Lhx2 (LIM homeobox 2) - Rat Genome Database

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Gene: Lhx2 (LIM homeobox 2) Rattus norvegicus
Analyze
Symbol: Lhx2
Name: LIM homeobox 2
RGD ID: 71076
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in neuron differentiation. Predicted to be active in nucleus. Orthologous to human LHX2 (LIM homeobox 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein LH-2; Lh-2; LH2A; LIM homeobox protein 2; LIM/homeobox protein Lhx2; LOC296706
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,523,345 - 42,553,646 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl342,535,744 - 42,553,645 (+)EnsemblGRCr8
mRatBN7.2322,113,619 - 22,143,909 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,126,007 - 22,143,908 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx325,594,877 - 25,612,777 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,179,870 - 34,197,771 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,991,800 - 32,009,717 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,628,674 - 22,658,447 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,640,545 - 22,658,446 (+)Ensemblrn6Rnor6.0
Rnor_5.0327,870,008 - 27,887,929 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4318,129,455 - 18,147,357 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera320,559,471 - 20,577,366 (+)NCBICelera
RGSC_v3.1318,025,179 - 18,043,730 (+)NCBI
Cytogenetic Map3q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amosite asbestos  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
dexamethasone  (EXP)
diclofenac  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flusilazole  (ISO)
fulvestrant  (ISO)
glyphosate  (EXP)
hydroxyurea  (ISO)
imidacloprid  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Gene Data Set MGD Curation, June 12, 2002
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Porter FD, etal., Development 1997 Aug;124(15):2935-44.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted. Vyas A, etal., J Comp Neurol 2003 Nov 24;466(4):545-53.
9. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Xu Y, etal., Proc Natl Acad Sci U S A 1993 Jan 1;90(1):227-31.
Additional References at PubMed
PMID:7513049   PMID:9697309   PMID:10431247   PMID:10482234   PMID:10593900   PMID:11165475   PMID:11719201   PMID:15173589   PMID:15295034   PMID:17005264   PMID:17493606   PMID:17991461  
PMID:18076286   PMID:18184563   PMID:19146846   PMID:19820705   PMID:21857657   PMID:22457488   PMID:22734700   PMID:24012369   PMID:26371318   PMID:28053041   PMID:34581932  


Genomics

Comparative Map Data
Lhx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,523,345 - 42,553,646 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl342,535,744 - 42,553,645 (+)EnsemblGRCr8
mRatBN7.2322,113,619 - 22,143,909 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,126,007 - 22,143,908 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx325,594,877 - 25,612,777 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,179,870 - 34,197,771 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,991,800 - 32,009,717 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,628,674 - 22,658,447 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,640,545 - 22,658,446 (+)Ensemblrn6Rnor6.0
Rnor_5.0327,870,008 - 27,887,929 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4318,129,455 - 18,147,357 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera320,559,471 - 20,577,366 (+)NCBICelera
RGSC_v3.1318,025,179 - 18,043,730 (+)NCBI
Cytogenetic Map3q12NCBI
LHX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,011,768 - 124,033,301 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9124,001,670 - 124,033,301 (+)Ensemblhg38GRCh38
GRCh379126,774,047 - 126,795,580 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369125,813,710 - 125,835,263 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349123,853,442 - 123,874,996NCBI
Celera997,421,143 - 97,442,696 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef996,387,559 - 96,409,113 (+)NCBIHuRef
CHM1_19126,922,665 - 126,944,218 (+)NCBICHM1_1
T2T-CHM13v2.09136,209,686 - 136,231,219 (+)NCBIT2T-CHM13v2.0
Lhx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,229,282 - 38,259,747 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,229,293 - 38,259,745 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38238,339,271 - 38,369,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,339,281 - 38,369,733 (+)Ensemblmm10GRCm38
MGSCv37238,206,828 - 38,225,248 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36238,173,317 - 38,191,737 (+)NCBIMGSCv36mm8
Celera240,107,977 - 40,108,866 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.31NCBI
Lhx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,998,242 - 4,018,875 (-)Ensembl
ChiLan1.0NW_0049554193,999,364 - 4,019,543 (-)NCBIChiLan1.0ChiLan1.0
LHX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,322,198 - 15,343,933 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1915,324,546 - 15,346,290 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0995,132,445 - 95,154,130 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19123,655,845 - 123,676,803 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9123,655,845 - 123,676,796 (+)EnsemblpanPan2panpan1.1
LHX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1958,825,505 - 58,859,311 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl958,825,492 - 58,845,883 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha958,022,250 - 58,042,687 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0959,745,814 - 59,766,310 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl959,745,801 - 59,766,240 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1958,502,870 - 58,523,325 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0958,819,702 - 58,840,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0958,910,400 - 58,930,871 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lhx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,627,290 - 192,645,467 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648712,395,812 - 12,414,003 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648712,395,817 - 12,413,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1264,900,591 - 264,920,890 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11264,900,931 - 264,920,888 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21298,708,264 - 298,728,222 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LHX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11214,110,122 - 14,133,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1214,110,068 - 14,132,026 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660791,939,043 - 1,961,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476010,951,837 - 10,982,592 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lhx2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1516,117,077 - 16,147,295 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lhx2
206 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:254
Count of miRNA genes:133
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000014452, ENSRNOT00000064507
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)33777225855937853Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)33779691953640235Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)33779691947904329Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
D3Got17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,131,405 - 22,131,609 (+)MAPPERmRatBN7.2
Rnor_6.0322,645,944 - 22,646,147NCBIRnor6.0
Rnor_5.0327,875,426 - 27,875,629UniSTSRnor5.0
RGSC_v3.4318,134,854 - 18,135,057RGDRGSC3.4
RGSC_v3.4318,134,854 - 18,135,057UniSTSRGSC3.4
Celera320,564,870 - 20,565,073UniSTS
RGSC_v3.1318,031,226 - 18,031,429RGD
RH 3.4 Map3224.2RGD
RH 3.4 Map3224.2UniSTS
RH 2.0 Map3103.6RGD
Cytogenetic Map3q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 12 64 148 82 78 59 33 59 6 237 120 7 136 42 82 19 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014452   ⟹   ENSRNOP00000014452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl322,640,604 - 22,657,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064507   ⟹   ENSRNOP00000061914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl342,535,744 - 42,553,645 (+)Ensembl
mRatBN7.2 Ensembl322,126,007 - 22,143,908 (+)Ensembl
Rnor_6.0 Ensembl322,640,545 - 22,658,446 (+)Ensembl
RefSeq Acc Id: NM_001106571   ⟹   NP_001100041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,535,744 - 42,553,645 (+)NCBI
mRatBN7.2322,126,007 - 22,143,908 (+)NCBI
Rnor_6.0322,640,545 - 22,658,446 (+)NCBI
Rnor_5.0327,870,008 - 27,887,929 (+)NCBI
RGSC_v3.4318,129,455 - 18,147,357 (+)RGD
Celera320,559,471 - 20,577,366 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234072   ⟹   XP_006234134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,535,788 - 42,553,646 (+)NCBI
mRatBN7.2322,126,036 - 22,143,909 (+)NCBI
Rnor_6.0322,640,577 - 22,658,447 (+)NCBI
Rnor_5.0327,870,008 - 27,887,929 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234073   ⟹   XP_006234135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,537,347 - 42,553,646 (+)NCBI
mRatBN7.2322,127,610 - 22,143,909 (+)NCBI
Rnor_6.0322,642,148 - 22,658,447 (+)NCBI
Rnor_5.0327,870,008 - 27,887,929 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761742   ⟹   XP_008759964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,536,018 - 42,553,646 (+)NCBI
mRatBN7.2322,126,329 - 22,143,909 (+)NCBI
Rnor_6.0322,640,763 - 22,658,447 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591665   ⟹   XP_017447154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,523,345 - 42,553,646 (+)NCBI
mRatBN7.2322,113,619 - 22,143,909 (+)NCBI
Rnor_6.0322,628,674 - 22,658,447 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063283527   ⟹   XP_063139597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,538,696 - 42,553,646 (+)NCBI
RefSeq Acc Id: NP_001100041   ⟸   NM_001106571
- UniProtKB: P36198 (UniProtKB/Swiss-Prot),   A6JEU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234134   ⟸   XM_006234072
- Peptide Label: isoform X1
- UniProtKB: P36198 (UniProtKB/Swiss-Prot),   D4A380 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234135   ⟸   XM_006234073
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008759964   ⟸   XM_008761742
- Peptide Label: isoform X2
- UniProtKB: P36198 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447154   ⟸   XM_017591665
- Peptide Label: isoform X2
- UniProtKB: P36198 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014452   ⟸   ENSRNOT00000014452
Ensembl Acc Id: ENSRNOP00000061914   ⟸   ENSRNOT00000064507
RefSeq Acc Id: XP_063139597   ⟸   XM_063283527
- Peptide Label: isoform X4
Protein Domains
Homeobox   LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36198-F1-model_v2 AlphaFold P36198 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71076 AgrOrtholog
BioCyc Gene G2FUF-49914 BioCyc
Ensembl Genes ENSRNOG00000010551 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064507 ENTREZGENE
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  LIM_Homeobox_TF UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
NCBI Gene Lhx2 ENTREZGENE
PANTHER LIM/HOMEOBOX PROTEIN LHX UniProtKB/Swiss-Prot
  LIM/HOMEOBOX PROTEIN LHX2 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
  LIM UniProtKB/Swiss-Prot
PhenoGen Lhx2 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010551 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
  LIM UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF46689 UniProtKB/Swiss-Prot
UniProt A6JEU2 ENTREZGENE, UniProtKB/TrEMBL
  D4A380 ENTREZGENE, UniProtKB/TrEMBL
  LHX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Lhx2  LIM homeobox 2  Lhx2  LIM homeobox protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-09 Lhx2  LIM homeobox protein 2  Lhx2_predicted  LIM homeobox protein 2 (predicted)  Data merged from RGD:1309617 737654 APPROVED
2005-01-12 Lhx2_predicted  LIM homeobox protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-07-09 Lhx2  LIM homeobox protein 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a homeodomain and two repeats of a LIM domain 70777
gene_protein 426 amino acids 70777