Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Phactr2 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PHACTR2 mRNA | CTD | PMID:22079256 | Phactr2 | Rat | 1,2-dichloroethane | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of PHACTR2 mRNA | CTD | PMID:28960355 | Phactr2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Phactr2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PHACTR2 mRNA | CTD | PMID:20702594 | Phactr2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PHACTR2 mRNA | CTD | PMID:33956508 | Phactr2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PHACTR2 mRNA | CTD | PMID:22298810 | Phactr2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PHACTR2 mRNA | CTD | PMID:22298810 | Phactr2 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | affects expression | ISO | Phactr2 (Mus musculus) | 6480464 | 2,3,7,8-tetrachlorodibenzofuran affects the expression of PHACTR2 mRNA | CTD | PMID:20702594 | Phactr2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Phactr2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of PHACTR2 mRNA | CTD | PMID:30951980 | Phactr2 | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | Phactr2 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of PHACTR2 promoter | CTD | PMID:33297965 | Phactr2 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PHACTR2 mRNA | CTD | PMID:28973697 | Phactr2 | Rat | 5-azacytidine | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Azacitidine results in increased expression of PHACTR2 mRNA | CTD | PMID:20823114 | Phactr2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PHACTR2 mRNA | CTD | PMID:25825206 | Phactr2 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of PHACTR2 mRNA | CTD | PMID:31881176 | Phactr2 | Rat | all-trans-retinoic acid | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PHACTR2 mRNA | CTD | PMID:33167477 | Phactr2 | Rat | aristolochic acid A | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PHACTR2 mRNA | CTD | PMID:33212167 | Phactr2 | Rat | arsenite(3-) | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PHACTR2 mRNA] | CTD | PMID:32406909 | Phactr2 | Rat | atrazine | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of PHACTR2 mRNA | CTD | PMID:22378314 | Phactr2 | Rat | benzo[a]pyrene | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of PHACTR2 mRNA | CTD | PMID:19770486 | Phactr2 | Rat | benzo[a]pyrene | affects methylation | ISO | PHACTR2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PHACTR2 promoter | CTD | PMID:27901495 | Phactr2 | Rat | benzo[a]pyrene | increases methylation | ISO | PHACTR2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PHACTR2 3' UTR | CTD | PMID:27901495 | Phactr2 | Rat | benzo[a]pyrene | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PHACTR2 mRNA | CTD | PMID:20106945|PMID:21632981 | Phactr2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PHACTR2 mRNA | CTD | PMID:19150397 | Phactr2 | Rat | beta-lapachone | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of PHACTR2 mRNA | CTD | PMID:38218311 | Phactr2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PHACTR2 mRNA | CTD | PMID:25181051 | Phactr2 | Rat | bisphenol A | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PHACTR2 mRNA | CTD | PMID:33221593 | Phactr2 | Rat | bisphenol A | decreases methylation | ISO | Phactr2 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of PHACTR2 intron | CTD | PMID:30044229 | Phactr2 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PHACTR2 gene | CTD | PMID:28505145 | Phactr2 | Rat | bisphenol F | increases expression | ISO | Phactr2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of PHACTR2 mRNA | CTD | PMID:30951980 | Phactr2 | Rat | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of PHACTR2 protein | CTD | PMID:28903499 | Phactr2 | Rat | Butylbenzyl phthalate | increases methylation | ISO | Phactr2 (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of PHACTR2 5' UTR | CTD | PMID:28392331 | Phactr2 | Rat | cadmium dichloride | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of PHACTR2 mRNA | CTD | PMID:18560533 | Phactr2 | Rat | cadmium dichloride | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of PHACTR2 mRNA | CTD | PMID:38382870 | Phactr2 | Rat | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of PHACTR2 promoter | CTD | PMID:22457795 | Phactr2 | Rat | caffeine | decreases phosphorylation | ISO | PHACTR2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PHACTR2 protein | CTD | PMID:35688186 | Phactr2 | Rat | carbamazepine | affects expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of PHACTR2 mRNA | CTD | PMID:25979313 | Phactr2 | Rat | carbon nanotube | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of PHACTR2 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Phactr2 | Rat | CGP 52608 | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PHACTR2 gene] | CTD | PMID:28238834 | Phactr2 | Rat | chlorpyrifos | increases expression | ISO | Phactr2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of PHACTR2 mRNA | CTD | PMID:37019170 | Phactr2 | Rat | chromium(6+) | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | chromium hexavalent ion results in decreased expression of PHACTR2 mRNA | CTD | PMID:30690063 | Phactr2 | Rat | cobalt dichloride | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PHACTR2 mRNA | CTD | PMID:19320972 | Phactr2 | Rat | coumestrol | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PHACTR2 mRNA | CTD | PMID:19167446 | Phactr2 | Rat | coumestrol | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of PHACTR2 mRNA | CTD | PMID:19167446 | Phactr2 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of PHACTR2 mRNA | CTD | PMID:26577399 | Phactr2 | Rat | cyclosporin A | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PHACTR2 mRNA | CTD | PMID:20106945|PMID:25562108|PMID:27989131 | Phactr2 | Rat | cytarabine | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of PHACTR2 mRNA | CTD | PMID:21198554 | Phactr2 | Rat | Dibutyl phosphate | affects expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PHACTR2 mRNA | CTD | PMID:37042841 | Phactr2 | Rat | dibutyl phthalate | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of PHACTR2 mRNA | CTD | PMID:21266533 | Phactr2 | Rat | dioxygen | multiple interactions | ISO | Phactr2 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PHACTR2 mRNA | CTD | PMID:30529165 | Phactr2 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PHACTR2 mRNA | CTD | PMID:21551480 | Phactr2 | Rat | dorsomorphin | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Phactr2 | Rat | elemental selenium | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Selenium results in decreased expression of PHACTR2 mRNA | CTD | PMID:19244175 | Phactr2 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of PHACTR2 mRNA | CTD | PMID:29391264 | Phactr2 | Rat | Enterolactone | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PHACTR2 mRNA | CTD | PMID:19167446 | Phactr2 | Rat | ethanol | affects expression | ISO | Phactr2 (Mus musculus) | 6480464 | Ethanol affects the expression of PHACTR2 mRNA | CTD | PMID:30319688 | Phactr2 | Rat | FR900359 | affects phosphorylation | ISO | PHACTR2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PHACTR2 protein | CTD | PMID:37730182 | Phactr2 | Rat | geldanamycin | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of PHACTR2 mRNA | CTD | PMID:26705709 | Phactr2 | Rat | glycidol | increases expression | EXP | | 6480464 | glycidol results in increased expression of PHACTR2 mRNA | CTD | PMID:24395379 | Phactr2 | Rat | lead diacetate | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | lead acetate results in decreased expression of PHACTR2 mRNA | CTD | PMID:22609695 | Phactr2 | Rat | leflunomide | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | leflunomide results in increased expression of PHACTR2 mRNA | CTD | PMID:28988120 | Phactr2 | Rat | methotrexate | affects response to substance | ISO | PHACTR2 (Homo sapiens) | 6480464 | PHACTR2 protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | Phactr2 | Rat | methylmercury chloride | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PHACTR2 mRNA | CTD | PMID:26272509 | Phactr2 | Rat | methylmercury chloride | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Phactr2 | Rat | paracetamol | affects expression | ISO | Phactr2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PHACTR2 mRNA | CTD | PMID:17562736 | Phactr2 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PHACTR2 mRNA | CTD | PMID:33387578 | Phactr2 | Rat | paracetamol | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PHACTR2 mRNA | CTD | PMID:21420995 | Phactr2 | Rat | phenylmercury acetate | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of PHACTR2 mRNA | CTD | PMID:26272509 | Phactr2 | Rat | phenylmercury acetate | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Phactr2 | Rat | pirinixic acid | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Phactr2 | Rat | potassium chromate | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PHACTR2 mRNA | CTD | PMID:22079256 | Phactr2 | Rat | potassium chromate | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PHACTR2 mRNA | CTD | PMID:22079256|PMID:22714537 | Phactr2 | Rat | quercetin | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of PHACTR2 mRNA | CTD | PMID:21632981 | Phactr2 | Rat | SB 431542 | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Phactr2 | Rat | selenium atom | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Selenium results in decreased expression of PHACTR2 mRNA | CTD | PMID:19244175 | Phactr2 | Rat | sodium arsenate | increases expression | ISO | Phactr2 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of PHACTR2 mRNA | CTD | PMID:21795629 | Phactr2 | Rat | sodium arsenite | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PHACTR2 mRNA | CTD | PMID:38568856 | Phactr2 | Rat | sulforaphane | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | sulforaphane results in increased expression of PHACTR2 mRNA | CTD | PMID:26833863 | Phactr2 | Rat | sunitinib | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of PHACTR2 mRNA | CTD | PMID:31533062 | Phactr2 | Rat | tetrachloromethane | affects expression | ISO | Phactr2 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of PHACTR2 mRNA | CTD | PMID:17484886 | Phactr2 | Rat | tetrachloromethane | increases expression | ISO | Phactr2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PHACTR2 mRNA | CTD | PMID:27339419 | Phactr2 | Rat | titanium dioxide | decreases methylation | ISO | Phactr2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of PHACTR2 gene | CTD | PMID:35295148 | Phactr2 | Rat | titanium dioxide | increases methylation | ISO | Phactr2 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of PHACTR2 gene | CTD | PMID:35295148 | Phactr2 | Rat | torcetrapib | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | torcetrapib results in increased expression of PHACTR2 mRNA | CTD | PMID:23228038 | Phactr2 | Rat | trichostatin A | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PHACTR2 mRNA | CTD | PMID:24935251|PMID:26272509 | Phactr2 | Rat | trichostatin A | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Phactr2 | Rat | triphenyl phosphate | affects expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PHACTR2 mRNA | CTD | PMID:37042841 | Phactr2 | Rat | troglitazone | decreases expression | ISO | Phactr2 (Mus musculus) | 6480464 | troglitazone results in decreased expression of PHACTR2 mRNA | CTD | PMID:28973697 | Phactr2 | Rat | valproic acid | decreases methylation | ISO | PHACTR2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PHACTR2 gene | CTD | PMID:29154799 | Phactr2 | Rat | valproic acid | increases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PHACTR2 mRNA | CTD | PMID:28001369 | Phactr2 | Rat | valproic acid | multiple interactions | ISO | PHACTR2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Phactr2 | Rat | valproic acid | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PHACTR2 mRNA | CTD | PMID:23179753|PMID:24935251|PMID:26272509|PMID:29154799 | Phactr2 | Rat | valproic acid | affects expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PHACTR2 mRNA | CTD | PMID:25979313 | Phactr2 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PHACTR2 mRNA | CTD | PMID:19015723 | Phactr2 | Rat | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of PHACTR2 gene | CTD | PMID:31079544 | Phactr2 | Rat | vitamin E | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of PHACTR2 mRNA | CTD | PMID:19244175 | Phactr2 | Rat | vorinostat | decreases expression | ISO | PHACTR2 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of PHACTR2 mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||






















