Heph (hephaestin) - Rat Genome Database

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Gene: Heph (hephaestin) Rattus norvegicus
Analyze
Symbol: Heph
Name: hephaestin
RGD ID: 71060
Description: Predicted to enable copper ion binding activity; ferrous iron binding activity; and ferroxidase activity. Predicted to be involved in iron ion transport. Predicted to act upstream of or within erythrocyte differentiation. Located in perinuclear region of cytoplasm. Orthologous to human HEPH (hephaestin); PARTICIPATES IN iron efflux pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X65,160,628 - 65,412,457 (+)NCBIGRCr8
mRatBN7.2X61,151,131 - 61,402,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX61,296,345 - 61,402,980 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX62,774,925 - 62,871,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X66,275,451 - 66,372,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X63,831,013 - 63,927,954 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X65,377,313 - 65,658,479 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX65,563,122 - 65,658,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X66,388,085 - 66,488,433 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X84,033,540 - 84,138,728 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X84,106,831 - 84,212,018 (+)NCBI
CeleraX61,712,172 - 61,814,411 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chromium(6+)  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ironing out Ferroportin. Drakesmith H, etal., Cell Metab. 2015 Nov 3;22(5):777-87. doi: 10.1016/j.cmet.2015.09.006. Epub 2015 Oct 1.
2. Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins. Frazer DM, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G931-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Cellular location of proteins related to iron absorption and transport. Simovich MJ, etal., Am J Hematol 2002 Mar;69(3):164-70.
11. Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma. Wang J, etal., Mol Med Rep. 2017 Dec;16(6):8735-8746. doi: 10.3892/mmr.2017.7711. Epub 2017 Oct 4.
Additional References at PubMed
PMID:17383861   PMID:17516501   PMID:17561842   PMID:18974313   PMID:20019163   PMID:20564203   PMID:21473866   PMID:22350470   PMID:22961397   PMID:25318588  


Genomics

Comparative Map Data
Heph
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X65,160,628 - 65,412,457 (+)NCBIGRCr8
mRatBN7.2X61,151,131 - 61,402,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX61,296,345 - 61,402,980 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX62,774,925 - 62,871,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X66,275,451 - 66,372,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X63,831,013 - 63,927,954 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X65,377,313 - 65,658,479 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX65,563,122 - 65,658,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X66,388,085 - 66,488,433 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X84,033,540 - 84,138,728 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X84,106,831 - 84,212,018 (+)NCBI
CeleraX61,712,172 - 61,814,411 (+)NCBICelera
Cytogenetic MapXq22NCBI
HEPH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X66,162,671 - 66,268,863 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX66,162,671 - 66,268,867 (+)EnsemblGRCh38hg38GRCh38
GRCh37X65,382,513 - 65,488,705 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X65,299,388 - 65,403,956 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X65,165,683 - 65,270,249NCBI
CeleraX65,729,951 - 65,834,741 (+)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX59,211,026 - 59,315,881 (+)NCBIHuRef
CHM1_1X65,275,270 - 65,380,018 (+)NCBICHM1_1
T2T-CHM13v2.0X64,590,334 - 64,696,504 (+)NCBIT2T-CHM13v2.0
Heph
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X95,499,042 - 95,618,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX95,498,965 - 95,618,091 (+)EnsemblGRCm39 Ensembl
GRCm38X96,455,436 - 96,574,485 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX96,455,359 - 96,574,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X93,650,775 - 93,769,824 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X92,658,180 - 92,777,204 (+)NCBIMGSCv36mm8
CeleraX83,458,771 - 83,577,333 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.69NCBI
Heph
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554755,625,150 - 5,704,234 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554755,625,177 - 5,704,234 (+)NCBIChiLan1.0ChiLan1.0
HEPH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X65,685,190 - 65,784,061 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X65,688,838 - 65,787,666 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X55,276,887 - 55,375,719 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X65,349,638 - 65,448,388 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX65,349,546 - 65,448,388 (+)Ensemblpanpan1.1panPan2
HEPH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X50,989,918 - 51,102,777 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX50,989,700 - 51,101,189 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX41,826,463 - 41,936,925 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X51,952,884 - 52,063,364 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX51,952,673 - 52,063,238 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X49,917,808 - 50,028,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X51,265,268 - 51,375,764 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X51,180,615 - 51,291,064 (+)NCBIUU_Cfam_GSD_1.0
Heph
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X51,189,534 - 51,267,810 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366351,954,947 - 2,022,101 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366351,954,771 - 2,022,061 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEPH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX52,314,935 - 52,397,380 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X52,314,911 - 52,397,384 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X58,896,080 - 58,975,042 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HEPH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X56,093,899 - 56,186,284 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX56,092,407 - 56,187,931 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660833,439,427 - 3,539,699 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Heph
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248981,028,882 - 1,122,461 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248981,031,859 - 1,122,391 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Heph
948 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:120
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000017312
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat

Markers in Region
DXGot151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X61,307,878 - 61,308,171 (+)MAPPERmRatBN7.2
Rnor_6.0X65,571,437 - 65,571,727NCBIRnor6.0
Rnor_5.0X66,401,445 - 66,401,735UniSTSRnor5.0
RGSC_v3.4X84,041,855 - 84,042,145UniSTSRGSC3.4
CeleraX61,720,487 - 61,720,777UniSTS
Cytogenetic MapXq31UniSTS
RH130633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X61,402,740 - 61,402,936 (+)MAPPERmRatBN7.2
Rnor_6.0X65,658,240 - 65,658,435NCBIRnor6.0
Rnor_5.0X66,488,194 - 66,488,389UniSTSRnor5.0
RGSC_v3.4X84,138,489 - 84,138,684UniSTSRGSC3.4
CeleraX61,814,172 - 61,814,367UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 10 6 12 6 25 22 34 11
Low 17 44 32 7 32 8 11 49 13 5 8
Below cutoff 3 3 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF246120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000017312   ⟹   ENSRNOP00000017312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX61,296,369 - 61,402,980 (+)Ensembl
Rnor_6.0 EnsemblX65,563,122 - 65,658,479 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092103   ⟹   ENSRNOP00000070353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX61,296,345 - 61,402,282 (+)Ensembl
Rnor_6.0 EnsemblX65,566,047 - 65,658,516 (+)Ensembl
RefSeq Acc Id: NM_133304   ⟹   NP_579838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,309,056 - 65,412,457 (+)NCBI
mRatBN7.2X61,299,564 - 61,402,980 (+)NCBI
Rnor_6.0X65,563,122 - 65,658,479 (+)NCBI
Rnor_5.0X66,388,085 - 66,488,433 (+)NCBI
RGSC_v3.4X84,033,540 - 84,138,728 (+)RGD
CeleraX61,712,172 - 61,814,411 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257048   ⟹   XP_006257110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,305,698 - 65,412,457 (+)NCBI
mRatBN7.2X61,296,261 - 61,402,980 (+)NCBI
Rnor_6.0X65,559,741 - 65,658,479 (+)NCBI
Rnor_5.0X66,388,085 - 66,488,433 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257049   ⟹   XP_006257111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,305,757 - 65,412,457 (+)NCBI
mRatBN7.2X61,296,362 - 61,402,980 (+)NCBI
Rnor_6.0X65,559,741 - 65,657,865 (+)NCBI
Rnor_5.0X66,388,085 - 66,488,433 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099420   ⟹   XP_038955348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,160,630 - 65,412,457 (+)NCBI
mRatBN7.2X61,151,131 - 61,402,980 (+)NCBI
RefSeq Acc Id: XM_039099421   ⟹   XP_038955349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,160,630 - 65,412,457 (+)NCBI
mRatBN7.2X61,151,131 - 61,402,980 (+)NCBI
RefSeq Acc Id: XM_039099422   ⟹   XP_038955350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,160,630 - 65,412,457 (+)NCBI
mRatBN7.2X61,151,131 - 61,402,980 (+)NCBI
RefSeq Acc Id: XM_039099423   ⟹   XP_038955351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,160,630 - 65,412,457 (+)NCBI
mRatBN7.2X61,151,131 - 61,402,980 (+)NCBI
RefSeq Acc Id: XM_039099424   ⟹   XP_038955352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,160,630 - 65,412,457 (+)NCBI
mRatBN7.2X61,151,131 - 61,402,366 (+)NCBI
RefSeq Acc Id: XM_039099426   ⟹   XP_038955354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,305,757 - 65,412,457 (+)NCBI
mRatBN7.2X61,296,260 - 61,402,366 (+)NCBI
RefSeq Acc Id: XM_063279760   ⟹   XP_063135830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,305,758 - 65,412,457 (+)NCBI
RefSeq Acc Id: XM_063279761   ⟹   XP_063135831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X65,160,628 - 65,399,994 (+)NCBI
RefSeq Acc Id: NP_579838   ⟸   NM_133304
- Peptide Label: precursor
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257110   ⟸   XM_006257048
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257111   ⟸   XM_006257049
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070353   ⟸   ENSRNOT00000092103
RefSeq Acc Id: ENSRNOP00000017312   ⟸   ENSRNOT00000017312
RefSeq Acc Id: XP_038955348   ⟸   XM_039099420
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955351   ⟸   XM_039099423
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955350   ⟸   XM_039099422
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955349   ⟸   XM_039099421
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955352   ⟸   XM_039099424
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955354   ⟸   XM_039099426
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL),   A0A8L2R2A9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135831   ⟸   XM_063279761
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135830   ⟸   XM_063279760
- Peptide Label: isoform X1
- UniProtKB: Q920H8 (UniProtKB/Swiss-Prot),   A6IQ46 (UniProtKB/TrEMBL)
Protein Domains
Plastocyanin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920H8-F1-model_v2 AlphaFold Q920H8 1-1157 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71060 AgrOrtholog
BioCyc Gene G2FUF-2184 BioCyc
Ensembl Genes ENSRNOG00000012294 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030920 UniProtKB/Swiss-Prot
  ENSRNOG00060024560 UniProtKB/Swiss-Prot
  ENSRNOG00065017695 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017312.6 UniProtKB/Swiss-Prot
  ENSRNOT00000092103.2 UniProtKB/TrEMBL
  ENSRNOT00055053648 UniProtKB/Swiss-Prot
  ENSRNOT00060042560 UniProtKB/Swiss-Prot
  ENSRNOT00065029613 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ceruloplasmin-like_CuRO_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu-oxidase_2 UniProtKB/Swiss-Prot
  Cu-oxidase_3 UniProtKB/Swiss-Prot
  Cu-oxidase_C UniProtKB/TrEMBL
  Cu-oxidase_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu-oxidase_N UniProtKB/TrEMBL
  Cu_oxidase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_oxidase_Cu_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cupredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117240 ENTREZGENE
PANTHER PTHR11709 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11709:SF221 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cu-oxidase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Heph PhenoGen
PROSITE MULTICOPPER_OXIDASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MULTICOPPER_OXIDASE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012294 RatGTEx
  ENSRNOG00055030920 RatGTEx
  ENSRNOG00060024560 RatGTEx
  ENSRNOG00065017695 RatGTEx
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R2A9 ENTREZGENE, UniProtKB/TrEMBL
  A6IQ46 ENTREZGENE, UniProtKB/TrEMBL
  HEPH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Heph  hephaestin      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed throughout the small intestine and colon 70762