Abhd5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase) - Rat Genome Database

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Gene: Abhd5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase) Rattus norvegicus
Analyze
Symbol: Abhd5
Name: abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
RGD ID: 1303237
Description: Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity; carboxylic ester hydrolase activity; and lipase activator activity. Acts upstream of or within lipid metabolic process. Located in lipid droplet. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to human ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; abhydrolase domain containing 5; abhydrolase domain-containing protein 5; CGI-58; CGI-58-like protein; lipid droplet-binding protein CGI-58; LOC316122
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88130,877,834 - 130,903,947 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8130,877,703 - 130,903,947 (+)EnsemblGRCr8
mRatBN7.28122,000,241 - 122,026,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,000,389 - 122,026,447 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8127,595,594 - 127,619,764 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08125,794,662 - 125,818,828 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08123,620,818 - 123,645,005 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08130,973,222 - 131,001,448 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8130,973,201 - 131,001,458 (+)Ensemblrn6Rnor6.0
Rnor_5.08130,136,551 - 130,164,777 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48122,148,937 - 122,173,147 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8121,121,379 - 121,145,558 (+)NCBICelera
RGSC_v3.18122,168,673 - 122,192,884 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
levonorgestrel  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
testosterone undecanoate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS)
lipid droplet  (IBA,IDA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. PNPLA3/adiponutrin functions in lipid droplet formation. Chamoun Z, etal., Biol Cell. 2013 May;105(5):219-33. doi: 10.1111/boc.201200036. Epub 2013 Apr 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome. Lefevre C, etal., Am J Hum Genet. 2001 Nov;69(5):1002-12. Epub 2001 Oct 2.
4. Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. MacPherson RE, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Apr 15;304(8):R644-50. doi: 10.1152/ajpregu.00418.2012. Epub 2013 Feb 13.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield. Ou J, etal., Nat Commun. 2019 Mar 6;10(1):1078. doi: 10.1038/s41467-019-08902-x.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. Yamaguchi T, etal., J Biol Chem 2004 Jul 16;279(29):30490-7. Epub 2004 May 10.
Additional References at PubMed
PMID:12477932   PMID:16679289   PMID:17074755   PMID:17308334   PMID:18606822   PMID:21148142   PMID:21498505   PMID:22383684   PMID:27590244  


Genomics

Comparative Map Data
Abhd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88130,877,834 - 130,903,947 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8130,877,703 - 130,903,947 (+)EnsemblGRCr8
mRatBN7.28122,000,241 - 122,026,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,000,389 - 122,026,447 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8127,595,594 - 127,619,764 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08125,794,662 - 125,818,828 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08123,620,818 - 123,645,005 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08130,973,222 - 131,001,448 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8130,973,201 - 131,001,458 (+)Ensemblrn6Rnor6.0
Rnor_5.08130,136,551 - 130,164,777 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48122,148,937 - 122,173,147 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8121,121,379 - 121,145,558 (+)NCBICelera
RGSC_v3.18122,168,673 - 122,192,884 (+)NCBI
Cytogenetic Map8q32NCBI
ABHD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38343,690,870 - 43,734,371 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl343,690,108 - 43,734,371 (+)Ensemblhg38GRCh38
GRCh37343,732,362 - 43,775,863 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36343,707,379 - 43,735,296 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34343,707,378 - 43,735,295NCBI
Celera343,670,699 - 43,702,531 (+)NCBICelera
Cytogenetic Map3p21.33NCBI
HuRef343,775,563 - 43,807,394 (+)NCBIHuRef
CHM1_1343,682,530 - 43,714,373 (+)NCBICHM1_1
T2T-CHM13v2.0343,706,458 - 43,749,966 (+)NCBIT2T-CHM13v2.0
Abhd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,180,681 - 122,210,589 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9122,180,673 - 122,210,589 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389122,351,616 - 122,381,524 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9122,351,608 - 122,381,524 (+)Ensemblmm10GRCm38
MGSCv379122,260,734 - 122,290,641 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369122,200,314 - 122,230,221 (+)NCBIMGSCv36mm8
Celera9122,816,005 - 122,845,910 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.03NCBI
Abhd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542027,482,709 - 27,508,360 (-)Ensembl
ChiLan1.0NW_00495542027,484,500 - 27,508,360 (-)NCBIChiLan1.0ChiLan1.0
ABHD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2243,637,759 - 43,677,319 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1343,642,524 - 43,672,420 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0343,580,752 - 43,612,637 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1344,640,215 - 44,669,885 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl344,640,215 - 44,669,885 (+)EnsemblpanPan2panpan1.1
ABHD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1232,584,813 - 2,619,204 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl232,586,678 - 2,737,583 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha232,622,390 - 2,656,835 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0232,837,297 - 2,871,778 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,837,304 - 2,871,784 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1232,673,959 - 2,708,185 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0232,804,668 - 2,839,064 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0232,772,747 - 2,807,406 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abhd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118199,292,423 - 199,319,725 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366951,644,581 - 1,672,117 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366951,644,758 - 1,672,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1327,006,208 - 27,056,744 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11327,006,331 - 27,053,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21329,834,219 - 29,881,698 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q12-q22NCBI
ABHD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,109,699 - 5,139,021 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl225,109,765 - 5,137,673 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041162,051,858 - 162,081,174 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abhd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473076,414,626 - 76,436,156 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473076,414,732 - 76,436,177 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Abhd5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18113,494,249 - 113,526,763 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:29
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000000239
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH129832  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28122,024,595 - 122,024,792 (+)MAPPERmRatBN7.2
Rnor_6.08130,999,597 - 130,999,793NCBIRnor6.0
Rnor_5.08130,162,926 - 130,163,122UniSTSRnor5.0
RGSC_v3.48122,173,190 - 122,173,386UniSTSRGSC3.4
Celera8121,145,601 - 121,145,797UniSTS
RH 3.4 Map81262.9UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000239   ⟹   ENSRNOP00000000239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8130,877,703 - 130,903,946 (+)Ensembl
mRatBN7.2 Ensembl8122,000,389 - 122,026,447 (+)Ensembl
Rnor_6.0 Ensembl8130,973,201 - 131,001,458 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110511   ⟹   ENSRNOP00000077546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8130,877,912 - 130,903,947 (+)Ensembl
mRatBN7.2 Ensembl8122,000,409 - 122,026,447 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116075   ⟹   ENSRNOP00000077694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,012,901 - 122,026,447 (+)Ensembl
RefSeq Acc Id: NM_212524   ⟹   NP_997689
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,872 - 130,902,053 (+)NCBI
mRatBN7.28122,000,369 - 122,024,553 (+)NCBI
Rnor_6.08130,973,222 - 130,999,554 (+)NCBI
Rnor_5.08130,136,551 - 130,164,777 (+)NCBI
RGSC_v3.48122,148,937 - 122,173,147 (+)RGD
Celera8121,121,379 - 121,145,558 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244107   ⟹   XP_006244169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,926 - 130,903,947 (+)NCBI
mRatBN7.28122,000,332 - 122,026,447 (+)NCBI
Rnor_6.08130,973,231 - 131,001,448 (+)NCBI
Rnor_5.08130,136,551 - 130,164,777 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244108   ⟹   XP_006244170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,878,156 - 130,903,947 (+)NCBI
mRatBN7.28122,000,568 - 122,026,447 (+)NCBI
Rnor_6.08130,973,814 - 131,001,448 (+)NCBI
Rnor_5.08130,136,551 - 130,164,777 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595704   ⟹   XP_017451193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,848 - 130,903,947 (+)NCBI
mRatBN7.28122,000,339 - 122,026,447 (+)NCBI
Rnor_6.08130,973,240 - 131,001,448 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081671   ⟹   XP_038937599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,927 - 130,903,947 (+)NCBI
mRatBN7.28122,000,343 - 122,026,447 (+)NCBI
RefSeq Acc Id: XM_039081672   ⟹   XP_038937600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,878,156 - 130,903,947 (+)NCBI
mRatBN7.28122,000,568 - 122,026,447 (+)NCBI
RefSeq Acc Id: XR_005487859
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,834 - 130,898,415 (+)NCBI
mRatBN7.28122,000,241 - 122,020,914 (+)NCBI
RefSeq Acc Id: NP_997689   ⟸   NM_212524
- UniProtKB: Q6QA69 (UniProtKB/Swiss-Prot),   A6I477 (UniProtKB/TrEMBL),   A0A8L2PZE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244169   ⟸   XM_006244107
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244170   ⟸   XM_006244108
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451193   ⟸   XM_017595704
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000239   ⟸   ENSRNOT00000000239
RefSeq Acc Id: XP_038937599   ⟸   XM_039081671
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937600   ⟸   XM_039081672
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077546   ⟸   ENSRNOT00000110511
Ensembl Acc Id: ENSRNOP00000077694   ⟸   ENSRNOT00000116075
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QA69-F1-model_v2 AlphaFold Q6QA69 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696396
Promoter ID:EPDNEW_R6921
Type:initiation region
Name:Abhd5_1
Description:abhydrolase domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08130,973,207 - 130,973,267EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303237 AgrOrtholog
BioCyc Gene G2FUF-28652 BioCyc
Ensembl Genes ENSRNOG00000000221 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000239 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132142 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  AB_hydrolase_1 UniProtKB/Swiss-Prot
KEGG Report rno:316122 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156550 IMAGE-MGC_LOAD
NCBI Gene 316122 ENTREZGENE
PANTHER 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ABHD5 UniProtKB/Swiss-Prot
  RE40534P-RELATED UniProtKB/Swiss-Prot
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot
PhenoGen Abhd5 PhenoGen
PRINTS ABHYDROLASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000221 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A8I5Y666 ENTREZGENE
  A0A8I5Y7N9_RAT UniProtKB/TrEMBL
  A0A8L2PZE5 ENTREZGENE, UniProtKB/TrEMBL
  A0JPK5_RAT UniProtKB/TrEMBL
  A6I477 ENTREZGENE, UniProtKB/TrEMBL
  ABHD5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-13 Abhd5  abhydrolase domain containing 5, lysophosphatidic acid acyltransferase  Abhd5  abhydrolase domain containing 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-09 Abhd5  abhydrolase domain containing 5  LOC316122  CGI-58-like protein  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-07-14 LOC316122  CGI-58-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mislocalization may be involved in pathogenesis of Chanarin-Dorfman syndrome in humans 1303992
gene_physical_interaction directly interacts with perilipin in lipid droplets; also binds to ADRP 1303992