Tmem184c (transmembrane protein 184C) - Rat Genome Database

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Gene: Tmem184c (transmembrane protein 184C) Rattus norvegicus
Analyze
Symbol: Tmem184c
Name: transmembrane protein 184C
RGD ID: 727852
Description: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human TMEM184C (transmembrane protein 184C); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AY228474; DNA sequence AY228474; hypothetical protein FLJ10846-like; LOC291946; MGC105290; Tmem34; transmembrane protein 34
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,249,403 - 47,265,502 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1947,249,500 - 47,265,949 (+)EnsemblGRCr8
mRatBN7.21930,345,183 - 30,361,275 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,345,290 - 30,361,269 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1937,178,287 - 37,194,253 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01937,832,159 - 37,848,126 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01940,081,246 - 40,097,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01934,041,128 - 34,057,165 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,041,219 - 34,057,159 (+)Ensemblrn6Rnor6.0
Rnor_5.01944,923,134 - 44,938,607 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41932,158,361 - 32,174,009 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1929,826,892 - 29,842,819 (+)NCBICelera
RGSC_v3.11932,163,186 - 32,178,891 (+)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Tmem184c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,249,403 - 47,265,502 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1947,249,500 - 47,265,949 (+)EnsemblGRCr8
mRatBN7.21930,345,183 - 30,361,275 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,345,290 - 30,361,269 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1937,178,287 - 37,194,253 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01937,832,159 - 37,848,126 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01940,081,246 - 40,097,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01934,041,128 - 34,057,165 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,041,219 - 34,057,159 (+)Ensemblrn6Rnor6.0
Rnor_5.01944,923,134 - 44,938,607 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41932,158,361 - 32,174,009 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1929,826,892 - 29,842,819 (+)NCBICelera
RGSC_v3.11932,163,186 - 32,178,891 (+)NCBI
Cytogenetic Map19q11NCBI
TMEM184C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,617,397 - 147,636,721 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4147,617,386 - 147,672,044 (+)Ensemblhg38GRCh38
GRCh374148,538,548 - 148,557,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,758,046 - 148,776,120 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344148,896,200 - 148,914,275NCBI
Celera4145,859,644 - 145,877,781 (+)NCBICelera
Cytogenetic Map4q31.23NCBI
HuRef4144,265,653 - 144,283,790 (+)NCBIHuRef
CHM1_14148,516,948 - 148,535,084 (+)NCBICHM1_1
T2T-CHM13v2.04150,941,481 - 150,960,807 (+)NCBIT2T-CHM13v2.0
Tmem184c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,322,607 - 78,337,343 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,322,611 - 78,337,327 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38877,595,978 - 77,610,714 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,595,982 - 77,610,698 (-)Ensemblmm10GRCm38
MGSCv37880,119,877 - 80,134,552 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36880,492,054 - 80,506,693 (-)NCBIMGSCv36mm8
Celera881,886,688 - 81,901,354 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.61NCBI
Tmem184c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,191,818 - 3,208,845 (+)Ensembl
ChiLan1.0NW_0049554283,191,833 - 3,212,267 (+)NCBIChiLan1.0ChiLan1.0
TMEM184C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23145,489,955 - 145,510,258 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14145,855,474 - 145,873,330 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04139,955,785 - 139,975,738 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14151,611,162 - 151,629,099 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,611,162 - 151,665,508 (+)EnsemblpanPan2panpan1.1
TMEM184C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,955,521 - 45,979,986 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,955,802 - 45,979,616 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1546,349,203 - 46,373,639 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01546,629,750 - 46,654,228 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1546,629,884 - 46,654,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11545,898,035 - 45,922,519 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01545,994,781 - 46,019,256 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,304,469 - 46,328,947 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TMEM184C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,084,639 - 81,140,413 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1881,115,140 - 81,140,465 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,231,328 - 86,247,037 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM184C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1794,114,222 - 94,133,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl794,114,784 - 94,137,316 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603773,817,897 - 73,840,081 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem184c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004625006240,734 - 261,491 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004625006240,377 - 261,533 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem184c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11146,367,810 - 146,382,862 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem184c
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:21
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000017226
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)194172060949971820Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 74 182 91 90 59 97 59 6 395 206 13 168 106 121 31 24 24

Sequence


Ensembl Acc Id: ENSRNOT00000017226   ⟹   ENSRNOP00000017225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1947,251,140 - 47,265,695 (+)Ensembl
mRatBN7.2 Ensembl1930,345,290 - 30,360,983 (+)Ensembl
Rnor_6.0 Ensembl1934,041,219 - 34,057,159 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095421   ⟹   ENSRNOP00000091823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1947,249,500 - 47,265,497 (+)Ensembl
mRatBN7.2 Ensembl1930,345,290 - 30,360,983 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116349   ⟹   ENSRNOP00000080369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1947,249,500 - 47,265,949 (+)Ensembl
mRatBN7.2 Ensembl1930,345,306 - 30,361,269 (+)Ensembl
RefSeq Acc Id: NM_178330   ⟹   NP_847900
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,249,531 - 47,265,496 (+)NCBI
mRatBN7.21930,345,310 - 30,361,269 (+)NCBI
Rnor_6.01934,041,219 - 34,057,159 (+)NCBI
Rnor_5.01944,923,134 - 44,938,607 (+)NCBI
RGSC_v3.41932,158,361 - 32,174,009 (+)RGD
Celera1929,826,892 - 29,842,819 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255422   ⟹   XP_006255484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,249,420 - 47,265,502 (+)NCBI
mRatBN7.21930,345,184 - 30,361,275 (+)NCBI
Rnor_6.01934,041,128 - 34,057,165 (+)NCBI
Rnor_5.01944,923,134 - 44,938,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063277895   ⟹   XP_063133965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,250,248 - 47,265,502 (+)NCBI
RefSeq Acc Id: XM_063277896   ⟹   XP_063133966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,249,403 - 47,264,258 (+)NCBI
RefSeq Acc Id: NP_847900   ⟸   NM_178330
- UniProtKB: Q810F5 (UniProtKB/Swiss-Prot),   A6IYK4 (UniProtKB/TrEMBL),   A0A8I6AF90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255484   ⟸   XM_006255422
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q8K2 (UniProtKB/TrEMBL),   A0A8I6AF90 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017225   ⟸   ENSRNOT00000017226
Ensembl Acc Id: ENSRNOP00000091823   ⟸   ENSRNOT00000095421
Ensembl Acc Id: ENSRNOP00000080369   ⟸   ENSRNOT00000116349
RefSeq Acc Id: XP_063133966   ⟸   XM_063277896
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063133965   ⟸   XM_063277895
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZPW6 (UniProtKB/TrEMBL),   A0A8I6AF90 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q810F5-F1-model_v2 AlphaFold Q810F5 1-503 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701057
Promoter ID:EPDNEW_R11580
Type:multiple initiation site
Name:Tmem184c_1
Description:transmembrane protein 184C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01934,041,282 - 34,041,342EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727852 AgrOrtholog
BioCyc Gene G2FUF-5904 BioCyc
Ensembl Genes ENSRNOG00000012860 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017226 ENTREZGENE
  ENSRNOT00000116349 ENTREZGENE
IMAGE_CLONE IMAGE:7316181 IMAGE-MGC_LOAD
InterPro Ostalpha/TMEM184C UniProtKB/Swiss-Prot
KEGG Report rno:291946 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105290 IMAGE-MGC_LOAD
NCBI Gene 291946 ENTREZGENE
PANTHER PTHR23423 UniProtKB/Swiss-Prot
Pfam Solute_trans_a UniProtKB/Swiss-Prot
PhenoGen Tmem184c PhenoGen
RatGTEx ENSRNOG00000012860 RatGTEx
SMART Solute_trans_a UniProtKB/Swiss-Prot
UniProt A0A8I5ZPW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF90 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q8K2 ENTREZGENE, UniProtKB/TrEMBL
  A6IYK4 ENTREZGENE, UniProtKB/TrEMBL
  Q810F5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Tmem184c  transmembrane protein 184C  Tmem34  transmembrane protein 34  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tmem34  transmembrane protein 34  AY228474  DNA sequence AY228474  Symbol and Name updated 1299863 APPROVED
2004-02-11 AY228474  DNA sequence AY228474  LOC291946  hypothetical protein FLJ10846-like  Symbol and Name updated 625702 APPROVED