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Gene: Lgsn (lengsin, lens protein with glutamine synthetase domain) Rattus norvegicus

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Symbol:

Lgsn

Name:

lengsin, lens protein with glutamine synthetase domain

RGD ID:

727925

Description:

Predicted to enable catalytic activity. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and membrane. Orthologous to human LGSN (lengsin, lens protein with glutamine synthetase domain); INTERACTS WITH acetamide; aconitine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Gluld1; glutamate-ammonia ligase (glutamine synthase) domain containing 1; glutamate-ammonia ligase (glutamine synthetase) domain containing 1; glutamate-ammonia ligase domain-containing protein 1; lengsin; lens glutamine synthase-like; Lgs

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	40,912,398 - 40,943,955 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	40,916,520 - 40,943,943 (+)	Ensembl				GRCr8
mRatBN7.2	9	33,416,362 - 33,447,919 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	33,420,484 - 33,447,907 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	41,913,213 - 41,940,643 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	47,045,193 - 47,072,615 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	45,327,050 - 45,354,472 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	37,458,603 - 37,490,117 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	37,462,693 - 37,490,108 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	36,263,149 - 36,294,523 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	29,844,176 - 29,871,557 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	31,238,716 - 31,265,934 (+)	NCBI		Celera
RGSC_v3.1	9	29,845,589 - 29,872,970 (+)	NCBI
Cytogenetic Map	9	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

acetamide (EXP)

aconitine (EXP)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

dinophysistoxin 1 (ISO)

endosulfan (EXP)

fenthion (ISO)

furan (EXP)

hydrogen peroxide (ISO)

Licochalcone B (ISO)

menadione (ISO)

methidathion (ISO)

methylisothiazolinone (ISO)

okadaic acid (ISO)

phenformin (EXP)

quercetin (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sulforaphane (ISO)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glutamine biosynthetic process (IBA,IEA)

nitrogen utilization (IBA)

Cellular Component

cytoplasm (IBA)

membrane (IBA)

plasma membrane (IEA,ISO)

Molecular Function

catalytic activity (IEA)

glutamine synthetase activity (IBA,IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18178558

Genomics

Comparative Map Data

Lgsn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	40,912,398 - 40,943,955 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	40,916,520 - 40,943,943 (+)	Ensembl				GRCr8
mRatBN7.2	9	33,416,362 - 33,447,919 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	33,420,484 - 33,447,907 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	41,913,213 - 41,940,643 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	47,045,193 - 47,072,615 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	45,327,050 - 45,354,472 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	37,458,603 - 37,490,117 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	37,462,693 - 37,490,108 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	36,263,149 - 36,294,523 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	29,844,176 - 29,871,557 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	31,238,716 - 31,265,934 (+)	NCBI		Celera
RGSC_v3.1	9	29,845,589 - 29,872,970 (+)	NCBI
Cytogenetic Map	9	q21	NCBI

LGSN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	63,275,951 - 63,573,607 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	63,275,951 - 63,319,983 (-)	Ensembl			hg38	GRCh38
GRCh37	6	63,985,856 - 64,029,888 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	64,047,515 - 64,087,841 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	64,047,520 - 64,087,841	NCBI
Celera	6	62,145,321 - 62,189,340 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI
HuRef	6	61,165,803 - 61,209,830 (-)	NCBI		HuRef
CHM1_1	6	64,152,120 - 64,196,163 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	64,421,831 - 64,588,322 (-)	NCBI		T2T-CHM13v2.0

Lgsn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	31,215,362 - 31,243,806 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	31,215,482 - 31,243,806 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	31,176,281 - 31,204,725 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	31,176,401 - 31,204,725 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	31,233,280 - 31,261,570 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	31,120,981 - 31,149,271 (+)	NCBI		MGSCv36	mm8
Celera	1	30,973,296 - 31,001,446 (+)	NCBI		Celera
Cytogenetic Map	1	B	NCBI
cM Map	1	11.53	NCBI

Lgsn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955502	483,191 - 552,272 (+)	Ensembl
ChiLan1.0	NW_004955502	522,492 - 551,842 (+)	NCBI	ChiLan1.0	ChiLan1.0

LGSN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	78,141,446 - 78,185,404 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	72,801,340 - 72,845,297 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	60,964,873 - 61,008,833 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	66,235,347 - 66,279,272 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	66,239,052 - 66,280,600 (-)	Ensembl			panPan2	panpan1.1

LGSN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	26,852,832 - 26,884,307 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	26,852,851 - 26,919,138 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	26,761,476 - 26,792,749 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	27,389,310 - 27,419,270 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	27,389,326 - 27,454,223 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	26,894,374 - 26,924,142 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	26,976,959 - 27,006,723 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	27,074,028 - 27,103,801 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lgsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	62,303,468 - 62,335,915 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	1,624,222 - 1,659,510 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	1,624,287 - 1,656,734 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LGSN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	82,360,774 - 82,387,717 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	82,360,058 - 82,388,479 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	92,641,343 - 92,671,894 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LGSN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	11,419,089 - 11,505,533 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666058	17,765,855 - 17,806,536 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lgsn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624753	21,650,655 - 21,679,764 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624753	21,645,389 - 21,694,557 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lgsn
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	107,902,350 - 107,916,554 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lgsn
206 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	134
Count of miRNA genes:	110
Interacting mature miRNAs:	117
Transcripts:	ENSRNOT00000016316
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5346479	50346479	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	8750492	53750492	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	31250432	68875676	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	29567664	74567664	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	496645	45496645	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	6214995	51214995	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	8750492	53750492	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	41763315	Rat
7207805	Bmd88	Bone mineral density QTL 88	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	9	31250432	65651574	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5346479	50416711	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	496645	45496645	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	21031430	49025574	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	496645	45496645	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	6214995	51214995	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	34960590	79960590	Rat
1598823	Memor16	Memory QTL 16	1.9		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	31456061	57460683	Rat

Markers in Region

BM389985

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	33,434,506 - 33,434,693 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	37,476,719 - 37,476,904	NCBI	Rnor6.0
Rnor_5.0	9	36,281,231 - 36,281,416	UniSTS	Rnor5.0
RGSC_v3.4	9	29,858,200 - 29,858,386	UniSTS	RGSC3.4
Celera	9	31,252,740 - 31,252,926	UniSTS
RH 3.4 Map	9	339.69	UniSTS
Cytogenetic Map	9	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hepatobiliary system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	1	58	27	34	26	26	66	2	57	27	65	8	5	5

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_181383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039083550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY280501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016316 ⟹ ENSRNOP00000016316

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	40,916,520 - 40,943,943 (+)	Ensembl
mRatBN7.2 Ensembl	9	33,420,484 - 33,447,907 (+)	Ensembl
Rnor_6.0 Ensembl	9	37,462,693 - 37,490,108 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100875 ⟹ ENSRNOP00000091136

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	40,929,567 - 40,943,943 (+)	Ensembl
mRatBN7.2 Ensembl	9	33,433,531 - 33,447,907 (+)	Ensembl

RefSeq Acc Id:

NM_181383 ⟹ NP_852048

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	40,916,520 - 40,943,944 (+)	NCBI
mRatBN7.2	9	33,420,484 - 33,447,908 (+)	NCBI
Rnor_6.0	9	37,462,693 - 37,490,106 (+)	NCBI
Rnor_5.0	9	36,263,149 - 36,294,523 (+)	NCBI
RGSC_v3.4	9	29,844,176 - 29,871,557 (+)	RGD
Celera	9	31,238,716 - 31,265,934 (+)	RGD

Sequence:

show sequence

GTTGGCAAGGCTGATTTACCGTAAGAAACGGTTGACATGAACGATGAAGGGGACCTTGCACAGG
AGGACACAACAAAAGATGAAGCAAACTCGACTGAAGGCAGCAGGGTGAACAAGTTGAAAAGGAC
AAGAAGAAAAGTCACCAAACCACATCTTTGCTCAGCAGATGGGGATGAAATCACCATGGCCAAT
TCCAGGGAGATGTCCAGAAACCAAACAGCAGATCTGAGCAAACCTGGCTCTGCTGAGTCTTGGT
CCTGGCACAATGCCAAAGACGCCCAAGATCAGATACCAGTGGTAAAATCTTCACTTCCCAGTGC
TGGTGCTCCTGATGCTGAATTCAACCCGAATACTGATCACACTCGGGACAATGCTCAGAGTTTG
ATCCTGCCTCAACTTTCTTCTAGAATGAAACACATCAAACAAGAAATGGCCAAAAATCACCTCC
AGTTTGTACGATTTGAAGCCACAGACTTGCACGGTGTCTCCAGATCTAAGAGCATCCCTGCACA
ATTTTTTCAAGAAAAAGTGATCCATGGAGTTTTCATGCCCCGTGGTTATCTGGAATTGATGCCG
AACCCTAAGGACAATGAGGTAAATCACATACGAGCCACGTGCTTCAATAGTGACATAGTCCTCA
TGCCAGAGCTGTCGACCTTTAGAGTCTTGCCTTGGGCAGAGAGGACTGCGCGGGTGATTTGTGA
CACCTTCACTGTGACGGGCGAGCCTCTGCTGACGTCCCCTAGGTACATCGCCAAGAGGCAGTTG
CGCCAGCTGCAGGATGCCGGCTTCTCTCTGCTGTCTGCCTTCATCTATGATTTCTGCATTTTCG
GTGTGCCCGAAGTGATCAATTCAAAGACCATATCTTTTCCTGCCTCGACATTACTAAGTAATCA
TGACCAGCCCTTCATGCAGGAGCTGGTTGACGGCTTGTATCACACAGGGGCAAATGTGGAGAGC
TTCTCCTCTTCTACCAGGCCTGGGCAAATGGAGATCTGTTTTCTCCCGGAGTTTGGCATTAGCT
CAGCGGATAATGCCTTCACCCTCAGAACAGGTGTCCAAGAAGTGGCCAGGAGATATAACTACAT
AGCAAGCCTTGTAATTGAGACTGGATTCTGCAACTCAGGAATTTTGTCTCATAGCATCTGGGAT
GTGAGCGGGAAGACAAACATGTTCTACAGTGGTTCTGGGGTGGAGAGGCTCACGCTCACCGGGA
AGAAGTGGTTGGCAGGCCTGCTGAAGCACTCTGCGGCTCTCAGCTGCCTGATGGCCCCTGCTGT
CAACTGCCGCAAACGCTACTGCAAGGACAGCAGAGACCTGAAGGACAGCGTGCCCACCACGTGG
GGATACAACGACAACAGCTGTGCCTTGAACGTCAAGTGTCATGGTGAAAAAGGCACCCAGATAG
AAAATAAATTAGGTTCGGCAACCGCGAACCCTTACCTGGTATTGGCCGCTACTGTGGCAGCAGG
CTTGGATGGTCTTCAGAGCAGTGATGGTGCTGCGGCTGAATCCGATGAGAGCCAGGATCTCTAT
CAACCAGAACCTTCCGAGATCCCTTTGAAGATGGAAGATGCCCTCGCCGCCCTAGAGCAAGATG
AGTGTCTGAAGCAGGCACTGGGAGAGACTTTCATTCGCTATTTTGTTGCCATGAAGAAGTACGA
ACTGGAAAATGAAGAAACAGACGCAGAGGGAAATAAATTCCTGGAGTATTTTATATAGGATGGA
ACTATAGAGATGTTATTATGACAAGTAGCTAGTTTATCAGAATGAAAAGATTGAGCCTTTGCAG
TTAACAACACTAGACAGCTTCTGCCCCTCCCCCACGGATTACTGGGCAGATGAAATGGGATTGG
TGAGATCCTGATTTCAGCTATAGACAATAAATTTGTGGTGAAACAGCAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017596436 ⟹ XP_017451925

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	40,912,398 - 40,943,955 (+)	NCBI
mRatBN7.2	9	33,416,362 - 33,447,919 (+)	NCBI
Rnor_6.0	9	37,458,603 - 37,490,117 (+)	NCBI

Sequence:

show sequence

AATGCCATTTACTTTTAGCAGTTTTAGAGCTTAACTAGTGGAGGCAGACATAGAAGGGCTGTTC
ATAAAATAATTTGCAGTGCAGAGTAAGGAAAAAGTACGTATATAGCATGGAGACAGAAGACAAT
TTTCTCGGGCAGTTAGAAGTGAAGCCCACAGCCGGCAAACATAACAGCGTCAACGCCAGACCAG
ACCAGCCAGGATGTTGTAACTGGCTATGGGAAGCCCCGCGTGAAAGCTGCTCTAACTTTGATCT
GTTACTGTGATGTCACATGTACAGCAACATGTGCTCTGCGTGTGGCACGAAAACGCTGGACACA
ACAAAAGATGAAGCAAACTCGACTGAAGGCAGCAGGGTGAACAAGTTGAAAAGGACAAGAAGAA
AAGTCACCAAACCACATCTTTGCTCAGCAGATGGGGATGAAATCACCATGGCCAATTCCAGGGA
GATGTCCAGAAACCAAACAGCAGATCTGAGCAAACCTGGCTCTGCTGAGTCTTGGTCCTGGCAC
AATGCCAAAGACGCCCAAGATCAGATACCAGTGGTAAAATCTTCACTTCCCAGTGCTGGTGCTC
CTGATGCTGAATTCAACCCGAATACTGATCACACTCGGGACAATGCTCAGAGTTTGATCCTGCC
TCAACTTTCTTCTAGAATGAAACACATCAAACAAGAAATGGCCAAAAATCACCTCCAGTTTGTA
CGATTTGAAGCCACAGACTTGCACGGTGTCTCCAGATCTAAGAGCATCCCTGCACAATTTTTTC
AAGAAAAAGTGATCCATGGAGTTTTCATGCCCCGTGGTTATCTGGAATTGATGCCGAACCCTAA
GGACAATGAGGTAAATCACATACGAGCCACGTGCTTCAATAGTGACATAGTCCTCATGCCAGAG
CTGTCGACCTTTAGAGTCTTGCCTTGGGCAGAGAGGACTGCGCGGGTGATTTGTGACACCTTCA
CTGTGACGGGCGAGCCTCTGCTGACGTCCCCTAGGTACATCGCCAAGAGGCAGTTGCGCCAGCT
GCAGGATGCCGGCTTCTCTCTGCTGTCTGCCTTCATCTATGATTTCTGCATTTTCGGTGTGCCC
GAAGTGATCAATTCAAAGACCATATCTTTTCCTGCCTCGACATTACTAAGTAATCATGACCAGC
CCTTCATGCAGGAGCTGGTTGACGGCTTGTATCACACAGGGGCAAATGTGGAGAGCTTCTCCTC
TTCTACCAGGCCTGGGCAAATGGAGATCTGTTTTCTCCCGGAGTTTGGCATTAGCTCAGCGGAT
AATGCCTTCACCCTCAGAACAGGTGTCCAAGAAGTGGCCAGGAGATATAACTACATAGCAAGCC
TTGTAATTGAGACTGGATTCTGCAACTCAGGAATTTTGTCTCATAGCATCTGGGATGTGAGCGG
GAAGACAAACATGTTCTACAGTGGTTCTGGGGTGGAGAGGCTCACGCTCACCGGGAAGAAGTGG
TTGGCAGGCCTGCTGAAGCACTCTGCGGCTCTCAGCTGCCTGATGGCCCCTGCTGTCAACTGCC
GCAAACGCTACTGCAAGGACAGCAGAGACCTGAAGGACAGCGTGCCCACCACGTGGGGATACAA
CGACAACAGCTGTGCCTTGAACGTCAAGTGTCATGGTGAAAAAGGCACCCAGATAGAAAATAAA
TTAGGTTCGGCAACCGCGAACCCTTACCTGGTATTGGCCGCTACTGTGGCAGCAGGCTTGGATG
GTCTTCAGAGCAGTGATGGTGCTGCGGCTGAATCCGATGAGAGCCAGGATCTCTATCAACCAGA
ACCTTCCGAGATCCCTTTGAAGATGGAAGATGCCCTCGCCGCCCTAGAGCAAGATGAGTGTCTG
AAGCAGGCACTGGGAGAGACTTTCATTCGCTATTTTGTTGCCATGAAGAAGTACGAACTGGAAA
ATGAAGAAACAGACGCAGAGGGAAATAAATTCCTGGAGTATTTTATATAGGATGGAACTATAGA
GATGTTATTATGACAAGTAGCTAGTTTATCAGAATGAAAAGATTGAGCCTTTGCAGTTAACAAC
ACTAGACAGCTTCTGCCCCTCCCCCACGGATTACTGGGCAGATGAAATGGGATTGGTGAGATCC
TGATTTCAGCTATAGACAATAAATTTGTGGTGAAACAGCATATGCAAACTT

hide sequence

RefSeq Acc Id:

XM_017596437 ⟹ XP_017451926

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	40,912,398 - 40,943,955 (+)	NCBI
mRatBN7.2	9	33,416,362 - 33,447,919 (+)	NCBI
Rnor_6.0	9	37,458,603 - 37,490,117 (+)	NCBI

Sequence:

show sequence

AATGCCATTTACTTTTAGCAGTTTTAGAGCTTAACTAGTGGAGGCAGACATAGAAGGGCTGTTC
ATAAAATAATTTGCAGTGCAGAGTAAGGAAAAAGTACGTATATAGCATGGAGACAGAAGACAAT
TTTCTCGGGCAGTTAGAAGTGAAGCCCACAGCCGGCAAACATAACAGCGTCAACGCCAGACCAG
ACCAGCCAGGATGTTGTAACTGGCTATGGGAAGCCCCGCGTGAAAGCTGCTCTAACTTTGATCT
GTTACTGTGATGTCACATGTACAGCAACATGTGCTCTGCGTGTGGCACGAAAACGCTGGGAGTC
AGGCATAAACGAGCATTTGTTGCTGGGCTATTCCAGGGCATTGCTCATACCCTGTGCCTTGGGC
ATGACAGAATCTGCGTTTATCTTTTATTACCTGCTGGATCGTCCTGGAAAGGACCTCCTGGAAT
TCATCATTCACTCCTTTGTTAGAGGTCTACATATAAATGCACCCTGAAGCCATCGCTGAAGGGA
GTGTGGTTGGCAAGGCTGATTTACCGTAAGAAACGGTTGACATGAACGATGAAGGGGACCTTGC
ACAGGAGGACACAACAAAAGATGAAGCAAACTCGACTGAAGGCAGCAGGGTGAACAAGTTGAAA
AGGACAAGAAGAAAAGTCACCAAACCACATCTTTGCTCAGCAGATGGGGATGAAATCACCATGG
CCAATTCCAGGGAGATGTCCAGAAACCAAACAGCAGATCTGAGCAAACCTGGCTCTGCTGAGTC
TTGGTCCTGGCACAATGCCAAAGACGCCCAAGATCAGATACCAGTGGTAAAATCTTCACTTCCC
AGTGCTGGTGCTCCTGATGCTGAATTCAACCCGAATACTGATCACACTCGGGACAATGCTCAGA
GTTTGATCCTGCCTCAACTTTCTTCTAGAATGAAACACATCAAACAAGAAATGGCCAAAAATCA
CCTCCAGTTTGTACGATTTGAAGCCACAGACTTGCACGGTGTCTCCAGATCTAAGAGCATCCCT
GCACAATTTTTTCAAGAAAAAGTGATCCATGGAGTTTTCATGCCCCGTGGTTATCTGGAATTGA
TGCCGAACCCTAAGGACAATGAGGTAAATCACATACGAGCCACGTGCTTCAATAGTGACATAGT
CCTCATGCCAGAGCTGTCGACCTTTAGAGTCTTGCCTTGGGCAGAGAGGACTGCGCGGGTGATT
TGTGACACCTTCACTGTGACGGGCGAGCCTCTGCTGACGTCCCCTAGGTACATCGCCAAGAGGC
AGTTGCGCCAGCTGCAGGATGCCGGCTTCTCTCTGCTGTCTGCCTTCATCTATGATTTCTGCAT
TTTCGGTGTGCCCGAAGTGATCAATTCAAAGACCATATCTTTTCCTGCCTCGACATTACTAAGT
AATCATGACCAGCCCTTCATGCAGGAGCTGGTTGACGGCTTGTATCACACAGGGGCAAATGTGG
AGAGCTTCTCCTCTTCTACCAGGCCTGGGCAAATGGAGATCTGTTTTCTCCCGGAGTTTGGCAT
TAGCTCAGCGGATAATGCCTTCACCCTCAGAACAGGTGTCCAAGAAGTGGCCAGGAGATATAAC
TACATAGCAAGCCTTGTAATTGAGACTGGATTCTGCAACTCAGGAATTTTGTCTCATAGCATCT
GGGATGTGAGCGGGAAGACAAACATGTTCTACAGTGGTTCTGGGGTGGAGAGGCTCACGCTCAC
CGGGAAGAAGTGGTTGGCAGGCCTGCTGAAGCACTCTGCGGCTCTCAGCTGCCTGATGGCCCCT
GCTGTCAACTGCCGCAAACGCTACTGCAAGGACAGCAGAGACCTGAAGGACAGCGTGCCCACCA
CGTGGGGATACAACGACAACAGCTGTGCCTTGAACGTCAAGTGTCATGGTGAAAAAGGCACCCA
GATAGAAAATAAATTAGGTTCGGCAACCGCGAACCCTTACCTGGTATTGGCCGCTACTGTGGCA
GCAGGCTTGGATGGTCTTCAGAGCAGTGATGGTGCTGCGGCTGAATCCGATGAGAGCCAGGATC
TCTATCAACCAGAACCTTCCGAGATCCCTTTGAAGATGGAAGATGCCCTCGCCGCCCTAGAGCA
AGATGAGTGTCTGAAGCAGGCACTGGGAGAGACTTTCATTCGCTATTTTGTTGCCATGAAGAAG
TACGAACTGGAAAATGAAGAAACAGACGCAGAGGGAAATAAATTCCTGGAGTATTTTATATAGG
ATGGAACTATAGAGATGTTATTATGACAAGTAGCTAGTTTATCAGAATGAAAAGATTGAGCCTT
TGCAGTTAACAACACTAGACAGCTTCTGCCCCTCCCCCACGGATTACTGGGCAGATGAAATGGG
ATTGGTGAGATCCTGATTTCAGCTATAGACAATAAATTTGTGGTGAAACAGCATATGCAAACTT

hide sequence

RefSeq Acc Id:

XM_039083550 ⟹ XP_038939478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	40,930,850 - 40,943,955 (+)	NCBI
mRatBN7.2	9	33,434,814 - 33,447,919 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_852048	(Get FASTA)	NCBI Sequence Viewer
	XP_017451925	(Get FASTA)	NCBI Sequence Viewer
	XP_017451926	(Get FASTA)	NCBI Sequence Viewer
	XP_038939478	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP34385	(Get FASTA)	NCBI Sequence Viewer
	EDL99326	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016316
	ENSRNOP00000016316.3
GenBank Protein	Q7TT51	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_852048 ⟸ NM_181383

- UniProtKB:

Q7TT51 (UniProtKB/Swiss-Prot), A6IN83 (UniProtKB/TrEMBL), A0A8I6ADX5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNDEGDLAQEDTTKDEANSTEGSRVNKLKRTRRKVTKPHLCSADGDEITMANSREMSRNQTADL
SKPGSAESWSWHNAKDAQDQIPVVKSSLPSAGAPDAEFNPNTDHTRDNAQSLILPQLSSRMKHI
KQEMAKNHLQFVRFEATDLHGVSRSKSIPAQFFQEKVIHGVFMPRGYLELMPNPKDNEVNHIRA
TCFNSDIVLMPELSTFRVLPWAERTARVICDTFTVTGEPLLTSPRYIAKRQLRQLQDAGFSLLS
AFIYDFCIFGVPEVINSKTISFPASTLLSNHDQPFMQELVDGLYHTGANVESFSSSTRPGQMEI
CFLPEFGISSADNAFTLRTGVQEVARRYNYIASLVIETGFCNSGILSHSIWDVSGKTNMFYSGS
GVERLTLTGKKWLAGLLKHSAALSCLMAPAVNCRKRYCKDSRDLKDSVPTTWGYNDNSCALNVK
CHGEKGTQIENKLGSATANPYLVLAATVAAGLDGLQSSDGAAAESDESQDLYQPEPSEIPLKME
DALAALEQDECLKQALGETFIRYFVAMKKYELENEETDAEGNKFLEYFI

hide sequence

RefSeq Acc Id:	XP_017451926 ⟸ XM_017596437
- Peptide Label:	isoform X2
- UniProtKB:	Q7TT51 (UniProtKB/Swiss-Prot), A6IN83 (UniProtKB/TrEMBL), A0A8I6ADX5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNDEGDLAQEDTTKDEANSTEGSRVNKLKRTRRKVTKPHLCSADGDEITMANSREMSRNQTADL SKPGSAESWSWHNAKDAQDQIPVVKSSLPSAGAPDAEFNPNTDHTRDNAQSLILPQLSSRMKHI KQEMAKNHLQFVRFEATDLHGVSRSKSIPAQFFQEKVIHGVFMPRGYLELMPNPKDNEVNHIRA TCFNSDIVLMPELSTFRVLPWAERTARVICDTFTVTGEPLLTSPRYIAKRQLRQLQDAGFSLLS AFIYDFCIFGVPEVINSKTISFPASTLLSNHDQPFMQELVDGLYHTGANVESFSSSTRPGQMEI CFLPEFGISSADNAFTLRTGVQEVARRYNYIASLVIETGFCNSGILSHSIWDVSGKTNMFYSGS GVERLTLTGKKWLAGLLKHSAALSCLMAPAVNCRKRYCKDSRDLKDSVPTTWGYNDNSCALNVK CHGEKGTQIENKLGSATANPYLVLAATVAAGLDGLQSSDGAAAESDESQDLYQPEPSEIPLKME DALAALEQDECLKQALGETFIRYFVAMKKYELENEETDAEGNKFLEYFI hide sequence

RefSeq Acc Id:	XP_017451925 ⟸ XM_017596436
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6ADX5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYSNMCSACGTKTLDTTKDEANSTEGSRVNKLKRTRRKVTKPHLCSADGDEITMANSREMSRNQ TADLSKPGSAESWSWHNAKDAQDQIPVVKSSLPSAGAPDAEFNPNTDHTRDNAQSLILPQLSSR MKHIKQEMAKNHLQFVRFEATDLHGVSRSKSIPAQFFQEKVIHGVFMPRGYLELMPNPKDNEVN HIRATCFNSDIVLMPELSTFRVLPWAERTARVICDTFTVTGEPLLTSPRYIAKRQLRQLQDAGF SLLSAFIYDFCIFGVPEVINSKTISFPASTLLSNHDQPFMQELVDGLYHTGANVESFSSSTRPG QMEICFLPEFGISSADNAFTLRTGVQEVARRYNYIASLVIETGFCNSGILSHSIWDVSGKTNMF YSGSGVERLTLTGKKWLAGLLKHSAALSCLMAPAVNCRKRYCKDSRDLKDSVPTTWGYNDNSCA LNVKCHGEKGTQIENKLGSATANPYLVLAATVAAGLDGLQSSDGAAAESDESQDLYQPEPSEIP LKMEDALAALEQDECLKQALGETFIRYFVAMKKYELENEETDAEGNKFLEYFI hide sequence

Ensembl Acc Id:

ENSRNOP00000016316 ⟸ ENSRNOT00000016316

RefSeq Acc Id:	XP_038939478 ⟸ XM_039083550
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000091136 ⟸ ENSRNOT00000100875

Protein Domains

GS beta-grasp GS catalytic

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TT51-F1-model_v2	AlphaFold	Q7TT51	1-561	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727925	AgrOrtholog
BioCyc Gene	G2FUF-27895	BioCyc
Ensembl Genes	ENSRNOG00000012205	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000016316	ENTREZGENE
	ENSRNOT00000016316.5	UniProtKB/Swiss-Prot
Gene3D-CATH	3.10.20.70	UniProtKB/Swiss-Prot
	Glutamine synthetase/guanido kinase, catalytic domain	UniProtKB/Swiss-Prot
InterPro	Gln_synt_N	UniProtKB/Swiss-Prot
	Gln_synt_N	UniProtKB/Swiss-Prot
	Gln_synth/guanido_kin_cat_dom	UniProtKB/Swiss-Prot
	Gln_synth_cat_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:316304	UniProtKB/Swiss-Prot
NCBI Gene	316304	ENTREZGENE
PANTHER	GLUTAMINE SYNTHETASE	UniProtKB/Swiss-Prot
	LENGSIN	UniProtKB/Swiss-Prot
Pfam	Gln-synt_C	UniProtKB/Swiss-Prot
PhenoGen	Lgsn	PhenoGen
PROSITE	GS_BETA_GRASP	UniProtKB/Swiss-Prot
	GS_CATALYTIC	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000012205	RatGTEx
SMART	Gln-synt_C	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54368	UniProtKB/Swiss-Prot
	SSF55931	UniProtKB/Swiss-Prot
UniProt	A0A8I6ADX5	ENTREZGENE, UniProtKB/TrEMBL
	A6IN83	ENTREZGENE, UniProtKB/TrEMBL
	LGSN_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-16	Lgsn	lengsin, lens protein with glutamine synthetase domain	Gluld1	glutamate-ammonia ligase (glutamine synthetase) domain containing 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Gluld1	glutamate-ammonia ligase (glutamine synthetase) domain containing 1		glutamate-ammonia ligase (glutamine synthase) domain containing 1	Name updated	1299863	APPROVED
2004-09-10	Gluld1	glutamate-ammonia ligase (glutamine synthase) domain containing 1	Lgs	lengsin	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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