Kat7 (lysine acetyltransferase 7) - Rat Genome Database

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Gene: Kat7 (lysine acetyltransferase 7) Rattus norvegicus
Analyze
Symbol: Kat7
Name: lysine acetyltransferase 7
RGD ID: 727966
Description: Predicted to enable several functions, including DNA replication origin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in several processes, including DNA replication-dependent chromatin disassembly; lymphocyte differentiation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to be part of histone H3-K14 acetyltransferase complex. Predicted to be active in chromatin and nucleus. Orthologous to human KAT7 (lysine acetyltransferase 7); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone acetyltransferase; histone acetyltransferase binding to ORC1; histone acetyltransferase KAT7; histone acetyltransferase MYST2; K (lysine) acetyltransferase 7; LOC303470; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2; MYST protein 2; MYST-2; Myst2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,718,335 - 80,752,387 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1080,718,335 - 80,752,387 (-)EnsemblGRCr8
mRatBN7.21080,221,519 - 80,255,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,221,524 - 80,255,567 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1085,169,638 - 85,203,116 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,667,701 - 84,701,179 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,060,461 - 80,093,801 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,095,067 - 83,128,342 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,095,068 - 83,128,297 (-)Ensemblrn6Rnor6.0
Rnor_5.01082,905,360 - 82,938,635 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41083,960,245 - 83,995,124 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1078,993,963 - 79,027,148 (-)NCBICelera
RGSC_v3.11083,974,615 - 84,009,494 (-)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological_process  (ND)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
DNA damage response  (IEA)
DNA repair  (IEA)
DNA replication  (IEA)
DNA replication-dependent chromatin disassembly  (IEA,ISO,ISS)
DNA-templated transcription  (IEA)
internal peptidyl-lysine acetylation  (ISO,ISS)
natural killer cell differentiation  (IEA,ISO,ISS)
positive regulation of DNA replication  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription, elongation  (IEA,ISO,ISS)
positive regulation of erythrocyte differentiation  (IEA,ISO,ISS)
positive regulation of hematopoietic stem cell proliferation  (IEA,ISO,ISS)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of cell growth  (IEA,ISO)
regulation of DNA biosynthetic process  (IEA,ISO)
regulation of DNA replication  (IEA,ISO)
regulation of DNA-templated DNA replication initiation  (IEA,ISO,ISS)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of nucleotide-excision repair  (IEA,ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA,IEA)
response to actinomycin D  (IEA,ISO)
response to anisomycin  (IEA,ISO)
response to dithiothreitol  (IEA,ISO)
response to hydroxyurea  (IEA,ISO)
response to sorbitol  (IEA,ISO)
stress-activated protein kinase signaling cascade  (IEA,ISO)
T cell differentiation  (IEA,ISO)
transcription initiation-coupled chromatin remodeling  (IEA,ISO)

Cellular Component
chromatin  (IBA)
chromosome  (IEA,ISO)
chromosome, centromeric region  (IEA)
cytosol  (IEA)
histone acetyltransferase complex  (IEA,ISO,ISS)
histone H3-K14 acetyltransferase complex  (IBA,IEA,ISO,ISS)
nucleolus  (ISO,ISS)
nucleoplasm  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)
site of DNA damage  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail. Pasheva E, etal., Biochemistry 2004 Mar 16;43(10):2935-40.
5. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Information Derived from GenBank Report RGD, Sept. 2003
10. Expression and characterization of androgen receptor coregulators, SRC-2 and HBO1, during human testis ontogenesis and in androgen signaling deficient patients. Vija L, etal., Mol Cell Endocrinol. 2013 Aug 15;375(1-2):140-8. doi: 10.1016/j.mce.2013.05.004. Epub 2013 May 24.
11. Estrogen receptor alpha (ERalpha) mediates 17beta-estradiol (E2)-activated expression of HBO1. Wang WZ, etal., J Exp Clin Cancer Res. 2010 Nov 1;29:140. doi: 10.1186/1756-9966-29-140.
Additional References at PubMed
PMID:16387653   PMID:21149574   PMID:21753189   PMID:21856198   PMID:24065767   PMID:24739512   PMID:26221039   PMID:26620551   PMID:27733580   PMID:28719581   PMID:31827282  


Genomics

Comparative Map Data
Kat7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,718,335 - 80,752,387 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1080,718,335 - 80,752,387 (-)EnsemblGRCr8
mRatBN7.21080,221,519 - 80,255,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,221,524 - 80,255,567 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1085,169,638 - 85,203,116 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,667,701 - 84,701,179 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,060,461 - 80,093,801 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,095,067 - 83,128,342 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,095,068 - 83,128,297 (-)Ensemblrn6Rnor6.0
Rnor_5.01082,905,360 - 82,938,635 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41083,960,245 - 83,995,124 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1078,993,963 - 79,027,148 (-)NCBICelera
RGSC_v3.11083,974,615 - 84,009,494 (-)NCBI
Cytogenetic Map10q26NCBI
KAT7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,788,681 - 49,835,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,788,624 - 49,835,026 (+)Ensemblhg38GRCh38
GRCh371747,866,043 - 47,912,388 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,221,070 - 45,261,457 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341745,221,069 - 45,261,455NCBI
Celera1744,321,054 - 44,361,451 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,230,982 - 43,271,467 (+)NCBIHuRef
CHM1_11747,929,929 - 47,970,416 (+)NCBICHM1_1
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBIT2T-CHM13v2.0
Kat7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,162,683 - 95,201,030 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,165,085 - 95,201,072 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381195,271,853 - 95,310,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,274,259 - 95,310,246 (-)Ensemblmm10GRCm38
MGSCv371195,135,573 - 95,171,515 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361195,090,349 - 95,126,291 (-)NCBIMGSCv36mm8
Celera11104,888,945 - 104,929,711 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Kat7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,770,201 - 11,802,992 (-)Ensembl
ChiLan1.0NW_00495545111,770,201 - 11,802,992 (-)NCBIChiLan1.0ChiLan1.0
KAT7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,973,572 - 66,014,081 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,780,142 - 70,820,659 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,875,921 - 43,916,352 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,605,488 - 48,645,784 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,605,488 - 48,645,784 (+)EnsemblpanPan2panpan1.1
KAT7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,841,916 - 25,875,245 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,842,054 - 25,873,674 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha925,299,759 - 25,333,077 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0926,636,607 - 26,669,932 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,636,747 - 26,669,932 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,404,467 - 25,437,791 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,663,435 - 25,696,975 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,792,761 - 25,826,342 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kat7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,269,839 - 25,299,915 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,772,046 - 11,805,759 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,775,224 - 11,805,489 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,970,962 - 26,008,302 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11225,970,966 - 26,005,006 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,975,192 - 26,009,289 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,508,888 - 43,548,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,510,483 - 43,548,517 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607714,224,947 - 14,264,537 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kat7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,859,443 - 5,892,527 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247955,859,974 - 5,892,519 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kat7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1959,074,094 - 59,107,891 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kat7
319 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:165
Interacting mature miRNAs:191
Transcripts:ENSRNOT00000031252
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)107369533983061459Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)107369533983061459Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031252   ⟹   ENSRNOP00000029608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,718,335 - 80,752,387 (-)Ensembl
mRatBN7.2 Ensembl1080,221,526 - 80,255,567 (-)Ensembl
Rnor_6.0 Ensembl1083,095,068 - 83,104,173 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082160   ⟹   ENSRNOP00000074972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,718,335 - 80,748,955 (-)Ensembl
mRatBN7.2 Ensembl1080,221,524 - 80,252,629 (-)Ensembl
Rnor_6.0 Ensembl1083,096,609 - 83,128,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104687   ⟹   ENSRNOP00000092089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,718,335 - 80,752,387 (-)Ensembl
mRatBN7.2 Ensembl1080,221,526 - 80,255,567 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109616   ⟹   ENSRNOP00000090504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,718,340 - 80,751,785 (-)Ensembl
mRatBN7.2 Ensembl1080,221,524 - 80,254,965 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116805   ⟹   ENSRNOP00000096120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,718,335 - 80,752,387 (-)Ensembl
mRatBN7.2 Ensembl1080,221,526 - 80,255,567 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119028   ⟹   ENSRNOP00000086835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,718,335 - 80,749,449 (-)Ensembl
mRatBN7.2 Ensembl1080,221,524 - 80,252,629 (-)Ensembl
RefSeq Acc Id: NM_001415103   ⟹   NP_001402032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,335 - 80,752,387 (-)NCBI
mRatBN7.21080,221,519 - 80,255,567 (-)NCBI
RefSeq Acc Id: NM_181081   ⟹   NP_851595
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,335 - 80,751,761 (-)NCBI
mRatBN7.21080,221,519 - 80,254,941 (-)NCBI
Rnor_6.01083,095,067 - 83,128,342 (-)NCBI
Rnor_5.01082,905,360 - 82,938,635 (-)NCBI
RGSC_v3.41083,960,245 - 83,995,124 (-)RGD
Celera1078,993,963 - 79,027,148 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086067   ⟹   XP_038941995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,339 - 80,751,854 (-)NCBI
mRatBN7.21080,221,520 - 80,255,030 (-)NCBI
RefSeq Acc Id: XM_039086068   ⟹   XP_038941996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,339 - 80,752,353 (-)NCBI
mRatBN7.21080,221,520 - 80,255,590 (-)NCBI
RefSeq Acc Id: XM_039086069   ⟹   XP_038941997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,339 - 80,751,854 (-)NCBI
mRatBN7.21080,221,520 - 80,255,030 (-)NCBI
RefSeq Acc Id: XM_039086070   ⟹   XP_038941998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,339 - 80,751,699 (-)NCBI
mRatBN7.21080,221,519 - 80,254,880 (-)NCBI
RefSeq Acc Id: XM_063269110   ⟹   XP_063125180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,339 - 80,752,353 (-)NCBI
RefSeq Acc Id: XM_063269111   ⟹   XP_063125181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,339 - 80,751,854 (-)NCBI
RefSeq Acc Id: XM_063269112   ⟹   XP_063125182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,718,339 - 80,752,353 (-)NCBI
RefSeq Acc Id: NP_851595   ⟸   NM_181081
- Peptide Label: isoform 1
- UniProtKB: Q80YN5 (UniProtKB/Swiss-Prot),   Q810T5 (UniProtKB/Swiss-Prot),   A7BJV7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029608   ⟸   ENSRNOT00000031252
Ensembl Acc Id: ENSRNOP00000074972   ⟸   ENSRNOT00000082160
RefSeq Acc Id: XP_038941998   ⟸   XM_039086070
- Peptide Label: isoform X7
- UniProtKB: A6HI94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941996   ⟸   XM_039086068
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLG6 (UniProtKB/TrEMBL),   A6HI91 (UniProtKB/TrEMBL),   A7BJV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941995   ⟸   XM_039086067
- Peptide Label: isoform X1
- UniProtKB: A7BJV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941997   ⟸   XM_039086069
- Peptide Label: isoform X3
- UniProtKB: A7BJV7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086835   ⟸   ENSRNOT00000119028
Ensembl Acc Id: ENSRNOP00000096120   ⟸   ENSRNOT00000116805
Ensembl Acc Id: ENSRNOP00000092089   ⟸   ENSRNOT00000104687
Ensembl Acc Id: ENSRNOP00000090504   ⟸   ENSRNOT00000109616
RefSeq Acc Id: NP_001402032   ⟸   NM_001415103
- Peptide Label: isoform 2
- UniProtKB: A0A8I6AGI2 (UniProtKB/TrEMBL),   A6HI92 (UniProtKB/TrEMBL),   A7BJV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125182   ⟸   XM_063269112
- Peptide Label: isoform X6
- UniProtKB: A7BJV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125180   ⟸   XM_063269110
- Peptide Label: isoform X4
- UniProtKB: A7BJV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125181   ⟸   XM_063269111
- Peptide Label: isoform X5
- UniProtKB: A7BJV7 (UniProtKB/TrEMBL)
Protein Domains
MYST-type HAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q810T5-F1-model_v2 AlphaFold Q810T5 1-612 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727966 AgrOrtholog
BioCyc Gene G2FUF-23560 BioCyc
Ensembl Genes ENSRNOG00000022664 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000104687 ENTREZGENE
  ENSRNOT00000109616 ENTREZGENE
  ENSRNOT00000109616.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116805 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  3.40.630.30 UniProtKB/Swiss-Prot
  4.10.320.30 UniProtKB/Swiss-Prot
  N-acetyl transferase-like UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  HAT_MYST-type UniProtKB/Swiss-Prot
  MYST_HAT UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  Zf-MYST UniProtKB/Swiss-Prot
  Znf_C2H2C UniProtKB/Swiss-Prot
  Znf_C2H2C_sf UniProtKB/Swiss-Prot
KEGG Report rno:303470 UniProtKB/Swiss-Prot
NCBI Gene 303470 ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE UniProtKB/Swiss-Prot
  HISTONE ACETYLTRANSFERASE KAT7 UniProtKB/Swiss-Prot
Pfam MOZ_SAS UniProtKB/Swiss-Prot
  zf-C2HC UniProtKB/Swiss-Prot
  zf-MYST UniProtKB/Swiss-Prot
PhenoGen Kat7 PhenoGen
PROSITE MYST_HAT UniProtKB/Swiss-Prot
  ZF_CCHHC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022664 RatGTEx
Superfamily-SCOP SSF103637 UniProtKB/Swiss-Prot
  SSF55729 UniProtKB/Swiss-Prot
UniProt A0A0G2K9F0_RAT UniProtKB/TrEMBL
  A0A8I6A312_RAT UniProtKB/TrEMBL
  A0A8I6AGI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLG6 ENTREZGENE, UniProtKB/TrEMBL
  A6HI91 ENTREZGENE, UniProtKB/TrEMBL
  A6HI92 ENTREZGENE, UniProtKB/TrEMBL
  A6HI94 ENTREZGENE, UniProtKB/TrEMBL
  A7BJV7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCG0_RAT UniProtKB/TrEMBL
  KAT7_RAT UniProtKB/Swiss-Prot
  Q80YN5 ENTREZGENE
  Q810T5 ENTREZGENE
UniProt Secondary Q80YN5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kat7  lysine acetyltransferase 7  Kat7  K (lysine) acetyltransferase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Kat7  K (lysine) acetyltransferase 7  Myst2  MYST histone acetyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Myst2  MYST histone acetyltransferase 2  LOC303470  histone acetyltransferase  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED