Parva (parvin, alpha) - Rat Genome Database

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Gene: Parva (parvin, alpha) Rattus norvegicus
Analyze
Symbol: Parva
Name: parvin, alpha
RGD ID: 71021
Description: Predicted to enable actin binding activity and protein kinase inhibitor activity. Involved in actin cytoskeleton organization. Part of protein-containing complex. Orthologous to human PARVA (parvin alpha); PARTICIPATES IN integrin mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actopaxin; Actp; alpha-parvin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,981,725 - 176,139,523 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1175,981,432 - 176,139,526 (+)EnsemblGRCr8
mRatBN7.21166,547,142 - 166,704,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,547,132 - 166,704,950 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1174,881,953 - 175,040,801 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,067,965 - 182,226,830 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01174,767,911 - 174,922,672 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01177,249,302 - 177,408,160 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1177,249,226 - 177,408,205 (+)Ensemblrn6Rnor6.0
Rnor_5.01184,227,712 - 184,383,031 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41170,232,441 - 170,387,843 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1164,422,597 - 164,576,541 (+)NCBICelera
RGSC_v3.11170,352,374 - 170,507,777 (+)NCBI
Cytogenetic Map1q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
propiconazole  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IBA,IEA,ISO)
cytoplasm  (IBA,ISO)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
focal adhesion  (IBA,IEA,ISO,ISS,NAS)
lamellipodium  (ISO)
nucleus  (ISO)
plasma membrane  (IEA)
protein-containing complex  (IDA)
Z disc  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Actopaxin is phosphorylated during mitosis and is a substrate for cyclin B1/cdc2 kinase. Curtis M, etal., Biochem J 2002 Apr 15;363(Pt 2):233-42.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells. Jung KY, etal., J Am Soc Nephrol. 2007 Jan;18(1):66-73. Epub 2006 Dec 13.
4. TGF-beta1-induced PINCH-1-ILK-alpha-parvin complex formation regulates mesangial cell proliferation and hypertrophy. Kim SM, etal., Exp Mol Med. 2007 Aug 31;39(4):514-23.
5. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion. Nikolopoulos SN and Turner CE, J Cell Biol 2000 Dec 25;151(7):1435-48.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11171322   PMID:11331308   PMID:15817463   PMID:19798050   PMID:20393563   PMID:21423176   PMID:23658024   PMID:25468996   PMID:25931508   PMID:29162887   PMID:30515554  


Genomics

Comparative Map Data
Parva
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,981,725 - 176,139,523 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1175,981,432 - 176,139,526 (+)EnsemblGRCr8
mRatBN7.21166,547,142 - 166,704,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,547,132 - 166,704,950 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1174,881,953 - 175,040,801 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,067,965 - 182,226,830 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01174,767,911 - 174,922,672 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01177,249,302 - 177,408,160 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1177,249,226 - 177,408,205 (+)Ensemblrn6Rnor6.0
Rnor_5.01184,227,712 - 184,383,031 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41170,232,441 - 170,387,843 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1164,422,597 - 164,576,541 (+)NCBICelera
RGSC_v3.11170,352,374 - 170,507,777 (+)NCBI
Cytogenetic Map1q33NCBI
PARVA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381112,376,436 - 12,535,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1112,377,482 - 12,535,356 (+)Ensemblhg38GRCh38
GRCh371112,399,118 - 12,556,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,355,722 - 12,507,986 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341112,355,678 - 12,508,919NCBI
Celera1112,524,458 - 12,676,606 (+)NCBICelera
Cytogenetic Map11p15.3NCBI
HuRef1112,075,562 - 12,234,995 (+)NCBIHuRef
CHM1_11112,397,901 - 12,555,768 (+)NCBICHM1_1
T2T-CHM13v2.01112,468,314 - 12,627,400 (+)NCBIT2T-CHM13v2.0
Parva
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397112,027,102 - 112,190,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7112,026,712 - 112,190,899 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387112,427,706 - 112,591,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7112,427,505 - 112,591,692 (+)Ensemblmm10GRCm38
MGSCv377119,571,220 - 119,735,202 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367112,218,887 - 112,382,869 (+)NCBIMGSCv36mm8
Celera7112,405,042 - 112,563,819 (+)NCBICelera
Cytogenetic Map7F1NCBI
cM Map758.76NCBI
Parva
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541427,813,745 - 27,960,743 (+)Ensembl
ChiLan1.0NW_00495541427,813,745 - 27,960,743 (+)NCBIChiLan1.0ChiLan1.0
PARVA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2914,820,723 - 14,975,758 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,785,176 - 14,943,318 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,544,232 - 12,701,517 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,237,446 - 12,394,986 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,237,446 - 12,387,584 (+)EnsemblpanPan2panpan1.1
PARVA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,382,447 - 35,536,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,382,462 - 35,536,776 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2134,919,902 - 35,050,892 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02136,260,512 - 36,428,746 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2136,261,661 - 36,428,744 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12135,521,317 - 35,688,912 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02135,697,872 - 35,865,269 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02135,985,531 - 36,152,922 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Parva
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494749,943,929 - 50,096,357 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365285,977,913 - 6,130,956 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365285,977,909 - 6,130,814 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARVA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl246,839,485 - 47,028,963 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1246,839,081 - 47,028,102 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2250,265,945 - 50,333,565 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARVA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,310,145 - 52,470,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl152,310,494 - 52,470,369 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038149,905,919 - 150,072,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Parva
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247664,391,010 - 4,544,842 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247664,390,952 - 4,544,550 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Parva
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1288,905,633 - 89,061,047 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Parva
968 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:51
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000021671
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1174182140176235262Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1170078537182384005Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Rat204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21166,643,448 - 166,643,622 (+)MAPPERmRatBN7.2
Rnor_6.01177,346,654 - 177,346,827NCBIRnor6.0
Rnor_5.01184,324,542 - 184,324,715UniSTSRnor5.0
RGSC_v3.41170,329,353 - 170,329,527RGDRGSC3.4
RGSC_v3.41170,329,354 - 170,329,527UniSTSRGSC3.4
Celera1164,518,082 - 164,518,259UniSTS
RGSC_v3.11170,449,288 - 170,449,461RGD
RH 3.4 Map11322.3RGD
RH 3.4 Map11322.3UniSTS
RH 2.0 Map1854.0RGD
SHRSP x BN Map183.5599RGD
FHH x ACI Map180.0199RGD
Cytogenetic Map1q33UniSTS
D1Got159  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81175,989,166 - 175,989,285 (+)Marker Load Pipeline
mRatBN7.21166,554,583 - 166,554,702 (+)MAPPERmRatBN7.2
Rnor_6.01177,256,684 - 177,256,802NCBIRnor6.0
Rnor_5.01184,235,094 - 184,235,212UniSTSRnor5.0
RGSC_v3.41170,239,823 - 170,239,941UniSTSRGSC3.4
RGSC_v3.41170,239,822 - 170,239,941RGDRGSC3.4
Celera1164,429,979 - 164,430,097UniSTS
RGSC_v3.11170,359,757 - 170,359,875RGD
RH 3.4 Map11320.4RGD
RH 3.4 Map11320.4UniSTS
RH 2.0 Map1854.4RGD
Cytogenetic Map1q33UniSTS
RH127352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21166,704,663 - 166,704,857 (+)MAPPERmRatBN7.2
Rnor_6.01177,407,866 - 177,408,059NCBIRnor6.0
Rnor_5.01184,385,754 - 184,385,947UniSTSRnor5.0
RGSC_v3.41170,390,566 - 170,390,759UniSTSRGSC3.4
Celera1164,579,263 - 164,579,456UniSTS
Cytogenetic Map1q33UniSTS
RH129473  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21166,704,713 - 166,704,897 (+)MAPPERmRatBN7.2
Rnor_6.01177,407,916 - 177,408,099NCBIRnor6.0
Rnor_5.01184,385,804 - 184,385,987UniSTSRnor5.0
RGSC_v3.41170,390,616 - 170,390,799UniSTSRGSC3.4
Celera1164,579,313 - 164,579,496UniSTS
RH 3.4 Map11316.4UniSTS
Cytogenetic Map1q33UniSTS
RH130233  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81176,136,487 - 176,136,668 (+)Marker Load Pipeline
mRatBN7.21166,701,922 - 166,702,103 (+)MAPPERmRatBN7.2
Rnor_6.01177,405,125 - 177,405,305NCBIRnor6.0
Rnor_5.01184,383,013 - 184,383,193UniSTSRnor5.0
RGSC_v3.41170,387,825 - 170,388,005UniSTSRGSC3.4
Celera1164,576,523 - 164,576,703UniSTS
RH 3.4 Map11322.3UniSTS
Cytogenetic Map1q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 57 59 6 321 157 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021671   ⟹   ENSRNOP00000021671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,547,145 - 166,702,273 (+)Ensembl
Rnor_6.0 Ensembl1177,249,226 - 177,408,205 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097427   ⟹   ENSRNOP00000090231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1175,981,432 - 176,139,526 (+)Ensembl
mRatBN7.2 Ensembl1166,547,132 - 166,704,950 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099634   ⟹   ENSRNOP00000088590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,069,514 - 176,139,526 (+)Ensembl
mRatBN7.2 Ensembl1166,634,938 - 166,702,273 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109964   ⟹   ENSRNOP00000092258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,547,143 - 166,702,258 (+)Ensembl
RefSeq Acc Id: NM_020656   ⟹   NP_065707
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,981,725 - 176,139,518 (+)NCBI
mRatBN7.21166,547,142 - 166,704,953 (+)NCBI
Rnor_6.01177,249,302 - 177,405,143 (+)NCBI
Rnor_5.01184,227,712 - 184,383,031 (+)NCBI
RGSC_v3.41170,232,441 - 170,387,843 (+)RGD
Celera1164,422,597 - 164,576,541 (+)RGD
Sequence:
RefSeq Acc Id: XM_017589619   ⟹   XP_017445108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,069,244 - 176,139,523 (+)NCBI
mRatBN7.21166,634,690 - 166,704,958 (+)NCBI
Rnor_6.01177,335,650 - 177,408,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063272098   ⟹   XP_063128168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,115,860 - 176,139,523 (+)NCBI
RefSeq Acc Id: XR_010056908
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,981,783 - 176,121,036 (+)NCBI
Protein Sequences
Protein RefSeqs NP_065707 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445108 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128168 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG09802 (Get FASTA)   NCBI Sequence Viewer  
  EDM17812 (Get FASTA)   NCBI Sequence Viewer  
  EDM17813 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088590
  ENSRNOP00000090231
GenBank Protein Q9HB97 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_065707   ⟸   NM_020656
- UniProtKB: Q9HB97 (UniProtKB/Swiss-Prot),   G3V818 (UniProtKB/TrEMBL),   A6I866 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445108   ⟸   XM_017589619
- Peptide Label: isoform X1
- UniProtKB: Q9HB97 (UniProtKB/Swiss-Prot),   A0A8I6AA82 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021671   ⟸   ENSRNOT00000021671
Ensembl Acc Id: ENSRNOP00000092258   ⟸   ENSRNOT00000109964
Ensembl Acc Id: ENSRNOP00000090231   ⟸   ENSRNOT00000097427
Ensembl Acc Id: ENSRNOP00000088590   ⟸   ENSRNOT00000099634
RefSeq Acc Id: XP_063128168   ⟸   XM_063272098
- Peptide Label: isoform X2
Protein Domains
Calponin-homology (CH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HB97-F1-model_v2 AlphaFold Q9HB97 1-372 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690322
Promoter ID:EPDNEW_R847
Type:initiation region
Name:Parva_1
Description:parvin, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01177,249,242 - 177,249,302EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71021 AgrOrtholog
BioCyc Gene G2FUF-57791 BioCyc
Ensembl Genes ENSRNOG00000015713 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000097427 ENTREZGENE
  ENSRNOT00000099634 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
InterPro CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  Parvin UniProtKB/Swiss-Prot
KEGG Report rno:57341 UniProtKB/Swiss-Prot
NCBI Gene 57341 ENTREZGENE
PANTHER ALPHA-PARVIN UniProtKB/Swiss-Prot
  PTHR12114 UniProtKB/Swiss-Prot
Pfam PF00307 UniProtKB/Swiss-Prot
PhenoGen Parva PhenoGen
PIRSF Parvin UniProtKB/Swiss-Prot
PROSITE PS50021 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015713 RatGTEx
SMART SM00033 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot
UniProt A0A8I6AA82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AD86_RAT UniProtKB/TrEMBL
  A6I866 ENTREZGENE, UniProtKB/TrEMBL
  A6I867_RAT UniProtKB/TrEMBL
  G3V818 ENTREZGENE
  PARVA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Parva  parvin, alpha      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation phosphorylated by cyclin B1/cdc2 kinase during mitosis; dephosphorylation may precede reformation of focal adhesions; 633557