Ttc12 (tetratricopeptide repeat domain 12) - Rat Genome Database

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Gene: Ttc12 (tetratricopeptide repeat domain 12) Rattus norvegicus
Analyze
Symbol: Ttc12
Name: tetratricopeptide repeat domain 12
RGD ID: 1303264
Description: Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be located in cytosol; nuclear membrane; and plasma membrane. Predicted to be active in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94947; tetratricopeptide repeat protein 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,696,381 - 58,743,857 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl858,696,385 - 58,742,717 (-)EnsemblGRCr8
mRatBN7.2849,799,916 - 49,847,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,799,920 - 49,847,087 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx855,304,063 - 55,349,980 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,582,939 - 53,628,859 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,447,199 - 51,493,116 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd859,518,530 - 59,564,284 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive861,717,385 - 61,763,141 (-)NCBILyon_Normotensive
Lyon_Hypertensive860,148,058 - 60,193,814 (-)NCBILyon_Hypertensive
F344_StmMcwi851,551,353 - 51,597,111 (-)NCBIF344_StmMcwi
Rnor_6.0853,770,685 - 53,818,873 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,770,681 - 53,816,447 (-)Ensemblrn6Rnor6.0
Rnor_5.0852,390,855 - 52,437,800 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4852,734,792 - 52,799,135 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera849,351,775 - 49,397,613 (-)NCBICelera
RGSC_v3.1852,753,849 - 52,818,189 (-)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. Bidwell LC, etal., Psychopharmacology (Berl). 2015 Apr;232(7):1177-86. doi: 10.1007/s00213-014-3748-2. Epub 2014 Oct 3.
2. TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. Ducci F, etal., Biol Psychiatry. 2011 Apr 1;69(7):650-60. doi: 10.1016/j.biopsych.2010.09.055. Epub 2010 Dec 17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Gelernter J, etal., Hum Mol Genet. 2006 Dec 15;15(24):3498-507. doi: 10.1093/hmg/ddl426. Epub 2006 Nov 3.
5. A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. Macare C, etal., Eur Neuropsychopharmacol. 2018 Oct;28(10):1103-1114. doi: 10.1016/j.euroneuro.2018.07.101. Epub 2018 Aug 11.
6. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. Nelson EC, etal., JAMA Psychiatry. 2013 Mar;70(3):325-33. doi: 10.1001/jamapsychiatry.2013.282.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. Hypermethylation of TTC12 gene in acute lymphoblastic leukemia. Wattanawaraporn R, etal., Leukemia. 2007 Nov;21(11):2370-3. doi: 10.1038/sj.leu.2404876. Epub 2007 Jul 26.
12. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Yang BZ, etal., Alcohol Clin Exp Res. 2008 Dec;32(12):2117-27. doi: 10.1111/j.1530-0277.2008.00800.x. Epub 2008 Sep 30.
13. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. Yang BZ, etal., Hum Mol Genet. 2007 Dec 1;16(23):2844-53. doi: 10.1093/hmg/ddm240. Epub 2007 Aug 30.
Additional References at PubMed
PMID:23300604  


Genomics

Comparative Map Data
Ttc12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,696,381 - 58,743,857 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl858,696,385 - 58,742,717 (-)EnsemblGRCr8
mRatBN7.2849,799,916 - 49,847,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,799,920 - 49,847,087 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx855,304,063 - 55,349,980 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,582,939 - 53,628,859 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,447,199 - 51,493,116 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd859,518,530 - 59,564,284 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive861,717,385 - 61,763,141 (-)NCBILyon_Normotensive
Lyon_Hypertensive860,148,058 - 60,193,814 (-)NCBILyon_Hypertensive
F344_StmMcwi851,551,353 - 51,597,111 (-)NCBIF344_StmMcwi
Rnor_6.0853,770,685 - 53,818,873 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,770,681 - 53,816,447 (-)Ensemblrn6Rnor6.0
Rnor_5.0852,390,855 - 52,437,800 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4852,734,792 - 52,799,135 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera849,351,775 - 49,397,613 (-)NCBICelera
RGSC_v3.1852,753,849 - 52,818,189 (-)NCBI
Cytogenetic Map8q23NCBI
TTC12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,314,583 - 113,373,297 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11113,314,579 - 113,383,544 (+)Ensemblhg38GRCh38
GRCh3711113,185,305 - 113,244,019 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,690,461 - 112,742,324 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411112,690,538 - 112,749,226NCBI
Celera11110,338,185 - 110,390,045 (+)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,112,836 - 109,164,715 (+)NCBIHuRef
CHM1_111113,068,217 - 113,120,081 (+)NCBICHM1_1
T2T-CHM13v2.011113,325,023 - 113,383,787 (+)NCBIT2T-CHM13v2.0
Ttc12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,348,261 - 49,397,572 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl949,348,263 - 49,397,525 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38949,436,961 - 49,486,275 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,436,963 - 49,486,225 (-)Ensemblmm10GRCm38
MGSCv37949,245,066 - 49,294,330 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36949,189,191 - 49,238,455 (-)NCBIMGSCv36mm8
Celera946,737,486 - 46,784,579 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.83NCBI
Ttc12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541214,945,116 - 15,011,708 (+)Ensembl
ChiLan1.0NW_00495541214,945,237 - 15,011,560 (+)NCBIChiLan1.0ChiLan1.0
TTC12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29114,058,945 - 114,110,778 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111115,153,311 - 115,205,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,194,610 - 108,253,161 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,037,530 - 112,089,324 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,037,620 - 112,106,537 (+)EnsemblpanPan2panpan1.1
TTC12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,829,873 - 19,874,934 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,829,874 - 19,873,145 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha519,751,625 - 19,796,713 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0519,850,774 - 19,895,839 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,850,775 - 19,894,042 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,913,255 - 19,958,310 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,814,463 - 19,859,535 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,862,293 - 19,907,355 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ttc12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,463,892 - 95,524,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366121,194,662 - 1,241,624 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366121,194,899 - 1,241,624 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTC12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl940,988,920 - 41,046,900 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1940,988,881 - 41,032,928 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2945,823,490 - 45,867,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTC12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11104,675,076 - 104,742,326 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1104,675,768 - 104,731,843 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604321,273,060 - 21,331,890 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttc12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247848,655,408 - 8,752,397 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247848,655,543 - 8,751,307 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ttc12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1843,923,675 - 43,970,945 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ttc12
370 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:28
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000011454
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
BE114671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,826,221 - 49,826,376 (+)MAPPERmRatBN7.2
Rnor_6.0853,796,990 - 53,797,144NCBIRnor6.0
Rnor_5.0852,416,928 - 52,417,082UniSTSRnor5.0
RGSC_v3.4852,779,670 - 52,779,824UniSTSRGSC3.4
Celera849,378,154 - 49,378,308UniSTS
RH 3.4 Map8536.1UniSTS
Cytogenetic Map8q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 44 59 6 308 144 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011454   ⟹   ENSRNOP00000011454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl858,696,385 - 58,742,144 (-)Ensembl
mRatBN7.2 Ensembl849,799,920 - 49,845,685 (-)Ensembl
Rnor_6.0 Ensembl853,770,681 - 53,816,447 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102297   ⟹   ENSRNOP00000097363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl858,696,385 - 58,742,717 (-)Ensembl
mRatBN7.2 Ensembl849,799,920 - 49,847,087 (-)Ensembl
RefSeq Acc Id: NM_001004246   ⟹   NP_001004246
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,696,381 - 58,742,144 (-)NCBI
mRatBN7.2849,799,916 - 49,845,685 (-)NCBI
Dahl_SR_JrHsd859,518,530 - 59,564,284 (-)NCBI
Lyon_Normotensive861,717,385 - 61,763,141 (-)NCBI
Lyon_Hypertensive860,148,058 - 60,193,814 (-)NCBI
F344_StmMcwi851,551,353 - 51,597,111 (-)NCBI
Rnor_6.0853,770,685 - 53,816,453 (-)NCBI
Rnor_5.0852,390,855 - 52,437,800 (-)NCBI
RGSC_v3.4852,734,792 - 52,799,135 (-)RGD
Celera849,351,775 - 49,397,613 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243004   ⟹   XP_006243066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,696,381 - 58,743,857 (-)NCBI
mRatBN7.2849,799,916 - 49,846,731 (-)NCBI
Rnor_6.0853,770,685 - 53,816,917 (-)NCBI
Rnor_5.0852,390,855 - 52,437,800 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243005   ⟹   XP_006243067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,696,381 - 58,743,689 (-)NCBI
mRatBN7.2849,799,916 - 49,847,222 (-)NCBI
Rnor_6.0853,770,685 - 53,817,940 (-)NCBI
Rnor_5.0852,390,855 - 52,437,800 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001004246   ⟸   NM_001004246
- UniProtKB: Q68FR0 (UniProtKB/TrEMBL),   F7FHS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243067   ⟸   XM_006243005
- Peptide Label: isoform X2
- UniProtKB: Q68FR0 (UniProtKB/TrEMBL),   F7FHS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243066   ⟸   XM_006243004
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GMH4 (UniProtKB/TrEMBL),   F7FHS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011454   ⟸   ENSRNOT00000011454
Ensembl Acc Id: ENSRNOP00000097363   ⟸   ENSRNOT00000102297

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FR0-F1-model_v2 AlphaFold Q68FR0 1-704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303264 AgrOrtholog
BioCyc Gene G2FUF-30582 BioCyc
Ensembl Genes ENSRNOG00000008595 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011454 ENTREZGENE
  ENSRNOT00000011454.7 UniProtKB/TrEMBL
  ENSRNOT00000102297 ENTREZGENE
  ENSRNOT00000102297.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113087 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  TPR_2 UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  TTC12 UniProtKB/TrEMBL
KEGG Report rno:300696 UniProtKB/TrEMBL
MGC_CLONE MGC:94947 IMAGE-MGC_LOAD
NCBI Gene 300696 ENTREZGENE
PANTHER PTHR46540 UniProtKB/TrEMBL
  TETRATRICOPEPTIDE REPEAT PROTEIN 12 UniProtKB/TrEMBL
Pfam TPR_1 UniProtKB/TrEMBL
  TPR_2 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PhenoGen Ttc12 PhenoGen
PROSITE TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008595 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A8I6GMH4 ENTREZGENE, UniProtKB/TrEMBL
  A6J4C0_RAT UniProtKB/TrEMBL
  A6J4C1_RAT UniProtKB/TrEMBL
  F7FHS8 ENTREZGENE, UniProtKB/TrEMBL
  Q68FR0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ttc12  tetratricopeptide repeat domain 12      Symbol and Name status set to approved 1299863 APPROVED
2005-09-30 Ttc12        Symbol and Name status set to provisional 70820 PROVISIONAL