Txn2 (thioredoxin 2) - Rat Genome Database

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Gene: Txn2 (thioredoxin 2) Rattus norvegicus
Analyze
Symbol: Txn2
Name: thioredoxin 2
RGD ID: 71040
Description: Contributes to peptide-methionine (R)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity; and protein-disulfide reductase activity. Involved in several processes, including response to axon injury; response to glucose; and response to hypoxia. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2); INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 4,4'-sulfonyldiphenol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93312; mt-Trx; MTRX; thioredoxin mitochondrial; thioredoxin, mitochondrial; thioredoxin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau6
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,377,338 - 111,390,940 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7111,386,805 - 111,390,022 (-)EnsemblGRCr8
mRatBN7.27109,496,772 - 109,510,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,496,761 - 109,510,359 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7111,246,688 - 111,260,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,470,248 - 113,483,753 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,438,298 - 113,451,891 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,144,350 - 119,158,173 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,144,351 - 119,158,201 (-)Ensemblrn6Rnor6.0
Rnor_5.07119,139,112 - 119,152,935 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47115,833,695 - 115,847,690 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7105,837,884 - 105,851,486 (-)NCBICelera
RGSC_v3.17115,867,761 - 115,881,914 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
abexinostat  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
auranofin  (EXP,ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
bosentan  (ISO)
brilliant green  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
corosolic acid  (ISO)
crystal violet  (ISO)
cyclosporin A  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dimethylarsinic acid  (EXP)
diquat  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
etoposide  (ISO)
eugenol  (ISO)
flavonoids  (EXP)
flutamide  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
L-ascorbic acid  (EXP)
lipopolysaccharide  (ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lycopene  (ISO)
mercury dichloride  (ISO)
methylene blue  (ISO)
Mitoquinone  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phlorizin  (ISO)
potassium dichromate  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium chromate  (ISO)
TCEP  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trans-isoeugenol  (ISO)
triapine  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IDA)
mitochondrion  (IBA,IEA,ISO)
neuronal cell body  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Gene expression profiling reveals complex changes following MEK-EE expression in cardiac myocytes. Badrian B and Bogoyevitch MA, Int J Biochem Cell Biol. 2007;39(2):349-65. Epub 2006 Sep 14.
3. Redox regulation of resveratrol-mediated switching of death signal into survival signal. Das S, etal., Free Radic Biol Med. 2008 Jan 1;44(1):82-90. Epub 2007 Sep 21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Severe liver steatosis correlates with nitrosative and oxidative stress in rats. Grattagliano I, etal., Eur J Clin Invest. 2008 Jul;38(7):523-30.
7. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Jia J, etal., Thromb Res. 2009 Mar;123(5):727-30. Epub 2009 Jan 6.
8. Thioredoxin as a reducing agent for mammalian methionine sulfoxide reductases B lacking resolving cysteine. Kim HY and Kim JR, Biochem Biophys Res Commun. 2008 Jul 4;371(3):490-4. Epub 2008 Apr 29.
9. Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation. Lima VV, etal., Hypertension. 2009 Feb;53(2):166-74. Epub 2009 Jan 12.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response. Morrison J, etal., Physiol Genomics. 2004 May 19;17(3):271-82.
13. Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily. Mukherjee S, etal., J Agric Food Chem. 2008 Jan 23;56(2):609-17. Epub 2007 Dec 29.
14. Protective effect of thioredoxins 1 and 2 in retinal ganglion cells after optic nerve transection and oxidative stress. Munemasa Y, etal., Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3535-43. Epub 2008 Apr 25.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Expression of novel antioxidant thioredoxin-2 in the rat brain. Rybnikova E, etal., Eur J Neurosci. 2000 May;12(5):1669-78.
19. The mitochondrial antioxidants thioredoxin-2 and Mn-superoxide dismutase are involved in the mechanisms of brain hypoxic tolerance. Samoilov MO, etal., Dokl Biol Sci 2002 Nov-Dec;387:498-500.
20. Cloning and expression of a novel mammalian thioredoxin. Spyrou G, etal., J Biol Chem 1997 Jan 31;272(5):2936-41.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Preconditioning enhances the expression of mitochondrial antioxidant thioredoxin-2 in the forebrain of rats exposed to severe hypobaric hypoxia. Stroev SA, etal., J Neurosci Res. 2004 Nov 15;78(4):563-9.
23. Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase. Turanov AA, etal., J Biol Chem. 2006 Aug 11;281(32):22953-63. Epub 2006 Jun 14.
24. N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury. Wang X, etal., Ann Neurol. 2007 Mar;61(3):263-71.
25. [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. Zhao XQ, etal., Sheng Li Xue Bao. 2010 Jun 25;62(3):261-8.
26. Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats. Zhu XL, etal., Neurosci Lett. 2009 Jan 2;449(1):24-7. Epub 2008 Sep 6.
Additional References at PubMed
PMID:12032145   PMID:14651853   PMID:15489334   PMID:16675629   PMID:17068286   PMID:18614015   PMID:20238036   PMID:20929858   PMID:23949220   PMID:25996168   PMID:26975474   PMID:28529127  
PMID:30236513  


Genomics

Comparative Map Data
Txn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,377,338 - 111,390,940 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7111,386,805 - 111,390,022 (-)EnsemblGRCr8
mRatBN7.27109,496,772 - 109,510,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,496,761 - 109,510,359 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7111,246,688 - 111,260,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,470,248 - 113,483,753 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,438,298 - 113,451,891 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,144,350 - 119,158,173 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,144,351 - 119,158,201 (-)Ensemblrn6Rnor6.0
Rnor_5.07119,139,112 - 119,152,935 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47115,833,695 - 115,847,690 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7105,837,884 - 105,851,486 (-)NCBICelera
RGSC_v3.17115,867,761 - 115,881,914 (-)NCBI
Cytogenetic Map7q34NCBI
TXN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,467,046 - 36,481,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,466,895 - 36,482,072 (-)Ensemblhg38GRCh38
GRCh372236,863,093 - 36,877,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,193,039 - 35,207,633 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342235,187,592 - 35,202,187NCBI
Celera2220,665,238 - 20,679,833 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2219,831,327 - 19,845,504 (-)NCBIHuRef
CHM1_12236,822,047 - 36,836,640 (-)NCBICHM1_1
T2T-CHM13v2.02236,927,219 - 36,941,813 (-)NCBIT2T-CHM13v2.0
Txn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,799,251 - 77,813,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1577,799,247 - 77,813,206 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381577,915,051 - 77,928,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,915,047 - 77,929,006 (-)Ensemblmm10GRCm38
MGSCv371577,745,481 - 77,759,424 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361577,742,306 - 77,756,249 (-)NCBIMGSCv36mm8
Celera1579,374,296 - 79,388,239 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1536.92NCBI
Txn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,041,559 - 23,056,018 (-)Ensembl
ChiLan1.0NW_00495541323,044,866 - 23,056,017 (-)NCBIChiLan1.0ChiLan1.0
TXN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,323,599 - 46,338,770 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,014,850 - 49,030,016 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02217,384,017 - 17,398,965 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,220,721 - 35,235,891 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,220,721 - 35,235,877 (-)EnsemblpanPan2panpan1.1
TXN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,947,647 - 27,960,634 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,948,571 - 27,959,910 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1027,901,673 - 27,914,661 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01028,733,351 - 28,746,338 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11028,461,701 - 28,474,674 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,769,602 - 28,782,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,948,151 - 28,961,119 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Txn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,299,941 - 11,310,299 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364924,311,287 - 4,321,763 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364924,310,394 - 4,320,714 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl511,264,645 - 11,283,395 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1511,264,470 - 11,289,388 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,997,069 - 9,010,525 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,168,693 - 19,185,898 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,169,286 - 19,185,735 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045106,687,070 - 106,704,531 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475211,249,656 - 11,260,118 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475211,248,640 - 11,260,118 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Txn2
64 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:304
Count of miRNA genes:163
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000067483
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH127320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27109,496,832 - 109,497,027 (+)MAPPERmRatBN7.2
Rnor_6.07119,144,411 - 119,144,605NCBIRnor6.0
Rnor_5.07119,139,173 - 119,139,367UniSTSRnor5.0
RGSC_v3.47115,833,756 - 115,833,950UniSTSRGSC3.4
Celera7105,837,945 - 105,838,139UniSTS
RH 3.4 Map7811.2UniSTS
Cytogenetic Map7q34UniSTS
RH132125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27109,508,226 - 109,508,411 (+)MAPPERmRatBN7.2
Rnor_6.07119,156,022 - 119,156,206NCBIRnor6.0
Rnor_5.07119,150,784 - 119,150,968UniSTSRnor5.0
RGSC_v3.47115,845,539 - 115,845,723UniSTSRGSC3.4
Celera7105,849,335 - 105,849,519UniSTS
RH 3.4 Map7811.2UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U73525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067483   ⟹   ENSRNOP00000060694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,496,761 - 109,510,359 (-)Ensembl
Rnor_6.0 Ensembl7119,144,351 - 119,158,173 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078528   ⟹   ENSRNOP00000074086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7111,386,805 - 111,390,022 (-)Ensembl
mRatBN7.2 Ensembl7109,506,243 - 109,510,359 (-)Ensembl
Rnor_6.0 Ensembl7119,144,351 - 119,158,201 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114822   ⟹   ENSRNOP00000088234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,505,286 - 109,510,359 (-)Ensembl
RefSeq Acc Id: NM_053331   ⟹   NP_445783
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,377,338 - 111,390,940 (-)NCBI
mRatBN7.27109,496,772 - 109,510,378 (-)NCBI
Rnor_6.07119,144,350 - 119,158,173 (-)NCBI
Rnor_5.07119,139,112 - 119,152,935 (-)NCBI
RGSC_v3.47115,833,695 - 115,847,690 (-)RGD
Celera7105,837,884 - 105,851,486 (-)RGD
Sequence:
RefSeq Acc Id: NP_445783   ⟸   NM_053331
- Peptide Label: precursor
- UniProtKB: P97615 (UniProtKB/Swiss-Prot),   A6HSH4 (UniProtKB/TrEMBL),   A6HSH0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060694   ⟸   ENSRNOT00000067483
Ensembl Acc Id: ENSRNOP00000074086   ⟸   ENSRNOT00000078528
Ensembl Acc Id: ENSRNOP00000088234   ⟸   ENSRNOT00000114822
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97615-F1-model_v2 AlphaFold P97615 1-166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695453
Promoter ID:EPDNEW_R5978
Type:initiation region
Name:Txn2_1
Description:thioredoxin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,158,177 - 119,158,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71040 AgrOrtholog
BioCyc Gene G2FUF-32851 BioCyc
Ensembl Genes ENSRNOG00000005614 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067483.4 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190504 IMAGE-MGC_LOAD
InterPro Thioredoxin UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_CS UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:79462 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93312 IMAGE-MGC_LOAD
NCBI Gene 79462 ENTREZGENE
PANTHER THIOREDOXIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
  THIOREDOXIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Thioredoxin UniProtKB/Swiss-Prot
PhenoGen Txn2 PhenoGen
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot
PROSITE THIOREDOXIN_1 UniProtKB/Swiss-Prot
  THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005614 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8L2R8B7_RAT UniProtKB/TrEMBL
  A6HSH0 ENTREZGENE, UniProtKB/TrEMBL
  A6HSH1_RAT UniProtKB/TrEMBL
  A6HSH4 ENTREZGENE, UniProtKB/TrEMBL
  P97615 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Txn2  thioredoxin 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains the thioredoxin-active site, Trp-Cys-Gly-Pro-Cys, but lacks structural cysteines and has a 60-amino acid extension at the N terminus which may be a mitochondrial translocation signal 70610
gene_expression expressed in heart, muscle, kidney, and adrenal gland 70610
gene_protein 166 amino acids 70610