtholog
BioCyc Gene G2FUF-18025 BioCyc
Ensembl Genes ENSRNOG00000003545 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004881 ENTREZGENE
  ENSRNOT00000004881.8 UniProtKB/TrEMBL
  ENSRNOT00000077153.3 UniProtKB/TrEMBL
  ENSRNOT00000098889 ENTREZGENE
  ENSRNOT00000098889.2 UniProtKB/TrEMBL
  ENSRNOT00000140387 ENTREZGENE
  ENSRNOT00000140387.1 UniProtKB/TrEMBL
  ENSRNOT00000150460 ENTREZGENE
  ENSRNOT00000150460.1 UniProtKB/TrEMBL
  ENSRNOT00000159999.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.860 UniProtKB/TrEMBL
  3.40.532.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125859 IMAGE-MGC_LOAD
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C12 UniProtKB/TrEMBL
  Peptidase_C12_UCH_sf UniProtKB/TrEMBL
  Ubiquitinyl_hydrolase_UCH37 UniProtKB/TrEMBL
  UCH37 UniProtKB/TrEMBL
  UCH_C UniProtKB/TrEMBL
MGC_CLONE MGC:105874 IMAGE-MGC_LOAD
NCBI Gene 360853 ENTREZGENE
PANTHER Peptidase_C12 UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 UniProtKB/TrEMBL
Pfam Peptidase_C12 UniProtKB/TrEMBL
  UCH_C UniProtKB/TrEMBL
PhenoGen Uchl5 PhenoGen
PIRSF Ubiquitinyl_hydrolase_UCH37 UniProtKB/TrEMBL
PRINTS UBCTHYDRLASE UniProtKB/TrEMBL
PROSITE UCH_DOMAIN UniProtKB/TrEMBL
  ULD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003545 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A0G2K2A5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL10 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L7V8_RAT UniProtKB/TrEMBL
  A0ABK0LG34_RAT UniProtKB/TrEMBL
  A0ABK0LGX9_RAT UniProtKB/TrEMBL
  A6ICP4 ENTREZGENE, UniProtKB/TrEMBL
  Q5HZY3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Uchl5  ubiquitin C-terminal hydrolase L5  Uchl5  ubiquitin carboxyl-terminal hydrolase L5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Uchl5  ubiquitin carboxyl-terminal hydrolase L5  Uchl5  ubiquitin carboxyl-terminal esterase L5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Uchl5  ubiquitin carboxyl-terminal esterase L5  Uchl5  ubiquitin carboxyl-terminal hydrolase L5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Uchl5  ubiquitin carboxyl-terminal hydrolase L5  Uchl5_predicted  ubiquitin carboxyl-terminal hydrolase L5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Uchl5_predicted  ubiquitin carboxyl-terminal hydrolase L5 (predicted)      Symbol and Name status set to approved 70820 APPROVED