Serping1 (serpin family G member 1) - Rat Genome Database

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Gene: Serping1 (serpin family G member 1) Rattus norvegicus
Analyze
Symbol: Serping1
Name: serpin family G member 1
RGD ID: 735225
Description: Predicted to enable complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway. Located in extracellular space. Used to study glioblastoma. Biomarker of acute myocardial infarction and acute necrotizing pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1); PARTICIPATES IN coagulation cascade pathway; kallikrein-kinin cascade pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C1 esterase inhibitor; C1 Inh; C1-IA; C1-inactivator; C1-inhibiting factor; C1Inh; MGC72585; plasma protease C1 inhibitor; serine (or cysteine) peptidase inhibitor, clade G, member 1; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary); serpin G1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; serpin peptidase inhibitor, clade G, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Arunc3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,249,410 - 90,259,299 (-)NCBIGRCr8
mRatBN7.2369,842,726 - 69,852,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,842,739 - 69,852,034 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,224,542 - 73,233,831 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,823,206 - 81,832,495 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,582,111 - 79,591,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,161,230 - 72,171,109 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,161,189 - 72,171,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,681,813 - 78,691,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,968,808 - 67,978,102 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1367,865,179 - 67,874,474 (-)NCBI
Celera369,198,069 - 69,207,363 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
danazol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hydralazine  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
lansoprazole  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methcathinone  (ISO)
methimazole  (EXP)
morphine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
olanzapine  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
pantoprazole  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
Ptaquiloside  (ISO)
rabeprazole  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model. Begieneman MP, etal., J Burn Care Res. 2012 Jul;33(4):544-51.
2. Myocardial infarction induces atrial inflammation that can be prevented by C1-esterase inhibitor. Begieneman MP, etal., J Clin Pathol. 2016 Dec;69(12):1093-1099. doi: 10.1136/jclinpath-2016-203639. Epub 2016 May 6.
3. Impact of combined C1 esterase inhibitor/coagulation factor XIII or N-acetylcysteine/tirilazad mesylate administration on leucocyte adherence and cytokine release in experimental endotoxaemia. Birnbaum J, etal., J Int Med Res. 2008 Jul-Aug;36(4):748-59.
4. Detection of C1 inhibitor (SERPING1/C1NH) mutations in exon 8 in patients with hereditary angioedema: evidence for 10 novel mutations. Blanch A, etal., Hum Mutat. 2002 Nov;20(5):405-6.
5. The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant. Bos IG, etal., J Biol Chem 2003 Aug 8;278(32):29463-70. Epub 2003 May 27.
6. Influence of C1-inhibitor on inflammation, edema and shock. Dickneite G Behring Inst Mitt. 1993 Dec;(93):299-305.
7. Refinement of tourniquet-induced peripheral ischemia/reperfusion injury in rats: comparison of 2 h vs 24 h reperfusion. Duehrkop C and Rieben R, Lab Anim. 2014 Apr;48(2):143-54. doi: 10.1177/0023677213516313.
8. C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage. Duehrkop C, etal., PLoS One. 2013 Aug 26;8(8):e72059. doi: 10.1371/journal.pone.0072059. eCollection 2013.
9. Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction. Emmens RW, etal., Cardiovasc Pathol. 2016 Jan-Feb;25(1):33-9. doi: 10.1016/j.carpath.2015.09.006. Epub 2015 Sep 25.
10. Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Fu J, etal., Biochem Biophys Res Commun. 2006 Oct 20;349(2):504-12. Epub 2006 Aug 22.
11. C1-inactivator is upregulated in glioblastoma. Förnvik K, etal., PLoS One. 2017 Sep 7;12(9):e0183086. doi: 10.1371/journal.pone.0183086. eCollection 2017.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Determination of a gene and environment risk model for age-related macular degeneration. Gibson J, etal., Br J Ophthalmol. 2010 Oct;94(10):1382-7. doi: 10.1136/bjo.2010.182568. Epub 2010 Jun 24.
14. Variation in complement component C1 inhibitor in age-related macular degeneration. Gibson J, etal., Immunobiology. 2012 Feb;217(2):251-5. doi: 10.1016/j.imbio.2011.07.015. Epub 2011 Jul 23.
15. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
16. C1-esterase inhibitor reduces infarct volume after cortical vein occlusion. Heimann A, etal., Brain Res. 1999 Aug 14;838(1-2):210-3.
17. Beneficial effects of C1 esterase inhibitor in murine traumatic shock. Kochilas L, etal., Shock. 1997 Sep;8(3):165-9.
18. Proteases and protease inhibitors in taurocholate-induced acute pancreatitis in rats. Kruse P, etal., Int J Pancreatol. 1999 Apr;25(2):113-21.
19. The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration. Lee AY, etal., Br J Ophthalmol. 2010 Jul;94(7):915-7. doi: 10.1136/bjo.2009.172007.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
22. Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese. Nakata I, etal., PLoS One. 2011 Apr 19;6(4):e19108. doi: 10.1371/journal.pone.0019108.
23. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. C1 inhibitor gene expression in patients with hereditary angioedema: quantitative evaluation by means of real-time RT-PCR. Pappalardo E, etal., J Allergy Clin Immunol. 2004 Sep;114(3):638-44.
26. Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects. Park KH, etal., Mol Vis. 2009;15:200-7. Epub 2009 Jan 23.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Fat-storing cells of the rat liver synthesize and secrete C1-esterase inhibitor; modulation by cytokines. Schwogler S, etal., Hepatology. 1992 Sep;16(3):794-802.
34. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
35. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
36. Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. Su Z, etal., J Intern Med. 2014 Feb 4. doi: 10.1111/joim.12214.
37. Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke. Tomasi S, etal., PLoS One. 2011;6(7):e21999. Epub 2011 Jul 14.
38. Age-related alterations in retinal neurovascular and inflammatory transcripts. Van Kirk CA, etal., Mol Vis. 2011;17:1261-74. Epub 2011 May 7.
39. Effects of C1 inhibitor and r-SP-C surfactant on oxygenation and histology in rats with lavage-induced acute lung injury. Vangerow B, etal., Intensive Care Med. 2001 Sep;27(9):1526-31.
40. Combined treatment with C1 esterase inhibitor and antithrombin III improves survival in severe acute experimental pancreatitis. Yamaguchi H, etal., Gut. 1997 Apr;40(4):531-5.
41. Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model. Zhang S, etal., J Vasc Surg. 2018 Jan 27. pii: S0741-5214(17)32653-8. doi: 10.1016/j.jvs.2017.10.072.
42. Safety and efficacy of prophylactic nanofiltered C1-inhibitor in hereditary angioedema. Zuraw BL and Kalfus I, Am J Med. 2012 Sep;125(9):938.e1-7. doi: 10.1016/j.amjmed.2012.02.020. Epub 2012 Jul 14.
43. C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. Zwijnenburg PJ, etal., J Infect Dis. 2007 Jul 1;196(1):115-23. Epub 2007 May 17.
Additional References at PubMed
PMID:9199246   PMID:9652403   PMID:10946292   PMID:11527969   PMID:15489334   PMID:16502470   PMID:19056867   PMID:22516433   PMID:23376485   PMID:23533145   PMID:24006456  


Genomics

Comparative Map Data
Serping1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,249,410 - 90,259,299 (-)NCBIGRCr8
mRatBN7.2369,842,726 - 69,852,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,842,739 - 69,852,034 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,224,542 - 73,233,831 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,823,206 - 81,832,495 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,582,111 - 79,591,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,161,230 - 72,171,109 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,161,189 - 72,171,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,681,813 - 78,691,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,968,808 - 67,978,102 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1367,865,179 - 67,874,474 (-)NCBI
Celera369,198,069 - 69,207,363 (-)NCBICelera
Cytogenetic Map3q24NCBI
SERPING1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,597,685 - 57,614,848 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,597,387 - 57,619,171 (+)EnsemblGRCh38hg38GRCh38
GRCh371157,365,158 - 57,382,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,121,603 - 57,138,902 (+)NCBINCBI36Build 36hg18NCBI36
Build 341157,121,733 - 57,138,895NCBI
Celera1154,721,543 - 54,738,843 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,713,821 - 53,731,117 (+)NCBIHuRef
CHM1_11157,231,240 - 57,248,536 (+)NCBICHM1_1
T2T-CHM13v2.01157,547,859 - 57,565,023 (+)NCBIT2T-CHM13v2.0
Serping1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,595,704 - 84,605,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,595,731 - 84,605,788 (-)EnsemblGRCm39 Ensembl
GRCm38284,765,360 - 84,775,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,765,387 - 84,775,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,605,517 - 84,615,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,566,224 - 84,576,243 (-)NCBIMGSCv36mm8
Celera286,360,569 - 86,370,824 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
Serping1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555112,545,285 - 2,557,982 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555112,545,337 - 2,557,850 (+)NCBIChiLan1.0ChiLan1.0
SERPING1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,754,075 - 58,771,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,773,949 - 59,791,183 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,838,502 - 52,855,781 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11156,309,685 - 56,326,639 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1156,309,686 - 56,326,639 (+)Ensemblpanpan1.1panPan2
SERPING1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,570,354 - 38,580,751 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,570,607 - 38,581,665 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,116,824 - 38,129,580 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,252,348 - 39,265,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1839,252,350 - 39,454,090 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11838,835,311 - 38,848,057 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,408,314 - 38,421,069 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,039,067 - 39,051,835 (-)NCBIUU_Cfam_GSD_1.0
Serping1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494714,797,581 - 14,810,679 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365814,908,458 - 4,924,645 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365814,911,403 - 4,924,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPING1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,324,158 - 13,338,663 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1213,324,160 - 13,338,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2212,957,676 - 12,972,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPING1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,617,122 - 15,634,540 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,616,674 - 15,633,855 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038112,967,736 - 112,984,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serping1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248643,091,083 - 3,103,090 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248643,091,397 - 3,103,084 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serping1
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:40
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000009817
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat

Markers in Region
RH128990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2369,842,834 - 69,843,013 (+)MAPPERmRatBN7.2
Rnor_6.0372,161,339 - 72,161,517NCBIRnor6.0
Rnor_5.0378,681,922 - 78,682,100UniSTSRnor5.0
RGSC_v3.4367,968,904 - 67,969,082UniSTSRGSC3.4
Celera369,198,165 - 69,198,343UniSTS
Cytogenetic Map3q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 23 56 41 19 41 6 9 19 35 37 11 6
Low 20 1 2 2 55 4 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000009817   ⟹   ENSRNOP00000009817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,842,739 - 69,852,034 (-)Ensembl
Rnor_6.0 Ensembl372,161,189 - 72,171,078 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095984   ⟹   ENSRNOP00000089347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,843,417 - 69,852,034 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117291   ⟹   ENSRNOP00000086831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,842,739 - 69,850,988 (-)Ensembl
RefSeq Acc Id: NM_199093   ⟹   NP_954524
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,249,423 - 90,258,717 (-)NCBI
mRatBN7.2369,842,739 - 69,852,034 (-)NCBI
Rnor_6.0372,161,243 - 72,170,537 (-)NCBI
Rnor_5.0378,681,813 - 78,691,622 (-)NCBI
RGSC_v3.4367,968,808 - 67,978,102 (-)RGD
Celera369,198,069 - 69,207,363 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234447   ⟹   XP_006234509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,249,410 - 90,259,299 (-)NCBI
mRatBN7.2369,842,726 - 69,852,583 (-)NCBI
Rnor_6.0372,161,230 - 72,171,109 (-)NCBI
Rnor_5.0378,681,813 - 78,691,622 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_954524 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234509 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61860 (Get FASTA)   NCBI Sequence Viewer  
  EDL79315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009817
  ENSRNOP00000009817.3
  ENSRNOP00000086831.1
  ENSRNOP00000089347.1
GenBank Protein Q6P734 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_954524   ⟸   NM_199093
- Peptide Label: precursor
- UniProtKB: Q6P734 (UniProtKB/Swiss-Prot),   A6HMR4 (UniProtKB/TrEMBL),   A0A8I6A6T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234509   ⟸   XM_006234447
- Peptide Label: isoform X1
- UniProtKB: Q6P734 (UniProtKB/Swiss-Prot),   A6HMR4 (UniProtKB/TrEMBL),   A0A8I6A6T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009817   ⟸   ENSRNOT00000009817
RefSeq Acc Id: ENSRNOP00000089347   ⟸   ENSRNOT00000095984
RefSeq Acc Id: ENSRNOP00000086831   ⟸   ENSRNOT00000117291
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P734-F1-model_v2 AlphaFold Q6P734 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692182
Promoter ID:EPDNEW_R2707
Type:initiation region
Name:Serping1_1
Description:serpin family G member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0372,171,046 - 72,171,106EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735225 AgrOrtholog
BioCyc Gene G2FUF-49156 BioCyc
Ensembl Genes ENSRNOG00000007457 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009817 ENTREZGENE
  ENSRNOT00000009817.5 UniProtKB/Swiss-Prot
  ENSRNOT00000095984.1 UniProtKB/TrEMBL
  ENSRNOT00000117291.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598525 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:295703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72585 IMAGE-MGC_LOAD
NCBI Gene 295703 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11461:SF159 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serping1 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007457 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A6T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABI1_RAT UniProtKB/TrEMBL
  A6HMR4 ENTREZGENE, UniProtKB/TrEMBL
  IC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serping1  serpin family G member 1  Serping1  serpin peptidase inhibitor, clade G (C1 inhibitor), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serping1  serpin peptidase inhibitor, clade G (C1 inhibitor), member 1  Serping1  serpin peptidase inhibitor, clade G, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serping1  serpin peptidase inhibitor, clade G, member 1  Serping1  serine (or cysteine) peptidase inhibitor, clade G, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Serping1  serine (or cysteine) peptidase inhibitor, clade G, member 1    serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency of the human homolog causes autosomal dominant hereditary angioedema 1302854