Flot1 (flotillin 1) - Rat Genome Database

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Gene: Flot1 (flotillin 1) Rattus norvegicus
Analyze
Symbol: Flot1
Name: flotillin 1
RGD ID: 70991
Description: Enables ionotropic glutamate receptor binding activity and protease binding activity. Predicted to be involved in several processes, including positive regulation of cell communication; positive regulation of cell-cell adhesion; and positive regulation of cellular component organization. Predicted to act upstream of with a positive effect on plasma membrane raft organization. Predicted to act upstream of or within axonogenesis and regulation of Rho protein signal transduction. Located in caveola. Part of flotillin complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone. Orthologous to human FLOT1 (flotillin 1); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: flotillin-1; Rareg; REG-2; reggie-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,922,662 - 2,932,906 (-)NCBIGRCr8
mRatBN7.2202,917,864 - 2,927,993 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,917,137 - 2,927,978 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,969,295 - 2,979,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,974,276 - 2,984,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,000,638 - 3,010,732 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,427,890 - 3,438,418 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,427,880 - 3,438,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,524,708 - 5,535,232 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,065,792 - 3,076,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,066,008 - 3,169,167 (-)NCBI
Celera20343,778 - 353,887 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
aconitine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
lovastatin  (ISO)
methidathion  (ISO)
microcystin RR  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
oleic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pravastatin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Flotillins bind to the dileucine sorting motif of beta-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting. John BA, etal., FEBS J. 2014 Apr;281(8):2074-87. doi: 10.1111/febs.12763. Epub 2014 Mar 6.
5. Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue. Kokubo H, etal., Brain Res. 2003 Mar 7;965(1-2):83-90.
6. Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons. Lang DM, etal., J Neurobiol 1998 Dec;37(4):502-23.
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Flotillin-1 promotes formation of glutamatergic synapses in hippocampal neurons. Swanwick CC, etal., Dev Neurobiol. 2010 Nov;70(13):875-83. doi: 10.1002/dneu.20828.
14. NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. Swanwick CC, etal., FEBS Lett. 2009 Apr 17;583(8):1226-30. Epub 2009 Mar 17.
15. Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. Volonte D, etal., Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H392-401. Epub 2007 Nov 2.
Additional References at PubMed
PMID:8889548   PMID:9153235   PMID:11001060   PMID:12370178   PMID:12388596   PMID:12967676   PMID:14581507   PMID:15469992   PMID:15545008   PMID:15934946   PMID:16455755   PMID:16785509  
PMID:17206938   PMID:17218121   PMID:17482312   PMID:17897319   PMID:18000879   PMID:18155272   PMID:18850735   PMID:19056867   PMID:19144954   PMID:19458231   PMID:19946888   PMID:20458337  
PMID:20600927   PMID:20682791   PMID:21119006   PMID:21187433   PMID:21399631   PMID:21413931   PMID:21423176   PMID:21696602   PMID:21700703   PMID:23319823   PMID:23376485   PMID:23533145  
PMID:23983584   PMID:24046456   PMID:24377861   PMID:25204797   PMID:25429154   PMID:25468996   PMID:25732136   PMID:25893292   PMID:27676653   PMID:30452906   PMID:35352799  


Genomics

Comparative Map Data
Flot1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,922,662 - 2,932,906 (-)NCBIGRCr8
mRatBN7.2202,917,864 - 2,927,993 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,917,137 - 2,927,978 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,969,295 - 2,979,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,974,276 - 2,984,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,000,638 - 3,010,732 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,427,890 - 3,438,418 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,427,880 - 3,438,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,524,708 - 5,535,232 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,065,792 - 3,076,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,066,008 - 3,169,167 (-)NCBI
Celera20343,778 - 353,887 (-)NCBICelera
Cytogenetic Map20p12NCBI
FLOT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,727,709 - 30,742,687 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,727,709 - 30,742,732 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,695,486 - 30,710,464 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,803,490 - 30,818,432 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,803,491 - 30,818,432NCBI
Celera632,293,643 - 32,308,593 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,495,459 - 30,510,242 (-)NCBIHuRef
CHM1_1630,697,639 - 30,712,561 (-)NCBICHM1_1
T2T-CHM13v2.0630,591,911 - 30,606,890 (-)NCBIT2T-CHM13v2.0
Flot1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,134,243 - 36,143,674 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,134,122 - 36,143,683 (+)EnsemblGRCm39 Ensembl
GRCm381735,823,320 - 35,832,789 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,823,230 - 35,832,791 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,960,302 - 35,969,732 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,431,410 - 35,440,840 (+)NCBIMGSCv36mm8
Celera1739,333,424 - 39,342,847 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
Flot1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583713,560 - 729,924 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955583717,246 - 729,924 (-)NCBIChiLan1.0ChiLan1.0
FLOT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,288,663 - 45,303,454 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,251,507 - 41,266,371 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,472,839 - 30,487,809 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,342,026 - 31,357,505 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,342,033 - 31,357,559 (-)Ensemblpanpan1.1panPan2
FLOT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112517,941 - 528,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12516,032 - 528,637 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12655,207 - 665,931 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012661,078 - 671,802 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12656,880 - 671,882 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112519,006 - 529,724 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012587,853 - 598,598 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012656,440 - 667,178 (-)NCBIUU_Cfam_GSD_1.0
Flot1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494634,021,923 - 34,035,815 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837380,288 - 401,071 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837387,012 - 401,076 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLOT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,253,162 - 23,265,106 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,253,157 - 23,265,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,975,124 - 26,987,109 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLOT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,714,354 - 41,725,820 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,714,402 - 41,725,397 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604430,425,408 - 30,437,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flot1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,992,929 - 25,003,759 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,992,961 - 25,000,463 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flot1
103 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000001098
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
D20Yum36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,923,662 - 2,924,126 (+)MAPPERmRatBN7.2
mRatBN7.2202,923,970 - 2,924,126 (+)MAPPERmRatBN7.2
Rnor_6.0203,433,998 - 3,434,548NCBIRnor6.0
Rnor_6.0203,434,393 - 3,434,548NCBIRnor6.0
Rnor_5.0205,531,211 - 5,531,366UniSTSRnor5.0
Rnor_5.0205,530,816 - 5,531,366UniSTSRnor5.0
RGSC_v3.4203,071,900 - 3,072,055UniSTSRGSC3.4
Celera20349,883 - 350,038UniSTS
Cytogenetic Map20p12UniSTS
RH129082  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,917,909 - 2,918,078 (+)MAPPERmRatBN7.2
Rnor_6.0203,427,936 - 3,428,104NCBIRnor6.0
Rnor_5.0205,524,754 - 5,524,922UniSTSRnor5.0
RGSC_v3.4203,065,838 - 3,066,006UniSTSRGSC3.4
Celera20343,824 - 343,992UniSTS
RH 3.4 Map2052.42UniSTS
Cytogenetic Map20p12UniSTS
RH131920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,928,448 - 2,928,631 (+)MAPPERmRatBN7.2
Rnor_6.0203,438,869 - 3,439,051NCBIRnor6.0
Rnor_5.0205,535,687 - 5,535,869UniSTSRnor5.0
RGSC_v3.4203,076,639 - 3,076,821UniSTSRGSC3.4
Celera20354,360 - 354,542UniSTS
RH 3.4 Map2052.72UniSTS
Cytogenetic Map20p12UniSTS
RH140901  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,917,863 - 2,918,014 (+)MAPPERmRatBN7.2
Rnor_6.0203,427,890 - 3,428,040NCBIRnor6.0
Rnor_5.0205,524,708 - 5,524,858UniSTSRnor5.0
RGSC_v3.4203,065,792 - 3,065,942UniSTSRGSC3.4
Celera20343,778 - 343,928UniSTS
RH 3.4 Map2052.32UniSTS
Cytogenetic Map20p12UniSTS
UniSTS:496739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,928,940 - 2,929,042 (+)MAPPERmRatBN7.2
Rnor_6.0203,439,361 - 3,439,462NCBIRnor6.0
Rnor_5.0205,536,179 - 5,536,280UniSTSRnor5.0
RGSC_v3.4203,077,131 - 3,077,232UniSTSRGSC3.4
Celera20354,852 - 354,953UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001098   ⟹   ENSRNOP00000001098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl202,917,864 - 2,927,976 (-)Ensembl
Rnor_6.0 Ensembl203,427,892 - 3,438,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,427,892 - 3,430,085 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,427,893 - 3,428,625 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl202,917,857 - 2,927,678 (-)Ensembl
Rnor_6.0 Ensembl203,427,880 - 3,438,098 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090039   ⟹   ENSRNOP00000071275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl202,917,864 - 2,927,976 (-)Ensembl
Rnor_6.0 Ensembl203,427,890 - 3,438,396 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091945   ⟹   ENSRNOP00000068968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl202,917,137 - 2,927,978 (-)Ensembl
Rnor_6.0 Ensembl203,435,966 - 3,438,360 (-)Ensembl
RefSeq Acc Id: NM_022701   ⟹   NP_073192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,922,662 - 2,932,771 (-)NCBI
mRatBN7.2202,917,864 - 2,927,976 (-)NCBI
Rnor_6.0203,427,890 - 3,438,396 (-)NCBI
Rnor_5.0205,524,708 - 5,535,232 (-)NCBI
RGSC_v3.4203,065,792 - 3,076,166 (-)RGD
Celera20343,778 - 353,887 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256024   ⟹   XP_006256086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,922,664 - 2,932,906 (-)NCBI
mRatBN7.2202,917,864 - 2,927,993 (-)NCBI
Rnor_6.0203,427,890 - 3,438,418 (-)NCBI
Rnor_5.0205,524,708 - 5,535,232 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063279497   ⟹   XP_063135567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,922,664 - 2,932,305 (-)NCBI
RefSeq Acc Id: XM_063279499   ⟹   XP_063135569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,922,664 - 2,932,274 (-)NCBI
RefSeq Acc Id: NP_073192   ⟸   NM_022701
- UniProtKB: Q9Z1E2 (UniProtKB/Swiss-Prot),   Q9Z1E1 (UniProtKB/Swiss-Prot),   A6KT86 (UniProtKB/TrEMBL),   A0A8L2PZR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256086   ⟸   XM_006256024
- Peptide Label: isoform X1
- UniProtKB: Q9Z1E2 (UniProtKB/Swiss-Prot),   Q9Z1E1 (UniProtKB/Swiss-Prot),   A6KT86 (UniProtKB/TrEMBL),   A0A8L2PZR2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071275   ⟸   ENSRNOT00000090039
Ensembl Acc Id: ENSRNOP00000068968   ⟸   ENSRNOT00000091945
Ensembl Acc Id: ENSRNOP00000001098   ⟸   ENSRNOT00000001098
RefSeq Acc Id: XP_063135567   ⟸   XM_063279497
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135569   ⟸   XM_063279499
- Peptide Label: isoform X3
Protein Domains
Band

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1E1-F1-model_v2 AlphaFold Q9Z1E1 1-428 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701306
Promoter ID:EPDNEW_R11825
Type:initiation region
Name:Flot1_1
Description:flotillin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,438,341 - 3,438,401EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70991 AgrOrtholog
BioCyc Gene G2FUF-4776 BioCyc
Ensembl Genes ENSRNOG00000000826 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006849 UniProtKB/Swiss-Prot
  ENSRNOG00060003581 UniProtKB/Swiss-Prot
  ENSRNOG00065029686 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001098.5 UniProtKB/TrEMBL
  ENSRNOT00000083657.2 UniProtKB/Swiss-Prot
  ENSRNOT00000090039.2 UniProtKB/Swiss-Prot
  ENSRNOT00000091945.2 UniProtKB/TrEMBL
  ENSRNOT00055011285 UniProtKB/Swiss-Prot
  ENSRNOT00060005876 UniProtKB/Swiss-Prot
  ENSRNOT00065051307 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598180 IMAGE-MGC_LOAD
InterPro Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flotillin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flotillin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72438 IMAGE-MGC_LOAD
NCBI Gene 64665 ENTREZGENE
PANTHER FLOTILLIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13806 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Flot1 PhenoGen
RatGTEx ENSRNOG00000000826 RatGTEx
  ENSRNOG00055006849 RatGTEx
  ENSRNOG00060003581 RatGTEx
  ENSRNOG00065029686 RatGTEx
SMART PHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JU52_RAT UniProtKB/TrEMBL
  A0A8L2PZR2 ENTREZGENE, UniProtKB/TrEMBL
  A6KT86 ENTREZGENE, UniProtKB/TrEMBL
  FLOT1_RAT UniProtKB/Swiss-Prot
  Q6MG17_RAT UniProtKB/TrEMBL
  Q9Z1E1 ENTREZGENE
  Q9Z1E2 ENTREZGENE
UniProt Secondary Q9Z1E2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Flot1  flotillin 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization enriched at the plasma membrane, micropatches in neurons and in nonneuronal cells 70739
gene_mapping found within the rat major histocompatibility RT1 complex 1300431