Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Adi1 | Rat | 17beta-estradiol | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of ADI1 mRNA | CTD | PMID:20660070 | Adi1 | Rat | 17beta-estradiol | decreases expression | ISO | Adi1 (Mus musculus) | 6480464 | Estradiol results in decreased expression of ADI1 mRNA | CTD | PMID:39298647 | Adi1 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | multiple interactions | ISO | Adi1 (Mus musculus) | 6480464 | [Flame Retardants results in increased abundance of 2,2',4,4'-tetrabromodiphenyl ether] which results in increased expression of more ... | CTD | PMID:38995820 | Adi1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ADI1 mRNA | CTD | PMID:20044593 | Adi1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Adi1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ADI1 mRNA | CTD | PMID:21570461 | Adi1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Adi1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ADI1 mRNA | CTD | PMID:20044593 | Adi1 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Adi1 (Mus musculus) | 6480464 | bisphenol S results in increased expression of ADI1 mRNA | CTD | PMID:39298647 | Adi1 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of ADI1 protein | CTD | PMID:34186270 | Adi1 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of ADI1 gene | CTD | PMID:31601247 | Adi1 | Rat | 4-hydroxynon-2-enal | increases expression | ISO | Adi1 (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in increased expression of ADI1 mRNA | CTD | PMID:19191707 | Adi1 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | ADI1 (Homo sapiens) | 6480464 | Decitabine affects the expression of ADI1 mRNA | CTD | PMID:23300844 | Adi1 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of ADI1 mRNA | CTD | PMID:31881176 | Adi1 | Rat | acrylamide | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of ADI1 mRNA | CTD | PMID:32763439 | Adi1 | Rat | actinomycin D | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of ADI1 protein | CTD | PMID:38460933 | Adi1 | Rat | all-trans-retinoic acid | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of ADI1 mRNA | CTD | PMID:23724009|PMID:33167477 | Adi1 | Rat | antirheumatic drug | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of ADI1 mRNA | CTD | PMID:16817978 | Adi1 | Rat | aristolochic acid A | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of ADI1 mRNA | CTD | PMID:33212167 | Adi1 | Rat | atrazine | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of ADI1 mRNA | CTD | PMID:22378314 | Adi1 | Rat | belinostat | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | belinostat results in decreased expression of ADI1 mRNA | CTD | PMID:27188386 | Adi1 | Rat | benzo[a]pyrene | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of ADI1 protein | CTD | PMID:33278487 | Adi1 | Rat | beta-lapachone | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of ADI1 mRNA | CTD | PMID:38218311 | Adi1 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased methylation of ADI1 more ... | CTD | PMID:33872906 | Adi1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of ADI1 mRNA | CTD | PMID:25181051 | Adi1 | Rat | bisphenol A | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ADI1 protein | CTD | PMID:34186270|PMID:37567409 | Adi1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ADI1 mRNA | CTD | PMID:30816183 | Adi1 | Rat | bisphenol A | affects expression | ISO | ADI1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of ADI1 mRNA | CTD | PMID:30903817 | Adi1 | Rat | bisphenol AF | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of ADI1 protein | CTD | PMID:34186270 | Adi1 | Rat | Bisphenol B | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of ADI1 protein | CTD | PMID:34186270 | Adi1 | Rat | bisphenol F | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of ADI1 protein | CTD | PMID:34186270 | Adi1 | Rat | carbamazepine | affects expression | ISO | ADI1 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of ADI1 mRNA | CTD | PMID:25979313 | Adi1 | Rat | carbon nanotube | decreases expression | ISO | Adi1 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of ADI1 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681|PMID:25620056 | Adi1 | Rat | CGP 52608 | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ADI1 gene] | CTD | PMID:28238834 | Adi1 | Rat | cisplatin | affects expression | ISO | ADI1 (Homo sapiens) | 6480464 | Cisplatin affects the expression of ADI1 mRNA | CTD | PMID:23300844 | Adi1 | Rat | cisplatin | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of ADI1 mRNA | CTD | PMID:27392435 | Adi1 | Rat | clofibrate | decreases expression | ISO | Adi1 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of ADI1 mRNA | CTD | PMID:17585979 | Adi1 | Rat | copper atom | decreases expression | ISO | Adi1 (Mus musculus) | 6480464 | Copper results in decreased expression of ADI1 mRNA | CTD | PMID:17205981 | Adi1 | Rat | copper(0) | decreases expression | ISO | Adi1 (Mus musculus) | 6480464 | Copper results in decreased expression of ADI1 mRNA | CTD | PMID:17205981 | Adi1 | Rat | copper(II) sulfate | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of ADI1 mRNA | CTD | PMID:19549813 | Adi1 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of ADI1 mRNA | CTD | PMID:26577399 | Adi1 | Rat | cyclosporin A | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of ADI1 mRNA | CTD | PMID:20106945|PMID:25562108 | Adi1 | Rat | decabromodiphenyl ether | increases expression | ISO | Adi1 (Mus musculus) | 6480464 | decabromobiphenyl ether results in increased expression of ADI1 mRNA | CTD | PMID:29699156 | Adi1 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of ADI1 mRNA | CTD | PMID:21266533 | Adi1 | Rat | diethylstilbestrol | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Diethylstilbestrol results in decreased expression of ADI1 mRNA | CTD | PMID:36621641 | Adi1 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of ADI1 mRNA | CTD | PMID:21551480 | Adi1 | Rat | dorsomorphin | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Adi1 | Rat | dutasteride | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Dutasteride results in decreased expression of ADI1 mRNA | CTD | PMID:20564326 | Adi1 | Rat | entinostat | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | entinostat results in decreased expression of ADI1 mRNA | CTD | PMID:27188386 | Adi1 | Rat | fenthion | increases expression | ISO | Adi1 (Mus musculus) | 6480464 | Fenthion results in increased expression of ADI1 mRNA | CTD | PMID:34813904 | Adi1 | Rat | fluoranthene | multiple interactions | ISO | Adi1 (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in decreased expression of ADI1 mRNA | CTD | PMID:28329830 | Adi1 | Rat | folic acid | decreases expression | ISO | Adi1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of ADI1 mRNA | CTD | PMID:25629700 | Adi1 | Rat | fulvestrant | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of ADI1 gene | CTD | PMID:31601247 | Adi1 | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of ADI1 mRNA | CTD | PMID:26194646 | Adi1 | Rat | glyphosate | increases expression | ISO | Adi1 (Mus musculus) | 6480464 | Glyphosate results in increased expression of ADI1 protein | CTD | PMID:37208198 | Adi1 | Rat | hydrogen peroxide | affects expression | ISO | ADI1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of ADI1 mRNA | CTD | PMID:20044591 | Adi1 | Rat | irinotecan | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of ADI1 mRNA | CTD | PMID:18927307 | Adi1 | Rat | isoniazide | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Isoniazid results in decreased expression of ADI1 protein | CTD | PMID:40015660 | Adi1 | Rat | ivermectin | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of ADI1 protein | CTD | PMID:32959892 | Adi1 | Rat | ketoconazole | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Ketoconazole results in decreased expression of ADI1 mRNA | CTD | PMID:36621641 | Adi1 | Rat | manganese atom | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of ADI1 more ... | CTD | PMID:39836092 | Adi1 | Rat | manganese(0) | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of ADI1 more ... | CTD | PMID:39836092 | Adi1 | Rat | manganese(II) chloride | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of ADI1 more ... | CTD | PMID:39836092 | Adi1 | Rat | methotrexate | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of ADI1 mRNA | CTD | PMID:16817978 | Adi1 | Rat | methyl methanesulfonate | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of ADI1 mRNA | CTD | PMID:23649840 | Adi1 | Rat | mibolerone | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | mibolerone results in increased expression of ADI1 mRNA; mibolerone results in increased expression of ADI1 more ... | CTD | PMID:17786183 | Adi1 | Rat | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased methylation of ADI1 more ... | CTD | PMID:33872906 | Adi1 | Rat | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of ADI1 mRNA | CTD | PMID:19041683 | Adi1 | Rat | nitrates | multiple interactions | ISO | Adi1 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of ADI1 more ... | CTD | PMID:35964746 | Adi1 | Rat | Nutlin-3 | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of ADI1 protein | CTD | PMID:38460933 | Adi1 | Rat | ozone | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of ADI1 mRNA | CTD | PMID:35430440 | Adi1 | Rat | paracetamol | affects expression | ISO | Adi1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of ADI1 mRNA | CTD | PMID:17562736 | Adi1 | Rat | perfluorooctanoic acid | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of ADI1 protein | CTD | PMID:22609092 | Adi1 | Rat | phenylmercury acetate | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of ADI1 mRNA | CTD | PMID:26272509 | Adi1 | Rat | phenylmercury acetate | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Adi1 | Rat | picoxystrobin | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | picoxystrobin results in increased expression of ADI1 mRNA | CTD | PMID:33512557 | Adi1 | Rat | pirinixic acid | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Adi1 | Rat | potassium chromate | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of ADI1 mRNA | CTD | PMID:22714537 | Adi1 | Rat | potassium dichromate | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of ADI1 protein | CTD | PMID:23718831 | Adi1 | Rat | progesterone | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of ADI1 mRNA | CTD | PMID:20660070 | Adi1 | Rat | pyrimidifen | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | pyrimidifen results in increased expression of ADI1 mRNA | CTD | PMID:33512557 | Adi1 | Rat | resveratrol | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | resveratrol results in increased expression of ADI1 protein | CTD | PMID:22349766 | Adi1 | Rat | rotenone | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Rotenone results in increased expression of ADI1 mRNA | CTD | PMID:33512557 | Adi1 | Rat | SB 431542 | multiple interactions | ISO | ADI1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Adi1 | Rat | silicon dioxide | increases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of ADI1 mRNA | CTD | PMID:25895662 | Adi1 | Rat | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of ADI1 protein | CTD | PMID:29459688 | Adi1 | Rat | sunitinib | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of ADI1 mRNA | CTD | PMID:31533062 | Adi1 | Rat | tetrachloromethane | decreases expression | ISO | Adi1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of ADI1 mRNA | CTD | PMID:27339419|PMID:31919559 | Adi1 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ADI1 mRNA | CTD | PMID:31150632 | Adi1 | Rat | thapsigargin | decreases expression | ISO | Adi1 (Mus musculus) | 6480464 | Thapsigargin results in decreased expression of ADI1 protein | CTD | PMID:24648495 | Adi1 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of ADI1 mRNA | CTD | PMID:23411599|PMID:34492290 | Adi1 | Rat | thiram | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Thiram results in decreased expression of ADI1 mRNA | CTD | PMID:38568856 | Adi1 | Rat | titanium dioxide | decreases methylation | ISO | Adi1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of ADI1 gene | CTD | PMID:35295148 | Adi1 | Rat | valproic acid | affects expression | ISO | Adi1 (Mus musculus) | 6480464 | Valproic Acid affects the expression of ADI1 mRNA | CTD | PMID:17963808 | Adi1 | Rat | valproic acid | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ADI1 mRNA | CTD | PMID:23179753|PMID:27188386|PMID:29154799 | Adi1 | Rat | valproic acid | increases methylation | ISO | ADI1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of ADI1 gene | CTD | PMID:29154799 | Adi1 | Rat | valproic acid | affects expression | ISO | ADI1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ADI1 mRNA | CTD | PMID:25979313 | Adi1 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of ADI1 mRNA | CTD | PMID:23034163 | Adi1 | Rat | vorinostat | decreases expression | ISO | ADI1 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of ADI1 mRNA; vorinostat results in decreased expression of ADI1 more ... | CTD | PMID:17593366|PMID:20543569|PMID:27188386 | | |||||||||||||||||||






















