Myo1b (myosin Ib) - Rat Genome Database

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Gene: Myo1b (myosin Ib) Rattus norvegicus
Analyze
Symbol: Myo1b
Name: myosin Ib
RGD ID: 70994
Description: Enables several functions, including actin filament binding activity; anion binding activity; and calmodulin binding activity. Involved in actin filament bundle assembly and actin filament-based movement. Located in several cellular components, including brush border; filopodium; and plasma membrane. Orthologous to human MYO1B (myosin IB); INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MMI-alpha; MMIa; myosin heavy chain myr 1; myosin I alpha; myosin-Ib; Myr1; unconventional myosin-Ib
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Myo1b_v2 ; Myo1b_v1 ; Myo1b_v3
Candidate Gene For: Vetf6
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8957,182,059 - 57,344,335 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl957,181,987 - 57,344,328 (+)EnsemblGRCr8
mRatBN7.2949,690,043 - 49,852,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx958,226,269 - 58,386,333 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,349,103 - 63,509,171 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,645,084 - 61,805,158 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,706,005 - 54,766,054 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,558,202 - 54,766,054 (+)Ensemblrn6Rnor6.0
Rnor_5.0954,267,753 - 54,414,264 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4946,756,678 - 46,917,169 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera947,338,666 - 47,497,975 (+)NCBICelera
RGSC_v3.1946,758,091 - 46,918,583 (+)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dimethylarsinous acid  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
erianin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
herbicide  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
malathion  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesotrione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phytoestrogen  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A model of stereocilia adaptation based on single molecule mechanical studies of myosin I. Batters C, etal., Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1895-905.
2. Ischemia disrupts myosin I beta in renal tubules. Boyd-White J, etal., Am J Physiol Cell Physiol 2001 Oct;281(4):C1326-35.
3. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. Chinthalapudi K, etal., J Biol Chem. 2011 Aug 26;286(34):29700-8. doi: 10.1074/jbc.M111.239210. Epub 2011 Jun 16.
4. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont RA, etal., J Assoc Res Otolaryngol 2002 Dec;3(4):375-89. Epub 2002 Feb 27.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Localization of myosin 1b to actin protrusions requires phosphoinositide binding. Komaba S and Coluccio LM, J Biol Chem. 2010 Sep 3;285(36):27686-93. doi: 10.1074/jbc.M109.087270. Epub 2010 Jul 7.
7. Control of myosin-I force sensing by alternative splicing. Laakso JM, etal., Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):698-702. doi: 10.1073/pnas.0911426107. Epub 2009 Dec 22.
8. Myosin surface loop 4 modulates inhibition of actomyosin 1b ATPase activity by tropomyosin. Lieto-Trivedi A, etal., Biochemistry. 2007 Mar 13;46(10):2779-86. Epub 2007 Feb 14.
9. Biochemical and motile properties of Myo1b splice isoforms. Lin T, etal., J Biol Chem. 2005 Dec 16;280(50):41562-7. Epub 2005 Oct 26.
10. Gene Data Set MGD Curation, June 12, 2002
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Identification, characterization and cloning of myr 1, a mammalian myosin-I. Ruppert C, etal., J Cell Biol 1993 Mar;120(6):1393-403.
14. Mammalian class I myosin, Myo1b, is monomeric and cross-links actin filaments as determined by hydrodynamic studies and electron microscopy. Stafford WF, etal., Biophys J. 2005 Jan;88(1):384-91. Epub 2004 Oct 8.
Additional References at PubMed
PMID:11208135   PMID:12490950   PMID:15980431   PMID:16219689   PMID:16981718   PMID:19056867   PMID:19199708   PMID:21666684   PMID:22114352   PMID:24625528   PMID:25468996   PMID:26195670  
PMID:26940917   PMID:33826361   PMID:33930467   PMID:35352799  


Genomics

Comparative Map Data
Myo1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8957,182,059 - 57,344,335 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl957,181,987 - 57,344,328 (+)EnsemblGRCr8
mRatBN7.2949,690,043 - 49,852,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx958,226,269 - 58,386,333 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,349,103 - 63,509,171 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,645,084 - 61,805,158 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,706,005 - 54,766,054 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,558,202 - 54,766,054 (+)Ensemblrn6Rnor6.0
Rnor_5.0954,267,753 - 54,414,264 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4946,756,678 - 46,917,169 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera947,338,666 - 47,497,975 (+)NCBICelera
RGSC_v3.1946,758,091 - 46,918,583 (+)NCBI
Cytogenetic Map9q22NCBI
MYO1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382191,245,404 - 191,425,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2191,245,064 - 191,425,820 (+)Ensemblhg38GRCh38
GRCh372192,110,130 - 192,290,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,818,375 - 191,998,287 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342191,935,635 - 192,115,548NCBI
Celera2185,704,728 - 185,884,766 (+)NCBICelera
Cytogenetic Map2q32.3NCBI
HuRef2183,969,542 - 184,149,826 (+)NCBIHuRef
CHM1_12192,115,938 - 192,295,960 (+)NCBICHM1_1
T2T-CHM13v2.02191,734,489 - 191,914,303 (+)NCBIT2T-CHM13v2.0
Myo1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39151,788,915 - 51,955,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl151,788,924 - 51,955,230 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38151,749,758 - 51,916,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl151,749,765 - 51,916,071 (-)Ensemblmm10GRCm38
MGSCv37151,806,609 - 51,972,818 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36151,694,310 - 51,860,497 (-)NCBIMGSCv36mm8
Celera152,287,894 - 52,454,494 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.58NCBI
Myo1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554037,826,058 - 7,966,624 (-)Ensembl
ChiLan1.0NW_0049554037,826,058 - 7,966,457 (-)NCBIChiLan1.0ChiLan1.0
MYO1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,929,632 - 94,109,104 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,944,469 - 94,124,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,549,494 - 78,728,819 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,465,078 - 196,644,188 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,465,078 - 196,644,188 (+)EnsemblpanPan2panpan1.1
MYO1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,748,287 - 1,921,360 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,747,974 - 1,920,349 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha372,693,497 - 2,869,182 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0371,632,808 - 1,808,623 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,632,819 - 1,808,620 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,642,176 - 1,819,468 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,610,548 - 1,786,134 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,638,672 - 1,814,273 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myo1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,833,909 - 150,005,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365066,832,670 - 7,004,273 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365066,832,132 - 7,004,262 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,874,412 - 96,066,990 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11595,874,398 - 96,066,408 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215107,300,243 - 107,411,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYO1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,773,372 - 76,951,006 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,773,042 - 76,951,235 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040122,527,490 - 122,705,871 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248544,738,061 - 4,896,030 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Myo1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14123,529,900 - 123,694,861 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Myo1b
1365 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:69
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000068433
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH124549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,851,840 - 49,852,063 (+)MAPPERmRatBN7.2
Rnor_6.0954,767,097 - 54,767,319NCBIRnor6.0
Rnor_6.0954,706,393 - 54,706,615NCBIRnor6.0
Rnor_5.0954,415,307 - 54,415,529UniSTSRnor5.0
Rnor_5.0954,473,434 - 54,473,656UniSTSRnor5.0
RGSC_v3.4946,918,212 - 46,918,434UniSTSRGSC3.4
Celera947,499,018 - 47,499,240UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 80 59 6 343 180 11 143 80 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001432365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000068433   ⟹   ENSRNOP00000061523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl957,182,014 - 57,344,328 (+)Ensembl
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
Rnor_6.0 Ensembl954,558,202 - 54,766,054 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098464   ⟹   ENSRNOP00000091336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl957,181,987 - 57,344,328 (+)Ensembl
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108379   ⟹   ENSRNOP00000095448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl957,182,014 - 57,344,328 (+)Ensembl
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114644   ⟹   ENSRNOP00000088031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl957,182,014 - 57,344,328 (+)Ensembl
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118845   ⟹   ENSRNOP00000082803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl957,182,014 - 57,344,328 (+)Ensembl
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
RefSeq Acc Id: NM_053986   ⟹   NP_446438
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,062 - 57,342,760 (+)NCBI
mRatBN7.2949,690,086 - 49,850,798 (+)NCBI
Rnor_6.0954,706,005 - 54,766,054 (+)NCBI
Rnor_5.0954,267,753 - 54,414,264 (+)NCBI
RGSC_v3.4946,756,678 - 46,917,169 (+)RGD
Celera947,338,666 - 47,497,975 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082950   ⟹   XP_038938878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
mRatBN7.2949,690,044 - 49,852,373 (+)NCBI
RefSeq Acc Id: XM_039082953   ⟹   XP_038938881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
mRatBN7.2949,690,045 - 49,852,373 (+)NCBI
RefSeq Acc Id: XM_039082955   ⟹   XP_038938883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
mRatBN7.2949,690,045 - 49,852,373 (+)NCBI
RefSeq Acc Id: XM_063266574   ⟹   XP_063122644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,204,144 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266575   ⟹   XP_063122645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266576   ⟹   XP_063122646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,204,144 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266577   ⟹   XP_063122647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,204,144 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266578   ⟹   XP_063122648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266579   ⟹   XP_063122649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,291,696 - 57,344,335 (+)NCBI
RefSeq Acc Id: NP_446438   ⟸   NM_053986
- UniProtKB: Q05096 (UniProtKB/Swiss-Prot),   A0A8I6GGN1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061523   ⟸   ENSRNOT00000068433
RefSeq Acc Id: XP_038938878   ⟸   XM_039082950
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938881   ⟸   XM_039082953
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038938883   ⟸   XM_039082955
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000095448   ⟸   ENSRNOT00000108379
Ensembl Acc Id: ENSRNOP00000088031   ⟸   ENSRNOT00000114644
Ensembl Acc Id: ENSRNOP00000091336   ⟸   ENSRNOT00000098464
Ensembl Acc Id: ENSRNOP00000082803   ⟸   ENSRNOT00000118845
RefSeq Acc Id: XP_063122645   ⟸   XM_063266575
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122648   ⟸   XM_063266578
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063122644   ⟸   XM_063266574
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122646   ⟸   XM_063266576
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122647   ⟸   XM_063266577
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AFE5 (UniProtKB/TrEMBL),   A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122649   ⟸   XM_063266579
- Peptide Label: isoform X8
Protein Domains
IQ   Myosin motor   TH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05096-F1-model_v2 AlphaFold Q05096 1-1136 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70994 AgrOrtholog
BioCyc Gene G2FUF-27603 BioCyc
Ensembl Genes ENSRNOG00000048152 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068433 ENTREZGENE
  ENSRNOT00000068433.4 UniProtKB/Swiss-Prot
  ENSRNOT00000098464 ENTREZGENE
  ENSRNOT00000108379 ENTREZGENE
  ENSRNOT00000118845 ENTREZGENE
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot
  1.20.5.190 UniProtKB/Swiss-Prot
  1.20.58.530 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  6.20.240.20 UniProtKB/Swiss-Prot
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  Myosin_head_motor_dom UniProtKB/Swiss-Prot
  Myosin_TH1 UniProtKB/Swiss-Prot
  MYSc_Myo1 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:117057 UniProtKB/Swiss-Prot
NCBI Gene 117057 ENTREZGENE
PANTHER MYOSIN UniProtKB/Swiss-Prot
  UNCONVENTIONAL MYOSIN-IB UniProtKB/Swiss-Prot
Pfam Myosin_head UniProtKB/Swiss-Prot
  Myosin_TH1 UniProtKB/Swiss-Prot
  PF00612 UniProtKB/Swiss-Prot
PhenoGen Myo1b PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  TH1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000048152 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot
  SM00015 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6AFE5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7W8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GGN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLM5 ENTREZGENE, UniProtKB/TrEMBL
  A6INX0_RAT UniProtKB/TrEMBL
  MYO1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Myo1b  myosin Ib      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the brush border of the proximal tubules 628448
gene_domains has 3 domains; the NH2 terminus is a 70-80 kDa region which has the actin and ATP binding site, an alpha helical neck containing 1-6 isoleucine-glutamine motifs and the carboxyl end domain comprised of amino acids that can interact with acidic phospholipi 628448
gene_function acts as an actin based motor 628448
gene_homology has sequence similarity to myosin-1 motor domains 70796
gene_process involved in the transportation of proteins into and throughout the brush border 628448
gene_process plays a role in endocytosis and intracellular trafficking 628448
gene_product member of the myosin superfamily 628448
gene_transcript alternative splice forms myr 1a, myr 1b, and myr 1c vary in their number of potential calmodulin/light chain binding sites 70796