Advanced Search (OLGA)

Gene: Kcnk18 (potassium two pore domain channel subfamily K member 18) Rattus norvegicus

Analyze

Symbol:

Kcnk18

Name:

potassium two pore domain channel subfamily K member 18

RGD ID:

1303091

Description:

Predicted to enable calcium-activated potassium channel activity; outward rectifier potassium channel activity; and potassium ion leak channel activity. Predicted to be involved in cellular response to pH; potassium ion export across plasma membrane; and regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in migraine. Orthologous to human KCNK18 (potassium two pore domain channel subfamily K member 18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; potassium channel, two pore domain subfamily K, member 18; tandem-pore K+ (K(2P)) channel; Tresk-2; two-pore-domain potassium channel TRESK

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KCNK18 (potassium two pore domain channel subfamily K member 18)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Kcnk18 (potassium channel, subfamily K, member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kcnk18 (potassium two pore domain channel subfamily K member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KCNK18 (potassium two pore domain channel subfamily K member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KCNK18 (potassium two pore domain channel subfamily K member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kcnk18 (potassium two pore domain channel subfamily K member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KCNK18 (potassium two pore domain channel subfamily K member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KCNK18 (potassium two pore domain channel subfamily K member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kcnk18 (potassium two pore domain channel subfamily K member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Kcnk18 (potassium two pore domain channel subfamily K member 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KCNK18 (potassium two pore domain channel subfamily K member 18)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kcnk18 (potassium channel, subfamily K, member 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kcnk18 (potassium channel, subfamily K, member 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10864	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	twk-48	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	twk-48	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	twk-39	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	twk-39	Alliance	DIOPT (InParanoid\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG43155	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	twk-13	Alliance	DIOPT (Hieranoid\|InParanoid\|PANTHER)
Caenorhabditis elegans (roundworm):	twk-40	Alliance	DIOPT (Hieranoid\|InParanoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG9194	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	twk-28	Alliance	DIOPT (Hieranoid\|InParanoid\|PANTHER)
Drosophila melanogaster (fruit fly):	sand	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	sand	Alliance	DIOPT (OMA\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	twk-7	Alliance	DIOPT (Hieranoid\|InParanoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG42594	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	kcnk18	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kcnk18	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	268,360,738 - 268,375,012 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	268,360,738 - 268,375,012 (+)	Ensembl				GRCr8
mRatBN7.2	1	258,374,671 - 258,388,945 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	258,374,671 - 258,388,945 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	266,580,176 - 266,594,492 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	273,286,195 - 273,300,505 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	265,927,693 - 265,941,666 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	280,383,579 - 280,397,784 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	280,383,579 - 280,397,784 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	287,744,272 - 287,758,268 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	265,749,192 - 265,764,641 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	254,028,695 - 254,042,550 (+)	NCBI		Celera
RGSC_v3.1	1	265,960,270 - 265,975,609 (+)	NCBI
Cytogenetic Map	1	q55	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

migraine (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

alpha-Sanshool (ISO)

arsane (ISO)

arsenic atom (ISO)

barium(0) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

chlorpyrifos (ISO)

gentamycin (EXP)

glyburide (ISO)

lidocaine (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

potassium atom (ISO)

propafenone (ISO)

quinidine (ISO)

quinine (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triethanolamine (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to pH (IEA,ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

potassium ion export across plasma membrane (IEA,ISO)

potassium ion transmembrane transport (IBA,IEA)

potassium ion transport (IEA,ISO,ISS)

regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (IEA,ISO,ISS)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

calcium-activated potassium channel activity (IEA,ISO)

metal ion binding (IEA)

outward rectifier potassium channel activity (IBA,IEA,ISO)

potassium channel activity (IEA)

potassium ion leak channel activity (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family.	Kang D, etal., J Biol Chem 2004 Jul 2;279(27):28063-70. Epub 2004 Apr 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12754259	PMID:14981085	PMID:19716403	PMID:20006580	PMID:23904616	PMID:30327410	PMID:33256222

Genomics

Comparative Map Data

Kcnk18
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	268,360,738 - 268,375,012 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	268,360,738 - 268,375,012 (+)	Ensembl				GRCr8
mRatBN7.2	1	258,374,671 - 258,388,945 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	258,374,671 - 258,388,945 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	266,580,176 - 266,594,492 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	273,286,195 - 273,300,505 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	265,927,693 - 265,941,666 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	280,383,579 - 280,397,784 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	280,383,579 - 280,397,784 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	287,744,272 - 287,758,268 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	265,749,192 - 265,764,641 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	254,028,695 - 254,042,550 (+)	NCBI		Celera
RGSC_v3.1	1	265,960,270 - 265,975,609 (+)	NCBI
Cytogenetic Map	1	q55	NCBI

KCNK18
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	117,197,489 - 117,210,299 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	117,196,957 - 117,210,752 (+)	Ensembl			hg38	GRCh38
GRCh37	10	118,957,000 - 118,969,810 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	118,946,990 - 118,959,800 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	118,946,989 - 118,959,800	NCBI
Celera	10	112,687,102 - 112,699,920 (+)	NCBI		Celera
Cytogenetic Map	10	q25.3	NCBI
HuRef	10	112,584,507 - 112,597,305 (+)	NCBI		HuRef
CHM1_1	10	119,241,229 - 119,254,016 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	118,091,991 - 118,104,789 (+)	NCBI		T2T-CHM13v2.0

Kcnk18
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	59,208,080 - 59,225,802 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	59,207,646 - 59,225,806 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	59,219,648 - 59,237,370 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	59,219,214 - 59,237,374 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	59,294,138 - 59,311,860 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	59,272,898 - 59,290,620 (+)	NCBI		MGSCv36	mm8
Celera	19	61,420,573 - 61,435,885 (+)	NCBI		Celera
Cytogenetic Map	19	D3	NCBI
cM Map	19	54.63	NCBI

Kcnk18
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	21,916,587 - 21,927,307 (+)	Ensembl
ChiLan1.0	NW_004955431	21,916,587 - 21,927,346 (+)	NCBI	ChiLan1.0	ChiLan1.0

KCNK18
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	129,063,298 - 129,082,154 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	129,068,636 - 129,086,687 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	113,775,944 - 113,792,520 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	117,206,815 - 117,219,701 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	117,206,815 - 117,219,701 (+)	Ensembl			panPan2	panpan1.1

KCNK18
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	27,694,532 - 27,707,607 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	27,694,532 - 27,706,453 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	27,838,011 - 27,851,088 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	28,224,259 - 28,237,339 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	28,224,259 - 28,236,185 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	27,785,267 - 27,798,331 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	27,798,855 - 27,810,744 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	27,993,454 - 28,006,542 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kcnk18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	18,508,340 - 18,519,675 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936486	7,041,623 - 7,075,224 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNK18
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	14	127,323,291 - 127,335,320 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	138,724,648 - 138,736,336 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNK18
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	109,994,379 - 110,009,295 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	109,995,843 - 110,008,739 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	71,252,146 - 71,266,091 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcnk18
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624737	29,414,733 - 29,425,855 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kcnk18
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	56,878,688 - 56,892,684 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	20
Interacting mature miRNAs:	21
Transcripts:	ENSRNOT00000042977, ENSRNOT00000064022
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	263946994	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1578775	Iddm21	Insulin dependent diabetes mellitus QTL 21	4.13		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	245782829	270518180	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	248619887	269633915	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	5e-06	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	247133834	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1600390	Niddm64	Non-insulin dependent diabetes mellitus QTL 64		0.003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	257624997	270518180	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
1598839	Rf56	Renal function QTL 56			renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	255849111	270518180	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	241569529	269633915	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	18	43	50	49	22	28	22	5	124	65	26	20	28	27

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001134912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY567970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU152989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000042977 ⟹ ENSRNOP00000039866

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	268,360,738 - 268,375,012 (+)	Ensembl
mRatBN7.2 Ensembl	1	258,374,705 - 258,388,868 (+)	Ensembl
Rnor_6.0 Ensembl	1	280,383,613 - 280,397,707 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000064022 ⟹ ENSRNOP00000060711

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	268,360,738 - 268,375,012 (+)	Ensembl
mRatBN7.2 Ensembl	1	258,374,671 - 258,388,945 (+)	Ensembl
Rnor_6.0 Ensembl	1	280,383,579 - 280,397,784 (+)	Ensembl

RefSeq Acc Id:

NM_001003820 ⟹ NP_001003820

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	268,360,738 - 268,375,012 (+)	NCBI
mRatBN7.2	1	258,374,671 - 258,388,945 (+)	NCBI
Rnor_6.0	1	280,383,613 - 280,397,707 (+)	NCBI
Rnor_5.0	1	287,744,272 - 287,758,268 (+)	NCBI
RGSC_v3.4	1	265,749,192 - 265,764,641 (+)	RGD
Celera	1	254,028,729 - 254,042,473 (+)	NCBI

Sequence:

show sequence

ATGGAGGCTGAGGAGCCACCTGAAGCCAGAAGACGCTGTCCCGAGGCCCTGGGGAAGGCCAGCG
GATGCTGCCCTGAGGCCCCGGGGAAGGCCAGAGGATGCTGTCCTGAGGCCCTGGGCAAGCTTCT
GCCCGGCCTCTGCTTCCTTTGCTGCCTGGTAACCTATGCGCTGGTGGGTGCTGCTCTCTTCTCC
GCTGTCGAGGGCCGCCCTGACCCAGAAGCAGAGGAGAACCCTGAGTTGAAGAAGTTCCTGGACA
AGCTGTGCAACATCCTGAAATGCAACCTGACAGTGGTTGAAGGTAGCAGGAAAGACCTGTGTGA
GCATCTACAGCAGCTCAAGCCCCAGTGGTTCAAGGCGCCTGAGGACTGGTCCTTCTTGAGTGCT
CTTTTCTTCTGCTGCACAGTGTTCAGCACAGTGGGTTATGGCCACATGTACCCCGTCACCAGGC
TGGGTAAGTTCCTGTGCATGCTATATGCACTCTTTGGAATCCCTTTAATGTTCCTGGTCCTCAC
AGACATCGGGGACATCCTGGCCGCCATCTTATCTAGGGCTTACAGCCGGTTCCAGGCTCTCCTT
TGCCTCCCCCGAGATATCTCCAAGTGGCGCCCCCTTCTGCTATGCCGGAAGCAGACTGACAGCA
AACCCGCAGATGAAGCCATCCCTCAGATTGTCATTGATGCTGGTGCAGACGAGCTCCTAGACCC
ACAGCCCAGCAGGGAGCCTGCATCTCCTAGCTGCAATGTGGAGCTGTTTGAGAGATTGGTTGCT
CGAGAGAAACAGAACGAGCTACAACCACCCATGCGGCCGGTCGAGAGGAGCAACTCGTGTCCCG
AGCTGGTGCTGGGGCGGCTGTCCTGTTCTATTCTTAGCAATCTGGATGAAGTGGGCCAGCAAGT
GGAGAGGCTGGACATCCCTCTCCCCGTCATCGCGCTGGTCATCTTCGCGTACATCTCCTGTGCA
GCTGCTATCCTGCCCTTCTGGGAGACCGACCTAGGCTTCGAGGATGCCTTCTACTTCTGCTTTG
TGACACTGACCACCATTGGGTTCGGGGACATCGTGTTAGTGCACCCTCACTTCTTCCTCTTCTT
CTCCATCTACATCATCGTGGGCATGGAGATCCTGTTCATCGCCTTCAAACTGATGCAGAACCGG
CTCCTGCACACCTACAAAACCCTCATGCTGTTTGTTTGCCAAAGAGAGGTTTCGCTACCTTGCT
AA

hide sequence

RefSeq Acc Id:

NM_001134912 ⟹ NP_001128384

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	268,360,738 - 268,375,012 (+)	NCBI
mRatBN7.2	1	258,374,671 - 258,388,945 (+)	NCBI
Rnor_6.0	1	280,383,579 - 280,397,784 (+)	NCBI
Rnor_5.0	1	287,744,272 - 287,758,268 (+)	NCBI
RGSC_v3.4	1	265,749,192 - 265,764,641 (+)	RGD
Celera	1	254,028,695 - 254,042,550 (+)	RGD

Sequence:

show sequence

TTCCTCCCATCCTATCCTCAGATGCATCAAGAGGATGGAGGCTGAGGAGCCACCTGAAGCCAGA
AGACGCTGTCCCGAGGCCCTGGGGAAGGCCAGCGGATGCTGCCCTGAGGCCCCGGGGAAGGCCA
GAGGATGCTGTCCTGAGGCCCTGGGCAAGCTTCTGCCCGGCCTCTGCTTCCTTTGCTGCCTGGT
AACCTATGCGCTGGTGGGTGCTGCTCTCTTCTCCGCTGTCGAGGGCCGCCCTGACCCAGAAGCA
GAGGAGAACCCTGAGTTGAAGAAGTTCCTGGACAAGCTGTGCAACATCCTGAAATGCAACCTGA
CAGGTTATGGCCACATGTACCCCGTCACCAGGCTGGGTAAGTTCCTGTGCATGCTATATGCACT
CTTTGGAATCCCTTTAATGTTCCTGGTCCTCACAGACATCGGGGACATCCTGGCCGCCATCTTA
TCTAGGGCTTACAGCCGGTTCCAGGCTCTCCTTTGCCTCCCCCGAGATATCTCCAAGTGGCGCC
CCCTTCTGCTATGCCGGAAGCAGACTGACAGCAAACCCGCAGATGAAGCCATCCCTCAGATTGT
CATTGATGCTGGTGCAGACGAGCTCCTAGACCCACAGCCCAGCAGGGAGCCTGCATCTCCTAGC
TGCAATGTGGAGCTGTTTGAGAGATTGGTTGCTCGAGAGAAACAGAACGAGCTACAACCACCCA
TGCGGCCGGTCGAGAGGAGCAACTCGTGTCCCGAGCTGGTGCTGGGGCGGCTGTCCTGTTCTAT
TCTTAGCAATCTGGATGAAGTGGGCCAGCAAGTGGAGAGGCTGGACATCCCTCTCCCCGTCATC
GCGCTGGTCATCTTCGCGTACATCTCCTGTGCAGCTGCTATCCTGCCCTTCTGGGAGACCGACC
TAGGCTTCGAGGATGCCTTCTACTTCTGCTTTGTGACACTGACCACCATTGGGTTCGGGGACAT
CGTGTTAGTGCACCCTCACTTCTTCCTCTTCTTCTCCATCTACATCATCGTGGGCATGGAGATC
CTGTTCATCGCCTTCAAACTGATGCAGAACCGGCTCCTGCACACCTACAAAACCCTCATGCTGT
TTGTTTGCCAAAGAGAGGTTTCGCTACCTTGCTAAAAAACAAACAAACAAACAAACAAACAAAC
AACAACAACAACAACAAAACCCCCGAGGGTTCTGGTGTCTCTGTGACA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001003820	(Get FASTA)	NCBI Sequence Viewer
	NP_001128384	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAS68516	(Get FASTA)	NCBI Sequence Viewer
	ABX56705	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000039866
	ENSRNOP00000039866.2
	ENSRNOP00000060711
GenBank Protein	Q6Q1P3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001003820 ⟸ NM_001003820
- Peptide Label:	isoform 1
- UniProtKB:	Q6Q1P3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MEAEEPPEARRRCPEALGKASGCCPEAPGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFS AVEGRPDPEAEENPELKKFLDKLCNILKCNLTVVEGSRKDLCEHLQQLKPQWFKAPEDWSFLSA LFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILAAILSRAYSRFQALL CLPRDISKWRPLLLCRKQTDSKPADEAIPQIVIDAGADELLDPQPSREPASPSCNVELFERLVA REKQNELQPPMRPVERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVIFAYISCA AAILPFWETDLGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNR LLHTYKTLMLFVCQREVSLPC hide sequence

RefSeq Acc Id:	NP_001128384 ⟸ NM_001134912
- Peptide Label:	isoform 2
- UniProtKB:	B5L2C1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEAEEPPEARRRCPEALGKASGCCPEAPGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFS AVEGRPDPEAEENPELKKFLDKLCNILKCNLTGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLT DIGDILAAILSRAYSRFQALLCLPRDISKWRPLLLCRKQTDSKPADEAIPQIVIDAGADELLDP QPSREPASPSCNVELFERLVAREKQNELQPPMRPVERSNSCPELVLGRLSCSILSNLDEVGQQV ERLDIPLPVIALVIFAYISCAAAILPFWETDLGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFF SIYIIVGMEILFIAFKLMQNRLLHTYKTLMLFVCQREVSLPC hide sequence

Ensembl Acc Id:

ENSRNOP00000039866 ⟸ ENSRNOT00000042977

Ensembl Acc Id:

ENSRNOP00000060711 ⟸ ENSRNOT00000064022

Protein Domains

Potassium channel

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6Q1P3-F1-model_v2	AlphaFold	Q6Q1P3	1-405	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303091	AgrOrtholog
BioCyc Gene	G2FUF-55255	BioCyc
Ensembl Genes	ENSRNOG00000032706	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000042977	ENTREZGENE
	ENSRNOT00000042977.5	UniProtKB/Swiss-Prot
	ENSRNOT00000064022	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
InterPro	2pore_dom_K_chnl	UniProtKB/Swiss-Prot
	2pore_dom_K_chnl_TASK	UniProtKB/Swiss-Prot
	K_chnl_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:445371	UniProtKB/Swiss-Prot
NCBI Gene	445371	ENTREZGENE
PANTHER	POTASSIUM CHANNEL SUBFAMILY K MEMBER 18	UniProtKB/Swiss-Prot
	PTHR11003	UniProtKB/Swiss-Prot
Pfam	Ion_trans_2	UniProtKB/Swiss-Prot
PhenoGen	Kcnk18	PhenoGen
PRINTS	2POREKCHANEL	UniProtKB/Swiss-Prot
	TASKCHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000032706	RatGTEx
Superfamily-SCOP	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
UniProt	B5L2C1	ENTREZGENE, UniProtKB/TrEMBL
	KCNKI_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Kcnk18	potassium two pore domain channel subfamily K member 18	Kcnk18	potassium channel, two pore domain subfamily K, member 18	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-26	Kcnk18	potassium channel, two pore domain subfamily K, member 18	Kcnk18	potassium channel, subfamily K, member 18	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Kcnk18	potassium channel, subfamily K, member 18	Tresk-2	tandem-pore K+ (K(2P)) channel	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-02-14	Tresk-2	tandem-pore K+ (K(2P)) channel			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM