PHACTR2 (phosphatase and actin regulator 2) - Rat Genome Database

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Gene: PHACTR2 (phosphatase and actin regulator 2) Sus scrofa
Analyze
Symbol: PHACTR2
Name: phosphatase and actin regulator 2
RGD ID: 14108378
Description: ENCODES a protein that exhibits actin binding (inferred); protein phosphatase inhibitor activity (inferred); INVOLVED IN actin cytoskeleton organization (inferred); ASSOCIATED WITH Alzheimer's disease (ortholog); COVID-19 (ortholog); familial hemophagocytic lymphohistiocytosis 4 (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatase and actin regulator 2 tv2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,443,970 - 21,722,922 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,438,744 - 21,723,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2123,765,368 - 23,938,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PHACTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,443,970 - 21,722,922 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,438,744 - 21,723,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2123,765,368 - 23,938,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHACTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386143,536,878 - 143,831,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6143,536,845 - 143,831,185 (+)EnsemblGRCh38hg38GRCh38
GRCh376143,858,015 - 144,152,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366143,971,010 - 144,194,015 (+)NCBINCBI36Build 36hg18NCBI36
Build 346143,971,092 - 144,188,885NCBI
Celera6144,669,714 - 144,892,732 (+)NCBICelera
Cytogenetic Map6q24.2NCBI
HuRef6141,493,526 - 141,716,094 (+)NCBIHuRef
CHM1_16144,192,176 - 144,415,204 (+)NCBICHM1_1
T2T-CHM13v2.06144,729,279 - 145,023,866 (+)NCBIT2T-CHM13v2.0
Phactr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391013,083,461 - 13,350,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1013,083,461 - 13,350,156 (-)EnsemblGRCm39 Ensembl
GRCm381013,207,717 - 13,474,525 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1013,207,717 - 13,474,412 (-)EnsemblGRCm38mm10GRCm38
MGSCv371012,933,201 - 13,043,966 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361012,903,593 - 13,014,358 (-)NCBIMGSCv36mm8
Celera1013,112,086 - 13,221,736 (-)NCBICelera
Cytogenetic Map10A2NCBI
cM Map104.72NCBI
Phactr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819,411,412 - 9,680,648 (-)NCBIGRCr8
mRatBN7.217,591,254 - 7,860,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17,597,927 - 7,860,289 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17,294,367 - 7,406,903 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0113,293,490 - 13,406,030 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017,576,655 - 7,689,192 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.017,352,050 - 7,633,991 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17,355,154 - 7,480,825 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018,990,542 - 9,040,039 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.417,988,527 - 8,102,667 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.117,988,526 - 8,102,667 (-)NCBI
Celera16,086,830 - 6,198,133 (-)NCBICelera
Cytogenetic Map1p13NCBI
Phactr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543616,619,552 - 16,694,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543616,607,279 - 16,690,412 (-)NCBIChiLan1.0ChiLan1.0
PHACTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25163,519,164 - 163,812,984 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16161,414,148 - 161,707,468 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06141,312,850 - 141,602,868 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16146,104,638 - 146,323,645 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6146,174,399 - 146,323,625 (+)Ensemblpanpan1.1panPan2
PHACTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1135,158,678 - 35,348,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl135,088,248 - 35,342,584 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha136,056,282 - 36,244,938 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0135,340,396 - 35,530,115 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl135,268,891 - 35,524,725 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1135,201,547 - 35,390,556 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0135,084,683 - 35,275,814 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0135,396,810 - 35,586,054 (+)NCBIUU_Cfam_GSD_1.0
Phactr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946130,096,980 - 130,292,200 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366252,343,821 - 2,538,326 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366252,336,455 - 2,474,032 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHACTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11329,401,562 - 29,702,719 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1329,401,382 - 29,560,452 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660401,527,693 - 1,840,292 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phactr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475310,456,910 - 10,742,311 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PHACTR2
10076 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 4 1 4 1 10 2 3 2
Low 8 2 1 1 13 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004567   ⟹   ENSSSCP00000004464
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl121,443,977 - 21,576,756 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000026115   ⟹   ENSSSCP00000025783
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl121,461,217 - 21,542,067 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000037187   ⟹   ENSSSCP00000043241
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl121,443,970 - 21,644,343 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000041834   ⟹   ENSSSCP00000053117
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl121,443,970 - 21,722,922 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000048036   ⟹   ENSSSCP00000033100
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl121,443,970 - 21,576,772 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000067369   ⟹   ENSSSCP00000065370
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl121,441,492 - 21,644,195 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000083039   ⟹   ENSSSCP00000063739
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl121,499,403 - 21,576,772 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000083203   ⟹   ENSSSCP00000065217
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl121,443,935 - 21,723,790 (-)Ensembl
RefSeq Acc Id: XM_021087139   ⟹   XP_020942798
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1121,438,744 - 21,723,255 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087148   ⟹   XP_020942807
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1121,438,744 - 21,723,255 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087155   ⟹   XP_020942814
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1121,438,744 - 21,576,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087161   ⟹   XP_020942820
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1121,438,746 - 21,644,271 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087164   ⟹   XP_020942823
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1121,438,746 - 21,577,009 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020942807   ⟸   XM_021087148
- Peptide Label: isoform X2
- UniProtKB: A0A8D1RY78 (UniProtKB/TrEMBL),   A0A8D1HPP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942798   ⟸   XM_021087139
- Peptide Label: isoform X1
- UniProtKB: A0A8D1UB61 (UniProtKB/TrEMBL),   A0A8D1HIG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942814   ⟸   XM_021087155
- Peptide Label: isoform X3
- UniProtKB: A0A481CKM4 (UniProtKB/TrEMBL),   A0A8D2A4T6 (UniProtKB/TrEMBL),   A0A8D1HJF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942820   ⟸   XM_021087161
- Peptide Label: isoform X4
- UniProtKB: A0A287AH56 (UniProtKB/TrEMBL),   A0A8D1RZX6 (UniProtKB/TrEMBL),   A0A8D1HT76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942823   ⟸   XM_021087164
- Peptide Label: isoform X5
- UniProtKB: M3UZ20 (UniProtKB/TrEMBL),   A0A8D1S490 (UniProtKB/TrEMBL),   A0A8D0YIR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000063739   ⟸   ENSSSCT00000083039
RefSeq Acc Id: ENSSSCP00000065217   ⟸   ENSSSCT00000083203
RefSeq Acc Id: ENSSSCP00000025783   ⟸   ENSSSCT00000026115
RefSeq Acc Id: ENSSSCP00000053117   ⟸   ENSSSCT00000041834
RefSeq Acc Id: ENSSSCP00000043241   ⟸   ENSSSCT00000037187
RefSeq Acc Id: ENSSSCP00000004464   ⟸   ENSSSCT00000004567
RefSeq Acc Id: ENSSSCP00000033100   ⟸   ENSSSCT00000048036
RefSeq Acc Id: ENSSSCP00000065370   ⟸   ENSSSCT00000067369


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004132 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00035003679 UniProtKB/TrEMBL
  ENSSSCG00045016507 UniProtKB/TrEMBL
  ENSSSCG00050039229 UniProtKB/TrEMBL
  ENSSSCG00055025510 UniProtKB/TrEMBL
  ENSSSCG00060070830 UniProtKB/TrEMBL
  ENSSSCG00065072007 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004567 ENTREZGENE
  ENSSSCT00000004567.5 UniProtKB/TrEMBL
  ENSSSCT00000026115.3 UniProtKB/TrEMBL
  ENSSSCT00000037187 ENTREZGENE
  ENSSSCT00000037187.3 UniProtKB/TrEMBL
  ENSSSCT00000041834 ENTREZGENE
  ENSSSCT00000041834.3 UniProtKB/TrEMBL
  ENSSSCT00000048036 ENTREZGENE
  ENSSSCT00000048036.3 UniProtKB/TrEMBL
  ENSSSCT00035004578.1 UniProtKB/TrEMBL
  ENSSSCT00035004602.1 UniProtKB/TrEMBL
  ENSSSCT00045028189.1 UniProtKB/TrEMBL
  ENSSSCT00045028272.1 UniProtKB/TrEMBL
  ENSSSCT00045028431.1 UniProtKB/TrEMBL
  ENSSSCT00045028602.1 UniProtKB/TrEMBL
  ENSSSCT00050052946.1 UniProtKB/TrEMBL
  ENSSSCT00055050394.1 UniProtKB/TrEMBL
  ENSSSCT00055050603.1 UniProtKB/TrEMBL
  ENSSSCT00055050805.1 UniProtKB/TrEMBL
  ENSSSCT00055050921.1 UniProtKB/TrEMBL
  ENSSSCT00055050986.1 UniProtKB/TrEMBL
  ENSSSCT00060096787.1 UniProtKB/TrEMBL
  ENSSSCT00065098961.1 UniProtKB/TrEMBL
  ENSSSCT00065099004.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1750 UniProtKB/TrEMBL
  6.10.140.2130 UniProtKB/TrEMBL
InterPro RPEL_repeat UniProtKB/TrEMBL
NCBI Gene PHACTR2 ENTREZGENE
PANTHER PHOSPHATASE AND ACTIN REGULATOR PHACTR UniProtKB/TrEMBL
  PTHR12751:SF5 UniProtKB/TrEMBL
Pfam RPEL UniProtKB/TrEMBL
PROSITE RPEL UniProtKB/TrEMBL
SMART RPEL UniProtKB/TrEMBL
UniProt A0A287AH56 ENTREZGENE, UniProtKB/TrEMBL
  A0A287B9F1_PIG UniProtKB/TrEMBL
  A0A481CKM4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0YIR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HIG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HJF1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HPP7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HT76 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1RY78 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1RZX6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1S490 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UB61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2A4T6 ENTREZGENE, UniProtKB/TrEMBL
  F1S716_PIG UniProtKB/TrEMBL
  I3LNV8_PIG UniProtKB/TrEMBL
  M3UZ20 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91366 ENTREZGENE