Kirrel1 (kirre like nephrin family adhesion molecule 1) - Rat Genome Database

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Pathways
Gene: Kirrel1 (kirre like nephrin family adhesion molecule 1) Rattus norvegicus
Analyze
Symbol: Kirrel1
Name: kirre like nephrin family adhesion molecule 1
RGD ID: 727883
Description: Predicted to enable cell adhesion molecule binding activity and myosin binding activity. Predicted to be involved in cell-cell adhesion; cell-cell junction maintenance; and glomerular filtration. Predicted to act upstream of or within positive regulation of actin filament polymerization and renal protein absorption. Located in cell projection membrane; cell-cell junction; and membrane raft. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Orthologous to human KIRREL1 (kirre like nephrin family adhesion molecule 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-diaminodiphenylmethane; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kin of IRRE like (Drosophila); kin of IRRE like 1; kin of IRRE like 1 (Drosophila); kin of IRRE-like protein 1; kin of irregular chiasm-like protein 1; Kirrel; Neph1; nephrin 1; nephrin-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82174,819,564 - 174,912,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2174,819,572 - 174,912,960 (-)EnsemblGRCr8
mRatBN7.22172,521,644 - 172,615,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2172,525,245 - 172,615,299 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2179,676,244 - 179,730,913 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02177,698,563 - 177,753,230 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,286,976 - 172,341,500 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02186,420,743 - 186,515,209 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2186,420,795 - 186,515,135 (-)Ensemblrn6Rnor6.0
Rnor_5.02205,825,636 - 205,919,683 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42179,114,757 - 179,169,185 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2166,483,236 - 166,536,703 (-)NCBICelera
RGSC_v3.12179,064,862 - 179,119,291 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane. Arif E, etal., Mol Cell Biol. 2011 May;31(10):2134-50. doi: 10.1128/MCB.05051-11. Epub 2011 Mar 14.
2. Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers. Barletta GM, etal., J Biol Chem 2003 May 23;278(21):19266-71. Epub 2003 Mar 19.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. Liu G, etal., J Clin Invest 2003 Jul;112(2):209-21.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11416156   PMID:15979540   PMID:16874800   PMID:17923684   PMID:18258597   PMID:18715943   PMID:18922801   PMID:21277866   PMID:21306299   PMID:23376485   PMID:23570724   PMID:25298195  


Genomics

Comparative Map Data
Kirrel1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82174,819,564 - 174,912,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2174,819,572 - 174,912,960 (-)EnsemblGRCr8
mRatBN7.22172,521,644 - 172,615,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2172,525,245 - 172,615,299 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2179,676,244 - 179,730,913 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02177,698,563 - 177,753,230 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,286,976 - 172,341,500 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02186,420,743 - 186,515,209 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2186,420,795 - 186,515,135 (-)Ensemblrn6Rnor6.0
Rnor_5.02205,825,636 - 205,919,683 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42179,114,757 - 179,169,185 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2166,483,236 - 166,536,703 (-)NCBICelera
RGSC_v3.12179,064,862 - 179,119,291 (-)NCBI
Cytogenetic Map2q34NCBI
KIRREL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,993,645 - 158,100,262 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,993,273 - 158,100,262 (+)Ensemblhg38GRCh38
GRCh371157,963,435 - 158,070,052 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,229,687 - 156,332,465 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341154,776,135 - 154,878,919NCBI
Celera1131,034,468 - 131,136,921 (+)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1129,321,031 - 129,423,944 (+)NCBIHuRef
CHM1_11159,359,575 - 159,462,305 (+)NCBICHM1_1
T2T-CHM13v2.01157,130,739 - 157,237,353 (+)NCBIT2T-CHM13v2.0
Kirrel1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39386,985,900 - 87,082,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl386,985,900 - 87,082,054 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38387,078,593 - 87,174,777 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,078,593 - 87,174,747 (-)Ensemblmm10GRCm38
MGSCv37386,882,514 - 86,978,669 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36387,168,739 - 87,227,036 (-)NCBIMGSCv36mm8
Celera387,105,684 - 87,203,142 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.18NCBI
Kirrel1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554689,821,303 - 9,916,667 (+)Ensembl
ChiLan1.0NW_0049554689,820,649 - 9,919,958 (+)NCBIChiLan1.0ChiLan1.0
KIRREL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2191,736,817 - 91,842,857 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1191,480,731 - 91,586,707 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01133,363,880 - 133,465,717 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11137,237,218 - 137,261,101 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1137,233,701 - 137,255,927 (+)EnsemblpanPan2panpan1.1
KIRREL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,530,930 - 23,593,957 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,530,885 - 23,594,236 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3823,556,953 - 23,620,213 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03823,696,328 - 23,762,792 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3823,699,336 - 23,763,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13823,440,193 - 23,506,559 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03823,993,900 - 24,059,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03824,394,780 - 24,461,104 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kirrel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050583,719,999 - 3,761,108 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936847821,479 - 841,988 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936847820,538 - 844,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIRREL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl492,176,746 - 92,290,610 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1492,173,897 - 92,290,887 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24100,513,435 - 100,628,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIRREL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1205,811,111 - 5,918,064 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl205,816,187 - 5,917,968 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660385,003,417 - 5,112,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kirrel1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247942,829,496 - 2,922,352 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247942,824,716 - 2,922,300 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kirrel1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1366,396,787 - 66,485,326 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kirrel1
551 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:82
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000031743
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
7771605Memor19Memory QTL 190.00001exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)2172499769175588177Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
7771603Bp371Blood pressure QTL 3710.00001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172499769175588177Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
BF396370  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,557,536 - 172,557,699 (+)MAPPERmRatBN7.2
Rnor_6.02186,456,981 - 186,457,143NCBIRnor6.0
Rnor_5.02205,861,464 - 205,861,626UniSTSRnor5.0
RGSC_v3.42179,145,193 - 179,145,355UniSTSRGSC3.4
Celera2166,513,759 - 166,513,921UniSTS
RH 3.4 Map21130.4UniSTS
Cytogenetic Map2q34UniSTS
PMC164293P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,527,567 - 172,527,770 (+)MAPPERmRatBN7.2
Rnor_6.02186,426,667 - 186,426,869NCBIRnor6.0
Rnor_5.02205,831,560 - 205,831,762UniSTSRnor5.0
RGSC_v3.42179,116,201 - 179,116,403UniSTSRGSC3.4
Celera2166,484,668 - 166,484,870UniSTS
Cytogenetic Map2q34UniSTS
AU049378  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,569,537 - 172,569,780 (+)MAPPERmRatBN7.2
Rnor_6.02186,468,982 - 186,469,224NCBIRnor6.0
Rnor_5.02205,873,465 - 205,873,707UniSTSRnor5.0
RGSC_v3.42179,157,194 - 179,157,436UniSTSRGSC3.4
Celera2166,525,761 - 166,526,003UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:234720  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,525,660 - 172,525,894 (+)MAPPERmRatBN7.2
Rnor_6.02186,424,760 - 186,424,993NCBIRnor6.0
Rnor_5.02205,829,653 - 205,829,886UniSTSRnor5.0
RGSC_v3.42179,114,294 - 179,114,527UniSTSRGSC3.4
Celera2166,482,773 - 166,483,006UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 28 59 6 292 128 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031743   ⟹   ENSRNOP00000033900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2174,819,572 - 174,912,960 (-)Ensembl
mRatBN7.2 Ensembl2172,525,245 - 172,614,888 (-)Ensembl
Rnor_6.0 Ensembl2186,425,223 - 186,480,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077375   ⟹   ENSRNOP00000070270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2174,819,572 - 174,860,392 (-)Ensembl
mRatBN7.2 Ensembl2172,525,245 - 172,615,299 (-)Ensembl
Rnor_6.0 Ensembl2186,420,795 - 186,515,135 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134383   ⟹   ENSRNOP00000100429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2174,819,572 - 174,912,943 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145740   ⟹   ENSRNOP00000099971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2174,819,572 - 174,847,434 (-)Ensembl
RefSeq Acc Id: NM_207606   ⟹   NP_997489
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,819,564 - 174,912,960 (-)NCBI
mRatBN7.22172,521,644 - 172,615,035 (-)NCBI
Rnor_6.02186,425,223 - 186,480,278 (-)NCBI
Rnor_5.02205,825,636 - 205,919,683 (-)NCBI
RGSC_v3.42179,114,757 - 179,169,185 (-)RGD
Celera2166,483,236 - 166,536,703 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232675   ⟹   XP_006232737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,819,564 - 174,912,998 (-)NCBI
mRatBN7.22172,521,644 - 172,615,057 (-)NCBI
Rnor_6.02186,420,743 - 186,515,209 (-)NCBI
Rnor_5.02205,825,636 - 205,919,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232676   ⟹   XP_006232738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,819,564 - 174,912,998 (-)NCBI
mRatBN7.22172,521,644 - 172,615,057 (-)NCBI
Rnor_6.02186,420,743 - 186,515,209 (-)NCBI
Rnor_5.02205,825,636 - 205,919,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232678   ⟹   XP_006232740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,819,564 - 174,912,998 (-)NCBI
mRatBN7.22172,521,644 - 172,615,057 (-)NCBI
Rnor_6.02186,420,743 - 186,515,208 (-)NCBI
Rnor_5.02205,825,636 - 205,919,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281893   ⟹   XP_063137963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,819,564 - 174,887,415 (-)NCBI
RefSeq Acc Id: NP_997489   ⟸   NM_207606
- Peptide Label: precursor
- UniProtKB: Q6X936 (UniProtKB/Swiss-Prot),   F1M7V1 (UniProtKB/Swiss-Prot),   Q80W67 (UniProtKB/Swiss-Prot),   A0A0G2JXH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232740   ⟸   XM_006232678
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JXH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232738   ⟸   XM_006232676
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232737   ⟸   XM_006232675
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033900   ⟸   ENSRNOT00000031743
Ensembl Acc Id: ENSRNOP00000070270   ⟸   ENSRNOT00000077375
RefSeq Acc Id: XP_063137963   ⟸   XM_063281893
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXH3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099971   ⟸   ENSRNOT00000145740
Ensembl Acc Id: ENSRNOP00000100429   ⟸   ENSRNOT00000134383
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6X936-F1-model_v2 AlphaFold Q6X936 1-789 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691417
Promoter ID:EPDNEW_R1938
Type:initiation region
Name:Kirrel1_1
Description:kirre like nephrin family adhesion molecule 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02186,515,050 - 186,515,110EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727883 AgrOrtholog
BioCyc Gene G2FUF-52558 BioCyc
Ensembl Genes ENSRNOG00000016408 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031743 ENTREZGENE
  ENSRNOT00000031743.2 UniProtKB/Swiss-Prot
  ENSRNOT00000134383 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro CD80_C2-set UniProtKB/Swiss-Prot
  Cell_adhesion_signaling UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
KEGG Report rno:310695 UniProtKB/Swiss-Prot
NCBI Gene 310695 ENTREZGENE
PANTHER KIN OF IRRE-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
  NEPHRIN UniProtKB/Swiss-Prot
Pfam C2-set_2 UniProtKB/Swiss-Prot
  I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
PhenoGen Kirrel1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016408 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A0G2JXH3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LB75_RAT UniProtKB/TrEMBL
  A0ABK0LCA7_RAT UniProtKB/TrEMBL
  A6J601_RAT UniProtKB/TrEMBL
  F1M7V1 ENTREZGENE
  KIRR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80W67 ENTREZGENE
UniProt Secondary F1M7V1 UniProtKB/Swiss-Prot
  Q80W67 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-21 Kirrel1  kirre like nephrin family adhesion molecule 1  Kirrel  kin of IRRE like (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Kirrel  kin of IRRE like (Drosophila)  Kirrel1  kin of IRRE like 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Kirrel1  kin of IRRE like 1 (Drosophila)  Neph1  nephrin 1  Symbol and Name updated 1299863 APPROVED