Flot2 (flotillin 2) - Rat Genome Database

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Gene: Flot2 (flotillin 2) Rattus norvegicus
Analyze
Symbol: Flot2
Name: flotillin 2
RGD ID: 70993
Description: Enables ionotropic glutamate receptor binding activity and protease binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of canonical NF-kappaB signal transduction; and protein localization to cell periphery. Located in caveola. Part of flotillin complex. Is active in glutamatergic synapse and presynaptic active zone membrane. Orthologous to human FLOT2 (flotillin 2); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: flotillin-2; MGC93331; REG-1; reggie-1; reggie1-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,424,084 - 63,445,811 (+)NCBIGRCr8
mRatBN7.21062,926,047 - 62,947,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,920,665 - 62,947,756 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,557,437 - 67,579,161 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,062,800 - 67,084,524 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,534,264 - 62,556,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,304,901 - 65,329,332 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,304,902 - 65,329,312 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,303,072 - 66,327,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,081,463 - 64,104,166 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,095,085 - 64,117,788 (+)NCBI
Celera1061,904,365 - 61,926,029 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Flotillins bind to the dileucine sorting motif of beta-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting. John BA, etal., FEBS J. 2014 Apr;281(8):2074-87. doi: 10.1111/febs.12763. Epub 2014 Mar 6.
5. Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons. Lang DM, etal., J Neurobiol 1998 Dec;37(4):502-23.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Association of membrane rafts and postsynaptic density: proteomics, biochemical, and ultrastructural analyses. Suzuki T, etal., J Neurochem. 2011 Oct;119(1):64-77. doi: 10.1111/j.1471-4159.2011.07404.x. Epub 2011 Aug 22.
12. NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. Swanwick CC, etal., FEBS Lett. 2009 Apr 17;583(8):1226-30. Epub 2009 Mar 17.
Additional References at PubMed
PMID:9153235   PMID:12477932   PMID:12927782   PMID:12967676   PMID:14599293   PMID:15886206   PMID:16452278   PMID:17206938   PMID:17416589   PMID:17482312   PMID:18237819   PMID:19056867  
PMID:19144954   PMID:19258392   PMID:19946888   PMID:20458337   PMID:20682791   PMID:21119006   PMID:21187433   PMID:21423176   PMID:21696602   PMID:22878913   PMID:23174179   PMID:23319823  
PMID:23376485   PMID:23533145   PMID:23983584   PMID:24013648   PMID:24046456   PMID:25105415   PMID:25204797   PMID:27676653   PMID:27993509   PMID:30452906   PMID:35352799  


Genomics

Comparative Map Data
Flot2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,424,084 - 63,445,811 (+)NCBIGRCr8
mRatBN7.21062,926,047 - 62,947,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,920,665 - 62,947,756 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,557,437 - 67,579,161 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,062,800 - 67,084,524 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,534,264 - 62,556,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,304,901 - 65,329,332 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,304,902 - 65,329,312 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,303,072 - 66,327,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,081,463 - 64,104,166 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,095,085 - 64,117,788 (+)NCBI
Celera1061,904,365 - 61,926,029 (+)NCBICelera
Cytogenetic Map10q25NCBI
FLOT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,879,339 - 28,897,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,879,335 - 28,897,733 (-)EnsemblGRCh38hg38GRCh38
GRCh371727,206,357 - 27,224,751 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,230,483 - 24,248,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 341724,230,483 - 24,248,696NCBI
Celera1724,065,775 - 24,084,131 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1723,414,667 - 23,432,931 (-)NCBIHuRef
CHM1_11727,268,892 - 27,287,277 (-)NCBICHM1_1
T2T-CHM13v2.01729,822,120 - 29,840,508 (-)NCBIT2T-CHM13v2.0
Flot2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,928,757 - 77,951,260 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1177,928,757 - 77,951,260 (+)EnsemblGRCm39 Ensembl
GRCm381178,037,931 - 78,060,434 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,037,931 - 78,060,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,851,443 - 77,873,934 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,856,499 - 77,876,627 (+)NCBIMGSCv36mm8
Celera1185,537,567 - 85,560,033 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Flot2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,276,860 - 4,298,523 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,276,847 - 4,298,523 (+)NCBIChiLan1.0ChiLan1.0
FLOT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21935,559,750 - 35,578,101 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,440,913 - 37,459,263 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01727,876,424 - 27,894,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,385,192 - 28,403,523 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,385,191 - 28,405,585 (+)Ensemblpanpan1.1panPan2
DHRS13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1943,050,929 - 43,066,886 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl943,052,114 - 43,071,742 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha942,206,071 - 42,222,098 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,868,682 - 43,884,709 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,868,682 - 43,884,742 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,652,184 - 42,668,203 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,944,151 - 42,960,172 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0943,022,851 - 43,038,879 (-)NCBIUU_Cfam_GSD_1.0
Flot2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560242,193,601 - 42,212,358 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365385,071,546 - 5,090,313 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365385,071,546 - 5,090,287 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLOT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1245,101,531 - 45,120,455 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11245,102,205 - 45,120,503 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,153,539 - 47,163,743 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLOT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,639,403 - 22,658,311 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,639,381 - 22,658,194 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660757,449,441 - 7,468,230 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flot2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,450,234 - 1,465,102 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,449,001 - 1,465,208 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flot2
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:812
Count of miRNA genes:203
Interacting mature miRNAs:237
Transcripts:ENSRNOT00000014104, ENSRNOT00000014118
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106134541366743655Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat

Markers in Region
AI548110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21062,925,791 - 62,925,948 (-)MAPPERmRatBN7.2
Rnor_6.01065,329,411 - 65,329,567NCBIRnor6.0
Rnor_5.01066,303,354 - 66,303,510UniSTSRnor5.0
RGSC_v3.41064,081,046 - 64,081,341UniSTSRGSC3.4
Celera1061,904,110 - 61,904,266UniSTS
Cytogenetic Map10q25UniSTS
RH138487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21062,942,983 - 62,943,103 (-)MAPPERmRatBN7.2
Rnor_6.01065,309,552 - 65,309,671NCBIRnor6.0
Rnor_5.01066,322,980 - 66,323,099UniSTSRnor5.0
RGSC_v3.41064,099,584 - 64,099,703UniSTSRGSC3.4
Celera1061,921,255 - 61,921,374UniSTS
Cytogenetic Map10q25UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 40 19 40 8 11 74 35 36 11 8
Low 1 1 1 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF023302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF023303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF023304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB581049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U64999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014104   ⟹   ENSRNOP00000014104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1062,926,020 - 62,947,756 (+)Ensembl
Rnor_6.0 Ensembl1065,304,902 - 65,329,312 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000014118   ⟹   ENSRNOP00000014118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1062,920,665 - 62,947,756 (+)Ensembl
Rnor_6.0 Ensembl1065,304,902 - 65,329,312 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078757   ⟹   ENSRNOP00000070199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1062,926,047 - 62,947,756 (+)Ensembl
Rnor_6.0 Ensembl1065,304,902 - 65,329,312 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088721   ⟹   ENSRNOP00000071636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1062,920,665 - 62,947,756 (+)Ensembl
Rnor_6.0 Ensembl1065,304,904 - 65,329,279 (-)Ensembl
RefSeq Acc Id: NM_001270800   ⟹   NP_001257729
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,424,100 - 63,445,811 (+)NCBI
mRatBN7.21062,926,047 - 62,947,759 (+)NCBI
Rnor_6.01065,304,901 - 65,329,312 (-)NCBI
Rnor_5.01066,303,072 - 66,327,750 (+)NCBI
Celera1061,904,365 - 61,926,029 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270801   ⟹   NP_001257730
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,424,100 - 63,445,811 (+)NCBI
mRatBN7.21062,926,047 - 62,947,759 (+)NCBI
Rnor_6.01065,304,901 - 65,329,312 (-)NCBI
Rnor_5.01066,303,072 - 66,327,750 (+)NCBI
Celera1061,904,365 - 61,926,029 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031830   ⟹   NP_114018
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,424,100 - 63,445,811 (+)NCBI
mRatBN7.21062,926,047 - 62,947,759 (+)NCBI
Rnor_6.01065,304,901 - 65,329,312 (-)NCBI
Rnor_5.01066,303,072 - 66,327,750 (+)NCBI
RGSC_v3.41064,081,463 - 64,104,166 (+)RGD
Celera1061,904,365 - 61,926,029 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073076
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,424,100 - 63,445,811 (+)NCBI
mRatBN7.21062,926,047 - 62,947,759 (+)NCBI
Rnor_6.01065,304,901 - 65,329,312 (-)NCBI
Rnor_5.01066,303,072 - 66,327,750 (+)NCBI
Celera1061,904,365 - 61,926,029 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073077
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,424,100 - 63,445,811 (+)NCBI
mRatBN7.21062,926,047 - 62,947,759 (+)NCBI
Rnor_6.01065,304,901 - 65,329,312 (-)NCBI
Rnor_5.01066,303,072 - 66,327,750 (+)NCBI
Celera1061,904,365 - 61,926,029 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597552   ⟹   XP_017453041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,424,128 - 63,445,811 (+)NCBI
mRatBN7.21062,926,072 - 62,947,759 (+)NCBI
Rnor_6.01065,304,901 - 65,329,239 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063269972   ⟹   XP_063126042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,424,084 - 63,445,811 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_114018   ⟸   NM_031830
- Peptide Label: isoform 1
- UniProtKB: A6HH00 (UniProtKB/TrEMBL),   A6HH02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257729   ⟸   NM_001270800
- Peptide Label: isoform 2
- UniProtKB: Q9QX33 (UniProtKB/Swiss-Prot),   Q9Z2S8 (UniProtKB/Swiss-Prot),   Q9Z2S9 (UniProtKB/Swiss-Prot),   A6HH01 (UniProtKB/TrEMBL),   A6HH02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257730   ⟸   NM_001270801
- Peptide Label: isoform 3
- UniProtKB: A0A0G2JXA8 (UniProtKB/TrEMBL),   A6HH03 (UniProtKB/TrEMBL),   A6HH02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453041   ⟸   XM_017597552
- Peptide Label: isoform X2
- UniProtKB: Q5XIW9 (UniProtKB/TrEMBL),   A6HH02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014104   ⟸   ENSRNOT00000014104
RefSeq Acc Id: ENSRNOP00000014118   ⟸   ENSRNOT00000014118
RefSeq Acc Id: ENSRNOP00000070199   ⟸   ENSRNOT00000078757
RefSeq Acc Id: ENSRNOP00000071636   ⟸   ENSRNOT00000088721
RefSeq Acc Id: XP_063126042   ⟸   XM_063269972
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXA8 (UniProtKB/TrEMBL),   A6HH03 (UniProtKB/TrEMBL)
Protein Domains
Band

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2S9-F1-model_v2 AlphaFold Q9Z2S9 1-428 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697474
Promoter ID:EPDNEW_R7988
Type:initiation region
Name:Flot2_1
Description:flotillin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01065,329,269 - 65,329,329EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70993 AgrOrtholog
BioCyc Gene G2FUF-24102 BioCyc
Ensembl Genes ENSRNOG00000009681 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014104.8 UniProtKB/TrEMBL
  ENSRNOT00000014118 ENTREZGENE
  ENSRNOT00000014118.8 UniProtKB/TrEMBL
  ENSRNOT00000078757 ENTREZGENE
  ENSRNOT00000078757.2 UniProtKB/TrEMBL
  ENSRNOT00000088721 ENTREZGENE
  ENSRNOT00000088721.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133999 IMAGE-MGC_LOAD
InterPro Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flotillin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flotillin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83764 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93331 IMAGE-MGC_LOAD
NCBI Gene 83764 ENTREZGENE
PANTHER FLOTILLIN-1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13806 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Flot2 PhenoGen
RatGTEx ENSRNOG00000009681 RatGTEx
SMART PHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JXA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K0Z1_RAT UniProtKB/TrEMBL
  A0A8L2Q6M6_RAT UniProtKB/TrEMBL
  A0A8L2Q6P0_RAT UniProtKB/TrEMBL
  A6HH00 ENTREZGENE, UniProtKB/TrEMBL
  A6HH01 ENTREZGENE, UniProtKB/TrEMBL
  A6HH02 ENTREZGENE, UniProtKB/TrEMBL
  A6HH03 ENTREZGENE, UniProtKB/TrEMBL
  FLOT2_RAT UniProtKB/Swiss-Prot
  Q5XIW9 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX33 ENTREZGENE
  Q9Z2S8 ENTREZGENE
  Q9Z2S9 ENTREZGENE
UniProt Secondary Q9QX33 UniProtKB/Swiss-Prot
  Q9Z2S8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Flot2  flotillin 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization enriched at the plasmamembrane and in micropatches in neurons and in nonneuronal cells 70739