Cyp2b21 (cytochrome P450, family 2, subfamily b, polypeptide 21) - Rat Genome Database

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Gene: Cyp2b21 (cytochrome P450, family 2, subfamily b, polypeptide 21) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2b21
Name: cytochrome P450, family 2, subfamily b, polypeptide 21
RGD ID: 735174
Description: Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); PARTICIPATES IN arachidonic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp2b13; cytochrome P450 CYP2B21; cytochrome P450, family 2, subfamily b, polypeptide 13; LOC292728
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,013,781 - 91,042,752 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,013,782 - 91,042,752 (-)EnsemblGRCr8
mRatBN7.2181,886,097 - 81,915,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,886,098 - 81,915,066 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,294,493 - 87,332,582 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,796,258 - 95,825,251 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,050,338 - 89,088,429 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,389,783 - 83,418,613 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,389,788 - 83,418,777 (-)Ensemblrn6Rnor6.0
Rnor_5.0184,644,037 - 84,672,867 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,658,154 - 81,687,123 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,311,454 - 76,340,411 (-)NCBICelera
RGSC_v3.1181,736,265 - 81,765,234 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Isolation and sequencing of the cDNA of a novel cytochrome P450 from rat oesophagus. Brookman-Amissah N, etal., Carcinogenesis 2001 Jan;22(1):155-60.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cyp2b21
172 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:176
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000049175
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
RH133739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,886,212 - 81,886,392 (+)MAPPERmRatBN7.2
Rnor_6.0183,389,899 - 83,390,078NCBIRnor6.0
Rnor_5.0184,644,153 - 84,644,332UniSTSRnor5.0
RGSC_v3.4181,658,270 - 81,658,449UniSTSRGSC3.4
Celera176,311,570 - 76,311,749UniSTS
RH 3.4 Map1826.0UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
1 1 1 17 23 31 12 4 12 6 24 9 1 8 1 35 19

Sequence


Ensembl Acc Id: ENSRNOT00000049175   ⟹   ENSRNOP00000042986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,013,782 - 91,042,752 (-)Ensembl
mRatBN7.2 Ensembl181,886,098 - 81,915,066 (-)Ensembl
Rnor_6.0 Ensembl183,389,788 - 83,418,777 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083650   ⟹   ENSRNOP00000073545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,886,098 - 81,915,066 (-)Ensembl
RefSeq Acc Id: NM_198733   ⟹   NP_942028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,013,781 - 91,042,752 (-)NCBI
mRatBN7.2181,886,097 - 81,915,066 (-)NCBI
Rnor_6.0183,389,783 - 83,418,613 (-)NCBI
Rnor_5.0184,644,037 - 84,672,867 (-)NCBI
RGSC_v3.4181,658,154 - 81,687,123 (-)RGD
Celera176,311,454 - 76,340,411 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_942028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF80366 (Get FASTA)   NCBI Sequence Viewer  
  EDM07984 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042986
  ENSRNOP00000042986.2
RefSeq Acc Id: NP_942028   ⟸   NM_198733
- Peptide Label: precursor
- UniProtKB: Q9JJ02 (UniProtKB/TrEMBL),   A6J9A0 (UniProtKB/TrEMBL),   G3V9D2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042986   ⟸   ENSRNOT00000049175
Ensembl Acc Id: ENSRNOP00000073545   ⟸   ENSRNOT00000083650

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9D2-F1-model_v2 AlphaFold G3V9D2 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735174 AgrOrtholog
BioCyc Gene G2FUF-60343 BioCyc
Ensembl Genes ENSRNOG00000032004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049175 ENTREZGENE
  ENSRNOT00000049175.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
KEGG Report rno:292728 UniProtKB/TrEMBL
NCBI Gene 292728 ENTREZGENE
PANTHER CYTOCHROME P450 2B6 UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp2b21 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP2B UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032004 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A6J9A0 ENTREZGENE, UniProtKB/TrEMBL
  G3V9D2 ENTREZGENE, UniProtKB/TrEMBL
  Q9JJ02 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp2b21  cytochrome P450, family 2, subfamily b, polypeptide 21  Cyp2b13  cytochrome P450, family 2, subfamily b, polypeptide 13  Name updated 1299863 APPROVED
2005-11-17 Cyp2b13  cytochrome P450, family 2, subfamily b, polypeptide 13      Symbol and Name updated 1299863 APPROVED