H2-M10.6l (histocompatibility 2, M region locus 10.6 like) - Rat Genome Database

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Gene: H2-M10.6l (histocompatibility 2, M region locus 10.6 like) Rattus norvegicus
Analyze
Symbol: H2-M10.6l (Ensembl: LOC102546590)
Name: histocompatibility 2, M region locus 10.6 like (Ensembl:HLA class I histocompatibility antigen, A-24 alpha chain-like)
RGD ID: 7624899
Description: Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class I. Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: H-2 class I histocompatibility antigen, Q10 alpha chain-like; HLA class I histocompatibility antigen, A-24 alpha chain-like; LOC102546590; patr class I histocompatibility antigen, A-126 alpha chain-like
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,963,483 - 1,974,371 (+)NCBIGRCr8
mRatBN7.2201,958,270 - 1,965,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,925,049 - 1,966,105 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0202,459,081 - 2,464,819 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0204,491,421 - 4,493,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera202,670,318 - 2,673,093 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in H2-M10.6l
182 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000103863   ⟹   ENSRNOP00000091516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,958,468 - 1,966,105 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107591   ⟹   ENSRNOP00000095941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,925,049 - 1,966,105 (+)Ensembl
RefSeq Acc Id: XM_039099370   ⟹   XP_038955298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,963,483 - 1,974,371 (+)NCBI
mRatBN7.2201,958,270 - 1,965,247 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038955298 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091516
  ENSRNOP00000091516.1
  ENSRNOP00000095941.1
Reference Protein Sequences
RefSeq Acc Id: XP_038955298   ⟸   XM_039099370
- UniProtKB: A0A8I6ADU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091516   ⟸   ENSRNOT00000103863
RefSeq Acc Id: ENSRNOP00000095941   ⟸   ENSRNOT00000107591
Protein Domains
Ig-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-4948 BioCyc
Ensembl Genes ENSRNOG00000062554 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000103863.1 UniProtKB/TrEMBL
  ENSRNOT00000107591.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.500.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC_I-like_Ag-recog UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_I_a_a1/a2 UniProtKB/TrEMBL
NCBI Gene LOC102546590 ENTREZGENE
PANTHER HISTOCOMPATIBILITY 2, M REGION LOCUS 10.1-RELATED UniProtKB/TrEMBL
  MHC CLASS I-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_I UniProtKB/TrEMBL
PhenoGen H2-M10.6l PhenoGen
PRINTS MHCCLASSI UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000062554 RatGTEx
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF54452 UniProtKB/TrEMBL
UniProt A0A8I6ADU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLV3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 H2-M10.6l  histocompatibility 2, M region locus 10.6 like  LOC102546590  HLA class I histocompatibility antigen, A-24 alpha chain-like  Symbol and Name Changed 1299863 APPROVED
2013-12-18 LOC102546590  HLA class I histocompatibility antigen, A-24 alpha chain-like      Symbol and Name status set to provisional 70820 PROVISIONAL