Metap2 (methionyl aminopeptidase 2) - Rat Genome Database

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Gene: Metap2 (methionyl aminopeptidase 2) Rattus norvegicus
Analyze
Symbol: Metap2
Name: methionyl aminopeptidase 2
RGD ID: 70995
Description: Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in protein processing and regulation of translational initiation. Predicted to be active in cytoplasm. Orthologous to human METAP2 (methionyl aminopeptidase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Amp2; initiation factor 2 associated 67 kDa protein; initiation factor 2-associated 67 kDa glycoprotein; MAP 2; metAP 2; methionine aminopeptidase; methionine aminopeptidase 2; Mnpep; p67; p67eIF2; peptidase M 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Metap2-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,299,433 - 30,327,477 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl730,299,433 - 30,327,521 (-)EnsemblGRCr8
mRatBN7.2728,412,429 - 28,440,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,411,608 - 28,440,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx730,402,812 - 30,430,792 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,565,048 - 32,593,032 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,342,482 - 32,370,504 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,762,241 - 34,789,456 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,762,231 - 34,789,479 (-)Ensemblrn6Rnor6.0
Rnor_5.0734,821,214 - 34,848,430 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4730,974,071 - 31,001,641 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera725,509,781 - 25,535,670 (-)NCBICelera
RGSC_v3.1730,994,341 - 31,021,912 (-)NCBI
Cytogenetic Map7q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumagillin  (EXP,ISO)
furan  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
ivermectin  (ISO)
L-ethionine  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
Mesaconitine  (EXP)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nitroxoline  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pinosylvin  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
triazoles  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Gene Data Set MGD Curation, June 12, 2002
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67). Wu S, etal., J Biol Chem 1993 May 25;268(15):10796-81.
Additional References at PubMed
PMID:7644482   PMID:8858118   PMID:12581743   PMID:15102683   PMID:17446530   PMID:21033716   PMID:22658674  


Genomics

Comparative Map Data
Metap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,299,433 - 30,327,477 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl730,299,433 - 30,327,521 (-)EnsemblGRCr8
mRatBN7.2728,412,429 - 28,440,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,411,608 - 28,440,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx730,402,812 - 30,430,792 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,565,048 - 32,593,032 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,342,482 - 32,370,504 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,762,241 - 34,789,456 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,762,231 - 34,789,479 (-)Ensemblrn6Rnor6.0
Rnor_5.0734,821,214 - 34,848,430 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4730,974,071 - 31,001,641 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera725,509,781 - 25,535,670 (-)NCBICelera
RGSC_v3.1730,994,341 - 31,021,912 (-)NCBI
Cytogenetic Map7q13NCBI
METAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381295,474,152 - 95,515,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1295,473,520 - 95,515,839 (+)Ensemblhg38GRCh38
GRCh371295,867,928 - 95,909,615 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,391,953 - 94,433,746 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341294,370,389 - 94,410,587NCBI
Celera1295,538,718 - 95,580,736 (+)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1292,936,350 - 92,977,989 (+)NCBIHuRef
CHM1_11295,833,252 - 95,875,049 (+)NCBICHM1_1
T2T-CHM13v2.01295,455,178 - 95,496,879 (+)NCBIT2T-CHM13v2.0
Metap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,694,351 - 93,732,952 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,694,351 - 93,732,955 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381093,858,489 - 93,897,090 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,858,489 - 93,897,093 (-)Ensemblmm10GRCm38
MGSCv371093,321,234 - 93,353,947 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361093,288,288 - 93,321,001 (-)NCBIMGSCv36mm8
Celera1095,828,659 - 95,861,285 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.69NCBI
Metap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540531,942,427 - 31,976,678 (+)Ensembl
ChiLan1.0 EnsemblNW_00495541612,398,435 - 12,400,441 (-)Ensembl
ChiLan1.0NW_00495540531,942,427 - 31,976,678 (+)NCBIChiLan1.0ChiLan1.0
METAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210103,548,786 - 103,590,522 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112103,545,904 - 103,586,912 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01293,068,921 - 93,109,098 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,461,418 - 96,503,087 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,461,549 - 96,503,508 (+)EnsemblpanPan2panpan1.1
METAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,363,494 - 35,398,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,363,528 - 35,398,168 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1535,750,123 - 35,785,289 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01536,028,074 - 36,063,311 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,028,136 - 36,064,772 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,301,082 - 35,336,182 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,395,570 - 35,430,722 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01535,658,719 - 35,693,877 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Metap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,573,140 - 24,610,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650711,624,060 - 11,660,875 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650711,624,696 - 11,661,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,888,674 - 87,926,148 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1587,890,821 - 87,926,155 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2592,091,623 - 92,127,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
METAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11190,872,672 - 90,914,257 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1190,872,699 - 90,912,499 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037154,255,439 - 154,297,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Metap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475011,726,303 - 11,756,671 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Metap2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11172,943,069 - 172,972,600 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Metap2
310 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:172
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000030056, ENSRNOT00000031571
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
AW529792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2728,412,512 - 28,412,671 (+)MAPPERmRatBN7.2
Rnor_6.0734,761,972 - 34,762,130NCBIRnor6.0
Rnor_5.0734,820,945 - 34,821,103UniSTSRnor5.0
RGSC_v3.4730,973,802 - 30,973,960UniSTSRGSC3.4
Celera725,509,512 - 25,509,670UniSTS
RH 3.4 Map7192.1UniSTS
Cytogenetic Map7q13UniSTS
RH143662  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q13UniSTS
RH135833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21849,612,619 - 49,612,738 (+)MAPPERmRatBN7.2
mRatBN7.21233,108,263 - 233,108,380 (+)MAPPERmRatBN7.2
Rnor_6.01254,019,891 - 254,020,007NCBIRnor6.0
Rnor_6.01851,219,309 - 51,219,427NCBIRnor6.0
Rnor_5.01850,418,025 - 50,418,143UniSTSRnor5.0
Rnor_5.01261,237,751 - 261,237,867UniSTSRnor5.0
RGSC_v3.41239,602,208 - 239,602,324UniSTSRGSC3.4
RGSC_v3.41851,879,290 - 51,879,408UniSTSRGSC3.4
Celera1847,760,366 - 47,760,484UniSTS
Celera1230,211,792 - 230,211,908UniSTS
Cytogenetic Map7q13UniSTS
Cytogenetic Map1q53UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030056   ⟹   ENSRNOP00000032680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl730,299,433 - 30,327,448 (-)Ensembl
mRatBN7.2 Ensembl728,412,781 - 28,440,434 (-)Ensembl
Rnor_6.0 Ensembl734,762,656 - 34,789,370 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000031571   ⟹   ENSRNOP00000030415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl730,299,778 - 30,327,431 (-)Ensembl
mRatBN7.2 Ensembl728,412,773 - 28,440,434 (-)Ensembl
Rnor_6.0 Ensembl734,762,231 - 34,789,479 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110473   ⟹   ENSRNOP00000087571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl730,299,433 - 30,327,521 (-)Ensembl
mRatBN7.2 Ensembl728,411,608 - 28,440,434 (-)Ensembl
RefSeq Acc Id: NM_022539   ⟹   NP_071984
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,299,433 - 30,327,448 (-)NCBI
mRatBN7.2728,412,429 - 28,440,448 (-)NCBI
Rnor_6.0734,762,241 - 34,789,456 (-)NCBI
Rnor_5.0734,821,214 - 34,848,430 (-)NCBI
RGSC_v3.4730,974,071 - 31,001,641 (-)RGD
Celera725,509,781 - 25,535,670 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079853   ⟹   XP_038935781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,299,775 - 30,327,477 (-)NCBI
mRatBN7.2728,412,771 - 28,440,458 (-)NCBI
RefSeq Acc Id: XM_039079854   ⟹   XP_038935782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,299,775 - 30,327,463 (-)NCBI
mRatBN7.2728,412,771 - 28,440,458 (-)NCBI
RefSeq Acc Id: NP_071984   ⟸   NM_022539
- UniProtKB: P38062 (UniProtKB/Swiss-Prot),   Q5BKA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030415   ⟸   ENSRNOT00000031571
Ensembl Acc Id: ENSRNOP00000032680   ⟸   ENSRNOT00000030056
RefSeq Acc Id: XP_038935782   ⟸   XM_039079854
- Peptide Label: isoform X2
- UniProtKB: P38062 (UniProtKB/Swiss-Prot),   F7FJ19 (UniProtKB/TrEMBL),   Q6IRK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935781   ⟸   XM_039079853
- Peptide Label: isoform X1
- UniProtKB: P38062 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000087571   ⟸   ENSRNOT00000110473
Protein Domains
Peptidase M24

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38062-F1-model_v2 AlphaFold P38062 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695150
Promoter ID:EPDNEW_R5675
Type:initiation region
Name:Metap2_1
Description:methionyl aminopeptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0734,789,488 - 34,789,548EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70995 AgrOrtholog
BioCyc Gene G2FUF-34381 BioCyc
BioCyc Pathway PWY-7799 [Arg/N-end rule pathway (eukaryotic)] BioCyc
  PWY-7800 [Ac/N-end rule pathway] BioCyc
BioCyc Pathway Image PWY-7799 BioCyc
  PWY-7800 BioCyc
Ensembl Genes ENSRNOG00000021881 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000030056 ENTREZGENE
  ENSRNOT00000031571 ENTREZGENE
  ENSRNOT00000110473 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  3.90.230.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099147 IMAGE-MGC_LOAD
  IMAGE:7122560 IMAGE-MGC_LOAD
InterPro Creatinase/aminopeptidase-like UniProtKB/Swiss-Prot
  Met_Aminopeptidase_Type2 UniProtKB/Swiss-Prot
  Pept_M24 UniProtKB/Swiss-Prot
  Pept_M24_MAP UniProtKB/Swiss-Prot
  Pept_M24A_MAP2 UniProtKB/Swiss-Prot
  Pept_M24A_MAP2_BS UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:64370 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108689 IMAGE-MGC_LOAD
  MGC:91685 IMAGE-MGC_LOAD
NCBI Gene 64370 ENTREZGENE
PANTHER METHIONINE AMINOPEPTIDASE 2 UniProtKB/Swiss-Prot
  METHIONINE AMINOPEPTIDASE 2 UniProtKB/Swiss-Prot
Pfam Peptidase_M24 UniProtKB/Swiss-Prot
PhenoGen Metap2 PhenoGen
PRINTS MAPEPTIDASE UniProtKB/Swiss-Prot
PROSITE MAP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021881 RatGTEx
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
  SSF55920 UniProtKB/Swiss-Prot
UniProt A0A8I6A902_RAT UniProtKB/TrEMBL
  A6IFZ5_RAT UniProtKB/TrEMBL
  F1LRI8_RAT UniProtKB/TrEMBL
  F7FJ19 ENTREZGENE
  MAP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BKA1 ENTREZGENE, UniProtKB/TrEMBL
  Q6IRK1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Metap2  methionyl aminopeptidase 2  Metap2  methionine aminopeptidase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Metap2  methionine aminopeptidase 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a highly charged N-terminal region with two basic polylysine blocks and an acidic aspartic acid block 70793
gene_protein 480 amino acids 70793