Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | schizophrenia | | ISO | KPNA1 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21743468 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | schizophrenia | | ISO | KPNA1 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21743468 | |
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# | Reference Title | Reference Citation |
1. | Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. | Dieterich DC, etal., PLoS Biol. 2008 Feb;6(2):e34. doi: 10.1371/journal.pbio.0060034. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
5. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
6. | GOA pipeline | RGD automated data pipeline |
7. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
8. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
9. | Molecular cloning and characterization of rat karyopherin alpha 1 gene: structure and expression. | Wang B, etal., Gene 2004 Apr 28;331:149-57. |
PMID:15603742 | PMID:16574786 | PMID:16906019 | PMID:17728463 | PMID:23106098 | PMID:27434733 | PMID:30053369 |
Kpna1 (Rattus norvegicus - Norway rat) |
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KPNA1 (Homo sapiens - human) |
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Kpna1 (Mus musculus - house mouse) |
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Kpna1 (Chinchilla lanigera - long-tailed chinchilla) |
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KPNA1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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KPNA1 (Canis lupus familiaris - dog) |
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Kpna1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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KPNA1 (Sus scrofa - pig) |
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KPNA1 (Chlorocebus sabaeus - green monkey) |
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Kpna1 (Heterocephalus glaber - naked mole-rat) |
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Variants in Kpna1
198 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
Kpna1 |
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BE113307 |
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AA800028 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 57 | 41 | 19 | 41 | 8 | 11 | 74 | 35 | 39 | 11 | 8 |
Low | 2 | ||||||||||||
Below cutoff |
RefSeq Transcripts | NM_198726 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_008768714 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017597922 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039088121 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039088122 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AY351984 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AY779025 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000011 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000078285 ⟹ ENSRNOP00000071569 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000084540 ⟹ ENSRNOP00000070449 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000097087 ⟹ ENSRNOP00000089735 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000117532 ⟹ ENSRNOP00000094957 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_198726 ⟹ NP_942021 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017597922 ⟹ XP_017453411 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039088121 ⟹ XP_038944049 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039088122 ⟹ XP_038944050 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_942021 | (Get FASTA) | NCBI Sequence Viewer |
XP_017453411 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038944049 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038944050 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAQ56727 | (Get FASTA) | NCBI Sequence Viewer |
AAX07452 | (Get FASTA) | NCBI Sequence Viewer | |
EDM11298 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000070449 | ||
ENSRNOP00000070449.1 | |||
ENSRNOP00000071569 | |||
ENSRNOP00000071569.2 | |||
ENSRNOP00000089735.1 | |||
ENSRNOP00000094957.1 | |||
GenBank Protein | P83953 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_942021 ⟸ NM_198726 |
- UniProtKB: | P83953 (UniProtKB/Swiss-Prot), Q56R20 (UniProtKB/TrEMBL), A0A0G2JXY5 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017453411 ⟸ XM_017597922 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P83953 (UniProtKB/Swiss-Prot), Q56R20 (UniProtKB/TrEMBL), A0A0G2JXY5 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000070449 ⟸ ENSRNOT00000084540 |
RefSeq Acc Id: | ENSRNOP00000071569 ⟸ ENSRNOT00000078285 |
RefSeq Acc Id: | XP_038944049 ⟸ XM_039088121 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P83953 (UniProtKB/Swiss-Prot), Q56R20 (UniProtKB/TrEMBL), A0A0G2JXY5 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038944050 ⟸ XM_039088122 |
- Peptide Label: | isoform X2 |
RefSeq Acc Id: | ENSRNOP00000094957 ⟸ ENSRNOT00000117532 |
RefSeq Acc Id: | ENSRNOP00000089735 ⟸ ENSRNOT00000097087 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P83953-F1-model_v2 | AlphaFold | P83953 | 1-538 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:735064 | AgrOrtholog |
BioCyc Gene | G2FUF-21209 | BioCyc |
Ensembl Genes | ENSRNOG00000051711 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000078285.2 | UniProtKB/TrEMBL |
ENSRNOT00000084540.2 | UniProtKB/TrEMBL | |
ENSRNOT00000097087.1 | UniProtKB/TrEMBL | |
ENSRNOT00000117532.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.20.5.690 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
1.25.10.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | ARM-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ARM-type_fold | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Arm_3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Armadillo | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Importin-a-like_IBB-bd_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Importin-a_IBB_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Importing_su_alpha | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:288064 | UniProtKB/TrEMBL |
NCBI Gene | 288064 | ENTREZGENE |
PANTHER | IMPORTIN ALPHA | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IMPORTIN SUBUNIT ALPHA-5 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Arm | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Arm_3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IBB | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Kpna1 | PhenoGen |
PIRSF | Importin_alpha | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | ARM_REPEAT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IBB | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000051711 | RatGTEx |
SMART | ARM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | ARM-type_fold | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A0G2JXY5 | ENTREZGENE, UniProtKB/TrEMBL |
A0A0G2K0T0_RAT | UniProtKB/TrEMBL | |
A0A8I6A8S8_RAT | UniProtKB/TrEMBL | |
A0A8I6AKK8_RAT | UniProtKB/TrEMBL | |
IMA1_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
Q56R20 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-02-11 | Kpna1 | karyopherin subunit alpha 1 | Kpna1 | karyopherin alpha 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2009-12-15 | Kpna1 | karyopherin alpha 1 | Kpna1 | karyopherin (importin) alpha 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2005-11-17 | Kpna1 | karyopherin (importin) alpha 1 | karyopherin alpha 1 (importin alpha 5) | Name updated | 1299863 | APPROVED | |
2005-07-08 | Kpna1 | karyopherin alpha 1 (importin alpha 5) | Symbol and Name status set to approved | 1299863 | APPROVED |
Note Type | Note | Reference |
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gene_expression | mRNA expression was found to be higher in heart, kidney, placenta, pancreas, and spleen and relatively lower in brain, liver, and skeletal muscle (by semi-quantitative RT-PCR) | 1302832 |
gene_homology | cDNA is 99% homolgous to mouse Kpna1 and 98% homologous to human KPNA1 | 1302832 |
gene_regulation | 6-OHDA treatment resulted in up to 2-fold increases in Kpna1 mRNA levels 2 weeks post-treatment with levels less but still higher than controls at 5 weeks post-treatment (p<0.05) | 1302832 |