Serping1 (serpin family G member 1) - Rat Genome Database

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Gene: Serping1 (serpin family G member 1) Rattus norvegicus
Analyze
Symbol: Serping1
Name: serpin family G member 1
RGD ID: 735225
Description: Predicted to enable complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway. Located in extracellular space. Used to study glioblastoma. Biomarker of acute myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1); PARTICIPATES IN coagulation cascade pathway; kallikrein-kinin cascade pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C1 esterase inhibitor; C1 Inh; C1-IA; C1-inactivator; C1-inhibiting factor; C1Inh; MGC72585; plasma protease C1 inhibitor; serine (or cysteine) peptidase inhibitor, clade G, member 1; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary); serpin G1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; serpin peptidase inhibitor, clade G, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Arunc3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,249,410 - 90,259,299 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl390,249,423 - 90,258,717 (-)EnsemblGRCr8
mRatBN7.2369,842,726 - 69,852,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,842,739 - 69,852,034 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx373,224,542 - 73,233,831 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,823,206 - 81,832,495 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,582,111 - 79,591,395 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,161,230 - 72,171,109 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,161,189 - 72,171,078 (-)Ensemblrn6Rnor6.0
Rnor_5.0378,681,813 - 78,691,622 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4367,968,808 - 67,978,102 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera369,198,069 - 69,207,363 (-)NCBICelera
RGSC_v3.1367,865,179 - 67,874,474 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
danazol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hydralazine  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
lansoprazole  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methcathinone  (ISO)
methimazole  (EXP)
morphine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
olanzapine  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
pantoprazole  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
Ptaquiloside  (ISO)
rabeprazole  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model. Begieneman MP, etal., J Burn Care Res. 2012 Jul;33(4):544-51.
2. Myocardial infarction induces atrial inflammation that can be prevented by C1-esterase inhibitor. Begieneman MP, etal., J Clin Pathol. 2016 Dec;69(12):1093-1099. doi: 10.1136/jclinpath-2016-203639. Epub 2016 May 6.
3. Impact of combined C1 esterase inhibitor/coagulation factor XIII or N-acetylcysteine/tirilazad mesylate administration on leucocyte adherence and cytokine release in experimental endotoxaemia. Birnbaum J, etal., J Int Med Res. 2008 Jul-Aug;36(4):748-59.
4. Detection of C1 inhibitor (SERPING1/C1NH) mutations in exon 8 in patients with hereditary angioedema: evidence for 10 novel mutations. Blanch A, etal., Hum Mutat. 2002 Nov;20(5):405-6.
5. The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant. Bos IG, etal., J Biol Chem 2003 Aug 8;278(32):29463-70. Epub 2003 May 27.
6. Influence of C1-inhibitor on inflammation, edema and shock. Dickneite G Behring Inst Mitt. 1993 Dec;(93):299-305.
7. Refinement of tourniquet-induced peripheral ischemia/reperfusion injury in rats: comparison of 2 h vs 24 h reperfusion. Duehrkop C and Rieben R, Lab Anim. 2014 Apr;48(2):143-54. doi: 10.1177/0023677213516313.
8. C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage. Duehrkop C, etal., PLoS One. 2013 Aug 26;8(8):e72059. doi: 10.1371/journal.pone.0072059. eCollection 2013.
9. Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction. Emmens RW, etal., Cardiovasc Pathol. 2016 Jan-Feb;25(1):33-9. doi: 10.1016/j.carpath.2015.09.006. Epub 2015 Sep 25.
10. Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Fu J, etal., Biochem Biophys Res Commun. 2006 Oct 20;349(2):504-12. Epub 2006 Aug 22.
11. C1-inactivator is upregulated in glioblastoma. Förnvik K, etal., PLoS One. 2017 Sep 7;12(9):e0183086. doi: 10.1371/journal.pone.0183086. eCollection 2017.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Determination of a gene and environment risk model for age-related macular degeneration. Gibson J, etal., Br J Ophthalmol. 2010 Oct;94(10):1382-7. doi: 10.1136/bjo.2010.182568. Epub 2010 Jun 24.
14. Variation in complement component C1 inhibitor in age-related macular degeneration. Gibson J, etal., Immunobiology. 2012 Feb;217(2):251-5. doi: 10.1016/j.imbio.2011.07.015. Epub 2011 Jul 23.
15. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
16. C1-esterase inhibitor reduces infarct volume after cortical vein occlusion. Heimann A, etal., Brain Res. 1999 Aug 14;838(1-2):210-3.
17. Beneficial effects of C1 esterase inhibitor in murine traumatic shock. Kochilas L, etal., Shock. 1997 Sep;8(3):165-9.
18. Proteases and protease inhibitors in taurocholate-induced acute pancreatitis in rats. Kruse P, etal., Int J Pancreatol. 1999 Apr;25(2):113-21.
19. The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration. Lee AY, etal., Br J Ophthalmol. 2010 Jul;94(7):915-7. doi: 10.1136/bjo.2009.172007.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
22. Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese. Nakata I, etal., PLoS One. 2011 Apr 19;6(4):e19108. doi: 10.1371/journal.pone.0019108.
23. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. C1 inhibitor gene expression in patients with hereditary angioedema: quantitative evaluation by means of real-time RT-PCR. Pappalardo E, etal., J Allergy Clin Immunol. 2004 Sep;114(3):638-44.
26. Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects. Park KH, etal., Mol Vis. 2009;15:200-7. Epub 2009 Jan 23.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Fat-storing cells of the rat liver synthesize and secrete C1-esterase inhibitor; modulation by cytokines. Schwogler S, etal., Hepatology. 1992 Sep;16(3):794-802.
34. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
35. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
36. Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. Su Z, etal., J Intern Med. 2014 Feb 4. doi: 10.1111/joim.12214.
37. Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke. Tomasi S, etal., PLoS One. 2011;6(7):e21999. Epub 2011 Jul 14.
38. Age-related alterations in retinal neurovascular and inflammatory transcripts. Van Kirk CA, etal., Mol Vis. 2011;17:1261-74. Epub 2011 May 7.
39. Effects of C1 inhibitor and r-SP-C surfactant on oxygenation and histology in rats with lavage-induced acute lung injury. Vangerow B, etal., Intensive Care Med. 2001 Sep;27(9):1526-31.
40. Combined treatment with C1 esterase inhibitor and antithrombin III improves survival in severe acute experimental pancreatitis. Yamaguchi H, etal., Gut. 1997 Apr;40(4):531-5.
41. Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model. Zhang S, etal., J Vasc Surg. 2018 Jan 27. pii: S0741-5214(17)32653-8. doi: 10.1016/j.jvs.2017.10.072.
42. Safety and efficacy of prophylactic nanofiltered C1-inhibitor in hereditary angioedema. Zuraw BL and Kalfus I, Am J Med. 2012 Sep;125(9):938.e1-7. doi: 10.1016/j.amjmed.2012.02.020. Epub 2012 Jul 14.
43. C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. Zwijnenburg PJ, etal., J Infect Dis. 2007 Jul 1;196(1):115-23. Epub 2007 May 17.
Additional References at PubMed
PMID:9199246   PMID:9652403   PMID:10946292   PMID:11527969   PMID:15489334   PMID:16502470   PMID:19056867   PMID:22516433   PMID:23376485   PMID:23533145   PMID:24006456  


Genomics

Comparative Map Data
Serping1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,249,410 - 90,259,299 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl390,249,423 - 90,258,717 (-)EnsemblGRCr8
mRatBN7.2369,842,726 - 69,852,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,842,739 - 69,852,034 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx373,224,542 - 73,233,831 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,823,206 - 81,832,495 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,582,111 - 79,591,395 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,161,230 - 72,171,109 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,161,189 - 72,171,078 (-)Ensemblrn6Rnor6.0
Rnor_5.0378,681,813 - 78,691,622 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4367,968,808 - 67,978,102 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera369,198,069 - 69,207,363 (-)NCBICelera
RGSC_v3.1367,865,179 - 67,874,474 (-)NCBI
Cytogenetic Map3q24NCBI
SERPING1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,597,685 - 57,614,848 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,597,387 - 57,619,246 (+)Ensemblhg38GRCh38
GRCh371157,365,158 - 57,382,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,121,603 - 57,138,902 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341157,121,733 - 57,138,895NCBI
Celera1154,721,543 - 54,738,843 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,713,821 - 53,731,117 (+)NCBIHuRef
CHM1_11157,231,240 - 57,248,536 (+)NCBICHM1_1
T2T-CHM13v2.01157,547,859 - 57,565,023 (+)NCBIT2T-CHM13v2.0
Serping1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,595,704 - 84,605,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,595,731 - 84,605,788 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38284,765,360 - 84,775,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,765,387 - 84,775,444 (-)Ensemblmm10GRCm38
MGSCv37284,605,517 - 84,615,586 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36284,566,224 - 84,576,243 (-)NCBIMGSCv36mm8
Celera286,360,569 - 86,370,824 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
Serping1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555112,545,285 - 2,557,982 (+)Ensembl
ChiLan1.0NW_0049555112,545,337 - 2,557,850 (+)NCBIChiLan1.0ChiLan1.0
SERPING1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,754,075 - 58,771,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,773,949 - 59,791,183 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,838,502 - 52,855,781 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11156,309,685 - 56,326,639 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1156,309,686 - 56,326,639 (+)EnsemblpanPan2panpan1.1
SERPING1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,570,354 - 38,580,751 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,570,607 - 38,581,665 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1838,116,824 - 38,129,580 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01839,252,348 - 39,265,152 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1839,252,350 - 39,454,090 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11838,835,311 - 38,848,057 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,408,314 - 38,421,069 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,039,067 - 39,051,835 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serping1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494714,797,581 - 14,810,679 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365814,908,458 - 4,924,645 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365814,911,403 - 4,924,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPING1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,324,158 - 13,338,663 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1213,324,160 - 13,338,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2212,957,676 - 12,972,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPING1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,617,122 - 15,634,540 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,616,674 - 15,633,855 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038112,967,736 - 112,984,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serping1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248643,091,083 - 3,103,090 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248643,091,397 - 3,103,084 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Serping1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1562,145,700 - 62,155,776 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serping1
91 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:40
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000009817
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH128990  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8390,249,518 - 90,249,697 (+)Marker Load Pipeline
mRatBN7.2369,842,834 - 69,843,013 (+)MAPPERmRatBN7.2
Rnor_6.0372,161,339 - 72,161,517NCBIRnor6.0
Rnor_5.0378,681,922 - 78,682,100UniSTSRnor5.0
RGSC_v3.4367,968,904 - 67,969,082UniSTSRGSC3.4
Celera369,198,165 - 69,198,343UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 50 59 6 314 150 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009817   ⟹   ENSRNOP00000009817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl390,249,423 - 90,258,717 (-)Ensembl
mRatBN7.2 Ensembl369,842,739 - 69,852,034 (-)Ensembl
Rnor_6.0 Ensembl372,161,189 - 72,171,078 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095984   ⟹   ENSRNOP00000089347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl390,250,101 - 90,258,717 (-)Ensembl
mRatBN7.2 Ensembl369,843,417 - 69,852,034 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117291   ⟹   ENSRNOP00000086831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl390,249,423 - 90,257,671 (-)Ensembl
mRatBN7.2 Ensembl369,842,739 - 69,850,988 (-)Ensembl
RefSeq Acc Id: NM_199093   ⟹   NP_954524
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,249,423 - 90,258,717 (-)NCBI
mRatBN7.2369,842,739 - 69,852,034 (-)NCBI
Rnor_6.0372,161,243 - 72,170,537 (-)NCBI
Rnor_5.0378,681,813 - 78,691,622 (-)NCBI
RGSC_v3.4367,968,808 - 67,978,102 (-)RGD
Celera369,198,069 - 69,207,363 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234447   ⟹   XP_006234509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,249,410 - 90,259,299 (-)NCBI
mRatBN7.2369,842,726 - 69,852,583 (-)NCBI
Rnor_6.0372,161,230 - 72,171,109 (-)NCBI
Rnor_5.0378,681,813 - 78,691,622 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001416777 (Get FASTA)   NCBI Sequence Viewer  
  NP_954524 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234509 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61860 (Get FASTA)   NCBI Sequence Viewer  
  EDL79315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009817
  ENSRNOP00000009817.3
GenBank Protein Q6P734 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_954524   ⟸   NM_199093
- Peptide Label: precursor
- UniProtKB: Q6P734 (UniProtKB/Swiss-Prot),   A6HMR4 (UniProtKB/TrEMBL),   A0A8I6A6T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234509   ⟸   XM_006234447
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000009817   ⟸   ENSRNOT00000009817
Ensembl Acc Id: ENSRNOP00000089347   ⟸   ENSRNOT00000095984
Ensembl Acc Id: ENSRNOP00000086831   ⟸   ENSRNOT00000117291
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P734-F1-model_v2 AlphaFold Q6P734 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692182
Promoter ID:EPDNEW_R2707
Type:initiation region
Name:Serping1_1
Description:serpin family G member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0372,171,046 - 72,171,106EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735225 AgrOrtholog
BioCyc Gene G2FUF-49156 BioCyc
Ensembl Genes ENSRNOG00000007457 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009817 ENTREZGENE
  ENSRNOT00000009817.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598525 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report rno:295703 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72585 IMAGE-MGC_LOAD
NCBI Gene 295703 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot
  PTHR11461:SF159 UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serping1 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007457 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
UniProt A0A8I6A6T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABI1_RAT UniProtKB/TrEMBL
  A6HMR4 ENTREZGENE, UniProtKB/TrEMBL
  IC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serping1  serpin family G member 1  Serping1  serpin peptidase inhibitor, clade G (C1 inhibitor), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serping1  serpin peptidase inhibitor, clade G (C1 inhibitor), member 1  Serping1  serpin peptidase inhibitor, clade G, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serping1  serpin peptidase inhibitor, clade G, member 1  Serping1  serine (or cysteine) peptidase inhibitor, clade G, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Serping1  serine (or cysteine) peptidase inhibitor, clade G, member 1    serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency of the human homolog causes autosomal dominant hereditary angioedema 1302854