Gene:	Fzd4 ( Rattus norvegicus ) frizzled homolog 4 (Drosophila)
Description:	a Wnt-binding protein that is associated with prostate cancer and retinal disease
Synonyms:	frizzled receptor 4 (Drosophila); frizzled receptor 4;
ArrayIDs:	1369468_at; 6354140; 6597797; 5687372; 6625369; 6150798; 6192624; 6121175; GE1198864; 5687550; 5922164; 6535537; 6398867; A_43_P12267;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: FZD4     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Fzd4     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Fzd4 genome assembly 3.1 1 146032165 - 146036072     Rat Celera Assembly 1 141540925 - 141544833     RGSC genome assembly v3.4 1 145953758 - 145957666     Cytogenetic 1 q32 Mus musculus Fzd4 Mouse genome assembly build 36.1 7 96552904 - 96558595     Cytogenetic 7 7 E1 Homo sapiens FZD4 human genome assembly 11 86334369 - 86344081     Human genome assembly build 36.2 11 86334369 - 86344081     Cytogenetic 11 q14.2   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology Wnt-protein binding,  protein binding,  non-G-protein coupled 7TM receptor activity ...  (details...)
Biological Process	Gene Ontology biological_process,  multicellular organismal development,  G-protein coupled receptor protein signaling pathway ...  (details...)
Cellular Component	Gene Ontology membrane,  integral to membrane,  cellular_component (details...)
Disease	Ontology Prostatic Neoplasms,  Prostatic Intraepithelial Neoplasia,  Retinal Diseases (details...)
Expression	Note Reference expresssed in ovarian granulosa cells 634517
Pathway	Ontology Wnt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: FRI IPI PROSITE: G_PROTEIN_RECEP_F2_4 IPI PROSITE: FZ IPI UNIPARC: UPI000012AE0E IPI KEGG Report: rno:64558 ENTREZGENE HomoloGene Group ID: 7325 ENTREZGENE Germonline: 71017 Pfam: Fz IPI Pfam: Frizzled IPI KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE InterPro: GPCR_2-like. IPI InterPro: Frizzled_related. IPI InterPro: Frizzled_dom_subgr. IPI InterPro: Frizzled_Cys-rich. IPI InterPro: Frizzled-like_dom. IPI InterPro: Frizzled. IPI IPI: IPI00214987 IPI Ensembl Protein: ENSRNOP00000023205 IPI Gene3D-CATH: Frizzled_Cys-rich IPI Entrez Gene: Fzd4 ENTREZGENE UniProt: FZD4_RAT IPI Ensembl Genes: ENSRNOG00000016848 IPI Superfamily-SCOP: Frizzled_Cys-rich IPI PANTHER: Fz_related IPI PRINTS: FRIZZLED. IPI
Sequences	Nucleotide: CH473956 Get FASTA Search GEO Profiles Nucleotide: AF183910 Get FASTA Search GEO Profiles Nucleotide: NM_022623 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: NP_072145 Get FASTA Protein: EDM18582 Get FASTA Protein: AAF01036 Get FASTA Protein: Q9QZH0 Get FASTA (View all 4 Protein Accessions)
Clusters	UniGene: 48736
References
Curated References	10 references in RGD related to Fzd4
Other References	3 other references at PubMed related to Fzd4
Database Information
RGD ID	71017
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 09-JUL-02: Fzd4 frizzled homolog 4 (Drosophila) APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 70877