Cacna1d Rat Gene (calcium channel, voltage-dependent, L type, alpha 1D subunit)

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Keyword

Gene:
Cacna1d ( Rattus norvegicus )
calcium channel, voltage-dependent, L type, alpha 1D subunit
Description: has high voltage L-type calcium channel activity that is sensitive to dihydropyridines
Synonyms: CaV1.3alpha1;
ArrayIDs: M99221_s_at; U49126_s_at; 5872150; 6137314; 6372359; 6012150; 1370637_at; 6311688; 1370640_a_at; 6260659; 6724407; 5977919; 6593851; 6023993; 6134145; 5720653; 6127973; 5699232; 5820913; 5865023; 6167110; 6656136; 6174347; 6219096; 6100809; 1383458_at; 1369086_a_at; 6649645; 6113332; D38101_s_at; 6723761; GE21598; 5886515; 6434137; U31772_s_at; 6261020; 6506799; 6406532; 6245208; M57682_at; 5716143; 5822164; U14005exon#1_s_at; 6589219; 6222439; 5784885; 6337616; 5943157; 6697952; 6422435; 6699958; 6338676; 5836043; 6351908; 5762242; 6295460; A_44_P1071120; 6650422; 5989048; 6190134; 6584592; 5834436; 5942480; 6690430; 6727481; 6103859; 6637695; 6329555; 6719828; 6407815; 6098775; 6144152; 6297237; A_44_P365462; 5658138;  (details...)
Gene Type: protein-coding

Additional Data

Curated Variants: Cacna1d_v1
Cacna1d_v2
Cacna1d_v3

primer pair: 634947

Homologs
Homo sapiens: CACNA1D     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Cacna1d     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Cacna1d genome assembly 3.1 16 5383256 - 5703359
Rat Celera Assembly 16 9667490 - 9955564
RH 3.4 16 1.3
RGSC genome assembly v3.4 16 5383259 - 5703361
Cytogenetic 16 p16
Mus musculus Cacna1d Mouse genome assembly build 36.1 14 30853125 - 31304342
Cytogenetic 14 14 B
Homo sapiens CACNA1D human genome assembly 3 53504115 - 53821001
Human genome assembly build 36.2 3 53504116 - 53821001
Cytogenetic 3 p14.3

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Note Reference

voltage-activated Ca2+ channel 628461

alpha 1 subunit is the main component of the Ca2+ channel 628461

Gene Ontology

voltage-gated calcium channel activity,  protein binding,  high voltage-gated calcium channel activity ... (details...)
Biological Process

Note Reference

mediates parathyroid hormone induction of increase in intracellular calcium 634679

may mediate hormone release in pituitary and pancreatic neuroendocrine cells 628461

Gene Ontology

transmembrane transport,  calcium ion transport,  G-protein signaling, coupled to cAMP nucleotide second messenger ... (details...)
Cellular Component

Gene Ontology

voltage-gated calcium channel complex,  apical plasma membrane,  membrane ... (details...)
Disease

Ontology

Deafness,  Memory Disorders (details...)
Phenotype

Ontology

hair cell degeneration,  decreased heart rate,  irregular heartbeat (details...)
Expression

Note Reference

expressed in brain and neuroendocrine GH3 cells 628461

Pathway

Ontology

insulin secretion pathway (details...)
Protein

Note Reference

neuroendocrine isoform of pore forming subunit of L-type calcium channel 634679

alpha 1 subunit is the main component of the Ca2+ channel

Domain

Note Reference

QXXER motif of the C terminus is not sufficient to confer sensitivity to inhibitory G proteins 628461

Regulation

Note Reference

channel activity is inhibited by activation of somatostatin and muscarinic receptors in the growth hormone- and prolactin-secreting anterior pituitary GH3 cell line 628461

External Links
Databases
DATABASE ID SOURCE
UNIPARC: UPI00000E8ADC IPI
UNIPARC: UPI0001B79E2C IPI
UNIPARC: UPI0001B79FEE IPI
UNIPARC: UPI000002A5B8 IPI
UNIPARC: UPI000002A5B7 IPI
UNIPARC: UPI000002A5B6 IPI
UNIPARC: UPI000002A5B5 IPI
UNIPARC: UPI000002A5B4 IPI
UNIPARC: UPI000002A5B3 IPI
UNIPARC: UPI000002A5B2 IPI
UNIPARC: UPI000002A5B1 IPI
UNIPARC: UPI000002A5BA IPI
UNIPARC: UPI000002A5B9 IPI
UNIPARC: UPI0000127274 IPI
UNIPARC: UPI00000E8978 IPI
UNIPARC: UPI0001B79FEC IPI
KEGG Report: rno:29716 ENTREZGENE
HomoloGene Group ID: 578 ENTREZGENE
Germonline: 70973
Pfam: Ca_chan_IQ IPI
Pfam: Ion_trans IPI
KEGG Pathway: 04270 ENTREZGENE
KEGG Pathway: 04930 ENTREZGENE
KEGG Pathway: 04010 ENTREZGENE
KEGG Pathway: 05410 ENTREZGENE
KEGG Pathway: 04912 ENTREZGENE
KEGG Pathway: 04260 ENTREZGENE
KEGG Pathway: 04020 ENTREZGENE
KEGG Pathway: 05412 ENTREZGENE
KEGG Pathway: 05010 ENTREZGENE
InterPro: VDCC_L_a1su. IPI
InterPro: VDCC_a1su_IQ. IPI
InterPro: VDCCAlpha1. IPI
InterPro: LVDCC_a1dsu. IPI
InterPro: Ion_trans. IPI
IPI: IPI00207969 IPI
IPI: IPI00949709 IPI
IPI: IPI00568196 IPI
IPI: IPI00562074 IPI
IPI: IPI00231117 IPI
IPI: IPI00231116 IPI
IPI: IPI00231114 IPI
IPI: IPI00339161 IPI
IPI: IPI00231112 IPI
IPI: IPI00231111 IPI
IPI: IPI00231110 IPI
IPI: IPI00231109 IPI
IPI: IPI00231809 IPI
IPI: IPI00231808 IPI
IPI: IPI00199764 IPI
IPI: IPI00198652 IPI
Ensembl Protein: ENSRNOP00000045203 IPI
Ensembl Protein: ENSRNOP00000043131 IPI
Ensembl Protein: ENSRNOP00000019520 IPI
Ensembl Protein: ENSRNOP00000017975 IPI
Ensembl Protein: ENSRNOP00000039306 IPI
Ensembl Protein: ENSRNOP00000051407 IPI
Ensembl Protein: ENSRNOP00000049809 IPI
Ensembl Protein: ENSRNOP00000041766 IPI
Ensembl Protein: ENSRNOP00000042492 IPI
Ensembl Protein: ENSRNOP00000043046 IPI
Entrez Gene: Cacna1d ENTREZGENE
UniProt: Q91XN9_RAT IPI
UniProt: Q8R2F3_RAT IPI
UniProt: Q91XN8_RAT IPI
UniProt: Q91WX8_RAT IPI
UniProt: Q8R2F4_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: Q91WX9_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: CAC1D_RAT IPI
UniProt: Q8R2F5_RAT IPI
Ensembl Genes: ENSRNOG00000013147 IPI
PANTHER: LVDCCAlpha1D IPI
PRINTS: LVDCCALPHA1D. IPI
PRINTS: LVDCCALPHA1. IPI
PRINTS: CACHANNEL. IPI
Sequences
Nucleotide: U49128 Get FASTA Search GEO Profiles
Nucleotide: U49127 Get FASTA Search GEO Profiles
Nucleotide: U49126 Get FASTA Search GEO Profiles
Nucleotide: U31772 Get FASTA Search GEO Profiles
Nucleotide: M99221 Get FASTA Search GEO Profiles
Nucleotide: M57682 Get FASTA Search GEO Profiles
Nucleotide: D38102 Get FASTA Search GEO Profiles
Nucleotide: D38101 Get FASTA Search GEO Profiles
Nucleotide: AF422932 Get FASTA Search GEO Profiles
Nucleotide: AF422931 Get FASTA Search GEO Profiles
Nucleotide: AF422930 Get FASTA Search GEO Profiles
Nucleotide: AF370012 Get FASTA Search GEO Profiles
Nucleotide: AF370011 Get FASTA Search GEO Profiles
Nucleotide: AF370010 Get FASTA Search GEO Profiles
Nucleotide: AF370009 Get FASTA Search GEO Profiles
Nucleotide: U14005 Get FASTA Search GEO Profiles
Nucleotide: CH474046 Get FASTA Search GEO Profiles
Nucleotide: NM_017298 Get FASTA Search GEO Profiles
(View all 18 Nucleotide Accessions)
Protein: Q91XN9 Get FASTA
Protein: Q91XN8 Get FASTA
Protein: Q91WX9 Get FASTA
Protein: Q91WX8 Get FASTA
Protein: Q8R2F5 Get FASTA
Protein: Q8R2F4 Get FASTA
Protein: Q8R2F3 Get FASTA
Protein: P27732 Get FASTA
Protein: AAB61636 Get FASTA
Protein: AAB61635 Get FASTA
Protein: AAB61634 Get FASTA
Protein: AAA89156 Get FASTA
Protein: AAA40895 Get FASTA
Protein: AAA42015 Get FASTA
Protein: BAA07283 Get FASTA
Protein: BAA07282 Get FASTA
Protein: AAL89642 Get FASTA
Protein: AAL89641 Get FASTA
Protein: AAL89640 Get FASTA
Protein: AAK72962 Get FASTA
Protein: AAK72961 Get FASTA
Protein: AAK72960 Get FASTA
Protein: AAK72959 Get FASTA
Protein: AAB60515 Get FASTA
Protein: EDL89005 Get FASTA
Protein: EDL89004 Get FASTA
Protein: EDL89003 Get FASTA
Protein: EDL89002 Get FASTA
Protein: EDL89001 Get FASTA
Protein: NP_058994 Get FASTA
(View all 30 Protein Accessions)
Clusters
UniGene: 89671

References
Curated References
19 references in RGD related to Cacna1d

Other References
26 other references at PubMed related to Cacna1d

Database Information
RGD ID 70973
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

09-JUL-02: Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 70877