Lrrn3 (leucine rich repeat neuronal 3) - Rat Genome Database

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Gene: Lrrn3 (leucine rich repeat neuronal 3) Rattus norvegicus
Analyze
Symbol: Lrrn3
Name: leucine rich repeat neuronal 3
RGD ID: 71066
Description: Predicted to enable signaling receptor activity. Predicted to act upstream of or within positive regulation of synapse assembly. Part of clathrin adaptor complex. Orthologous to human LRRN3 (leucine rich repeat neuronal 3); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leucine rich repeat protein 3, neuronal; leucine-rich repeat neuronal protein 3; neuronal leucine-rich repeat protein 3; neuronal leucine-rich repeat protein-3; NLRR-3; Nlrr3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8664,216,164 - 64,247,293 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl664,215,878 - 64,247,614 (-)EnsemblGRCr8
mRatBN7.2658,489,060 - 58,520,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl658,489,010 - 58,520,330 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx658,781,617 - 58,812,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0659,096,565 - 59,127,407 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010000884.19,132 - 11,876 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0661,374,328 - 61,405,195 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl661,374,328 - 61,405,195 (-)Ensemblrn6Rnor6.0
Rnor_5.0670,956,733 - 70,987,862 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4660,745,501 - 60,776,261 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera657,518,117 - 57,548,974 (-)NCBICelera
RGSC_v3.1660,748,626 - 60,779,384 (-)NCBI
Cytogenetic Map6q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Archazolid B  (ISO)
aripiprazole  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP)
curcumin  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fipronil  (EXP)
gentamycin  (EXP)
GW 4064  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mapping the microtubule binding regions of calponin. Fattoum A, etal., Biochemistry 2003 Feb 11;42(5):1274-82.
2. Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. Fukamachi K, etal., Biochem Biophys Res Commun 2001 Sep 14;287(1):257-63.
3. Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. Fukamachi K, etal., J Biol Chem 2002 Nov 15;277(46):43549-52.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:21685698   PMID:24613359   PMID:26192016  


Genomics

Comparative Map Data
Lrrn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8664,216,164 - 64,247,293 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl664,215,878 - 64,247,614 (-)EnsemblGRCr8
mRatBN7.2658,489,060 - 58,520,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl658,489,010 - 58,520,330 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx658,781,617 - 58,812,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0659,096,565 - 59,127,407 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010000884.19,132 - 11,876 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0661,374,328 - 61,405,195 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl661,374,328 - 61,405,195 (-)Ensemblrn6Rnor6.0
Rnor_5.0670,956,733 - 70,987,862 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4660,745,501 - 60,776,261 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera657,518,117 - 57,548,974 (-)NCBICelera
RGSC_v3.1660,748,626 - 60,779,384 (-)NCBI
Cytogenetic Map6q21NCBI
LRRN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387111,091,127 - 111,125,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7111,091,006 - 111,125,454 (+)Ensemblhg38GRCh38
GRCh377110,731,183 - 110,765,510 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367110,518,298 - 110,552,746 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347110,325,133 - 110,359,411NCBI
Celera7105,543,350 - 105,577,801 (+)NCBICelera
Cytogenetic Map7q31.1NCBI
HuRef7105,099,093 - 105,133,547 (+)NCBIHuRef
CHM1_17110,664,791 - 110,699,239 (+)NCBICHM1_1
T2T-CHM13v2.07112,409,397 - 112,443,727 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27110,098,162 - 110,132,623 (+)NCBI
Lrrn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391241,501,667 - 41,536,056 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1241,501,667 - 41,536,430 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381241,451,668 - 41,486,057 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1241,451,668 - 41,486,431 (-)Ensemblmm10GRCm38
MGSCv371242,178,255 - 42,212,338 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361241,962,091 - 41,996,174 (-)NCBIMGSCv36mm8
Celera1242,872,974 - 42,907,092 (-)NCBICelera
Cytogenetic Map12B1NCBI
cM Map1218.94NCBI
Lrrn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541014,954,301 - 14,986,896 (+)Ensembl
ChiLan1.0NW_00495541014,954,301 - 14,986,896 (+)NCBIChiLan1.0ChiLan1.0
LRRN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26147,934,886 - 147,971,839 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17196,207,426 - 196,241,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07103,072,402 - 103,106,880 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17115,787,503 - 115,821,979 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7115,819,307 - 115,821,433 (+)EnsemblpanPan2panpan1.1
LRRN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11450,893,254 - 50,928,475 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1450,925,878 - 50,928,004 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1450,347,780 - 50,382,993 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01450,849,398 - 50,884,609 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1450,849,313 - 50,884,599 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11450,954,378 - 50,989,584 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01450,637,915 - 50,673,104 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01451,010,041 - 51,045,270 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrrn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511870,516,170 - 70,552,561 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366533,667,513 - 3,702,203 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366533,667,518 - 3,702,203 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1834,425,836 - 34,465,665 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11834,424,774 - 34,465,661 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21837,449,572 - 37,489,384 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12179,942,736 - 79,977,110 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2179,974,437 - 79,976,560 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604223,860,832 - 23,894,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473918,735,922 - 18,772,465 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473918,733,055 - 18,772,468 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lrrn3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1754,614,478 - 54,617,509 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lrrn3
398 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:125
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000008655
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 63 150 91 90 59 60 59 6 306 155 11 129 69 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008655   ⟹   ENSRNOP00000008655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl664,215,878 - 64,247,614 (-)Ensembl
mRatBN7.2 Ensembl658,489,010 - 58,520,330 (-)Ensembl
Rnor_6.0 Ensembl661,374,328 - 61,405,195 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118309   ⟹   ENSRNOP00000092172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl658,489,058 - 58,506,333 (-)Ensembl
RefSeq Acc Id: NM_030856   ⟹   NP_110483
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8664,216,426 - 64,247,293 (-)NCBI
mRatBN7.2658,489,322 - 58,520,189 (-)NCBI
Rnor_6.0661,374,328 - 61,405,195 (-)NCBI
Rnor_5.0670,956,733 - 70,987,862 (-)NCBI
RGSC_v3.4660,745,501 - 60,776,261 (-)RGD
Celera657,518,117 - 57,548,974 (-)RGD
Sequence:
RefSeq Acc Id: XM_063262546   ⟹   XP_063118616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8664,216,164 - 64,227,160 (-)NCBI
RefSeq Acc Id: XM_063262547   ⟹   XP_063118617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8664,216,164 - 64,246,884 (-)NCBI
Protein Sequences
Protein RefSeqs NP_110483 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118616 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118617 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG00604 (Get FASTA)   NCBI Sequence Viewer  
  AAH81791 (Get FASTA)   NCBI Sequence Viewer  
  EDM03346 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008655
GenBank Protein Q9ESY6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_110483   ⟸   NM_030856
- Peptide Label: precursor
- UniProtKB: Q9ESY6 (UniProtKB/Swiss-Prot),   Q642E4 (UniProtKB/Swiss-Prot),   A0A0G2JSI7 (UniProtKB/TrEMBL),   A6HBE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008655   ⟸   ENSRNOT00000008655
Ensembl Acc Id: ENSRNOP00000092172   ⟸   ENSRNOT00000118309
RefSeq Acc Id: XP_063118617   ⟸   XM_063262547
- Peptide Label: isoform X1
- UniProtKB: Q9ESY6 (UniProtKB/Swiss-Prot),   Q642E4 (UniProtKB/Swiss-Prot),   A0A0G2JSI7 (UniProtKB/TrEMBL),   A6HBE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118616   ⟸   XM_063262546
- Peptide Label: isoform X1
- UniProtKB: Q9ESY6 (UniProtKB/Swiss-Prot),   Q642E4 (UniProtKB/Swiss-Prot),   A0A0G2JSI7 (UniProtKB/TrEMBL),   A6HBE1 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESY6-F1-model_v2 AlphaFold Q9ESY6 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694573
Promoter ID:EPDNEW_R5098
Type:single initiation site
Name:Lrrn3_1
Description:leucine rich repeat neuronal 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0661,405,231 - 61,405,291EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71066 AgrOrtholog
BioCyc Gene G2FUF-37721 BioCyc
Ensembl Genes ENSRNOG00000006368 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000008655 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124169 IMAGE-MGC_LOAD
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  SLRP UniProtKB/Swiss-Prot
KEGG Report rno:81514 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93401 IMAGE-MGC_LOAD
NCBI Gene 81514 ENTREZGENE
PANTHER AGAP008170-PA UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
PhenoGen Lrrn3 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006368 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
UniProt A0A0G2JSI7 ENTREZGENE, UniProtKB/TrEMBL
  A6HBE1 ENTREZGENE, UniProtKB/TrEMBL
  LRRN3_RAT UniProtKB/Swiss-Prot
  Q642E4 ENTREZGENE
  Q9ESY6 ENTREZGENE
UniProt Secondary Q642E4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Lrrn3  leucine rich repeat neuronal 3  Lrrn3  leucine rich repeat protein 3, neuronal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Lrrn3  leucine rich repeat protein 3, neuronal      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the leucine rich repeat superfamily 633284
gene_regulation amplification of EGF phosphorylation requires C-terminal calthrin-mediated endocytosis motifs 633284