Srr (serine racemase) - Rat Genome Database

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Gene: Srr (serine racemase) Rattus norvegicus
Analyze
Symbol: Srr
Name: serine racemase
RGD ID: 735094
Description: Enables several functions, including heterocyclic compound binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in alpha-amino acid metabolic process; response to ketamine; and response to xenobiotic stimulus. Located in apical part of cell. Orthologous to human SRR (serine racemase); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; nonketotic hyperglycinemia pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; MGC94291
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,267,936 - 60,285,094 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1060,268,859 - 60,285,100 (-)EnsemblGRCr8
mRatBN7.21059,769,563 - 59,786,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1059,769,571 - 59,787,011 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1064,417,009 - 64,433,206 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01063,922,598 - 63,938,789 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,384,982 - 59,401,173 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01061,756,138 - 61,772,327 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1061,756,138 - 61,772,293 (-)Ensemblrn6Rnor6.0
Rnor_5.01061,477,874 - 61,493,655 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41062,217,481 - 62,234,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1058,801,057 - 58,816,824 (-)NCBICelera
RGSC_v3.11062,231,104 - 62,248,454 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (ISO)
D-aspartic acid  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
ethylenediaminetetraacetic acid  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
GSK-J4  (ISO)
hydroxylamine  (ISO)
L-aspartic acid  (ISO)
L-methionine  (ISO)
L-serine  (EXP)
lead diacetate  (ISO)
LY294002  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methyllycaconitine  (EXP,ISO)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
norketamine  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
pyridoxal 5'-phosphate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical part of cell  (IDA)
cytoplasm  (IBA,IEA,ISO)
neuronal cell body  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cellular distribution of D-serine, serine racemase and D-amino acid oxidase in the rat vestibular sensory epithelia. Dememes D, etal., Neuroscience. 2006 Feb;137(3):991-7. Epub 2005 Nov 14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the D-serine levels in rat brain. Hashimoto A, etal., Eur J Pharmacol. 2007 Jan 19;555(1):17-22. Epub 2006 Oct 10.
4. Rat cerebral serine racemase: amino acid deletion and truncation at carboxy terminus. Konno R Neurosci Lett 2003 Oct 2;349(2):111-4.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory. Mothet JP, etal., Aging Cell. 2006 Jun;5(3):267-74.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei. Puyal J, etal., J Comp Neurol. 2006 Aug 1;497(4):610-21.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. Smith MA, etal., J Biol Chem. 2010 Apr 23;285(17):12873-81. doi: 10.1074/jbc.M109.050062. Epub 2010 Jan 27.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain. Takeyama K, etal., Eur J Pharmacol. 2006 Jul 1;540(1-3):82-6. Epub 2006 Apr 28.
15. Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Wolosker H, etal., Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):721-5.
16. Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase. Yoshikawa M, etal., J Pharmacol Sci. 2008 Jul;107(3):270-6. Epub 2008 Jul 5.
Additional References at PubMed
PMID:10557334   PMID:11054547   PMID:12021263   PMID:15193426   PMID:15312798   PMID:15337321   PMID:15536068   PMID:15681805   PMID:15684087   PMID:15710237   PMID:16314870   PMID:16517698  
PMID:17293453   PMID:17880399   PMID:18516911   PMID:18812225   PMID:18974604   PMID:19800712   PMID:23022330   PMID:23361961   PMID:25336657   PMID:25493718   PMID:26505919   PMID:26553873  
PMID:27387750   PMID:27693471   PMID:30053369   PMID:38761177  


Genomics

Comparative Map Data
Srr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,267,936 - 60,285,094 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1060,268,859 - 60,285,100 (-)EnsemblGRCr8
mRatBN7.21059,769,563 - 59,786,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1059,769,571 - 59,787,011 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1064,417,009 - 64,433,206 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01063,922,598 - 63,938,789 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,384,982 - 59,401,173 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01061,756,138 - 61,772,327 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1061,756,138 - 61,772,293 (-)Ensemblrn6Rnor6.0
Rnor_5.01061,477,874 - 61,493,655 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41062,217,481 - 62,234,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1058,801,057 - 58,816,824 (-)NCBICelera
RGSC_v3.11062,231,104 - 62,248,454 (-)NCBI
Cytogenetic Map10q24NCBI
SRR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38172,303,378 - 2,325,264 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl172,303,383 - 2,325,260 (+)Ensemblhg38GRCh38
GRCh37172,207,237 - 2,228,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36172,153,998 - 2,175,303 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34172,153,997 - 2,175,303NCBI
Celera172,223,105 - 2,244,656 (+)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef172,102,020 - 2,123,254 (+)NCBIHuRef
CHM1_1172,215,887 - 2,237,496 (+)NCBICHM1_1
T2T-CHM13v2.0172,190,459 - 2,212,603 (+)NCBIT2T-CHM13v2.0
Srr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,794,853 - 74,818,427 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1174,797,185 - 74,816,774 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381174,904,027 - 74,927,533 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,906,359 - 74,925,948 (-)Ensemblmm10GRCm38
MGSCv371174,719,861 - 74,739,300 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361174,722,991 - 74,741,898 (-)NCBIMGSCv36mm8
Celera1182,412,517 - 82,431,921 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.76NCBI
Srr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955481871,654 - 937,770 (-)Ensembl
ChiLan1.0NW_004955481919,692 - 940,066 (-)NCBIChiLan1.0ChiLan1.0
SRR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,883,643 - 9,905,686 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,851,013 - 11,873,067 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0172,294,440 - 2,316,244 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1172,182,839 - 2,200,704 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl172,182,839 - 2,200,704 (+)EnsemblpanPan2panpan1.1
SRR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha945,555,778 - 45,576,362 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0947,236,976 - 47,257,595 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl947,237,076 - 47,297,874 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1946,003,950 - 46,024,528 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0946,298,440 - 46,319,034 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0946,353,700 - 46,374,300 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560245,483,998 - 45,506,406 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365388,361,135 - 8,383,820 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365388,362,033 - 8,383,820 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1248,386,881 - 48,408,039 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11248,386,915 - 48,407,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SRR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,940,870 - 1,958,165 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,940,893 - 1,956,783 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605920,004,892 - 20,022,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,977,574 - 4,988,945 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247864,969,742 - 4,988,874 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Srr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1993,644,598 - 93,660,279 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srr
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:81
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000046110
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000046110   ⟹   ENSRNOP00000050774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1060,268,859 - 60,285,009 (-)Ensembl
mRatBN7.2 Ensembl1059,770,489 - 59,786,639 (-)Ensembl
Rnor_6.0 Ensembl1061,756,138 - 61,772,293 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085394   ⟹   ENSRNOP00000070927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1060,268,859 - 60,285,100 (-)Ensembl
mRatBN7.2 Ensembl1059,771,166 - 59,787,011 (-)Ensembl
Rnor_6.0 Ensembl1061,756,753 - 61,772,284 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092338   ⟹   ENSRNOP00000075831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1061,757,242 - 61,772,250 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092475   ⟹   ENSRNOP00000089897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1059,769,571 - 59,776,104 (-)Ensembl
RefSeq Acc Id: NM_198757   ⟹   NP_942052
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,268,858 - 60,285,009 (-)NCBI
mRatBN7.21059,770,488 - 59,786,639 (-)NCBI
Rnor_6.01061,756,138 - 61,772,293 (-)NCBI
Rnor_5.01061,477,874 - 61,493,655 (-)NCBI
RGSC_v3.41062,217,481 - 62,234,831 (-)RGD
Celera1058,801,057 - 58,816,824 (-)RGD
Sequence:
RefSeq Acc Id: XM_008768015   ⟹   XP_008766237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,267,936 - 60,285,049 (-)NCBI
mRatBN7.21059,769,563 - 59,786,684 (-)NCBI
Rnor_6.01061,756,267 - 61,772,327 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086014   ⟹   XP_038941942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,267,936 - 60,285,049 (-)NCBI
mRatBN7.21059,769,563 - 59,786,688 (-)NCBI
RefSeq Acc Id: XM_063269062   ⟹   XP_063125132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,267,936 - 60,285,049 (-)NCBI
RefSeq Acc Id: XM_063269063   ⟹   XP_063125133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,267,936 - 60,284,997 (-)NCBI
RefSeq Acc Id: XM_063269064   ⟹   XP_063125134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,267,936 - 60,285,092 (-)NCBI
RefSeq Acc Id: XM_063269065   ⟹   XP_063125135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,267,936 - 60,285,049 (-)NCBI
RefSeq Acc Id: XM_063269066   ⟹   XP_063125136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,267,936 - 60,285,034 (-)NCBI
RefSeq Acc Id: XM_063269067   ⟹   XP_063125137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,267,936 - 60,285,094 (-)NCBI
RefSeq Acc Id: NP_942052   ⟸   NM_198757
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766237   ⟸   XM_008768015
- Peptide Label: isoform X1
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075831   ⟸   ENSRNOT00000092338
Ensembl Acc Id: ENSRNOP00000070927   ⟸   ENSRNOT00000085394
Ensembl Acc Id: ENSRNOP00000050774   ⟸   ENSRNOT00000046110
RefSeq Acc Id: XP_038941942   ⟸   XM_039086014
- Peptide Label: isoform X1
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089897   ⟸   ENSRNOT00000092475
RefSeq Acc Id: XP_063125137   ⟸   XM_063269067
- Peptide Label: isoform X1
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125134   ⟸   XM_063269064
- Peptide Label: isoform X1
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125135   ⟸   XM_063269065
- Peptide Label: isoform X1
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125132   ⟸   XM_063269062
- Peptide Label: isoform X1
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125136   ⟸   XM_063269066
- Peptide Label: isoform X1
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125133   ⟸   XM_063269063
- Peptide Label: isoform X1
- UniProtKB: Q76EQ0 (UniProtKB/Swiss-Prot),   A6HGP0 (UniProtKB/TrEMBL),   A0A8L2R439 (UniProtKB/TrEMBL)
Protein Domains
Tryptophan synthase beta chain-like PALP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76EQ0-F1-model_v2 AlphaFold Q76EQ0 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697419
Promoter ID:EPDNEW_R7942
Type:initiation region
Name:Srr_1
Description:serine racemase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01061,772,255 - 61,772,315EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735094 AgrOrtholog
BioCyc Gene G2FUF-24237 BioCyc
BioCyc Pathway PWY-8140 [serine racemization] BioCyc
BioCyc Pathway Image PWY-8140 BioCyc
Ensembl Genes ENSRNOG00000002991 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046110 ENTREZGENE
  ENSRNOT00000046110.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1100 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132082 IMAGE-MGC_LOAD
InterPro PLP-dep UniProtKB/Swiss-Prot
  Ser/Thr_deHydtase_PyrdxlP-BS UniProtKB/Swiss-Prot
  Trypto_synt_PLP_dependent UniProtKB/Swiss-Prot
KEGG Report rno:303306 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94291 IMAGE-MGC_LOAD
NCBI Gene 303306 ENTREZGENE
PANTHER SERINE / THREONINE RACEMASE FAMILY MEMBER UniProtKB/Swiss-Prot
  SERINE RACEMASE UniProtKB/Swiss-Prot
Pfam PALP UniProtKB/Swiss-Prot
PhenoGen Srr PhenoGen
PROSITE DEHYDRATASE_SER_THR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002991 RatGTEx
Superfamily-SCOP SSF53686 UniProtKB/Swiss-Prot
UniProt A0A8L2R439 ENTREZGENE, UniProtKB/TrEMBL
  A6HGN9_RAT UniProtKB/TrEMBL
  A6HGP0 ENTREZGENE, UniProtKB/TrEMBL
  Q76EQ0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Srr  serine racemase      Symbol and Name status set to approved 1299863 APPROVED