Serinc1 (serine incorporator 1) - Rat Genome Database

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Gene: Serinc1 (serine incorporator 1) Rattus norvegicus
Analyze
Symbol: Serinc1
Name: serine incorporator 1
RGD ID: 727843
Description: Enables acetyltransferase activator activity; enzyme binding activity; and protein-macromolecule adaptor activity. Involved in membrane biogenesis; phosphatidylserine metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum membrane and plasma membrane. Orthologous to human SERINC1 (serine incorporator 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LRRGT00191; Tde1l; Tde2; tumor differentially expressed 1 protein-like; tumor differentially expressed 1, like; tumor differentially expressed protein 1-like; tumor differentially expressed protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82037,396,497 - 37,415,433 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2037,396,497 - 37,443,124 (-)EnsemblGRCr8
mRatBN7.22036,850,062 - 36,868,999 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2036,850,076 - 36,896,691 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2037,870,080 - 37,888,964 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02037,260,777 - 37,279,665 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02037,987,832 - 38,006,720 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02038,966,016 - 38,985,056 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2038,967,238 - 38,985,036 (-)Ensemblrn6Rnor6.0
Rnor_5.02040,703,831 - 40,722,871 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42036,541,193 - 36,560,101 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2038,164,769 - 38,183,684 (-)NCBICelera
RGSC_v3.12036,554,996 - 36,573,901 (-)NCBI
Cytogenetic Map20q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
levetiracetam  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. Inuzuka M, etal., J Biol Chem. 2005 Oct 21;280(42):35776-83. Epub 2005 Aug 24.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. Identification of TDE2 gene and its expression in non-small cell lung cancer. Player A, etal., Int J Cancer 2003 Nov 1;107(2):238-43.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10637174   PMID:12477932   PMID:23376485  


Genomics

Comparative Map Data
Serinc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82037,396,497 - 37,415,433 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2037,396,497 - 37,443,124 (-)EnsemblGRCr8
mRatBN7.22036,850,062 - 36,868,999 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2036,850,076 - 36,896,691 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2037,870,080 - 37,888,964 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02037,260,777 - 37,279,665 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02037,987,832 - 38,006,720 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02038,966,016 - 38,985,056 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2038,967,238 - 38,985,036 (-)Ensemblrn6Rnor6.0
Rnor_5.02040,703,831 - 40,722,871 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42036,541,193 - 36,560,101 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2038,164,769 - 38,183,684 (-)NCBICelera
RGSC_v3.12036,554,996 - 36,573,901 (-)NCBI
Cytogenetic Map20q12NCBI
SERINC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386122,443,351 - 122,471,807 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6122,443,348 - 122,471,854 (-)Ensemblhg38GRCh38
GRCh376122,764,496 - 122,792,952 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366122,806,192 - 122,834,651 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346122,806,191 - 122,834,651NCBI
Celera6123,508,786 - 123,537,260 (-)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6120,341,469 - 120,369,953 (-)NCBIHuRef
CHM1_16123,028,296 - 123,056,788 (-)NCBICHM1_1
T2T-CHM13v2.06123,631,640 - 123,660,124 (-)NCBIT2T-CHM13v2.0
Serinc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391057,391,870 - 57,408,573 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1057,391,870 - 57,408,626 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381057,515,774 - 57,532,529 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1057,515,774 - 57,532,530 (-)Ensemblmm10GRCm38
MGSCv371057,235,580 - 57,252,335 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361057,204,193 - 57,220,864 (-)NCBIMGSCv36mm8
Celera1058,334,364 - 58,351,120 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.19NCBI
Serinc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554364,416,134 - 4,435,263 (-)Ensembl
ChiLan1.0NW_0049554364,414,629 - 4,435,353 (-)NCBIChiLan1.0ChiLan1.0
SERINC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25142,437,407 - 142,465,931 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16140,336,651 - 140,365,182 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06120,231,789 - 120,260,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16124,356,203 - 124,384,659 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6124,356,204 - 124,384,659 (-)EnsemblpanPan2panpan1.1
SERINC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,813,404 - 61,845,345 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,739,224 - 61,845,296 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha162,623,435 - 62,655,373 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0162,017,867 - 62,049,811 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,991,621 - 62,049,856 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,952,560 - 61,984,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0161,739,772 - 61,771,692 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0162,388,783 - 62,420,655 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serinc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946112,709,078 - 112,729,330 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368021,346,708 - 1,366,989 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368021,346,565 - 1,366,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERINC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl140,099,328 - 40,141,541 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1140,099,323 - 40,141,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2144,437,423 - 44,446,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERINC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11351,324,071 - 51,353,226 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1351,324,049 - 51,351,536 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604023,624,518 - 23,653,234 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serinc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247988,618,671 - 8,644,780 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247988,618,750 - 8,641,291 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Serinc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11834,200,806 - 34,219,682 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serinc1
127 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:114
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000001066
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203215696745978663Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
AU048742  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14q11UniSTS
Cytogenetic Map13q27UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map20q11UniSTS
RH133897  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22036,850,124 - 36,850,320 (+)MAPPERmRatBN7.2
Rnor_6.02038,966,079 - 38,966,274NCBIRnor6.0
Rnor_5.02040,703,894 - 40,704,089UniSTSRnor5.0
RGSC_v3.42036,541,256 - 36,541,451UniSTSRGSC3.4
Celera2038,164,832 - 38,165,027UniSTS
RH 3.4 Map20392.7UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001066   ⟹   ENSRNOP00000001066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2037,396,497 - 37,415,433 (-)Ensembl
mRatBN7.2 Ensembl2036,850,076 - 36,868,961 (-)Ensembl
Rnor_6.0 Ensembl2038,967,238 - 38,985,036 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074379   ⟹   ENSRNOP00000064593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2037,396,497 - 37,443,124 (-)Ensembl
mRatBN7.2 Ensembl2036,850,076 - 36,896,691 (-)Ensembl
RefSeq Acc Id: NM_182951   ⟹   NP_891996
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82037,396,497 - 37,415,433 (-)NCBI
mRatBN7.22036,850,062 - 36,868,999 (-)NCBI
Rnor_6.02038,966,016 - 38,985,056 (-)NCBI
Rnor_5.02040,703,831 - 40,722,871 (-)NCBI
RGSC_v3.42036,541,193 - 36,560,101 (-)RGD
Celera2038,164,769 - 38,183,684 (-)RGD
Sequence:
RefSeq Acc Id: NP_891996   ⟸   NM_182951
- UniProtKB: Q7TNK0 (UniProtKB/Swiss-Prot),   A6K4C4 (UniProtKB/TrEMBL),   A6K4C3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001066   ⟸   ENSRNOT00000001066
Ensembl Acc Id: ENSRNOP00000064593   ⟸   ENSRNOT00000074379
Protein Domains
Reverse transcriptase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNK0-F1-model_v2 AlphaFold Q7TNK0 1-453 view protein structure
AF-M0R5C9-F1-model_v2 AlphaFold M0R5C9 1-1607 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701635
Promoter ID:EPDNEW_R12159
Type:initiation region
Name:Serinc1_1
Description:serine incorporator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02038,985,046 - 38,985,106EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727843 AgrOrtholog
BioCyc Gene G2FUF-3587 BioCyc
Ensembl Genes ENSRNOG00000029360 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001066 ENTREZGENE
  ENSRNOT00000001066.7 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7315523 IMAGE-MGC_LOAD
InterPro TDE1/TMS UniProtKB/Swiss-Prot
KEGG Report rno:294421 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105269 IMAGE-MGC_LOAD
NCBI Gene 294421 ENTREZGENE
PANTHER PTHR10383 UniProtKB/Swiss-Prot
  PTHR10383:SF15 UniProtKB/Swiss-Prot
Pfam Serinc UniProtKB/Swiss-Prot
PhenoGen Serinc1 PhenoGen
RatGTEx ENSRNOG00000029360 RatGTEx
UniProt A6K4C3 ENTREZGENE, UniProtKB/TrEMBL
  A6K4C4 ENTREZGENE, UniProtKB/TrEMBL
  A6K4C5_RAT UniProtKB/TrEMBL
  A6K4C6_RAT UniProtKB/TrEMBL
  M0R5C9_RAT UniProtKB/TrEMBL
  Q7TNK0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Serinc1  serine incorporator 1  Tde2  tumor differentially expressed 1, like  Symbol and Name updated 1299863 APPROVED
2004-09-10 Tde2  tumor differentially expressed 1, like  Tde1l    Symbol and Name updated 1299863 APPROVED