Mapk12 (mitogen-activated protein kinase 12) - Rat Genome Database

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Gene: Mapk12 (mitogen-activated protein kinase 12) Rattus norvegicus
Analyze
Symbol: Mapk12
Name: mitogen-activated protein kinase 12
RGD ID: 70975
Description: Enables ATP binding activity and MAP kinase activity. Involved in negative regulation of cell cycle. Located in cytoplasm. Orthologous to human MAPK12 (mitogen-activated protein kinase 12); PARTICIPATES IN p38 MAPK signaling pathway; amyotrophic lateral sclerosis pathway; Chagas disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ERK-6; extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; MGC156834; mitogen-activated protein kinase p38 gamma; SAP kinase-3; Sapk3; stress-activated protein kinase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,085,647 - 122,096,307 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7122,085,913 - 122,096,307 (-)EnsemblGRCr8
mRatBN7.27120,206,005 - 120,216,711 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,206,271 - 120,216,664 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7121,957,298 - 121,967,689 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,183,463 - 124,193,852 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,146,469 - 124,156,860 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,109,214 - 130,120,918 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,109,663 - 130,120,579 (-)Ensemblrn6Rnor6.0
Rnor_5.07129,795,269 - 129,805,662 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47127,430,881 - 127,441,274 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7116,680,166 - 116,690,559 (-)NCBICelera
RGSC_v3.17127,465,110 - 127,475,504 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amsacrine  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucitol  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
etoposide  (ISO)
formononetin  (ISO)
lapatinib  (ISO)
lipopolysaccharide  (ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (ISO)
monosodium L-glutamate  (EXP)
myristicin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel dichloride  (EXP)
nilotinib  (ISO)
Nonylphenol  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
xanthohumol  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IDA,IEA)
mitochondrion  (IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells. Conrad PW, etal., J Biol Chem. 1999 Aug 13;274(33):23570-6.
2. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3). Court NW, etal., J Mol Cell Cardiol 2002 Apr;34(4):413-26.
3. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. Hasegawa M, etal., J Biol Chem. 1999 Apr 30;274(18):12626-31.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. Mertens S, etal., FEBS Lett 1996 Apr 1;383(3):273-6.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2. Sabio G, etal., Biochem J 2004 May 15;380(Pt 1):19-30.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. Yin J, etal., J Pineal Res. 2006 Sep;41(2):124-9.
Additional References at PubMed
PMID:8633070   PMID:9199504   PMID:10508788   PMID:12788083   PMID:15158451   PMID:15729360   PMID:15850461   PMID:15878399   PMID:27574735   PMID:31505169   PMID:34814904  


Genomics

Comparative Map Data
Mapk12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,085,647 - 122,096,307 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7122,085,913 - 122,096,307 (-)EnsemblGRCr8
mRatBN7.27120,206,005 - 120,216,711 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,206,271 - 120,216,664 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7121,957,298 - 121,967,689 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,183,463 - 124,193,852 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,146,469 - 124,156,860 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,109,214 - 130,120,918 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,109,663 - 130,120,579 (-)Ensemblrn6Rnor6.0
Rnor_5.07129,795,269 - 129,805,662 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47127,430,881 - 127,441,274 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7116,680,166 - 116,690,559 (-)NCBICelera
RGSC_v3.17127,465,110 - 127,475,504 (-)NCBI
Cytogenetic Map7q34NCBI
MAPK12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,252,901 - 50,261,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,245,450 - 50,261,734 (-)Ensemblhg38GRCh38
GRCh372250,691,330 - 50,700,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,033,458 - 49,042,216 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342248,993,787 - 49,002,546NCBI
Celera2234,566,234 - 34,574,992 (-)NCBICelera
Cytogenetic Map22q13.33NCBI
HuRef2233,590,177 - 33,594,692 (-)NCBIHuRef
CHM1_12250,650,085 - 50,658,843 (-)NCBICHM1_1
T2T-CHM13v2.02250,759,904 - 50,768,686 (-)NCBIT2T-CHM13v2.0
Mapk12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,014,787 - 89,025,270 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,014,787 - 89,024,906 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381589,130,584 - 89,141,577 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,130,584 - 89,140,703 (-)Ensemblmm10GRCm38
MGSCv371588,961,014 - 88,971,133 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361588,958,350 - 88,968,376 (-)NCBIMGSCv36mm8
Celera1591,259,147 - 91,269,271 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.65NCBI
Mapk12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,279,344 - 33,286,422 (-)Ensembl
ChiLan1.0NW_00495541333,278,913 - 33,285,920 (-)NCBIChiLan1.0ChiLan1.0
MAPK12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,159,076 - 60,167,863 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12262,845,236 - 62,854,000 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,481,898 - 30,490,769 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,481,263 - 49,489,600 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2249,481,763 - 49,489,599 (-)EnsemblpanPan2panpan1.1
MAPK12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,986,828 - 16,994,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,986,828 - 16,994,937 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1016,964,857 - 16,973,137 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01017,713,650 - 17,721,939 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,713,717 - 17,721,934 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,437,731 - 17,446,013 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,761,009 - 17,769,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,893,208 - 17,901,489 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mapk12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945552,302 - 560,245 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936629552,296 - 560,461 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936629552,302 - 560,245 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5429,770 - 437,975 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.15429,635 - 437,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11932,742,625 - 32,754,152 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604592,601,986 - 92,612,032 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624752510,601 - 518,065 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624752510,593 - 518,065 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mapk12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11258,434,314 - 258,443,900 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mapk12
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:129
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000044376
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7118556868125929417Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH128844  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,206,034 - 120,206,219 (+)MAPPERmRatBN7.2
Rnor_6.07130,109,244 - 130,109,428NCBIRnor6.0
Rnor_5.07129,795,033 - 129,795,217UniSTSRnor5.0
RGSC_v3.47127,430,645 - 127,430,829UniSTSRGSC3.4
Celera7116,679,930 - 116,680,114UniSTS
RH 3.4 Map7958.5UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 49 59 6 313 149 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000044376   ⟹   ENSRNOP00000046455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7122,085,913 - 122,096,307 (-)Ensembl
mRatBN7.2 Ensembl7120,206,271 - 120,216,664 (-)Ensembl
Rnor_6.0 Ensembl7130,109,663 - 130,120,579 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093842   ⟹   ENSRNOP00000086001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7122,085,913 - 122,096,307 (-)Ensembl
mRatBN7.2 Ensembl7120,206,271 - 120,216,664 (-)Ensembl
RefSeq Acc Id: NM_021746   ⟹   NP_068514
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,085,913 - 122,096,307 (-)NCBI
mRatBN7.27120,206,271 - 120,216,664 (-)NCBI
Rnor_6.07130,109,480 - 130,119,873 (-)NCBI
Rnor_5.07129,795,269 - 129,805,662 (-)NCBI
RGSC_v3.47127,430,881 - 127,441,274 (-)RGD
Celera7116,680,166 - 116,690,559 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079833   ⟹   XP_038935761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,085,647 - 122,096,190 (-)NCBI
mRatBN7.27120,206,005 - 120,216,711 (-)NCBI
RefSeq Acc Id: NP_068514   ⟸   NM_021746
- UniProtKB: Q63538 (UniProtKB/Swiss-Prot),   A6K7K1 (UniProtKB/TrEMBL),   A0A8I6A4Z8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046455   ⟸   ENSRNOT00000044376
RefSeq Acc Id: XP_038935761   ⟸   XM_039079833
- Peptide Label: isoform X1
- UniProtKB: A6K7K2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086001   ⟸   ENSRNOT00000093842
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63538-F1-model_v2 AlphaFold Q63538 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70975 AgrOrtholog
BioCyc Gene G2FUF-32461 BioCyc
Ensembl Genes ENSRNOG00000031233 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044376 ENTREZGENE
  ENSRNOT00000044376.5 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623226 IMAGE-MGC_LOAD
  IMAGE:7122406 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_p38-like UniProtKB/Swiss-Prot
  p38gamma UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
KEGG Report rno:60352 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72466 IMAGE-MGC_LOAD
  MGC:94035 IMAGE-MGC_LOAD
NCBI Gene 60352 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Mapk12 PhenoGen
PRINTS P38MAPKINASE UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031233 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6A4Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0JPR2_RAT UniProtKB/TrEMBL
  A6K7K1 ENTREZGENE, UniProtKB/TrEMBL
  A6K7K2 ENTREZGENE, UniProtKB/TrEMBL
  A6K7K3_RAT UniProtKB/TrEMBL
  MK12_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HA3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Mapk12  mitogen-activated protein kinase 12      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by dual threonine/tyrosine phosphorylation within a TGY sequence 70781