Nup98 (nucleoporin 98 and 96 precursor) - Rat Genome Database

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Gene: Nup98 (nucleoporin 98 and 96 precursor) Rattus norvegicus
Analyze
Symbol: Nup98
Name: nucleoporin 98 and 96 precursor
RGD ID: 71033
Description: Enables nuclear localization sequence binding activity. Involved in protein import into nucleus. Located in nucleus. Part of nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor); PARTICIPATES IN CRM1 export pathway; mRNA nuclear export pathway; influenza A pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 98 kDa nucleoporin; nuclear pore complex protein Nup98; nuclear pore complex protein Nup98-Nup96; nucleoporin 98; nucleoporin 98kDa; nucleoporin Nup98
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,906,405 - 166,003,366 (-)NCBIGRCr8
mRatBN7.21156,494,423 - 156,591,415 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,494,423 - 156,591,415 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,472,406 - 164,569,303 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,652,494 - 171,749,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,530,067 - 164,627,102 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,213,866 - 167,308,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,213,866 - 167,308,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,402,761 - 173,497,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,598,048 - 159,696,720 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,712,571 - 159,775,713 (-)NCBI
Celera1154,562,755 - 154,659,380 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenthion  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
potassium chromate  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
thapsigargin  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of mRNA trafficking by nuclear pore complexes. Bonnet A and Palancade B, Genes (Basel). 2014 Sep 2;5(3):767-91. doi: 10.3390/genes5030767.
2. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. Frosst P, etal., J Cell Biol. 2002 Feb 18;156(4):617-30. Epub 2002 Feb 11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. Hussey DJ, etal., Blood. 1999 Sep 15;94(6):2072-9.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Moroianu J, etal., Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6532-6.
9. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13). Panagopoulos I, etal., Genes Chromosomes Cancer 2003 Jan;36(1):107-12.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Radu A, etal., Cell 1995 Apr 21;81(2):215-22.
14. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Radu A, etal., Proc Natl Acad Sci U S A 1995 Feb 28;92(5):1769-73.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9348540   PMID:10087256   PMID:12802065   PMID:15146057   PMID:15229283   PMID:15615787   PMID:17360435   PMID:20407419   PMID:25931508   PMID:28221134  


Genomics

Comparative Map Data
Nup98
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,906,405 - 166,003,366 (-)NCBIGRCr8
mRatBN7.21156,494,423 - 156,591,415 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,494,423 - 156,591,415 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,472,406 - 164,569,303 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,652,494 - 171,749,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,530,067 - 164,627,102 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,213,866 - 167,308,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,213,866 - 167,308,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,402,761 - 173,497,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,598,048 - 159,696,720 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,712,571 - 159,775,713 (-)NCBI
Celera1154,562,755 - 154,659,380 (-)NCBICelera
Cytogenetic Map1q32NCBI
NUP98
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38113,675,010 - 3,797,554 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl113,671,083 - 3,797,792 (-)EnsemblGRCh38hg38GRCh38
GRCh37113,696,240 - 3,818,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,652,816 - 3,775,468 (-)NCBINCBI36Build 36hg18NCBI36
Build 34113,652,816 - 3,775,468NCBI
Celera113,701,320 - 3,824,093 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,430,150 - 3,552,853 (-)NCBIHuRef
CHM1_1113,695,309 - 3,818,528 (-)NCBICHM1_1
T2T-CHM13v2.0113,740,382 - 3,862,891 (-)NCBIT2T-CHM13v2.0
Nup98
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,768,607 - 101,859,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,768,605 - 101,859,383 (-)EnsemblGRCm39 Ensembl
GRCm387102,119,400 - 102,210,166 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,119,398 - 102,210,176 (-)EnsemblGRCm38mm10GRCm38
MGSCv377109,282,717 - 109,358,634 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367102,008,024 - 102,083,941 (-)NCBIMGSCv36mm8
Celera7102,501,532 - 102,578,156 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.71NCBI
Nup98
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,499,406 - 19,607,075 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,499,577 - 19,607,075 (-)NCBIChiLan1.0ChiLan1.0
NUP98
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v295,940,414 - 6,063,306 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1115,179,925 - 5,302,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0113,553,379 - 3,669,367 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1113,660,482 - 3,782,552 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl113,661,568 - 3,767,443 (-)Ensemblpanpan1.1panPan2
NUP98
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,231,585 - 26,348,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,220,963 - 26,336,020 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2126,000,857 - 26,119,031 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02126,440,102 - 26,558,550 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,440,111 - 26,558,538 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12126,231,727 - 26,349,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,447,562 - 26,565,737 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,349,660 - 26,468,000 (-)NCBIUU_Cfam_GSD_1.0
Nup98
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,513,173 - 59,620,245 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,112,663 - 1,220,634 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,112,724 - 1,219,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUP98
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,319,650 - 6,419,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.196,319,616 - 6,419,652 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,103,733 - 7,180,578 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NUP98
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,924,514 - 63,050,060 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl162,925,050 - 63,050,111 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604362,849,965 - 62,977,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nup98
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248175,123,977 - 5,245,286 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248175,125,658 - 5,245,453 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nup98
564 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:586
Count of miRNA genes:253
Interacting mature miRNAs:307
Transcripts:ENSRNOT00000027575, ENSRNOT00000027590
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1155866514158592016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat

Markers in Region
AI849286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,494,611 - 156,494,748 (+)MAPPERmRatBN7.2
Rnor_6.01167,214,055 - 167,214,191NCBIRnor6.0
Rnor_5.01173,402,950 - 173,403,086UniSTSRnor5.0
RGSC_v3.41159,598,237 - 159,598,373UniSTSRGSC3.4
Celera1154,562,944 - 154,563,080UniSTS
Cytogenetic Map1q32UniSTS
AI407154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,571,296 - 156,571,448 (+)MAPPERmRatBN7.2
Rnor_6.01167,288,732 - 167,288,883NCBIRnor6.0
Rnor_5.01173,477,340 - 173,477,491UniSTSRnor5.0
RGSC_v3.41159,675,842 - 159,675,993UniSTSRGSC3.4
Celera1154,638,989 - 154,639,140UniSTS
RH 3.4 Map11281.7UniSTS
Cytogenetic Map1q32UniSTS
RH134310  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,524,269 - 156,524,455 (+)MAPPERmRatBN7.2
Rnor_6.01167,241,703 - 167,241,888NCBIRnor6.0
Rnor_5.01173,430,598 - 173,430,783UniSTSRnor5.0
RGSC_v3.41159,629,149 - 159,629,334UniSTSRGSC3.4
Celera1154,591,983 - 154,592,168UniSTS
RH 3.4 Map11279.5UniSTS
Cytogenetic Map1q32UniSTS
RH141638  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,564,737 - 156,564,927 (+)MAPPERmRatBN7.2
Rnor_6.01167,282,173 - 167,282,362NCBIRnor6.0
Rnor_5.01173,470,781 - 173,470,970UniSTSRnor5.0
RGSC_v3.41159,669,283 - 159,669,472UniSTSRGSC3.4
Celera1154,632,434 - 154,632,623UniSTS
RH 3.4 Map11284.5UniSTS
Cytogenetic Map1q32UniSTS
AA799609  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,494,576 - 156,494,697 (+)MAPPERmRatBN7.2
Rnor_6.01167,214,020 - 167,214,140NCBIRnor6.0
Rnor_5.01173,402,915 - 173,403,035UniSTSRnor5.0
RGSC_v3.41159,598,202 - 159,598,322UniSTSRGSC3.4
Celera1154,562,909 - 154,563,029UniSTS
RH 3.4 Map11278.8UniSTS
Cytogenetic Map1q32UniSTS
AA924744  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,528,798 - 156,529,000 (+)MAPPERmRatBN7.2
Rnor_6.01167,246,232 - 167,246,433NCBIRnor6.0
Rnor_5.01173,435,127 - 173,435,328UniSTSRnor5.0
RGSC_v3.41159,633,678 - 159,633,879UniSTSRGSC3.4
Celera1154,596,512 - 154,596,713UniSTS
RH 3.4 Map11279.6UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 7 7 74 35 41 11 7
Low 7 1 4 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027575   ⟹   ENSRNOP00000027575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,494,423 - 156,591,415 (-)Ensembl
Rnor_6.0 Ensembl1167,213,866 - 167,308,851 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000027590   ⟹   ENSRNOP00000027590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,527,841 - 156,591,402 (-)Ensembl
Rnor_6.0 Ensembl1167,246,109 - 167,308,827 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117464   ⟹   ENSRNOP00000094157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,494,423 - 156,591,415 (-)Ensembl
RefSeq Acc Id: NM_031074   ⟹   NP_112336
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,906,405 - 166,003,366 (-)NCBI
mRatBN7.21156,494,423 - 156,591,415 (-)NCBI
Rnor_6.01167,213,866 - 167,308,851 (-)NCBI
Rnor_5.01173,402,761 - 173,497,459 (-)NCBI
RGSC_v3.41159,598,048 - 159,696,720 (-)RGD
Celera1154,562,755 - 154,659,380 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_112336   ⟸   NM_031074
- Peptide Label: proprotein
- UniProtKB: D3ZMW4 (UniProtKB/Swiss-Prot),   P49793 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027575   ⟸   ENSRNOT00000027575
RefSeq Acc Id: ENSRNOP00000027590   ⟸   ENSRNOT00000027590
RefSeq Acc Id: ENSRNOP00000094157   ⟸   ENSRNOT00000117464
Protein Domains
Peptidase S59

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49793-F1-model_v2 AlphaFold P49793 1-1816 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690267
Promoter ID:EPDNEW_R790
Type:multiple initiation site
Name:Nup98_1
Description:nucleoporin 98
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01167,308,828 - 167,308,888EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71033 AgrOrtholog
BioCyc Gene G2FUF-58254 BioCyc
Ensembl Genes ENSRNOG00000020347 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065022678 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027575 ENTREZGENE
  ENSRNOT00000027575.8 UniProtKB/Swiss-Prot
  ENSRNOT00000027590.7 UniProtKB/TrEMBL
  ENSRNOT00000117464.1 UniProtKB/TrEMBL
  ENSRNOT00065038783 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.2360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1610.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleoporin_FG_rpt UniProtKB/TrEMBL
  Nucleoporin_S59-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nup96 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S59 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S59_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81738 UniProtKB/Swiss-Prot
NCBI Gene 81738 ENTREZGENE
PANTHER NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23198 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nucleoporin2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleoporin_FG UniProtKB/TrEMBL
  Nup96 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nup98_GLEBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NUP98 RGD
PhenoGen Nup98 PhenoGen
PROSITE NUP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020347 RatGTEx
  ENSRNOG00065022678 RatGTEx
Superfamily-SCOP SSF82215 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ALK1_RAT UniProtKB/TrEMBL
  A6I722_RAT UniProtKB/TrEMBL
  A6I723_RAT UniProtKB/TrEMBL
  D3ZMW4 ENTREZGENE
  F1LPQ1_RAT UniProtKB/TrEMBL
  NUP98_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary D3ZMW4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-03 Nup98  nucleoporin 98 and 96 precursor  Nup98  nucleoporin 98  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Nup98  nucleoporin 98  Nup98  nucleoporin 98kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Nup98  nucleoporin 98kDa  Nup98  nucleoporin 98  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Nup98  nucleoporin 98      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleoplasmic side of the nuclear pore complex 70632
gene_domains contains GLFG and FG repeats and some FXFG repeats 70632