RGD Reference Report - Planar cell polarity signaling in vertebrates. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Planar cell polarity signaling in vertebrates.

Authors: Jones, C  Chen, P 
Citation: Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32.
RGD ID: 2293492
Pubmed: PMID:17226800   (View Abstract at PubMed)
PMCID: PMC4158832   (View Article at PubMed Central)
DOI: DOI:10.1002/bies.20526   (Journal Full-text)

Planar cell polarity (PCP) refers to the polarization of a field of cells within the plane of a cell sheet. This form of polarization is required for diverse cellular processes in vertebrates, including convergent extension (CE), the establishment of PCP in epithelial tissues and ciliogenesis. Perhaps the most distinct example of vertebrate PCP is the uniform orientation of stereociliary bundles at the apices of sensory hair cells in the mammalian auditory sensory organ. The establishment of PCP in the mammalian cochlea occurs concurrently with CE in this ciliated epithelium, therefore linking three cellular processes regulated by the vertebrate PCP pathway in the same tissue and emerging as a model system for dissecting PCP signaling. This review summarizes the morphogenesis of this model system to assist the interpretation of the emerging data and proposes molecular mechanisms underlying PCP signaling in vertebrates.

Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Celsr1  (cadherin, EGF LAG seven-pass G-type receptor 1)
Daam1  (dishevelled associated activator of morphogenesis 1)
Dvl2  (dishevelled segment polarity protein 2)
Fzd3  (frizzled class receptor 3)
Fzd6  (frizzled class receptor 6)
Prickle1  (prickle planar cell polarity protein 1)
Prickle2  (prickle planar cell polarity protein 2)
Ptk7  (protein tyrosine kinase 7)
Scrib  (scribble planar cell polarity protein)
Vangl2  (VANGL planar cell polarity protein 2)

Genes (Mus musculus)
Celsr1  (cadherin, EGF LAG seven-pass G-type receptor 1)
Daam1  (dishevelled associated activator of morphogenesis 1)
Dvl2  (dishevelled segment polarity protein 2)
Fzd3  (frizzled class receptor 3)
Fzd6  (frizzled class receptor 6)
Prickle1  (prickle planar cell polarity protein 1)
Prickle2  (prickle planar cell polarity protein 2)
Ptk7  (PTK7 protein tyrosine kinase 7)
Scrib  (scribbled planar cell polarity)
Vangl2  (VANGL planar cell polarity 2)

Genes (Homo sapiens)
CELSR1  (cadherin EGF LAG seven-pass G-type receptor 1)
DAAM1  (dishevelled associated activator of morphogenesis 1)
DVL2  (dishevelled segment polarity protein 2)
FZD3  (frizzled class receptor 3)
FZD6  (frizzled class receptor 6)
PRICKLE1  (prickle planar cell polarity protein 1)
PRICKLE2  (prickle planar cell polarity protein 2)
PTK7  (protein tyrosine kinase 7 (inactive))
SCRIB  (scribble planar cell polarity protein)
VANGL2  (VANGL planar cell polarity protein 2)


Additional Information