Prss46 (protease, serine, 46) - Rat Genome Database

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Gene: Prss46 (protease, serine, 46) Rattus norvegicus
Analyze
Symbol: Prss46
Name: protease, serine, 46
RGD ID: 1302970
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human PRSS46P (serine protease 46, pseudogene); INTERACTS WITH atrazine; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: serine protease 46; Tessp6; testis-specific serine protease-6
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,707,687 - 119,719,461 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,707,687 - 119,719,461 (+)EnsemblGRCr8
mRatBN7.28110,829,275 - 110,841,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,829,266 - 110,841,123 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,448,016 - 116,454,931 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,647,226 - 114,654,141 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,490,046 - 112,496,961 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,121,671 - 119,133,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,121,669 - 119,133,546 (+)Ensemblrn6Rnor6.0
Rnor_5.08118,460,084 - 118,471,867 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,238,452 - 115,245,337 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8110,116,548 - 110,123,433 (+)NCBICelera
RGSC_v3.18115,257,906 - 115,264,792 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Prss46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,707,687 - 119,719,461 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,707,687 - 119,719,461 (+)EnsemblGRCr8
mRatBN7.28110,829,275 - 110,841,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,829,266 - 110,841,123 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,448,016 - 116,454,931 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,647,226 - 114,654,141 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,490,046 - 112,496,961 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,121,671 - 119,133,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,121,669 - 119,133,546 (+)Ensemblrn6Rnor6.0
Rnor_5.08118,460,084 - 118,471,867 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,238,452 - 115,245,337 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8110,116,548 - 110,123,433 (+)NCBICelera
RGSC_v3.18115,257,906 - 115,264,792 (+)NCBI
Cytogenetic Map8q32NCBI
PRSS46P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,719,583 - 46,736,427 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,719,583 - 46,736,429 (-)Ensemblhg38GRCh38
GRCh38.p14 Ensembl346,719,749 - 46,736,388 (-)Ensemblhg38GRCh38
GRCh37346,761,073 - 46,777,917 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p21.31NCBI
HuRef346,803,923 - 46,820,771 (-)NCBIHuRef
CHM1_1346,711,189 - 46,728,057 (-)NCBICHM1_1
T2T-CHM13v2.0346,735,668 - 46,752,512 (-)NCBIT2T-CHM13v2.0
Prss46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,673,574 - 110,685,586 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,673,574 - 110,685,590 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389110,844,506 - 110,856,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,844,506 - 110,856,522 (+)Ensemblmm10GRCm38
MGSCv379110,747,010 - 110,759,026 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369110,689,322 - 110,701,338 (+)NCBIMGSCv36mm8
Celera9110,575,237 - 110,582,022 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
PRSS46P
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,675,802 - 46,694,532 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,680,572 - 46,699,302 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,618,007 - 46,635,153 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,721,393 - 47,737,885 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC101967592
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,999,038 - 201,014,801 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936596548,354 - 563,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11329,640,448 - 29,665,549 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,911,542 - 32,916,508 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103227550
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,142,559 - 8,170,057 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041158,991,731 - 158,994,235 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prss46
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:28
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000028479
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
BE101765  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88119,719,261 - 119,719,446 (+)Marker Load Pipeline
mRatBN7.28110,840,849 - 110,841,034 (+)MAPPERmRatBN7.2
Rnor_6.08119,133,252 - 119,133,436NCBIRnor6.0
Rnor_5.08118,471,662 - 118,471,846UniSTSRnor5.0
RGSC_v3.48115,245,320 - 115,245,504UniSTSRGSC3.4
Celera8110,123,416 - 110,123,600UniSTS
RH 3.4 Map81191.7UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
2 12 19 28 15 19 4 2 4 6 61 40 8 13 7 46 15

Sequence


Ensembl Acc Id: ENSRNOT00000028479   ⟹   ENSRNOP00000028479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,707,687 - 119,719,461 (+)Ensembl
mRatBN7.2 Ensembl8110,829,266 - 110,841,123 (+)Ensembl
Rnor_6.0 Ensembl8119,121,669 - 119,133,546 (+)Ensembl
RefSeq Acc Id: NM_001008865   ⟹   NP_001008865
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,707,687 - 119,719,461 (+)NCBI
mRatBN7.28110,829,275 - 110,841,049 (+)NCBI
Rnor_6.08119,126,384 - 119,133,269 (+)NCBI
Rnor_5.08118,460,084 - 118,471,867 (+)NCBI
RGSC_v3.48115,238,452 - 115,245,337 (+)RGD
Celera8110,116,548 - 110,123,433 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008865 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE48385 (Get FASTA)   NCBI Sequence Viewer  
  EDL77052 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028479
  ENSRNOP00000028479.6
GenBank Protein Q6IE63 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008865   ⟸   NM_001008865
- UniProtKB: Q6IE63 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028479   ⟸   ENSRNOT00000028479
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE63-F1-model_v2 AlphaFold Q6IE63 1-314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696338
Promoter ID:EPDNEW_R6863
Type:initiation region
Name:Prss46_1
Description:protease, serine, 46
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,121,694 - 119,121,754EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302970 AgrOrtholog
BioCyc Gene G2FUF-29050 BioCyc
Ensembl Genes ENSRNOG00000020981 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028479 ENTREZGENE
  ENSRNOT00000028479.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Ser/Thr_Proteases_Immune/Dev UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
KEGG Report rno:408245 UniProtKB/Swiss-Prot
NCBI Gene 408245 ENTREZGENE
PANTHER TRYPTASE-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss46 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020981 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt PRS46_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-09-15 Prss46  protease, serine, 46  Tessp6  testis-specific serine protease-6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Tessp6  testis-specific serine protease-6      Symbol and Name status set to provisional 70820 PROVISIONAL