Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of EIF5B mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | affects expression | ISO | Eif5b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of EIF5B mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Estradiol results in increased expression of EIF5B mRNA | CTD | PMID:31614463 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Eif5b (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Eif5b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EIF5B mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EIF5B mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Eif5b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EIF5B mRNA | CTD | PMID:21570461 and PMID:26377647 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,4,6-tribromophenol | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of EIF5B mRNA | CTD | PMID:19162173 | acrolein | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EIF5B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of EIF5B mRNA | CTD | PMID:32699268 | aflatoxin B1 | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of EIF5B mRNA | CTD | PMID:19770486 | alpha-pinene | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EIF5B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of EIF5B mRNA | CTD | PMID:32699268 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of EIF5B mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of EIF5B mRNA | CTD | PMID:24449571 | apigenin | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | Apigenin results in increased expression of EIF5B mRNA | CTD | PMID:22359648 | aristolochic acid A | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of EIF5B mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Eif5b (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of EIF5B mRNA | CTD | PMID:23650126 | benzatropine | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of EIF5B protein | CTD | PMID:34122009 | benzatropine | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Benztropine results in increased expression of EIF5B protein | CTD | PMID:34122009 | benzo[a]pyrene | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of EIF5B mRNA | CTD | PMID:32234424 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bis(2-chloroethyl) sulfide | increases phosphorylation | ISO | EIF5B (Homo sapiens) | 6480464 | Mustard Gas results in increased phosphorylation of EIF5B protein | CTD | PMID:19845377 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EIF5B mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | bisphenol A results in increased expression of EIF5B mRNA | CTD | PMID:33670352 | bisphenol A | decreases expression | ISO | Eif5b (Mus musculus) | 6480464 | bisphenol A results in decreased expression of EIF5B mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EIF5B mRNA | CTD | PMID:34947998 | Bisphenol B | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | bisphenol B results in increased expression of EIF5B protein | CTD | PMID:34186270 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of EIF5B mRNA | CTD | PMID:21297351 | caffeine | affects phosphorylation | ISO | EIF5B (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of EIF5B protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to EIF5B gene] | CTD | PMID:28238834 | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of EIF5B mRNA | CTD | PMID:23125180 | chromium(6+) | affects expression | ISO | Eif5b (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of EIF5B mRNA | CTD | PMID:28472532 | cisplatin | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | Cisplatin affects the reaction [Piroxicam results in decreased expression of EIF5B mRNA] | CTD | PMID:21858171 | cisplatin | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of EIF5B mRNA | CTD | PMID:27594783 | clobetasol | decreases expression | ISO | Eif5b (Mus musculus) | 6480464 | Clobetasol results in decreased expression of EIF5B mRNA | CTD | PMID:27462272 | clofibrate | multiple interactions | ISO | Eif5b (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of EIF5B mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EIF5B mRNA] | CTD | PMID:17585979 | clofibrate | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | Clofibrate results in increased expression of EIF5B mRNA | CTD | PMID:17585979 | clozapine | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Clozapine results in increased expression of EIF5B protein | CTD | PMID:34122009 | cobalt dichloride | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of EIF5B mRNA | CTD | PMID:19376846 | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of EIF5B mRNA | CTD | PMID:17898221 | coumarin | affects phosphorylation | ISO | EIF5B (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of EIF5B protein | CTD | PMID:35688186 | CU-O LINKAGE | decreases phosphorylation | ISO | EIF5B (Homo sapiens) | 6480464 | cupric oxide results in decreased phosphorylation of EIF5B protein | CTD | PMID:25470785 | Cuprizon | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of EIF5B protein | CTD | PMID:34122009 | decabromodiphenyl ether | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | decabromobiphenyl ether results in increased expression of EIF5B protein | CTD | PMID:31675489 | deoxynivalenol | affects phosphorylation | ISO | Eif5b (Mus musculus) | 6480464 | deoxynivalenol affects the phosphorylation of EIF5B protein | CTD | PMID:23811945 | dextran sulfate | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | Dextran Sulfate results in increased expression of EIF5B mRNA | CTD | PMID:35093514 | dicrotophos | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of EIF5B mRNA | CTD | PMID:28302478 | disodium selenite | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of EIF5B mRNA | CTD | PMID:18175754 | elemental selenium | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of IF2 mRNA | CTD | PMID:19244175 | elemental selenium | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Selenium results in decreased expression of IF2 mRNA | CTD | PMID:19244175 | enzyme inhibitor | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EIF5B protein | CTD | PMID:23301498 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of EIF5B mRNA | CTD | PMID:15353170 | ethanol | multiple interactions | ISO | Eif5b (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of EIF5B mRNA | CTD | PMID:30319688 | ethanol | affects expression | ISO | Eif5b (Mus musculus) | 6480464 | Ethanol affects the expression of EIF5B mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of EIF5B mRNA | CTD | PMID:23649840 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of EIF5B mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of EIF5B mRNA | CTD | PMID:24136188 | FR900359 | affects phosphorylation | ISO | EIF5B (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of EIF5B protein | CTD | PMID:37730182 | glyphosate | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Glyphosate results in increased expression of EIF5B mRNA | CTD | PMID:31874349 | gold atom | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Polyethyleneimine binds to Gold] which results in decreased expression of EIF5B mRNA | CTD | PMID:28433809 | gold atom | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Gold analog results in decreased expression of EIF5B mRNA | CTD | PMID:36057382 | gold(0) | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Polyethyleneimine binds to Gold] which results in decreased expression of EIF5B mRNA | CTD | PMID:28433809 | gold(0) | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Gold analog results in decreased expression of EIF5B mRNA | CTD | PMID:36057382 | hexadecanoic acid | increases phosphorylation | ISO | EIF5B (Homo sapiens) | 6480464 | Palmitic Acid results in increased phosphorylation of EIF5B protein | CTD | PMID:28073184 | ivermectin | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of EIF5B protein | CTD | PMID:32959892 | methyl methanesulfonate | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of EIF5B mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of EIF5B mRNA | CTD | PMID:28001369 | miconazole | decreases expression | ISO | Eif5b (Mus musculus) | 6480464 | Miconazole results in decreased expression of EIF5B mRNA | CTD | PMID:27462272 | mitomycin C | affects response to substance | ISO | EIF5B (Homo sapiens) | 6480464 | EIF5B protein affects the susceptibility to Mitomycin | CTD | PMID:16217747 | mono(2-ethylhexyl) phthalate | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of EIF5B mRNA | CTD | PMID:22401849 | ozone | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EIF5B mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Eif5b (Mus musculus) | 6480464 | Acetaminophen affects the expression of EIF5B mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of EIF5B mRNA | CTD | PMID:33387578 | paracetamol | multiple interactions | ISO | Eif5b (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of EIF5B mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EIF5B mRNA] | CTD | PMID:17585979 | PCB138 | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | perfluorooctanoic acid | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of EIF5B protein | CTD | PMID:26879310 | piroxicam | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | Cisplatin affects the reaction [Piroxicam results in decreased expression of EIF5B mRNA] | CTD | PMID:21858171 | piroxicam | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of EIF5B mRNA | CTD | PMID:21858171 | SB 431542 | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of EIF5B protein | CTD | PMID:37664457 | selenium atom | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of IF2 mRNA | CTD | PMID:19244175 | selenium atom | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Selenium results in decreased expression of IF2 mRNA | CTD | PMID:19244175 | sodium arsenate | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | sodium arsenate results in increased expression of EIF5B mRNA | CTD | PMID:30953684 | sodium arsenite | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of EIF5B protein | CTD | PMID:30528433 | sodium arsenite | decreases expression | ISO | Eif5b (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of EIF5B mRNA | CTD | PMID:36209798 | sodium fluoride | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of EIF5B mRNA | CTD | PMID:27862939 | sulindac | increases expression | EXP | | 6480464 | Sulindac results in increased expression of EIF5B mRNA | CTD | PMID:24136188 | sunitinib | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of EIF5B mRNA | CTD | PMID:31533062 | tert-butyl hydroperoxide | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of EIF5B mRNA | CTD | PMID:15336504 | testosterone enanthate | affects expression | ISO | EIF5B (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of IF2 mRNA | CTD | PMID:17440010 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of EIF5B mRNA | CTD | PMID:31150632 | thapsigargin | increases expression | ISO | Eif5b (Mus musculus) | 6480464 | Thapsigargin results in increased expression of EIF5B protein | CTD | PMID:24648495 | titanium dioxide | decreases expression | ISO | Eif5b (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of EIF5B mRNA | CTD | PMID:29264374 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of EIF5B mRNA | CTD | PMID:33387578 | tungsten | decreases expression | ISO | Eif5b (Mus musculus) | 6480464 | Tungsten results in decreased expression of EIF5B mRNA | CTD | PMID:30912803 | tunicamycin | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of EIF5B mRNA | CTD | PMID:29453283 | valproic acid | increases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EIF5B mRNA | CTD | PMID:23179753 | valproic acid | affects expression | ISO | EIF5B (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EIF5B mRNA | CTD | PMID:25979313 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of EIF5B mRNA | CTD | PMID:19015723 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of EIF5B mRNA | CTD | PMID:23555832 | vitamin E | multiple interactions | ISO | EIF5B (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of IF2 mRNA | CTD | PMID:19244175 | vitamin E | decreases expression | ISO | EIF5B (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of IF2 mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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