Advanced Search (OLGA)

Gene: Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin) Rattus norvegicus

Analyze

Symbol:

Spg7

Name:

SPG7 matrix AAA peptidase subunit, paraplegin

RGD ID:

727940

Description:

Predicted to enable metalloendopeptidase activity. Involved in mitochondrial outer membrane permeabilization involved in programmed cell death. Predicted to be located in mitochondrial inner membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

mitochondrial inner membrane m-AAA protease component paraplegin; paraplegin; spastic paraplegia 7 homolog; spastic paraplegia 7 homolog (human); SPG7, paraplegin matrix AAA peptidase subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Spg7 (SPG7, paraplegin matrix AAA peptidase subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Homo sapiens (human):	SETDB2 (SET domain bifurcated histone lysine methyltransferase 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Spg7 (SPG7, paraplegin matrix AAA peptidase subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	spg7 (SPG7 matrix AAA peptidase subunit, paraplegin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ppgn-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ppgn-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spg7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spg7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y47C4A.1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	Y47C4A.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	spg7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	68,025,619 - 68,059,754 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	68,025,612 - 68,059,754 (+)	Ensembl				GRCr8
mRatBN7.2	19	51,117,088 - 51,151,228 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	51,117,057 - 51,150,484 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	57,911,092 - 57,945,311 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,592,011 - 58,626,149 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	60,809,698 - 60,843,918 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	55,880,549 - 55,914,729 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	55,880,561 - 55,915,502 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	66,586,319 - 66,618,933 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	53,400,904 - 53,433,742 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	50,353,488 - 50,385,526 (+)	NCBI		Celera
RGSC_v3.1	19	53,405,784 - 53,438,623 (+)	NCBI
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hereditary spastic paraplegia 7 (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-acetamidofluorene (EXP)

3-chloropropane-1,2-diol (EXP)

bisphenol A (EXP)

epoxiconazole (ISO)

ethanol (ISO)

fenthion (ISO)

fipronil (EXP)

furan (EXP)

genistein (EXP)

gentamycin (EXP)

inulin (ISO)

methidathion (ISO)

methotrexate (ISO)

methoxychlor (EXP)

N-nitrosodiethylamine (EXP)

nitrates (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

rotenone (EXP)

tamoxifen (ISO)

testosterone (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterograde axonal transport (ISO)

biological_process (ND)

mitochondrial outer membrane permeabilization involved in programmed cell death (IEA,IMP)

mitochondrial protein processing (IBA,IEA)

mitochondrion organization (IEA,ISO)

proteolysis (IEA)

regulation of calcium import into the mitochondrion (IEA,ISS)

regulation of mitochondrial membrane permeability (IEA,IMP)

Cellular Component

axon cytoplasm (IEA)

m-AAA complex (IBA,IEA,ISO)

membrane (IEA)

mitochondrial inner membrane (IEA,ISO,ISS)

mitochondrial permeability transition pore complex (IEA)

mitochondrion (IEA,ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATP-dependent peptidase activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

metalloendopeptidase activity (IBA,IEA,ISS)

metallopeptidase activity (IEA)

nucleotide binding (IEA)

peptidase activity (IEA)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.	Shanmughapriya S, etal., Mol Cell. 2015 Oct 1;60(1):47-62. doi: 10.1016/j.molcel.2015.08.009. Epub 2015 Sep 17.

Additional References at PubMed

PMID:11549317	PMID:14651853	PMID:14722615	PMID:18614015	PMID:19656850

Genomics

Comparative Map Data

Spg7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	68,025,619 - 68,059,754 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	68,025,612 - 68,059,754 (+)	Ensembl				GRCr8
mRatBN7.2	19	51,117,088 - 51,151,228 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	51,117,057 - 51,150,484 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	57,911,092 - 57,945,311 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,592,011 - 58,626,149 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	60,809,698 - 60,843,918 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	55,880,549 - 55,914,729 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	55,880,561 - 55,915,502 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	66,586,319 - 66,618,933 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	53,400,904 - 53,433,742 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	50,353,488 - 50,385,526 (+)	NCBI		Celera
RGSC_v3.1	19	53,405,784 - 53,438,623 (+)	NCBI
Cytogenetic Map	19	q12	NCBI

SPG7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	89,490,970 - 89,499,282 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	89,490,719 - 89,557,766 (+)	Ensembl			hg38	GRCh38
GRCh37	16	89,574,802 - 89,624,174 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	88,102,306 - 88,151,675 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	16	88,102,305 - 88,151,674	NCBI
Celera	16	74,638,312 - 74,687,680 (+)	NCBI		Celera
Cytogenetic Map	16	q24.3	NCBI
HuRef	16	75,270,019 - 75,319,275 (+)	NCBI		HuRef
CHM1_1	16	90,968,590 - 90,976,192 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	95,571,346 - 95,579,922 (+)	NCBI		T2T-CHM13v2.0

Spg7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	123,792,247 - 123,824,499 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	123,789,681 - 123,824,499 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	123,065,508 - 123,097,760 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	123,062,942 - 123,097,760 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	125,589,408 - 125,621,651 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	125,951,269 - 125,983,845 (+)	NCBI		MGSCv36	mm8
Celera	8	127,301,723 - 127,334,887 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	72.04	NCBI

Spg7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	3,109,892 - 3,140,958 (+)	Ensembl
ChiLan1.0	NW_004955541	3,092,968 - 3,141,157 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPG7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	99,290,474 - 99,341,056 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	105,207,771 - 105,258,390 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	70,258,902 - 70,309,438 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	89,866,884 - 89,917,867 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	89,866,884 - 89,917,867 (+)	Ensembl			panPan2	panpan1.1

SPG7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	63,984,716 - 64,023,271 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	63,985,658 - 64,023,621 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	63,996,864 - 64,035,406 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	64,212,077 - 64,250,632 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	64,210,575 - 64,256,137 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	64,231,998 - 64,270,537 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	64,069,471 - 64,108,027 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	64,476,292 - 64,514,838 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Spg7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	24,698,215 - 24,730,707 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936641	452,475 - 484,220 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936641	451,762 - 484,229 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPG7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	74,862,524 - 74,916,214 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	74,862,551 - 74,916,033 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	592,653 - 647,540 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spg7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	346,492 - 377,882 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624746	344,754 - 377,939 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	165
Count of miRNA genes:	118
Interacting mature miRNAs:	135
Transcripts:	ENSRNOT00000047754
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	46226778	74246245	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	44385134	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	61249161	74246245	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	41722546	74246245	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat

Markers in Region

AU015315

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	51,149,839 - 51,150,083 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	55,913,339 - 55,913,582	NCBI	Rnor6.0
Rnor_5.0	19	66,618,674 - 66,618,917	UniSTS	Rnor5.0
RGSC_v3.4	19	53,433,483 - 53,433,726	UniSTS	RGSC3.4
Celera	19	50,385,267 - 50,385,510	UniSTS
Cytogenetic Map	19	q12	UniSTS

BE103433

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	51,134,159 - 51,134,311 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	55,897,659 - 55,897,810	NCBI	Rnor6.0
Rnor_5.0	19	66,603,417 - 66,603,568	UniSTS	Rnor5.0
RGSC_v3.4	19	53,418,002 - 53,418,153	UniSTS	RGSC3.4
Celera	19	50,370,586 - 50,370,737	UniSTS
RH 3.4 Map	19	710.01	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_181388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010060009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010060010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC141337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY278739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000047754 ⟹ ENSRNOP00000048848

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	68,025,619 - 68,059,752 (+)	Ensembl
mRatBN7.2 Ensembl	19	51,117,057 - 51,150,099 (+)	Ensembl
Rnor_6.0 Ensembl	19	55,880,561 - 55,913,598 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091712 ⟹ ENSRNOP00000073276

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	68,025,612 - 68,059,754 (+)	Ensembl
mRatBN7.2 Ensembl	19	51,117,090 - 51,150,484 (+)	Ensembl
Rnor_6.0 Ensembl	19	55,880,603 - 55,915,502 (+)	Ensembl

RefSeq Acc Id:

NM_001399110 ⟹ NP_001386039

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	68,025,619 - 68,059,752 (+)	NCBI
mRatBN7.2	19	51,117,089 - 51,151,228 (+)	NCBI

RefSeq Acc Id:

NM_181388 ⟹ NP_852053

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	68,025,619 - 68,059,752 (+)	NCBI
mRatBN7.2	19	51,117,089 - 51,151,228 (+)	NCBI
Rnor_6.0	19	55,880,561 - 55,913,598 (+)	NCBI
Rnor_5.0	19	66,586,319 - 66,618,933 (+)	NCBI
RGSC_v3.4	19	53,400,904 - 53,433,742 (+)	RGD
Celera	19	50,353,488 - 50,385,526 (+)	RGD

Sequence:

show sequence

TGACCGTTAGGGCGGCCGGAGCCCCACTGCGCAGGCGCCGCTCTCGGCACCATGGCGGCCGCGT
TGCTGCTGCTTCGCGCGCTCCGCCAGAGCCCGGAGCCCGGGCCCTGGCGGCTGTGGGCCCAGCT
CTCAGGCAGGAGCCCCGGCCTCTTCTCCGGGGCCGGCGGTAGGCGGCCGTACGTAGTCCGTGGG
ACTCCGATTGGCCTGGCTGCGGCTGGAGGCCACACGCCTCAGAGCTTGCTATTGCGAATACTGA
CCCCTAGCTTTGAAGGTGTTAGCGGATTGTTACTGAAACGGCATATAGTTCCAAGTGCAATCAG
ACTGTGGCAGCTTTCAGGTAGTACTTTGTATTTTAACACCTCAGGGTTGAAGCAGAAGAACAAA
GATGATGATAAACCCAAAGGCAAAGCCCCGGAAGATGACGAAGAAGAGAGGAGGCGGAAGGAGC
GGGAAGACCAGATGTACCGGGAGAGGCTGCGCACCTTGTTCATCATCGCCATCGTGATGAGCCT
GCTCAACTCCCTCAGCACAAGTGGCGGCAGCATCTCCTGGGCTGACTTCGTCAACGAGATGCTG
GCTAAAGGCGAGGTGCAGCGTGTGCAGGTGGTGCCCGAGAGTGATGTGGTGGAAGTCTACCTGC
ATCCAGGAGCTGTGGTGTTTGGGCGGCCTCGGCTGGCCTTGATGTACCGGATGCAGGTTGCAAA
CATCGACAAATTTGAAGAGAAGCTTCGAGCTGCTGAAGATGAACTGAACATCGAGAGCAAGGAC
AGGATTCCCGTGTCCTACAAGCGGACAGGATTCTTTGGAAATGCCCTCTATGCCCTGGGGATGA
CTGCAGTGGGCTTGGCCATCCTGTGGTATGTTTTCAGACTGGCTGGGATGACCGGAAGGGAAGG
CGGATTCAGTGCCTTTAATCAGCTTAAAATGGCGCGCTTCACCATCGTGGACGGGAAGACGGGG
AAAGGAGTCAGCTTCCAGGATGTGGCGGGAATGCACGAAGCCAAGCTGGAAGTCCGAGAGTTTG
TGGATTATCTGAAGAGCCCGGAGCGTTTCCTTCAGCTGGGTGCCAAGGTTCCAAAGGGTGCCCT
GCTGCTGGGACCCCCTGGTTGTGGGAAGACGCTGTTGGCCAAGGCAGTGGCCACGGAGGCTCAG
GTGCCCTTTTTAGCAATGGCTGGCCCAGAGTTTGTGGAGGTCATTGGAGGCCTGGGAGCCGCCC
GAGTGCGCAGCCTCTTCAAGGAAGCCCGGGCCAGGGCCCCTTGCATTGTGTACATTGATGAGAT
CGATGCTGTGGGGAAGAAGCGCTCCACCTCCATGTCCGGGTTCTCCAACACAGAAGAGGAGCAG
ACCCTCAACCAGCTCCTCGTAGAGATGGACGGAATGGGCACCGCAGACCACGTCATCGTCTTGG
CATCCACCAACCGAGCCGATGTCCTGGACAACGCTCTGATGAGGCCCGGTCGGCTCGACAGGCA
CGTCTTCATCGATCTTCCCACTCTCCAGGAGAGGCGGGAGATTTTCGAGCAGCACCTGAAAGGC
CTCAAGTTGACCCAGCCCAGCAGTTTTTACTCCCAGCGGCTGGCAGAGCTGACTCCTGGATTCA
GTGGAACTGCTAAAAAGAGTAAGATCCTTTCCAAGGAGGAGCAGAGAGTGGTTGCTTTCCATGA
GTCTGGCCATGCCCTGGTCGGTTGGCTGCTGGAACACACGGAGGCTGTGATGAAGGTCTCCATA
GCACCTCGGACAAACGCTGCTCTGGGCTTCTCTCAGATGCTCCCTCGGGACCAGTACCTCTTCA
CCAAGGAGCAGCTGTTTGAGCGGATGTGCATGGCCCTAGGCGGCCGTGCAGCTGAAGCCATCTC
ATTCAGCAGGGTCACCTCTGGGGCCCAGGATGATTTGAGGAAGGTTACCCGTATCGCCTACTCC
ATGGTGAAACAGTTTGGGATGGCTCCTAGCATTGGGCCCGTATCCTTCCCTGAGGCACAAGAGG
GCCTCGTGGGCATTGGACGCCGTCCCTTCAGCCAGGGTCTCCAGCAGATGATGGACCATGAAGC
AAGACTGCTGGTGGCCAGAGCCTACAGACACACTGAGAAGGTGCTGCTGGACAACCTGGACAAG
CTGCAGGCGCTGGCGAATGCCCTTCTGGAAAAGGAAGTGATAAACTATGAGGACATTGAGGCGC
TCATTGGCCCGCCGCCCCATGGGCCAAAGAAAATGATTGCACCACAGAAATGGATTGATGCTGA
AAAGGAGAAACAAGCCTCAGGGGAGGAGGAGGCTCCGGCTCCCTAGCCCCCACCTCCAAGGCCC
AGATAATGGCTTCCTCCATGCACCTGCAGTTATCACAGAACTTGTCATAGCTGCCCTCCACCTC
CGAGATGCTTTTCACCTGAACTTAAACCTCAGCCTCTGTCAGCTCTCTGGTTTCTGATGAAGAC
TTGTGATATCTATTTATTGATTTATGATTAGTAAATTGTTTGCAGAG

hide sequence

RefSeq Acc Id:

XM_039097806 ⟹ XP_038953734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	68,025,638 - 68,059,754 (+)	NCBI
mRatBN7.2	19	51,117,088 - 51,151,228 (+)	NCBI

RefSeq Acc Id:

XM_063278101 ⟹ XP_063134171

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	68,027,803 - 68,059,754 (+)	NCBI

RefSeq Acc Id:

XR_010060009

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	68,025,638 - 68,056,458 (+)	NCBI

RefSeq Acc Id:

XR_010060010

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	68,025,638 - 68,054,789 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386039	(Get FASTA)	NCBI Sequence Viewer
	NP_852053	(Get FASTA)	NCBI Sequence Viewer
	XP_038953734	(Get FASTA)	NCBI Sequence Viewer
	XP_063134171	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP35059	(Get FASTA)	NCBI Sequence Viewer
	EDL92777	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048848
	ENSRNOP00000073276
GenBank Protein	Q7TT47	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_852053 ⟸ NM_181388
- Peptide Label:	isoform 1
- UniProtKB:	A0A2H2GPM9 (UniProtKB/TrEMBL), A6IZU9 (UniProtKB/TrEMBL), A0A8L2R710 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAALLLLRALRQSPEPGPWRLWAQLSGRSPGLFSGAGGRRPYVVRGTPIGLAAAGGHTPQSLL LRILTPSFEGVSGLLLKRHIVPSAIRLWQLSGSTLYFNTSGLKQKNKDDDKPKGKAPEDDEEER RRKEREDQMYRERLRTLFIIAIVMSLLNSLSTSGGSISWADFVNEMLAKGEVQRVQVVPESDVV EVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIESKDRIPVSYKRTGFFGNALY ALGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKTGKGVSFQDVAGMHEAKLE VREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGG LGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTSMSGFSNTEEEQTLNQLLVEMDGMGTADH VIVLASTNRADVLDNALMRPGRLDRHVFIDLPTLQERREIFEQHLKGLKLTQPSSFYSQRLAEL TPGFSGTAKKSKILSKEEQRVVAFHESGHALVGWLLEHTEAVMKVSIAPRTNAALGFSQMLPRD QYLFTKEQLFERMCMALGGRAAEAISFSRVTSGAQDDLRKVTRIAYSMVKQFGMAPSIGPVSFP EAQEGLVGIGRRPFSQGLQQMMDHEARLLVARAYRHTEKVLLDNLDKLQALANALLEKEVINYE DIEALIGPPPHGPKKMIAPQKWIDAEKEKQASGEEEAPAP hide sequence

Ensembl Acc Id:

ENSRNOP00000048848 ⟸ ENSRNOT00000047754

Ensembl Acc Id:

ENSRNOP00000073276 ⟸ ENSRNOT00000091712

RefSeq Acc Id:	XP_038953734 ⟸ XM_039097806
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2R710 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001386039 ⟸ NM_001399110
- Peptide Label:	isoform 2
- UniProtKB:	Q7TT47 (UniProtKB/Swiss-Prot), A0A0G2K536 (UniProtKB/Swiss-Prot), A0A8L2R710 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063134171 ⟸ XM_063278101
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2R710 (UniProtKB/TrEMBL)

Protein Domains

AAA+ ATPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TT47-F1-model_v2	AlphaFold	Q7TT47	1-781	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701215

Promoter ID:

EPDNEW_R11739

Type:

multiple initiation site

Name:

Spg7_1

Description:

SPG7, paraplegin matrix AAA peptidase subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	55,880,593 - 55,880,653	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727940	AgrOrtholog
BioCyc Gene	G2FUF-5350	BioCyc
Ensembl Genes	ENSRNOG00000015150	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000047754	ENTREZGENE
	ENSRNOT00000091712	ENTREZGENE
Gene3D-CATH	1.10.8.60	UniProtKB/Swiss-Prot
	1.20.58.760	UniProtKB/Swiss-Prot
	3.40.1690.20	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot
	AAA_lid_3	UniProtKB/Swiss-Prot
	ATP-dep_Zn_Metalloprotease	UniProtKB/Swiss-Prot
	ATPase_AAA_core	UniProtKB/Swiss-Prot
	FtsH	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	Pept_M41_FtsH_extracell	UniProtKB/Swiss-Prot
	Peptidase_M41	UniProtKB/Swiss-Prot
	Peptidase_M41-like	UniProtKB/Swiss-Prot
KEGG Report	rno:353231	UniProtKB/Swiss-Prot
NCBI Gene	353231	ENTREZGENE
PANTHER	ATP-DEPENDENT PROTEASE	UniProtKB/Swiss-Prot
	PARAPLEGIN	UniProtKB/Swiss-Prot
Pfam	AAA	UniProtKB/Swiss-Prot
	AAA_lid_3	UniProtKB/Swiss-Prot
	FtsH_ext	UniProtKB/Swiss-Prot
	Peptidase_M41	UniProtKB/Swiss-Prot
PhenoGen	Spg7	PhenoGen
RatGTEx	ENSRNOG00000015150	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF140990	UniProtKB/Swiss-Prot
	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A0G2K536	ENTREZGENE
	A0A2H2GPM9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2R710	ENTREZGENE, UniProtKB/TrEMBL
	A6IZU9	ENTREZGENE, UniProtKB/TrEMBL
	Q7TT47	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	A0A0G2K536	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-02	Spg7	SPG7 matrix AAA peptidase subunit, paraplegin	Spg7	SPG7, paraplegin matrix AAA peptidase subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-05-18	Spg7	SPG7, paraplegin matrix AAA peptidase subunit	Spg7	spastic paraplegia 7 homolog (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-08	Spg7	spastic paraplegia 7 homolog (human)			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - MGI