H2-m10.6l (histocompatibility 2, M region locus 10.6 like) - Rat Genome Database

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Gene: H2-m10.6l (histocompatibility 2, M region locus 10.6 like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: H2-m10.6l (Ensembl: AABR07044308.2)
Name: histocompatibility 2, M region locus 10.6 like
RGD ID: 7624899
Description: Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); asthma (multiple); eye disease (multiple); inner ear disease (multiple); and vasculitis (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: H-2 class I histocompatibility antigen, Q10 alpha chain-like; HLA class I histocompatibility antigen, A-24 alpha chain-like; LOC102546590; patr class I histocompatibility antigen, A-126 alpha chain-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,963,483 - 1,974,371 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl201,967,890 - 1,970,088 (+)EnsemblGRCr8
mRatBN7.2201,958,270 - 1,965,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,925,049 - 1,966,105 (+)EnsemblmRatBN7.2
Rnor_6.0202,459,081 - 2,464,819 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0204,491,421 - 4,493,581 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera202,670,318 - 2,673,093 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in H2-m10.6l
250 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013629303Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
4 2 7 2 4 5 3 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000039155   ⟹   ENSRNOP00000085199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl201,967,890 - 1,970,088 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103863   ⟹   ENSRNOP00000091516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,958,468 - 1,966,105 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107591   ⟹   ENSRNOP00000095941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,925,049 - 1,966,105 (+)Ensembl
RefSeq Acc Id: XM_039099370   ⟹   XP_038955298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,963,483 - 1,974,371 (+)NCBI
mRatBN7.2201,958,270 - 1,965,247 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038955298 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085199
  ENSRNOP00000085199.2
RefSeq Acc Id: XP_038955298   ⟸   XM_039099370
- UniProtKB: A0A8I6ADU9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091516   ⟸   ENSRNOT00000103863
Ensembl Acc Id: ENSRNOP00000095941   ⟸   ENSRNOT00000107591
Ensembl Acc Id: ENSRNOP00000085199   ⟸   ENSRNOT00000039155

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7624899 AgrOrtholog
BioCyc Gene G2FUF-4948 BioCyc
Ensembl Genes ENSRNOG00000051398 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000062554 Ensembl
Ensembl Transcript ENSRNOT00000039155 ENTREZGENE
  ENSRNOT00000039155.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.500.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC_class-I_related UniProtKB/TrEMBL
  MHC_I-like_Ag-recog UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_I_a_a1/a2 UniProtKB/TrEMBL
NCBI Gene LOC102546590 ENTREZGENE
PANTHER HISTOCOMPATIBILITY 2, M REGION LOCUS 10.1-RELATED UniProtKB/TrEMBL
  MHC CLASS I-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_I UniProtKB/TrEMBL
PhenoGen H2-m10.6l PhenoGen
PRINTS MHCCLASSI UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051398 RatGTEx
  ENSRNOG00000062554 RatGTEx
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF54452 UniProtKB/TrEMBL
UniProt A0A8I5ZYQ2_RAT UniProtKB/TrEMBL
  A0A8I6ADU9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-02-04 H2-m10.6l  histocompatibility 2, M region locus 10.6 like  H2-M10.6l  histocompatibility 2, M region locus 10.6 like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 H2-M10.6l  histocompatibility 2, M region locus 10.6 like  LOC102546590  HLA class I histocompatibility antigen, A-24 alpha chain-like  Symbol and Name Changed 1299863 APPROVED
2013-12-18 LOC102546590  HLA class I histocompatibility antigen, A-24 alpha chain-like      Symbol and Name status set to provisional 70820 PROVISIONAL