Rfwd3 (ring finger and WD repeat domain 3) - Rat Genome Database

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Gene: Rfwd3 (ring finger and WD repeat domain 3) Rattus norvegicus
Analyze
Symbol: Rfwd3
Name: ring finger and WD repeat domain 3
RGD ID: 1305243
Description: Predicted to enable MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Predicted to be located in nucleus and site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group W. Orthologous to human RFWD3 (ring finger and WD repeat domain 3); INTERACTS WITH bisphenol A; cobalt dichloride; ochratoxin A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase RFWD3-like; LOC361409; NEWGENE_1305243; RGD1305243; similar to hypothetical protein FLJ34389
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,145,221 - 56,177,871 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,145,221 - 56,177,815 (-)EnsemblGRCr8
mRatBN7.21939,235,883 - 39,268,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,236,787 - 39,268,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,040,108 - 46,073,335 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,693,440 - 46,726,667 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,993,968 - 49,026,584 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,477,121 - 43,499,068 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,964,586 - 42,972,101 (+)Ensemblrn6Rnor6.0
Rnor_5.01954,289,116 - 54,310,716 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01953,787,638 - 53,798,031 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,190,144 - 41,222,888 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,624,795 - 38,656,471 (-)NCBICelera
RGSC_v3.11941,195,928 - 41,258,147 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20173098   PMID:21504906   PMID:26474068   PMID:28575657   PMID:28575658   PMID:28691929  


Genomics

Comparative Map Data
Rfwd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,145,221 - 56,177,871 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,145,221 - 56,177,815 (-)EnsemblGRCr8
mRatBN7.21939,235,883 - 39,268,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,236,787 - 39,268,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,040,108 - 46,073,335 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,693,440 - 46,726,667 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,993,968 - 49,026,584 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,477,121 - 43,499,068 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,964,586 - 42,972,101 (+)Ensemblrn6Rnor6.0
Rnor_5.01954,289,116 - 54,310,716 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01953,787,638 - 53,798,031 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,190,144 - 41,222,888 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,624,795 - 38,656,471 (-)NCBICelera
RGSC_v3.11941,195,928 - 41,258,147 (-)NCBI
Cytogenetic Map19q12NCBI
RFWD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381674,621,399 - 74,666,877 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1674,621,393 - 74,666,912 (-)Ensemblhg38GRCh38
GRCh371674,655,297 - 74,700,775 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,212,798 - 73,258,280 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1658,948,218 - 58,993,367 (-)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1660,404,913 - 60,450,359 (-)NCBIHuRef
CHM1_11676,067,246 - 76,112,724 (-)NCBICHM1_1
T2T-CHM13v2.01680,668,129 - 80,713,619 (-)NCBIT2T-CHM13v2.0
Rfwd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,997,576 - 112,026,854 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8111,997,576 - 112,026,854 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388111,270,944 - 111,300,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,270,944 - 111,300,222 (-)Ensemblmm10GRCm38
MGSCv378113,794,844 - 113,824,122 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368114,157,617 - 114,186,895 (-)NCBIMGSCv36mm8
Celera8115,495,609 - 115,526,062 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.98NCBI
Rfwd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554842,824,422 - 2,858,283 (+)Ensembl
ChiLan1.0NW_0049554842,824,057 - 2,857,321 (+)NCBIChiLan1.0ChiLan1.0
RFWD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21884,335,645 - 84,381,765 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11690,257,688 - 90,303,816 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01655,187,178 - 55,233,265 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11674,541,448 - 74,586,951 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1674,541,450 - 74,586,951 (-)EnsemblpanPan2panpan1.1
RFWD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1575,960,909 - 76,001,088 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl575,960,955 - 76,000,467 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha575,936,552 - 75,976,729 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0576,317,468 - 76,357,876 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl576,317,515 - 76,357,874 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,220,089 - 76,259,587 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0576,042,941 - 76,083,200 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,535,192 - 76,575,417 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rfwd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,002,371 - 36,042,495 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,544,953 - 23,586,740 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,544,974 - 23,586,716 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RFWD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl612,952,253 - 12,994,052 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1612,952,243 - 12,994,053 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,883,190 - 12,925,878 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RFWD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,045,408 - 53,092,214 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl553,045,465 - 53,092,494 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366632332,173 - 78,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rfwd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,225,293 - 12,253,246 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474612,217,287 - 12,252,183 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rfwd3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11730,967,881 - 31,000,388 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rfwd3
122 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH130976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,236,824 - 39,237,042 (-)MAPPERmRatBN7.2
Rnor_6.01942,970,735 - 42,970,952NCBIRnor6.0
Rnor_5.01953,797,776 - 53,797,993UniSTSRnor5.0
RGSC_v3.41941,191,086 - 41,191,303UniSTSRGSC3.4
Celera1938,625,737 - 38,625,954UniSTS
RH 3.4 Map19485.4UniSTS
Cytogenetic Map19q12UniSTS
BE117599  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,244,279 - 39,244,471 (+)MAPPERmRatBN7.2
Rnor_6.01943,474,742 - 43,474,931NCBIRnor6.0
Rnor_5.01954,286,248 - 54,286,437UniSTSRnor5.0
RGSC_v3.41941,198,540 - 41,198,731UniSTSRGSC3.4
Celera1938,633,194 - 38,633,384UniSTS
RH 3.4 Map19485.4UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1956,145,221 - 56,177,815 (-)Ensembl
mRatBN7.2 Ensembl1939,236,787 - 39,268,479 (-)Ensembl
Rnor_6.0 Ensembl1942,964,586 - 42,972,101 (+)Ensembl
RefSeq Acc Id: NM_001402201   ⟹   NP_001389130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,145,221 - 56,177,815 (-)NCBI
mRatBN7.21939,235,883 - 39,268,479 (-)NCBI
RefSeq Acc Id: NM_001402202   ⟹   NP_001389131
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,145,221 - 56,177,815 (-)NCBI
mRatBN7.21939,235,883 - 39,268,479 (-)NCBI
RefSeq Acc Id: XM_063277726   ⟹   XP_063133796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,145,221 - 56,177,871 (-)NCBI
RefSeq Acc Id: XM_063277727   ⟹   XP_063133797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,145,221 - 56,177,871 (-)NCBI
RefSeq Acc Id: XM_063277728   ⟹   XP_063133798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,145,221 - 56,177,534 (-)NCBI
RefSeq Acc Id: NP_001389130   ⟸   NM_001402201
- Peptide Label: isoform 1
- UniProtKB: A6IZ86 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001389131   ⟸   NM_001402202
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A1A6 (UniProtKB/TrEMBL),   A6IZ86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133797   ⟸   XM_063277727
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133796   ⟸   XM_063277726
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133798   ⟸   XM_063277728
- Peptide Label: isoform X3
Protein Domains
RING-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305243 AgrOrtholog
Ensembl Genes ENSRNOG00000051461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078854 ENTREZGENE
  ENSRNOT00000078854.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro RFWD3 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WD40_RFWD3 UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene Rfwd3 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE RFWD3 UniProtKB/TrEMBL
  PTHR16047 UniProtKB/TrEMBL
Pfam WD40_RFWD3 UniProtKB/TrEMBL
  zf-RING_2 UniProtKB/TrEMBL
PhenoGen Rfwd3 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051461 RatGTEx
SMART RING UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A8I6A1A6 ENTREZGENE, UniProtKB/TrEMBL
  A6IZ86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rfwd3  ring finger and WD repeat domain 3  NEWGENE_1305243  ring finger and WD repeat domain 3  Data merged from RGD:9168979 737654 PROVISIONAL
2014-08-25 NEWGENE_1305243  ring finger and WD repeat domain 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Rfwd3  ring finger and WD repeat domain 3  RGD1305243_predicted  similar to hypothetical protein FLJ34389 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305243_predicted  similar to hypothetical protein FLJ34389 (predicted)  LOC361409_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361409_predicted  similar to hypothetical protein FLJ34389 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL