Prdx6 (peroxiredoxin 6) - Rat Genome Database

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Gene: Prdx6 (peroxiredoxin 6) Rattus norvegicus
Analyze
Symbol: Prdx6
Name: peroxiredoxin 6
RGD ID: 71005
Description: Enables 1-acylglycerophosphocholine O-acyltransferase activity and glutathione peroxidase activity. Involved in hydrogen peroxide catabolic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol and mitochondrion. Orthologous to human PRDX6 (peroxiredoxin 6); PARTICIPATES IN phenylalanine metabolic pathway; INTERACTS WITH (R)-adrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-Cys peroxiredoxin; 1-Cys PRX; acidic calcium-independent phospholipase A2; aiPLA2; antioxidant protein 2; glutathione-dependent peroxiredoxin; LPC acyltransferase 5; LPCAT-5; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase; NSGPx; peroxiredoxin-6; thiol-specific antioxidant protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,062,082 - 76,072,631 (-)NCBIGRCr8
mRatBN7.21373,528,746 - 73,539,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1373,528,210 - 73,539,355 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1376,121,248 - 76,131,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01377,405,434 - 77,415,988 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01374,665,337 - 74,675,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,077,567 - 79,088,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,077,033 - 79,088,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01383,972,564 - 83,983,110 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41376,824,968 - 76,835,517 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11376,838,625 - 76,849,719 (-)NCBI
Celera1373,317,100 - 73,327,649 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
diethyldithiocarbamic acid  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (EXP)
fructose  (EXP)
fumonisin B1  (ISO)
glutathione  (EXP)
herbicide  (ISO)
homocysteine  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methylene blue  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
Nonylphenol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
picloram  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
Propiverine  (EXP)
Pyridostigmine bromide  (EXP)
pyrogallol  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichlopyr  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO)
lysosome  (IEA)
mitochondrion  (IBA,IEA)
nucleus  (ISO)
perinuclear region of cytoplasm  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat. Acar N, etal., Acta Histochem. 2014 Oct;116(8):1289-300. doi: 10.1016/j.acthis.2014.07.012. Epub 2014 Aug 27.
2. Study of structure of secretory 28 kDa protein from the rat olfactory epithelium Andreeva SG, etal., Bioorg Khim 1998 Nov;24(11):816-21.
3. A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6. Fisher AB, etal., J Lipid Res. 2016 Apr;57(4):587-96. doi: 10.1194/jlr.M064758. Epub 2016 Feb 1.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. TARGETED DISRUPTION OF PEROXIREDOXIN 6 GENE RENDERS THE HEART VULNERABLE TO ISCHEMIA REPERFUSION INJURY. Nagy N, etal., Am J Physiol Heart Circ Physiol. 2006 Jun 9;.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins. Nilsson A, etal., J Proteome Res. 2007 Oct;6(10):3952-61. Epub 2007 Sep 18.
12. Novel 28-kDa secretory protein from rat olfactory epithelium. Peshenko IV, etal., FEBS Lett 1996 Feb 26;381(1-2):12-14.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3epsilon. Sorokina EM, etal., Am J Physiol Cell Physiol. 2011 Jun;300(6):C1430-41. doi: 10.1152/ajpcell.00285.2010. Epub 2011 Feb 23.
17. Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis. Wang X, etal., Atherosclerosis. 2004 Nov;177(1):61-70.
Additional References at PubMed
PMID:8999971   PMID:9587003   PMID:10893423   PMID:12732627   PMID:16186110   PMID:16330552   PMID:17135244   PMID:17556052   PMID:17633531   PMID:17652308   PMID:18184874   PMID:18614015  
PMID:18694738   PMID:19056867   PMID:19140803   PMID:19188445   PMID:19351539   PMID:19725078   PMID:19946888   PMID:20458337   PMID:20716133   PMID:22166015   PMID:22663767   PMID:23376485  
PMID:23533145   PMID:23580065   PMID:23623867   PMID:24447893   PMID:25468996   PMID:25938937   PMID:27412928   PMID:27660222   PMID:28596967   PMID:29476059   PMID:31238863   PMID:32018008  
PMID:33159299   PMID:34482185   PMID:34863856   PMID:36209344   PMID:36401357  


Genomics

Comparative Map Data
Prdx6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,062,082 - 76,072,631 (-)NCBIGRCr8
mRatBN7.21373,528,746 - 73,539,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1373,528,210 - 73,539,355 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1376,121,248 - 76,131,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01377,405,434 - 77,415,988 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01374,665,337 - 74,675,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,077,567 - 79,088,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,077,033 - 79,088,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01383,972,564 - 83,983,110 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41376,824,968 - 76,835,517 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11376,838,625 - 76,849,719 (-)NCBI
Celera1373,317,100 - 73,327,649 (-)NCBICelera
Cytogenetic Map13q22NCBI
PRDX6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,477,335 - 173,488,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,477,330 - 173,488,815 (+)EnsemblGRCh38hg38GRCh38
GRCh371173,446,474 - 173,457,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,713,109 - 171,724,569 (+)NCBINCBI36Build 36hg18NCBI36
Celera1146,555,898 - 146,567,358 (+)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1144,671,177 - 144,682,637 (+)NCBIHuRef
CHM1_11174,868,919 - 174,880,398 (+)NCBICHM1_1
T2T-CHM13v2.01172,835,491 - 172,846,972 (+)NCBIT2T-CHM13v2.0
Prdx6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,067,682 - 161,078,780 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,067,682 - 161,078,789 (-)EnsemblGRCm39 Ensembl
GRCm381161,240,112 - 161,251,210 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,240,112 - 161,251,219 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,170,243 - 163,181,297 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361163,076,789 - 163,087,843 (-)NCBIMGSCv36mm8
Celera1163,685,242 - 163,696,325 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
Prdx6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540613,717,267 - 13,728,216 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540613,717,267 - 13,728,216 (+)NCBIChiLan1.0ChiLan1.0
PRDX6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2176,243,727 - 76,255,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1175,917,520 - 75,929,098 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01148,988,836 - 149,000,345 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11152,694,606 - 152,706,521 (+)NCBIpanpan1.1PanPan1.1panPan2
PRDX6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1725,663,238 - 25,675,855 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl725,663,579 - 25,675,754 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,195,499 - 25,208,542 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0725,414,335 - 25,427,625 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl725,410,888 - 25,427,580 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1725,333,015 - 25,346,019 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0725,411,171 - 25,424,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0725,560,133 - 25,573,439 (-)NCBIUU_Cfam_GSD_1.0
Prdx6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,376,675 - 96,386,886 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648114,222,696 - 14,233,641 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648114,223,422 - 14,233,634 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDX6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,857,644 - 115,868,892 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,857,629 - 115,868,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29127,491,864 - 127,503,134 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRDX6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12555,706,920 - 55,719,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2555,706,885 - 55,718,665 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605557,279,199 - 57,290,948 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prdx6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247718,282,062 - 8,294,340 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247718,282,622 - 8,293,799 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prdx6
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:64
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000034583
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat

Markers in Region
RH128089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21373,528,768 - 73,528,964 (+)MAPPERmRatBN7.2
mRatBN7.21053,609,492 - 53,609,702 (+)MAPPERmRatBN7.2
Rnor_6.01055,491,074 - 55,491,283NCBIRnor6.0
Rnor_6.01379,077,590 - 79,077,785NCBIRnor6.0
Rnor_5.01383,972,587 - 83,972,782UniSTSRnor5.0
Rnor_5.01055,233,453 - 55,233,662UniSTSRnor5.0
RGSC_v3.41055,660,814 - 55,661,023UniSTSRGSC3.4
RGSC_v3.41376,824,991 - 76,825,186UniSTSRGSC3.4
Celera1373,317,123 - 73,317,318UniSTS
Celera1052,775,812 - 52,776,021UniSTS
Cytogenetic Map13q22UniSTS
Cytogenetic Map10q24UniSTS
RH134407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21373,528,230 - 73,528,413 (+)MAPPERmRatBN7.2
mRatBN7.21053,608,960 - 53,609,144 (+)MAPPERmRatBN7.2
Rnor_6.01055,490,542 - 55,490,725NCBIRnor6.0
Rnor_6.01379,077,053 - 79,077,235NCBIRnor6.0
Rnor_5.01383,972,050 - 83,972,232UniSTSRnor5.0
Rnor_5.01055,232,921 - 55,233,104UniSTSRnor5.0
RGSC_v3.41055,660,282 - 55,660,465UniSTSRGSC3.4
RGSC_v3.41376,824,454 - 76,824,636UniSTSRGSC3.4
Celera1373,316,586 - 73,316,768UniSTS
Celera1052,775,280 - 52,775,463UniSTS
RH 3.4 Map13447.6UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map13q22UniSTS
BE116085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21373,533,843 - 73,534,023 (+)MAPPERmRatBN7.2
Rnor_6.01379,082,665 - 79,082,844NCBIRnor6.0
Rnor_5.01383,977,662 - 83,977,841UniSTSRnor5.0
RGSC_v3.41376,830,066 - 76,830,245UniSTSRGSC3.4
Celera1373,322,198 - 73,322,377UniSTS
RH 3.4 Map13441.5UniSTS
Cytogenetic Map13q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 2 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034583   ⟹   ENSRNOP00000030323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1379,077,033 - 79,088,127 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1379,079,283 - 79,080,055 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100083   ⟹   ENSRNOP00000084274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1373,528,210 - 73,538,736 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117915   ⟹   ENSRNOP00000085822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1373,528,445 - 73,539,355 (-)Ensembl
RefSeq Acc Id: NM_053576   ⟹   NP_446028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,062,082 - 76,072,631 (-)NCBI
mRatBN7.21373,528,746 - 73,539,295 (-)NCBI
Rnor_6.01379,077,567 - 79,088,113 (-)NCBI
Rnor_5.01383,972,564 - 83,983,110 (-)NCBI
RGSC_v3.41376,824,968 - 76,835,517 (-)RGD
Celera1373,317,100 - 73,327,649 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB66341 (Get FASTA)   NCBI Sequence Viewer  
  CAA76732 (Get FASTA)   NCBI Sequence Viewer  
  EDM09416 (Get FASTA)   NCBI Sequence Viewer  
  EDM09417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084274.1
  ENSRNOP00000085822.1
GenBank Protein O35244 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446028   ⟸   NM_053576
- UniProtKB: O35244 (UniProtKB/Swiss-Prot),   A6ID81 (UniProtKB/TrEMBL),   A0A8I5ZYW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030323   ⟸   ENSRNOT00000034583
RefSeq Acc Id: ENSRNOP00000085822   ⟸   ENSRNOT00000117915
RefSeq Acc Id: ENSRNOP00000084274   ⟸   ENSRNOT00000100083
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35244-F1-model_v2 AlphaFold O35244 1-224 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698932
Promoter ID:EPDNEW_R9457
Type:initiation region
Name:Prdx6_1
Description:peroxiredoxin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01379,088,142 - 79,088,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71005 AgrOrtholog
BioCyc Gene G2FUF-17724 BioCyc
Ensembl Genes ENSRNOG00000002896 Ensembl
  ENSRNOG00000066585 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000100083.1 UniProtKB/TrEMBL
  ENSRNOT00000117915.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AhpC/TSA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin_AhpC-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRX_1cys UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94167 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 94167 ENTREZGENE
PANTHER MCG48959-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXIREDOXIN-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 1-cysPrx_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AhpC-TSA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prdx6 PhenoGen
PIRSF AHPC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002896 RatGTEx
  ENSRNOG00000066585 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZYW1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A038_RAT UniProtKB/TrEMBL
  A6ID80_RAT UniProtKB/TrEMBL
  A6ID81 ENTREZGENE, UniProtKB/TrEMBL
  O35244 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prdx6  peroxiredoxin 6      Symbol and Name status set to approved 1299863 APPROVED
2003-05-22 Prdx6  peroxiredoxin 6  Prdx5  peroxiredoxin 5  Symbol and Name updated to reflect Human and Mouse nomenclature 629527 PROVISIONAL
2002-07-09 Prdx5  peroxiredoxin 5      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference