Myh10 (myosin heavy chain 10) - Rat Genome Database

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Gene: Myh10 (myosin heavy chain 10) Rattus norvegicus
Analyze
Symbol: Myh10
Name: myosin heavy chain 10
RGD ID: 71000
Description: Enables identical protein binding activity. Involved in actin filament bundle organization; cell adhesion; and regulation of modification of postsynaptic actin cytoskeleton. Located in lamellipodium. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human MYH10 (myosin heavy chain 10); PARTICIPATES IN myocarditis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cellular myosin heavy chain type B; cellular myosin heavy chain, type B; MCH-B; MCH-B(B2); myosin heavy chain 10, non-muscle; myosin heavy chain nonmuscle type B; myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscle type B; myosin, heavy chain 10, non-muscle; myosin, heavy polypeptide 10, non-muscle; myosin-10; NMMHC II-b; NMMHC-B; NMMHC-IIB; non-muscle myosin heavy chain B; non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain IIB; nonmuscle myosin heavy chain-B; SMemb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Myh10_v1   Myh10_v2  
Candidate Gene For: Vetf10
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81053,891,955 - 54,024,032 (+)NCBIGRCr8
mRatBN7.21053,393,901 - 53,525,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,394,389 - 53,525,165 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,054,246 - 58,186,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,543,278 - 57,675,562 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,052,353 - 53,184,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,274,910 - 55,406,738 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,275,411 - 55,406,732 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,017,110 - 55,148,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,445,288 - 55,576,096 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,458,910 - 55,589,717 (+)NCBI
Celera1052,561,720 - 52,692,270 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Myh10Ratautism spectrum disorder  ISOMYH10 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868
Myh10Ratcongenital fibrosis of the extraocular muscles  ISOMYH10 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital fibrosis of extraocular musclesClinVarPMID:25741868
Myh10Ratgenetic disease  ISOMYH10 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868
Myh10RatHypertelorism  ISOMYH10 (Homo sapiens)8554872ClinVar Annotator: match by term: HypertelorismClinVar 
Myh10Ratjaw-winking syndrome  ISOMYH10 (Homo sapiens)8554872ClinVar Annotator: match by term: Jaw-winking syndromeClinVarPMID:25741868
Myh10RatNeurodevelopmental Disorders  ISOMYH10 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25003005 more ...
Myh10Ratobesity  ISOMYH10 (Homo sapiens)8554872ClinVar Annotator: match by term: ObesityClinVarPMID:25741868
Object Symbol
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Original Reference(s)
Myh10Ratfocal segmental glomerulosclerosis  ISOMYH10 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9678433

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Original Reference(s)
Myh10Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMYH10 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MYH10 mRNACTDPMID:22079256
Myh10Rat1,2-dichloroethane affects expressionISOMyh10 (Mus musculus)6480464ethylene dichloride affects the expression of MYH10 mRNACTDPMID:28960355
Myh10Rat1,2-dimethylhydrazine increases expressionISOMyh10 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of MYH10 mRNACTDPMID:22206623
Myh10Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of MYH10 mRNACTDPMID:30723492
Myh10Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of MYH10 mRNACTDPMID:17557909
Myh10Rat17beta-estradiol multiple interactionsISOMYH10 (Homo sapiens)6480464Estradiol affects the localization of and results in increased expression of and results in increased phosphorylation of and affects the activity of MYH10 protein more ...CTDPMID:16901965
Myh10Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of MYH10 mRNACTDPMID:32145629
Myh10Rat17beta-estradiol affects expressionISOMYH10 (Homo sapiens)6480464Estradiol affects the expression of MYH10 mRNACTDPMID:22574217
Myh10Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOMYH10 (Homo sapiens)64804642 more ...CTDPMID:31675489
Myh10Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of MYH10 mRNACTDPMID:22298810 and PMID:34747641
Myh10Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MYH10 mRNACTDPMID:33387578
Myh10Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMyh10 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MYH10 mRNACTDPMID:26290441
Myh10Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMyh10 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of MYH10 mRNACTDPMID:25270620
Myh10Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Myh10Rat2,4,6-tribromophenol decreases expressionISOMYH10 (Homo sapiens)64804642 more ...CTDPMID:31675489
Myh10Rat2,6-dimethoxyphenol multiple interactionsISOMYH10 (Homo sapiens)6480464[Furaldehyde co-treated with pyrogallol 1 more ...CTDPMID:38598786
Myh10Rat2-methylcholine affects expressionISOMYH10 (Homo sapiens)6480464beta-methylcholine affects the expression of MYH10 mRNACTDPMID:21179406
Myh10Rat3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expressionEXP 6480464Puromycin Aminonucleoside results in increased expression of MYH10 proteinCTDPMID:7671567
Myh10Rat3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects expressionEXP 6480464Puromycin Aminonucleoside affects the expression of MYH10 mRNA and Puromycin Aminonucleoside affects the expression of MYH10 proteinCTDPMID:7671567 and PMID:8918620
Myh10Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:23196670

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Biological Process
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Original Reference(s)
Myh10Ratactin cytoskeleton organization acts_upstream_of_or_withinISOMyh10 (Mus musculus)1624291MGI:107927 more ...RGDPMID:16249236
Myh10Ratactin cytoskeleton organization acts_upstream_of_or_withinIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratactin filament bundle assembly  IMP 12798526 RGD 
Myh10Ratactin filament bundle distribution  IMP 12798526 RGD 
Myh10Ratactin filament-based movement acts_upstream_of_or_withinISOMYH10 (Homo sapiens)1624291 PMID:15845534RGDPMID:15845534
Myh10Ratactin filament-based movement acts_upstream_of_or_withinIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratactomyosin structure organization involved_inIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratactomyosin structure organization involved_inIBAMGI:1930780 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh10Ratactomyosin structure organization involved_inISOMYH10 (Homo sapiens)1624291 PMID:24072716RGDPMID:24072716
Myh10Ratadult heart development acts_upstream_of_or_withinIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratadult heart development acts_upstream_of_or_withinISOMyh10 (Mus musculus)1624291MGI:2386439 more ...RGDPMID:10712438 more ...
Myh10Rataorta development acts_upstream_of_or_withinISOMyh10 (Mus musculus)1624291 PMID:25807483RGDPMID:25807483
Myh10Rataorta development acts_upstream_of_or_withinIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Rataxon guidance acts_upstream_of_or_withinISOMyh10 (Mus musculus)1624291MGI:2386445 PMID:15880105RGDPMID:15880105
Myh10Rataxon guidance acts_upstream_of_or_withinIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Rataxonogenesis acts_upstream_of_or_withinIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Rataxonogenesis acts_upstream_of_or_withinISOMyh10 (Mus musculus)1624291MGI:2386445 PMID:11283949RGDPMID:11283949
Myh10Ratbrain development acts_upstream_of_or_withinIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratbrain development acts_upstream_of_or_withinISOMyh10 (Mus musculus)1624291MGI:3664764 more ...RGDPMID:16481398
Myh10Ratcardiac muscle cell proliferation acts_upstream_of_or_withinISOMyh10 (Mus musculus)1624291MGI:2386445 PMID:12893741RGDPMID:12893741
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Cellular Component
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Original Reference(s)
Myh10Ratactomyosin located_inISOMYH10 (Homo sapiens)1624291 PMID:24072716RGDPMID:24072716
Myh10Ratactomyosin located_inIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Rataxon located_inIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Rataxon located_inISOMyh10 (Mus musculus)1624291 PMID:15880105RGDPMID:15880105
Myh10Ratbrush border located_inIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratbrush border located_inISOMyh10 (Mus musculus)1624291 PMID:22114352RGDPMID:22114352
Myh10Ratcell cortex located_inIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratcell cortex located_inIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratcell cortex located_inISOMyh10 (Mus musculus)1624291 PMID:8482409 and PMID:9725909RGDPMID:8482409 and PMID:9725909
Myh10Ratcell cortex located_inISOMYH10 (Homo sapiens)1624291 PMID:7699007RGDPMID:7699007
Myh10Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Myh10Ratcell surface is_active_inISOMYH10 (Homo sapiens)1624291 PMID:25428876RGDPMID:25428876
Myh10Ratcell surface is_active_inIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratcleavage furrow located_inIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratcleavage furrow located_inISOMYH10 (Homo sapiens)1624291 PMID:11029059 and PMID:7699007RGDPMID:11029059 and PMID:7699007
Myh10Ratcytoplasm located_inISOMYH10 (Homo sapiens)1624291 PMID:7699007RGDPMID:7699007
Myh10Ratcytoplasm located_inISOMyh10 (Mus musculus)1624291 PMID:12724421 more ...RGDPMID:12724421 more ...
Myh10Ratcytoplasm located_inIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratcytoplasm is_active_inIBACGD:CAL0000200546 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh10Ratcytoplasm located_inIEAUniProtKB:Q61879 and ensembl:ENSMUSP000000996711600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Myh10Ratactin binding enablesIEAUniProtKB-KW:KW-00091600115GO_REF:0000043UniProtGO_REF:0000043
Myh10Ratactin filament binding contributes_toISOMYH10 (Homo sapiens)1624291 PMID:24072716RGDPMID:24072716
Myh10Ratactin filament binding enablesIBAFB:FBgn0026059 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh10Ratactin filament binding enablesIEAInterPro:IPR0089891600115GO_REF:0000002InterProGO_REF:0000002
Myh10Ratactin filament binding enablesIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10Ratactin filament binding enablesISOMYH10 (Homo sapiens)1624291 PMID:15845534RGDPMID:15845534
Myh10RatADP binding enablesISOMYH10 (Homo sapiens)1624291 PMID:15845534RGDPMID:15845534
Myh10RatADP binding enablesIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10RatATP binding enablesISOMYH10 (Homo sapiens)1624291 PMID:15845534RGDPMID:15845534
Myh10RatATP binding enablesIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
Myh10RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Myh10RatATP binding enablesIEAInterPro:IPR001609 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Myh10RatATP binding enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myh10Ratcalmodulin binding enablesIEAUniProtKB-KW:KW-01121600115GO_REF:0000043UniProtGO_REF:0000043
Myh10Ratcytoskeletal motor activity enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myh10Ratcytoskeletal motor activity enablesIEAInterPro:IPR001609 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Myh10Ratidentical protein binding  IDA 12798516 RGD 
Myh10Ratmicrofilament motor activity contributes_toISOMYH10 (Homo sapiens)1624291 PMID:24072716RGDPMID:24072716
Myh10Ratmicrofilament motor activity enablesIBAFB:FBgn0264695 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh10Ratmicrofilament motor activity enablesIEAUniProtKB:P35580 and ensembl:ENSP000003535901600115GO_REF:0000107EnsemblGO_REF:0000107
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Myh10Ratmyocarditis pathway  IEA 6907045 KEGGrno:05416

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#
Reference Title
Reference Citation
1. Gas6-Axl Pathway. The Role of Redox-Dependent Association of Axl With Nonmuscle Myosin IIB. Cavet ME, etal., Hypertension. 2010 May 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Microtubule guidance tested through controlled cell geometry. Huda S, etal., J Cell Sci. 2012 Dec 1;125(Pt 23):5790-9. doi: 10.1242/jcs.110494. Epub 2012 Sep 19.
5. Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B. Itoh K and Adelstein RS, J Biol Chem 1995 Jun 16;270(24):14533-40.
6. Molecular architecture of synaptic actin cytoskeleton in hippocampal neurons reveals a mechanism of dendritic spine morphogenesis. Korobova F and Svitkina T, Mol Biol Cell. 2010 Jan 1;21(1):165-76. doi: 10.1091/mbc.e09-07-0596. Epub 2009 Nov 4.
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis. Miura K, etal., Nephrol Dial Transplant. 2013 Dec;28(12):2993-3003. doi: 10.1093/ndt/gft350. Epub 2013 Sep 15.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation. Rex CS, etal., Neuron. 2010 Aug 26;67(4):603-17. doi: 10.1016/j.neuron.2010.07.016.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Endogenous species of mammalian nonmuscle myosin IIA and IIB include activated monomers and heteropolymers. Shutova MS, etal., Curr Biol. 2014 Sep 8;24(17):1958-68. doi: 10.1016/j.cub.2014.07.070. Epub 2014 Aug 14.
17. Developmentally regulated expression of a nonmuscle myosin heavy chain IIB inserted isoform in rat brain. Takahashi M, etal., Biochem Biophys Res Commun 1999 May 27;259(1):29-33.
18. Molecular cloning and functional analysis of the promoter region of rat nonmuscle myosin heavy chain-B gene. Yam JW, etal., Biochem Biophys Res Commun 2000 Oct 5;276(3):1203-9.
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PMID:7699007   PMID:8482409   PMID:9356462   PMID:9725909   PMID:10712438   PMID:11029059   PMID:11283949   PMID:11961408   PMID:12724421   PMID:12893741   PMID:14617807   PMID:14699073  
PMID:15034141   PMID:15177565   PMID:15347643   PMID:15774463   PMID:15845534   PMID:15880105   PMID:16012337   PMID:16249236   PMID:16481398   PMID:16641100   PMID:16778019   PMID:16895968  
PMID:17377397   PMID:17973598   PMID:19623632   PMID:20124353   PMID:20131911   PMID:20603131   PMID:21126233   PMID:21372011   PMID:21630459   PMID:21700703   PMID:22114352   PMID:22174310  
PMID:22262309   PMID:23354122   PMID:23533145   PMID:24072716   PMID:24265776   PMID:24625528   PMID:24752242   PMID:25220605   PMID:25807483   PMID:26239291   PMID:29476059   PMID:29956586  
PMID:32357304   PMID:32654195   PMID:35352799  



Myh10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81053,891,955 - 54,024,032 (+)NCBIGRCr8
mRatBN7.21053,393,901 - 53,525,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,394,389 - 53,525,165 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,054,246 - 58,186,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,543,278 - 57,675,562 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,052,353 - 53,184,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,274,910 - 55,406,738 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,275,411 - 55,406,732 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,017,110 - 55,148,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,445,288 - 55,576,096 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,458,910 - 55,589,717 (+)NCBI
Celera1052,561,720 - 52,692,270 (+)NCBICelera
Cytogenetic Map10q24NCBI
MYH10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,474,212 - 8,630,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,474,207 - 8,631,376 (-)EnsemblGRCh38hg38GRCh38
GRCh37178,377,530 - 8,534,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,318,255 - 8,474,761 (-)NCBINCBI36Build 36hg18NCBI36
Build 34178,318,254 - 8,474,761NCBI
Celera178,408,358 - 8,564,898 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef178,276,713 - 8,433,166 (-)NCBIHuRef
CHM1_1178,386,377 - 8,542,853 (-)NCBICHM1_1
T2T-CHM13v2.0178,380,372 - 8,536,822 (-)NCBIT2T-CHM13v2.0
Myh10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,581,228 - 68,707,451 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,582,385 - 68,707,458 (+)EnsemblGRCm39 Ensembl
GRCm381168,691,915 - 68,816,626 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1168,691,559 - 68,816,632 (+)EnsemblGRCm38mm10GRCm38
MGSCv371168,505,417 - 68,630,126 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361168,508,162 - 68,632,737 (+)NCBIMGSCv36mm8
Celera1175,631,165 - 75,761,610 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1141.95NCBI
Myh10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,298,527 - 8,427,459 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,298,514 - 8,427,459 (+)NCBIChiLan1.0ChiLan1.0
MYH10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,118,242 - 65,274,685 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11769,927,439 - 70,084,120 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,023,922 - 43,180,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11747,756,244 - 47,912,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1747,761,322 - 47,911,192 (+)Ensemblpanpan1.1panPan2
MYH10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1533,239,800 - 33,360,459 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl533,241,266 - 33,360,934 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,375,328 - 33,497,290 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0533,342,579 - 33,463,814 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,342,582 - 33,463,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,309,962 - 33,431,940 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,265,077 - 33,387,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,444,924 - 33,565,595 (-)NCBIUU_Cfam_GSD_1.0
Myh10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560248,223,102 - 48,358,045 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,694,102 - 1,832,364 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,697,283 - 1,832,571 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11253,647,579 - 53,781,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21256,123,499 - 56,235,665 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYH10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,837,527 - 7,989,687 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,835,843 - 7,989,788 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605913,394,355 - 13,546,918 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myh10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478611,040,951 - 11,185,627 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478611,039,436 - 11,190,935 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Myh10
461 total Variants

Predicted Target Of
Summary Value
Count of predictions:244
Count of miRNA genes:150
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000065895
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 72 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat

1 to 10 of 72 rows
MARC_24284-24285:1030045561:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21053,524,497 - 53,525,008 (+)MAPPERmRatBN7.2
Rnor_6.01055,406,065 - 55,406,575NCBIRnor6.0
Rnor_5.01055,147,627 - 55,148,137UniSTSRnor5.0
RGSC_v3.41055,575,427 - 55,575,937UniSTSRGSC3.4
Celera1052,691,601 - 52,692,111UniSTS
Cytogenetic Map10q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 21 of 21 rows
RefSeq Transcripts NM_031520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB034800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC126877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF139055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF139899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ759430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U73303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENSRNOT00000065895   ⟹   ENSRNOP00000062744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,394,389 - 53,525,165 (+)Ensembl
Rnor_6.0 Ensembl1055,275,411 - 55,406,732 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105761   ⟹   ENSRNOP00000077816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,394,841 - 53,525,165 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107493   ⟹   ENSRNOP00000095410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,394,389 - 53,525,165 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109864   ⟹   ENSRNOP00000090090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,394,389 - 53,525,165 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113616   ⟹   ENSRNOP00000087937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,394,389 - 53,525,165 (+)Ensembl
RefSeq Acc Id: NM_031520   ⟹   NP_113708
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,893,264 - 54,024,032 (+)NCBI
mRatBN7.21053,394,389 - 53,525,167 (+)NCBI
Rnor_6.01055,275,411 - 55,406,734 (+)NCBI
Rnor_5.01055,017,110 - 55,148,300 (+)NCBI
RGSC_v3.41055,445,288 - 55,576,096 (+)RGD
Celera1052,561,720 - 52,692,270 (+)RGD
Sequence:
RefSeq Acc Id: XM_017597544   ⟹   XP_017453033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,891,955 - 54,023,950 (+)NCBI
mRatBN7.21053,393,901 - 53,523,654 (+)NCBI
Rnor_6.01055,274,910 - 55,406,738 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063269925   ⟹   XP_063125995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,894,229 - 54,023,950 (+)NCBI
RefSeq Acc Id: XM_063269926   ⟹   XP_063125996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,892,797 - 54,023,950 (+)NCBI
RefSeq Acc Id: XM_063269927   ⟹   XP_063125997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,892,797 - 54,023,950 (+)NCBI
RefSeq Acc Id: XM_063269928   ⟹   XP_063125998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,892,798 - 54,023,950 (+)NCBI
RefSeq Acc Id: XM_063269929   ⟹   XP_063125999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,894,229 - 54,023,950 (+)NCBI
1 to 5 of 12 rows
1 to 5 of 12 rows
RefSeq Acc Id: NP_113708   ⟸   NM_031520
- UniProtKB: Q9JLT0 (UniProtKB/Swiss-Prot),   A6HFL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453033   ⟸   XM_017597544
- Peptide Label: isoform X1
- UniProtKB: Q9JLT0 (UniProtKB/Swiss-Prot),   A0A8I6GLM0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062744   ⟸   ENSRNOT00000065895
Ensembl Acc Id: ENSRNOP00000087937   ⟸   ENSRNOT00000113616
Ensembl Acc Id: ENSRNOP00000077816   ⟸   ENSRNOT00000105761
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLT0-F1-model_v2 AlphaFold Q9JLT0 1-1976 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697299
Promoter ID:EPDNEW_R7822
Type:initiation region
Name:Myh10_1
Description:myosin heavy chain 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01055,275,500 - 55,275,560EPDNEW


1 to 40 of 50 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24626 BioCyc
Ensembl Genes ENSRNOG00000002886 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000065895 ENTREZGENE
  ENSRNOT00000105761 ENTREZGENE
  ENSRNOT00000107493 ENTREZGENE
  ENSRNOT00000109864 ENTREZGENE
  ENSRNOT00000113616 ENTREZGENE
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot
  1.10.287.1490 UniProtKB/Swiss-Prot
  1.20.5.340 UniProtKB/Swiss-Prot
  1.20.5.4820 UniProtKB/Swiss-Prot
  1.20.58.530 UniProtKB/Swiss-Prot
  2.30.30.360 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.2420 UniProtKB/Swiss-Prot
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  Myosin_head_motor_dom UniProtKB/Swiss-Prot
  Myosin_N UniProtKB/Swiss-Prot
  Myosin_S1_N UniProtKB/Swiss-Prot
  Myosin_tail UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:79433 UniProtKB/Swiss-Prot
NCBI Gene 79433 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/Swiss-Prot
  MYOSIN-10 UniProtKB/Swiss-Prot
Pfam Myosin_head UniProtKB/Swiss-Prot
  Myosin_N UniProtKB/Swiss-Prot
  Myosin_tail_1 UniProtKB/Swiss-Prot
  PF00612 UniProtKB/Swiss-Prot
PhenoGen Myh10 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  SH3_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002886 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot
  SM00015 UniProtKB/Swiss-Prot
Superfamily-SCOP Myosin rod fragments UniProtKB/Swiss-Prot
1 to 40 of 50 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Myh10  myosin heavy chain 10  Myh10  myosin, heavy chain 10, non-muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Myh10  myosin, heavy chain 10, non-muscle  Myh10  myosin, heavy polypeptide 10, non-muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Myh10  myosin, heavy polypeptide 10, non-muscle    myosin heavy chain 10, non-muscle  Name updated 1299863 APPROVED
2002-07-09 Myh10  myosin heavy chain 10, non-muscle      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference