Klk1c3 (kallikrein 1-related peptidase C3) - Rat Genome Database

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Gene: Klk1c3 (kallikrein 1-related peptidase C3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Klk1c3
Name: kallikrein 1-related peptidase C3
RGD ID: 735032
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1); INTERACTS WITH bisphenol A; Cuprizon; Monobutylphthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glandular kallikrein-3, submandibular; glandular kallikrein-3, submandibular-like; kallikrein; kallikrein 1-related peptidase c10-like 2; kallikrein 3; Klk-3; Klk1c10l2; KLK3; LOC108348116; LOC292872; rGK-3; RSGK-50; RSKG-50; S1 kallikrein; submaxillary gland S1 kallikrein; tissue kallikrein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,808,150 - 103,811,931 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1103,807,777 - 103,811,931 (+)EnsemblGRCr8
mRatBN7.2194,671,636 - 94,675,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,671,618 - 94,675,417 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,057,022 - 100,060,817 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,529,666 - 108,533,455 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,820,201 - 101,823,992 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,141,205 - 100,163,945 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,164,400 - 100,165,425 (+)Ensemblrn6Rnor6.0
Rnor_5.01101,229,510 - 101,230,585 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01101,225,238 - 101,229,053 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4194,653,305 - 94,658,098 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,938,397 - 88,942,392 (+)NCBICelera
RGSC_v3.1194,733,106 - 94,736,206 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin. Ashley PL and MacDonald RJ, Biochemistry 1985 Aug 13;24(17):4512-20.
2. Tissue-specific expression of kallikrein-related genes in the rat. Ashley PL and MacDonald RJ, Biochemistry 1985 Aug 13;24(17):4520-7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1908019   PMID:2550051   PMID:8662704   PMID:15203212   PMID:17366701   PMID:18068196   PMID:18689794  


Genomics

Variants

.
Variants in Klk1c3
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000025777
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
7 16 13 18 12 6 9 6 2 96 34 3 3 49 65 6

Sequence


Ensembl Acc Id: ENSRNOT00000025777   ⟹   ENSRNOP00000025777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,809,841 - 103,811,931 (+)Ensembl
mRatBN7.2 Ensembl194,671,618 - 94,675,417 (+)Ensembl
Rnor_6.0 Ensembl1100,161,872 - 100,163,896 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080334   ⟹   ENSRNOP00000075468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,809,552 - 103,811,931 (+)Ensembl
mRatBN7.2 Ensembl194,673,038 - 94,675,417 (+)Ensembl
Rnor_6.0 Ensembl1100,164,400 - 100,165,425 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121588   ⟹   ENSRNOP00000110304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,807,777 - 103,811,931 (+)Ensembl
RefSeq Acc Id: NM_001271315   ⟹   NP_001258244
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,808,150 - 103,811,931 (+)NCBI
mRatBN7.2194,671,636 - 94,675,417 (+)NCBI
Rnor_6.01100,160,166 - 100,163,945 (+)NCBI
Rnor_5.01101,229,510 - 101,230,585 (+)NCBI
Celera188,938,436 - 88,942,399 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258244 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41465 (Get FASTA)   NCBI Sequence Viewer  
  AAA42080 (Get FASTA)   NCBI Sequence Viewer  
  AAA58782 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000110304
GenBank Protein P15950 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258244   ⟸   NM_001271315
- Peptide Label: precursor
- UniProtKB: A0A0A0MXZ4 (UniProtKB/TrEMBL),   Q63275 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075468   ⟸   ENSRNOT00000080334
Ensembl Acc Id: ENSRNOP00000025777   ⟸   ENSRNOT00000025777
Ensembl Acc Id: ENSRNOP00000110304   ⟸   ENSRNOT00000121588
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAN9-F1-model_v2 AlphaFold A0A0G2KAN9 1-188 view protein structure
AF-P15950-F1-model_v2 AlphaFold P15950 1-188 view protein structure
AF-A0A0A0MXZ4-F1-model_v2 AlphaFold A0A0A0MXZ4 1-234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735032 AgrOrtholog
BioCyc Gene G2FUF-59797 BioCyc
Ensembl Genes ENSRNOG00000033414 Ensembl, ENTREZGENE
  ENSRNOG00000054979 Ensembl
Ensembl Transcript ENSRNOT00000121588 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
NCBI Gene 292872 ENTREZGENE
PANTHER KALLIKREIN-1 UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Klk1c3 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033414 RatGTEx
  ENSRNOG00000054979 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0A0A0MXZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAN9_RAT UniProtKB/TrEMBL
  A0ABK0M040_RAT UniProtKB/TrEMBL
  KLK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63275 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Klk1c3  kallikrein 1-related peptidase C3  LOC108348116  glandular kallikrein-3, submandibular-like  Data merged from RGD:11460610 737654 PROVISIONAL
2016-08-02 LOC108348116  glandular kallikrein-3, submandibular-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-06-29 Klk1c3  kallikrein 1-related peptidase C3  Klk1c10l2  kallikrein 1-related peptidase c10-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-07 Klk1c10l2  kallikrein 1-related peptidase c10-like 2  LOC292872  kallikrein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 LOC292872  kallikrein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression limited to the submaxillary gland 1302557