Brca1<i><sup>m1Uwm</sup></i> (BRCA1, DNA repair associated; mutation 1, University of Wisconsin-Madison) - Rat Genome Database

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Gene: Brca1m1Uwm (BRCA1, DNA repair associated; mutation 1, University of Wisconsin-Madison) Rattus norvegicus
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Symbol: Brca1m1Uwm
Name: BRCA1, DNA repair associated; mutation 1, University of Wisconsin-Madison
RGD ID: 728298
Description: produced by N-ethyl-N-nitrosourea (ENU)-induced germline mutations in Sprague Dawley (SD) rats; mutation from A to G at the exon 21/22 border causes a frameshift and premature stop codon
Type: allele  of Brca1  
Previously known as: Brca1m1Uwm; Brca1^[m1Uwm]; Brca1m1Uwm
Is Marker For: Strains:   SD-Brca1m1Uwm
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.11090,586,742 - 90,588,138 (-)NCBI



References

References - curated
# Reference Title Reference Citation
1. Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Zan Y, etal., Nat Biotechnol 2003 Jun;21(6):645-51.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Brca1m1Uwm-var1 chr10 86919758 86919758 A G point_mutation GRCr8
Brca1m1Uwm-var1 chr10 86419516 86419516 A G point_mutation mRatBN7.2
Brca1m1Uwm-var1 chr10 89396896 89396896 A G point_mutation Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Brca1m1Uwm
SD-Brca1m1Uwm    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
GenBank Nucleotide AF080590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-12 Brca1m1Uwm    Brca1m1Uwm  breast cancer 1, mutation 1, University of Wisconsin-Madison  Symbol updated 737654 APPROVED
2004-12-14 Brca1m1Uwm  breast cancer 1, mutation 1, University of Wisconsin-Madison      Symbol and Name status set to approved 1299863 APPROVED