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Gene: Pias2 (protein inhibitor of activated STAT, 2) Rattus norvegicus

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Symbol:

Pias2

Name:

protein inhibitor of activated STAT, 2

RGD ID:

71056

Description:

Enables nuclear receptor binding activity and protein domain specific binding activity. Involved in several processes, including androgen receptor signaling pathway; positive regulation of dendrite morphogenesis; and response to testosterone. Acts upstream of or within regulation of androgen receptor signaling pathway. Located in nucleus. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2); PARTICIPATES IN androgen signaling pathway; Jak-Stat signaling pathway; hepatitis C pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; bisphenol A; finasteride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS2; Miz1; Msx-interacting-zinc finger; PiasX; PIASxα; PIASxβ; protein inhibitor of activated STAT 2; protein inhibitor of activated STAT x

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PIAS2 (protein inhibitor of activated STAT 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Pias2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pias2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PIAS2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PIAS2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pias2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PIAS2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PIAS2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pias2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pias2 (protein inhibitor of activated STAT 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pias2 (protein inhibitor of activated STAT 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PIAS2 (protein inhibitor of activated STAT 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pias2 (protein inhibitor of activated STAT, 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NFI1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NFI1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Su(var)2-10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Su(var)2-10	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gei-17	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gei-17	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SIZ1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SIZ1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pias2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pias2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	72,883,008 - 72,989,486 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	72,882,890 - 73,006,662 (+)	Ensembl				GRCr8
mRatBN7.2	18	70,608,034 - 70,714,295 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	70,607,665 - 70,710,033 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	72,729,105 - 72,813,704 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	73,398,313 - 73,482,913 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	71,254,907 - 71,339,508 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	73,479,863 - 73,524,956 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	73,378,662 - 73,524,956 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	73,147,273 - 73,203,947 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	74,078,683 - 74,123,668 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	69,148,881 - 69,219,197 (+)	NCBI		Celera
RGSC_v3.1	18	74,151,955 - 74,196,941 (+)	NCBI
Cytogenetic Map	18	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol AF (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

crocidolite asbestos (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

finasteride (EXP)

flutamide (EXP)

FR900359 (ISO)

furan (EXP)

gallic acid (ISO)

glyphosate (ISO)

hydrogen peroxide (ISO)

lead nitrate (ISO)

mercury atom (ISO)

mercury dichloride (ISO)

mercury(0) (ISO)

metformin (ISO)

methoxyacetic acid (EXP)

N-methyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

Nor-9-carboxy-delta9-THC (ISO)

okadaic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenethyl caffeate (EXP)

pirinixic acid (EXP,ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (EXP)

theophylline (ISO)

thimerosal (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen receptor signaling pathway (IMP)

DNA-templated transcription (ISO)

endoplasmic reticulum unfolded protein response (ISO)

negative regulation of androgen receptor signaling pathway (ISO)

negative regulation of DNA-templated transcription (IEA)

positive regulation of dendrite morphogenesis (IMP)

positive regulation of DNA-templated transcription (IMP,ISO)

positive regulation of transcription by RNA polymerase II (ISO)

protein sumoylation (IBA,IEA,ISO,ISS)

regulation of androgen receptor signaling pathway (IDA)

regulation of DNA-templated transcription (IDA)

regulation of macromolecule metabolic process (IEA)

regulation of osteoblast differentiation (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

response to testosterone (IEP)

SMAD protein signal transduction (ISO)

spermatogenesis (IEP)

transforming growth factor beta receptor signaling pathway (ISO)

Cellular Component

chromatin (IBA)

nuclear body (ISO)

nuclear speck (IEA)

nucleoplasm (ISO)

nucleus (IDA,IEA,ISO)

PML body (IEA,ISO,ISS)

Molecular Function

DNA binding (IEA,ISO)

metal ion binding (IEA)

nuclear androgen receptor binding (IPI)

nuclear estrogen receptor binding (IPI)

nuclear glucocorticoid receptor binding (IPI)

protein binding (IPI,ISO)

protein domain specific binding (IPI)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

SUMO ligase activity (IBA,ISO)

SUMO transferase activity (ISO)

transcription coregulator activity (IBA)

transcription corepressor activity (ISO)

transferase activity (IEA)

ubiquitin protein ligase binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

androgen signaling pathway (IMP)

hepatitis C pathway (IEA)

Jak-Stat signaling pathway (IEA,ISO)

small cell lung carcinoma pathway (IEA)

ubiquitin/proteasome degradation pathway (IEA)

External Pathway Database Links

KEGG Pathway

Hepatitis C

References

References - curated

#	Reference Title	Reference Citation
1.	Tollip is a mediator of protein sumoylation.	Ciarrocchi A, etal., PLoS One. 2009;4(2):e4404. Epub 2009 Feb 9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.	Kotaja N, etal., Mol Endocrinol. 2000 Dec;14(12):1986-2000.
4.	Gene Data Set	MGD Curation, June 12, 2002
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins.	Moilanen AM, etal., J Biol Chem 1999 Feb 5;274(6):3700-4.
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis.	Shalizi A, etal., J Neurosci. 2007 Sep 12;27(37):10037-46.
13.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14.	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.	Tang Z, etal., J Biol Chem. 2005 Nov 18;280(46):38153-9. Epub 2005 Sep 6.
15.	JAK/STAT signal transduction: regulators and implication in hematological malignancies.	Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
16.	Expression of the E3 SUMO-1 ligases PIASx and PIAS1 during spermatogenesis in the rat.	Yan W, etal., Gene Expr Patterns. 2003 Jun;3(3):301-8.

Additional References at PubMed

PMID:9256341	PMID:11104669	PMID:11477070	PMID:11893729	PMID:12077349	PMID:12855578	PMID:14752048	PMID:15489334	PMID:15767674	PMID:16352593	PMID:16522640	PMID:16675951
PMID:16777850	PMID:16816390	PMID:17283066	PMID:17623776	PMID:18579533	PMID:18628979	PMID:20408817	PMID:21630459	PMID:22082260	PMID:22406621	PMID:23145142	PMID:26175529
PMID:26581215	PMID:34947973

Genomics

Comparative Map Data

Pias2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	72,883,008 - 72,989,486 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	72,882,890 - 73,006,662 (+)	Ensembl				GRCr8
mRatBN7.2	18	70,608,034 - 70,714,295 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	70,607,665 - 70,710,033 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	72,729,105 - 72,813,704 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	73,398,313 - 73,482,913 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	71,254,907 - 71,339,508 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	73,479,863 - 73,524,956 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	73,378,662 - 73,524,956 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	73,147,273 - 73,203,947 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	74,078,683 - 74,123,668 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	69,148,881 - 69,219,197 (+)	NCBI		Celera
RGSC_v3.1	18	74,151,955 - 74,196,941 (+)	NCBI
Cytogenetic Map	18	q12.3	NCBI

PIAS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	46,803,218 - 46,920,145 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	46,803,218 - 46,920,160 (-)	Ensembl			hg38	GRCh38
GRCh37	18	44,383,181 - 44,500,108 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	42,646,058 - 42,751,464 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	18	41,199,736 - 41,278,688 (-)	NCBI		Celera
Cytogenetic Map	18	q21.1	NCBI
HuRef	18	41,247,384 - 41,354,863 (-)	NCBI		HuRef
CHM1_1	18	44,317,116 - 44,424,599 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	46,993,864 - 47,110,811 (-)	NCBI		T2T-CHM13v2.0

Pias2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	77,152,883 - 77,243,406 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	77,152,904 - 77,241,496 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	77,065,176 - 77,155,710 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	77,065,208 - 77,153,800 (+)	Ensembl			mm10	GRCm38
MGSCv37	18	77,303,947 - 77,394,447 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	77,269,658 - 77,358,250 (+)	NCBI		MGSCv36	mm8
Celera	18	78,248,789 - 78,338,301 (+)	NCBI		Celera
Cytogenetic Map	18	E3	NCBI
cM Map	18	52.07	NCBI

Pias2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	32,270,348 - 32,358,312 (-)	Ensembl
ChiLan1.0	NW_004955402	32,263,616 - 32,358,532 (-)	NCBI	ChiLan1.0	ChiLan1.0

PIAS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	64,208,389 - 64,339,057 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	49,900,990 - 50,031,671 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	40,067,901 - 40,196,078 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	43,622,455 - 43,728,675 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	43,622,455 - 43,728,675 (-)	Ensembl			panPan2	panpan1.1

PIAS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	44,436,100 - 44,583,657 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	44,454,095 - 44,583,657 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	43,919,876 - 44,074,373 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	44,389,023 - 44,544,213 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	44,407,125 - 44,536,625 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	44,089,020 - 44,244,180 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	44,143,064 - 44,298,190 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	44,426,838 - 44,581,948 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pias2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	40,745,308 - 40,828,055 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936517	82,332 - 144,586 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936517	72,676 - 152,926 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PIAS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	96,441,676 - 96,545,780 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	96,401,635 - 96,545,798 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PIAS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	33,967,894 - 34,075,824 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	33,967,999 - 34,067,910 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	8,306,725 - 8,446,143 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pias2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	10,434,550 - 10,530,766 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624778	10,426,788 - 10,530,854 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pias2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	54,904,379 - 54,991,320 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pias2
654 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	160
Count of miRNA genes:	125
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000023886
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	50795212	86134022	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
1331730	Scl27	Serum cholesterol level QTL 27	3.826		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	54490801	86134022	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
61384	Bp48	Blood pressure QTL 48	19.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	62892257	79484461	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	64383762	79484311	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	57825243	85493247	Rat
631834	Sach3	Saccharin preference QTL 3	3.9	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	18	38575919	83575919	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	36121626	81121626	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	45620306	86134022	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	48915737	86134022	Rat
7794793	Mcs34	Mammary carcinoma susceptibility QTL 34	1.54		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	18	65635567	85897775	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	48915737	86134022	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	48915737	86134022	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	65846447	86134022	Rat
1598832	Glom11	Glomerulus QTL 11	2.9		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	53266671	86134022	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	45620306	86134022	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	50795212	86134022	Rat
631675	Iddm15	Insulin dependent diabetes mellitus QTL 15			urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	18	62892257	79484461	Rat
2301969	Bp324	Blood pressure QTL 324	4.05		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61982204	76619168	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	61446853	86134022	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	40462383	85462383	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	54490801	76272247	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat

Markers in Region

RH142489

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	70,687,279 - 70,687,454 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	73,514,926 - 73,515,100	NCBI	Rnor6.0
Rnor_5.0	18	73,182,346 - 73,182,520	UniSTS	Rnor5.0
RGSC_v3.4	18	74,113,747 - 74,113,921	UniSTS	RGSC3.4
Celera	18	69,209,257 - 69,209,431	UniSTS
RH 3.4 Map	18	747.0	UniSTS
Cytogenetic Map	18	q12.3	UniSTS

RH143406

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	70,687,846 - 70,687,946 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	73,515,493 - 73,515,592	NCBI	Rnor6.0
Rnor_5.0	18	73,182,913 - 73,183,012	UniSTS	Rnor5.0
RGSC_v3.4	18	74,114,314 - 74,114,413	UniSTS	RGSC3.4
Celera	18	69,209,824 - 69,209,923	UniSTS
RH 3.4 Map	18	748.5	UniSTS
Cytogenetic Map	18	q12.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001393764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_053337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097149	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC139391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF044058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023886 ⟹ ENSRNOP00000023886

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	72,883,160 - 72,972,510 (+)	Ensembl
mRatBN7.2 Ensembl	18	70,626,661 - 70,703,964 (+)	Ensembl
Rnor_6.0 Ensembl	18	73,378,662 - 73,524,956 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101274 ⟹ ENSRNOP00000097965

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	72,901,707 - 73,006,662 (+)	Ensembl
mRatBN7.2 Ensembl	18	70,626,522 - 70,702,066 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104069 ⟹ ENSRNOP00000092568

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	72,901,732 - 72,981,334 (+)	Ensembl
mRatBN7.2 Ensembl	18	70,650,408 - 70,697,322 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107723 ⟹ ENSRNOP00000092581

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	72,901,981 - 72,978,739 (+)	Ensembl
mRatBN7.2 Ensembl	18	70,626,837 - 70,703,977 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110007 ⟹ ENSRNOP00000086650

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	72,901,723 - 72,975,290 (+)	Ensembl
mRatBN7.2 Ensembl	18	70,607,665 - 70,703,977 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119543 ⟹ ENSRNOP00000097087

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	72,901,707 - 72,994,244 (+)	Ensembl
mRatBN7.2 Ensembl	18	70,626,522 - 70,710,033 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000129444 ⟹ ENSRNOP00000103276

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	72,882,890 - 72,986,278 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000145398 ⟹ ENSRNOP00000109402

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	72,901,707 - 72,986,278 (+)	Ensembl

RefSeq Acc Id:

NM_001393764 ⟹ NP_001380693

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,901,707 - 72,986,278 (+)	NCBI
mRatBN7.2	18	70,626,511 - 70,711,087 (+)	NCBI

RefSeq Acc Id:

NM_053337 ⟹ NP_445789

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,901,707 - 72,973,996 (+)	NCBI
mRatBN7.2	18	70,626,511 - 70,698,805 (+)	NCBI
Rnor_6.0	18	73,479,863 - 73,524,956 (+)	NCBI
Rnor_5.0	18	73,147,273 - 73,203,947 (+)	NCBI
RGSC_v3.4	18	74,078,683 - 74,123,668 (+)	RGD
Celera	18	69,148,881 - 69,219,197 (+)	RGD

Sequence:

show sequence

CCCGCCGCGTCTAGAGCGGCGCCCAGTGCAGGATGTTGCAGGAGACGGCGGCGGTGTCGTTGGC
GGTAGCGGGCGGAGGAGCGGTGACGGCTGAGGCGCCCGCGGGCGGGATAAAATGGCGGATTTCG
AGGAGTTGAGGAATATGGTTTCTAGTTTTAGGGTTTCTGAATTACAAGTGTTACTGGGCTTTGC
TGGACGGAATAAAAGTGGGCGCAAGCATGACCTCCTGATGAGGGCGTTGCATTTACTGAAGAGT
GGCTGCAGCCCTGCGGTTCAGATTAAAATTCGAGAATTATACAGACGCCGATACCCACGGACAC
TTGAAGGACTTTCTGATCTATCCACAATCAAATCTTCAGTTTTCAGTTTGGATGGTAGCTCATC
ACCAGTAGAGCCTGACTTGGCCGTGGCTGGGATCCACTCGTTGCCTTCTACTTCCATTGCACCT
CATTCACCGTCATCTCCTGTCGCTTCTGTGCTGCTTCAAGACACTAAGCCCACGTTTGAGATGC
AGCAACCATCTCCTCCCATTCCTCCTGTCCATCCTGACGTGCAGTTAAAAACGCTGCCCTTCTA
TGACGTCCTTGATGTTCTCATCAAGCCCACAAGTTTAGTTCAAAGCAGTATTCAGCGGTTTCAA
GAGAAGTTTTTTATTTTTGCTTTGACACCCCAGCAAGTTAGAGAGATATGCATTTCAAGGGATT
TTTTGCCAGGTGGCAGGAGAGACTACACAGTCCAAGTCCAGCTGCGACTTTGCTTGGCAGAGAC
CAGTTGCCCTCAAGAAGATAACTATCCCAATAGTTTGTGTATAAAAGTAAATGGGAAACTCTTT
CCTTTGCCTGGCTATGCACCACCACCTAAAAATGGGATCGAACAGAAGCGTCCTGGACGCCCCC
TGAATATTACATCTTTAGTGAGATTGTCTTCAGCTGTGCCAAATCAGATTTCTATTTCTTGGGC
ATCTGAAATTGGAAAGAATTACTCCATGTCTGTGTATCTTGTACGACAGCTTACATCAGCCATG
TTATTACAGAGATTAAAAATGAAAGGTATTAGAAATCCTGATCATTCCAAAGCACTCATTAAAG
AAAAACTTACTGCAGATCCTGATAGTGAAATTGCTACAACTAGTCTTCGAGTGTCCTTGATGTG
CCCTTTAGGAAAAATGAGGCTGACAATCCCGTGCCGCGCAGTGACGTGTACACATCTGCAGTGC
TTTGATGCTGCCCTGTATCTTCAGATGAATGAGAAGAAGCCCACCTGGATTTGTCCTGTTTGTG
ACAAAAAGGCTGCCTATGAGAGTCTGATACTAGATGGGCTTTTTATGGAAATTCTCAATGACTG
TTCTGATGTGGATGAGATCAAATTCCAGGAAGATGGTTCCTGGTGCCCCATGAGACCTAAGAAA
GAAGCTATGAAAGTAACCAGCCAGCCCTGTACAAAAGTAGAAAGTTCAAGTGTCTTTAGTAAAC
CTTGTTCAGTGACTGTAGCCAGTGATGCAAGCAAGAAGAAGATTGATGTTATTGATCTAACAAT
AGAGAGCTCTTCTGATGAAGAGGAAGACCCTCCCGCCAAAAGGAAATGCATCTTTATGTCAGAA
ACACAAAGCAGTCCAACCAAAGGGGTTCTCATGTATCAGCCATCTTCTGTAAGGGTGCCCAGTG
TGACTTCAGTTGATCCTGCTGCTATTCCACCTTCATTAACAGACTACTCAGTACCATTCCACCA
CACGCCAGTGTCGAGCATGTCATCAGATTTGCCAGGAGAACAAAGAAGAAATGATATTAATAAC
GAAGTGCAGCTTGGAACATCTTCTGATACTGTGCAACAGTGAATGCAAAATAAAACAKAATTTG
TA

hide sequence

RefSeq Acc Id:

XM_039097142 ⟹ XP_038953070

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,981,336 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,707,414 (+)	NCBI

RefSeq Acc Id:

XM_039097143 ⟹ XP_038953071

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,981,336 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,707,414 (+)	NCBI

RefSeq Acc Id:

XM_039097144 ⟹ XP_038953072

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,192 - 72,981,336 (+)	NCBI
mRatBN7.2	18	70,608,034 - 70,707,414 (+)	NCBI

RefSeq Acc Id:

XM_039097145 ⟹ XP_038953073

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,972,505 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,699,490 (+)	NCBI

RefSeq Acc Id:

XM_039097146 ⟹ XP_038953074

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,989,486 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,714,295 (+)	NCBI

RefSeq Acc Id:

XM_039097147 ⟹ XP_038953075

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,897,237 - 72,981,336 (+)	NCBI
mRatBN7.2	18	70,625,934 - 70,707,414 (+)	NCBI

RefSeq Acc Id:

XM_039097149 ⟹ XP_038953077

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,902,007 - 72,981,336 (+)	NCBI
mRatBN7.2	18	70,626,828 - 70,707,414 (+)	NCBI

RefSeq Acc Id:

XM_039097151 ⟹ XP_038953079

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,978,278 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,703,112 (+)	NCBI

RefSeq Acc Id:

XM_039097152 ⟹ XP_038953080

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,978,278 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,707,414 (+)	NCBI

RefSeq Acc Id:

XM_039097153 ⟹ XP_038953081

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,978,278 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,703,129 (+)	NCBI

RefSeq Acc Id:

XM_039097154 ⟹ XP_038953082

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,989,486 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,714,295 (+)	NCBI

RefSeq Acc Id:

XM_039097155 ⟹ XP_038953083

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,972,505 (+)	NCBI
mRatBN7.2	18	70,619,281 - 70,700,109 (+)	NCBI

RefSeq Acc Id:

XM_063277603 ⟹ XP_063133673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,008 - 72,981,336 (+)	NCBI

RefSeq Acc Id:

XM_063277604 ⟹ XP_063133674

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,102 - 72,981,336 (+)	NCBI

RefSeq Acc Id:

XM_063277605 ⟹ XP_063133675

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,901,986 - 72,981,336 (+)	NCBI

RefSeq Acc Id:

XM_063277606 ⟹ XP_063133676

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,883,102 - 72,972,505 (+)	NCBI

RefSeq Acc Id:

XM_063277607 ⟹ XP_063133677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,897,237 - 72,981,336 (+)	NCBI

RefSeq Acc Id:

XM_063277608 ⟹ XP_063133678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,901,986 - 72,981,336 (+)	NCBI

RefSeq Acc Id:

XM_063277609 ⟹ XP_063133679

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,897,237 - 72,989,486 (+)	NCBI

RefSeq Acc Id:

XM_063277610 ⟹ XP_063133680

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,902,007 - 72,972,505 (+)	NCBI

RefSeq Acc Id:

XM_063277611 ⟹ XP_063133681

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,897,237 - 72,978,278 (+)	NCBI

RefSeq Acc Id:

XM_063277612 ⟹ XP_063133682

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,897,237 - 72,972,505 (+)	NCBI

RefSeq Acc Id:

XM_063277613 ⟹ XP_063133683

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	72,902,007 - 72,972,505 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001380693	(Get FASTA)	NCBI Sequence Viewer
	NP_445789	(Get FASTA)	NCBI Sequence Viewer
	XP_038953070	(Get FASTA)	NCBI Sequence Viewer
	XP_038953071	(Get FASTA)	NCBI Sequence Viewer
	XP_038953072	(Get FASTA)	NCBI Sequence Viewer
	XP_038953073	(Get FASTA)	NCBI Sequence Viewer
	XP_038953074	(Get FASTA)	NCBI Sequence Viewer
	XP_038953075	(Get FASTA)	NCBI Sequence Viewer
	XP_038953077	(Get FASTA)	NCBI Sequence Viewer
	XP_038953079	(Get FASTA)	NCBI Sequence Viewer
	XP_038953080	(Get FASTA)	NCBI Sequence Viewer
	XP_038953081	(Get FASTA)	NCBI Sequence Viewer
	XP_038953082	(Get FASTA)	NCBI Sequence Viewer
	XP_038953083	(Get FASTA)	NCBI Sequence Viewer
	XP_063133673	(Get FASTA)	NCBI Sequence Viewer
	XP_063133674	(Get FASTA)	NCBI Sequence Viewer
	XP_063133675	(Get FASTA)	NCBI Sequence Viewer
	XP_063133676	(Get FASTA)	NCBI Sequence Viewer
	XP_063133677	(Get FASTA)	NCBI Sequence Viewer
	XP_063133678	(Get FASTA)	NCBI Sequence Viewer
	XP_063133679	(Get FASTA)	NCBI Sequence Viewer
	XP_063133680	(Get FASTA)	NCBI Sequence Viewer
	XP_063133681	(Get FASTA)	NCBI Sequence Viewer
	XP_063133682	(Get FASTA)	NCBI Sequence Viewer
	XP_063133683	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD13349	(Get FASTA)	NCBI Sequence Viewer
	AAH78775	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023886
	ENSRNOP00000086650
	ENSRNOP00000092581
	ENSRNOP00000103276
	ENSRNOP00000109402
GenBank Protein	Q6AZ28	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_445789 ⟸ NM_053337
- Peptide Label:	isoform 2
- UniProtKB:	Q9Z177 (UniProtKB/Swiss-Prot), Q6AZ28 (UniProtKB/Swiss-Prot), A6KMU1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRR YPRTLEGLSDLSTIKSSVFSLDGSSSPVEPDLAVAGIHSLPSTSIAPHSPSSPVASVLLQDTKP TFEMQQPSPPIPPVHPDVQLKTLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREIC ISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKR PGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSK ALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWI CPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSS VFSKPCSVTVASDASKKKIDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSV RVPSVTSVDPAAIPPSLTDYSVPFHHTPVSSMSSDLPGEQRRNDINNEVQLGTSSDTVQQ hide sequence

Ensembl Acc Id:

ENSRNOP00000023886 ⟸ ENSRNOT00000023886

RefSeq Acc Id:	XP_038953072 ⟸ XM_039097144
- Peptide Label:	isoform X4
- UniProtKB:	A6KMU4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953074 ⟸ XM_039097146
- Peptide Label:	isoform X7
- UniProtKB:	A6KMU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953082 ⟸ XM_039097154
- Peptide Label:	isoform X11
- UniProtKB:	F1LRP3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953070 ⟸ XM_039097142
- Peptide Label:	isoform X2
- UniProtKB:	A6KMU4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953071 ⟸ XM_039097143
- Peptide Label:	isoform X3
- UniProtKB:	A6KMU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953080 ⟸ XM_039097152
- Peptide Label:	isoform X11
- UniProtKB:	F1LRP3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953081 ⟸ XM_039097153
- Peptide Label:	isoform X11
- UniProtKB:	F1LRP3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953079 ⟸ XM_039097151
- Peptide Label:	isoform X11
- UniProtKB:	F1LRP3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953083 ⟸ XM_039097155
- Peptide Label:	isoform X12
- UniProtKB:	F1LRP3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953073 ⟸ XM_039097145
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I6AHS4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953075 ⟸ XM_039097147
- Peptide Label:	isoform X8
- UniProtKB:	A6KMU4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953077 ⟸ XM_039097149
- Peptide Label:	isoform X9
- UniProtKB:	A6KMU2 (UniProtKB/TrEMBL), A6KMU4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000092581 ⟸ ENSRNOT00000107723

Ensembl Acc Id:

ENSRNOP00000092568 ⟸ ENSRNOT00000104069

Ensembl Acc Id:

ENSRNOP00000097087 ⟸ ENSRNOT00000119543

Ensembl Acc Id:

ENSRNOP00000086650 ⟸ ENSRNOT00000110007

Ensembl Acc Id:

ENSRNOP00000097965 ⟸ ENSRNOT00000101274

RefSeq Acc Id:	NP_001380693 ⟸ NM_001393764
- Peptide Label:	isoform 1
- UniProtKB:	A6KMU4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133673 ⟸ XM_063277603
- Peptide Label:	isoform X1
- UniProtKB:	A6KMU4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133674 ⟸ XM_063277604
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I6A470 (UniProtKB/TrEMBL), A6KMU4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133676 ⟸ XM_063277606
- Peptide Label:	isoform X13
- UniProtKB:	A0A8I6AHS4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133679 ⟸ XM_063277609
- Peptide Label:	isoform X16
- UniProtKB:	A0A8I6GLW8 (UniProtKB/TrEMBL), A0A8I6B6K3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133677 ⟸ XM_063277607
- Peptide Label:	isoform X14
- UniProtKB:	A0A8I6B6K3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133681 ⟸ XM_063277611
- Peptide Label:	isoform X18
- UniProtKB:	F1LRP3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133682 ⟸ XM_063277612
- Peptide Label:	isoform X19
- UniProtKB:	F1LRP3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133675 ⟸ XM_063277605
- Peptide Label:	isoform X10
- UniProtKB:	A0A8I6GK87 (UniProtKB/TrEMBL), A6KMU4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133678 ⟸ XM_063277608
- Peptide Label:	isoform X15
- UniProtKB:	A6KMU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133680 ⟸ XM_063277610
- Peptide Label:	isoform X17
- UniProtKB:	A6KMU3 (UniProtKB/TrEMBL), A0A8I6AHS4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133683 ⟸ XM_063277613
- Peptide Label:	isoform X20
- UniProtKB:	F1LRP3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000103276 ⟸ ENSRNOT00000129444

Ensembl Acc Id:

ENSRNOP00000109402 ⟸ ENSRNOT00000145398

Protein Domains

PINIT SAP SP-RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AZ28-F1-model_v2	AlphaFold	Q6AZ28	1-572	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:71056	AgrOrtholog
BioCyc Gene	G2FUF-6946	BioCyc
Ensembl Genes	ENSRNOG00000017493	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000023886	ENTREZGENE
	ENSRNOT00000107723	ENTREZGENE
	ENSRNOT00000110007	ENTREZGENE
	ENSRNOT00000129444	ENTREZGENE
	ENSRNOT00000145398	ENTREZGENE
Gene3D-CATH	1.10.720.30	UniProtKB/Swiss-Prot
	2.60.120.780	UniProtKB/Swiss-Prot
	3.30.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7111628	IMAGE-MGC_LOAD
InterPro	PINIT	UniProtKB/Swiss-Prot
	PINIT_sf	UniProtKB/Swiss-Prot
	SAP_dom	UniProtKB/Swiss-Prot
	SAP_dom_sf	UniProtKB/Swiss-Prot
	Znf_MIZ	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot
KEGG Report	rno:83422	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93310	IMAGE-MGC_LOAD
NCBI Gene	83422	ENTREZGENE
PANTHER	PTHR10782:SF12	UniProtKB/Swiss-Prot
	ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	PINIT	UniProtKB/Swiss-Prot
	SAP	UniProtKB/Swiss-Prot
	zf-MIZ	UniProtKB/Swiss-Prot
PhenoGen	Pias2	PhenoGen
PROSITE	PINIT	UniProtKB/Swiss-Prot
	SAP	UniProtKB/Swiss-Prot
	ZF_SP_RING	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017493	RatGTEx
SMART	SAP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF68906	UniProtKB/Swiss-Prot
UniProt	A0A8I6A470	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AHS4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6B6K3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GK87	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GLW8	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LF60_RAT	UniProtKB/TrEMBL
	A0ABK0LP71_RAT	UniProtKB/TrEMBL
	A6KMU1	ENTREZGENE, UniProtKB/TrEMBL
	A6KMU2	ENTREZGENE, UniProtKB/TrEMBL
	A6KMU3	ENTREZGENE, UniProtKB/TrEMBL
	A6KMU4	ENTREZGENE, UniProtKB/TrEMBL
	A6KMU6	ENTREZGENE, UniProtKB/TrEMBL
	F1LRP3	ENTREZGENE, UniProtKB/TrEMBL
	PIAS2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9Z177	ENTREZGENE
UniProt Secondary	Q9Z177	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-02-06	Pias2	protein inhibitor of activated STAT, 2	Pias2	protein inhibitor of activated STAT 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Pias2	protein inhibitor of activated STAT 2	Miz1	Msx-interacting-zinc finger	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Miz1	Msx-interacting-zinc finger			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	binds to DNA-binding domain/zinc finger region of androgen receptor	70792
gene_protein	572 amino acids	70792

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

External Pathway Database Links

External Pathway Database Links

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RGD Manual Annotations

Imported Annotations - KEGG (archival)

External Pathway Database Links

External Pathway Database Links