Gene:	Prickle1 ( Rattus norvegicus ) prickle homolog 1 (Drosophila)
Description:	plays a role in the nuclear localization of transcriptional regulators REST4 and REST/NRSF; may act as a nuclear receptor for transcription factors
Synonyms:	prickle-like 1 (Drosophila); Rilp; REST/NRSF-interacting lim domain protein;
ArrayIDs:	A_43_P17721; 1379369_at; 1395805_at; rc_AI171526_at; 6081903; 5723791; GE1298197; 1376509_at; 6606884; 5988629; A_44_P463759; 5661930; 5653865; rc_AI137981_at; 5844786; 6668925; 6466868; 6382471; 6087839;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PRICKLE1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Prickle1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Prickle1 Rat Celera Assembly 7 121036584 - 121132517     RGSC genome assembly v3.4 7 131967232 - 132063070     Cytogenetic 7 q35     genome assembly 3.1 7 132044813 - 132052370 Mus musculus Prickle1 Mouse genome assembly build 36.1 15 93329545 - 93426322     Cytogenetic 15 15 E3 Homo sapiens PRICKLE1 human genome assembly 12 41139340 - 41269745     Human genome assembly build 36.2 12 41139341 - 41269745     Cytogenetic 12 q12   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology zinc ion binding,  transcription factor binding,  metal ion binding (details...)
Biological Process	Gene Ontology protein import into nucleus (details...)
Cellular Component	Gene Ontology nucleus,  nuclear membrane,  cytoplasm ...  (details...)
Pathway	Ontology the planar cell polarity Wnt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE Ensembl Protein: ENSRNOP00000031476 IPI SMART: LIM IPI IPI: IPI00361687 IPI PROSITE: PET IPI PROSITE: LIM_DOMAIN_2 IPI PROSITE: LIM_DOMAIN_1 IPI Gene3D-CATH: Znf_LIM IPI Entrez Gene: Prickle1 ENTREZGENE UNIPARC: UPI00004C2CF0 IPI KEGG Report: rno:315259 ENTREZGENE Ensembl Genes: ENSRNOG00000022772 IPI UniProt: PRIC1_RAT IPI HomoloGene Group ID: 17686 ENTREZGENE Germonline: 735090 Pfam: PET IPI Pfam: LIM IPI KEGG Pathway: 04310 ENTREZGENE InterPro: Znf_LIM. IPI InterPro: PET_domain. IPI
Sequences	Nucleotide: XM_001057421 Get FASTA Search GEO Profiles Nucleotide: XM_001057488 Get FASTA Search GEO Profiles Nucleotide: NM_199396 Get FASTA Search GEO Profiles Nucleotide: XM_001075319 Get FASTA Search GEO Profiles Nucleotide: CH474027 Get FASTA Search GEO Profiles Nucleotide: XM_235609 Get FASTA Search GEO Profiles Nucleotide: AF399843 Get FASTA Search GEO Profiles (View all 7 Nucleotide Accessions) Protein: XP_001057421 Get FASTA Protein: NP_955428 Get FASTA Protein: XP_001075319 Get FASTA Protein: XP_001057488 Get FASTA Protein: Q71QF9 Get FASTA Protein: AAQ03034 Get FASTA Protein: EDL76631 Get FASTA Protein: EDL76630 Get FASTA Protein: EDL76629 Get FASTA Protein: XP_235609 Get FASTA (View all 10 Protein Accessions)
Clusters	UniGene: 141040
References
Curated References	3 references in RGD related to Prickle1
Other References	2 other references at PubMed related to Prickle1
Database Information
RGD ID	735090
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 15-DEC-08: Prickle1 prickle homolog 1 (Drosophila) Prickle1 prickle-like 1 (Drosophila) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 08-JUL-05: Prickle1 prickle-like 1 (Drosophila) APPROVED Symbol and Name status set to approved 1299863