Gria3 (glutamate ionotropic receptor AMPA type subunit 3) - Rat Genome Database

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Gene: Gria3 (glutamate ionotropic receptor AMPA type subunit 3) Rattus norvegicus
Analyze
Symbol: Gria3
Name: glutamate ionotropic receptor AMPA type subunit 3
RGD ID: 70958
Description: Enables AMPA glutamate receptor activity and amyloid-beta binding activity. Involved in regulation of receptor recycling; response to fungicide; and response to lithium ion. Located in several cellular components, including dendrite; perikaryon; and synaptic cleft. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 94. Orthologous to human GRIA3 (glutamate ionotropic receptor AMPA type subunit 3); PARTICIPATES IN glutamate signaling pathway; long term depression; INTERACTS WITH (+)-pilocarpine; 1-nitropropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AMPA-selective glutamate receptor 3; GluA3; GluR-3; GluR-C; GluR-K3; GLUR3; glutamate receptor 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X125,103,975 - 125,369,690 (+)NCBIGRCr8
mRatBN7.2X120,238,515 - 120,504,106 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX120,238,534 - 120,504,096 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX122,364,427 - 122,627,112 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X125,885,906 - 126,148,553 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X123,482,751 - 123,745,405 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X127,561,843 - 127,829,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX127,562,660 - 127,829,753 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X127,655,758 - 127,922,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,452,523 - 3,718,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X3,460,084 - 3,724,042 (-)NCBI
CeleraX119,369,614 - 119,631,774 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-nitropropane  (EXP)
17beta-estradiol  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-(5-fluorouracil-1-yl)-L-alanine  (ISO)
3-methylcholanthrene  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
anthracen-2-amine  (EXP)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (EXP)
bisphenol A  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cefaloridine  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
Citreoviridin  (ISO)
cocaine  (EXP,ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
Diacetoxyscirpenol  (ISO)
dibenzofurans  (ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
Heliotrine  (EXP)
inulin  (ISO)
kainic acid  (EXP,ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
morphine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
olanzapine  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pyrethrins  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
sodium arsenite  (ISO)
sterigmatocystin  (EXP)
sulforaphane  (ISO)
testosterone  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Co-localization of AMPA receptor subunits in the nucleus of the solitary tract in the rat. Aicher SA, etal., Brain Res 2002 Dec 27;958(2):454-8.
2. The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. Dev KK, etal., Neuropharmacology. 1999 May;38(5):635-44.
3. Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. Du J, etal., J Neurosci. 2004 Jul 21;24(29):6578-89.
4. Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density. Feligioni M, etal., J Neurochem. 2006 Oct;99(2):549-60. Epub 2006 Aug 11.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Structure and organization of heteromeric AMPA-type glutamate receptors. Herguedas B, etal., Science. 2016 Apr 29;352(6285):aad3873. doi: 10.1126/science.aad3873. Epub 2016 Mar 10.
8. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. Hirbec H, etal., J Biol Chem. 2002 May 3;277(18):15221-4. Epub 2002 Mar 12.
9. AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. Kato AS, etal., Neuron. 2008 Sep 25;59(6):986-96. doi: 10.1016/j.neuron.2008.07.034.
10. A family of AMPA-selective glutamate receptors. Keinanen K, etal., Science 1990 Aug 3;249(4968):556-60.
11. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Kurschner C, etal., Mol Cell Neurosci. 1998 Jun;11(3):161-72.
12. Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex. Levy RB and Aoki C, J Neurosci. 2002 Jun 15;22(12):5001-15.
13. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
14. The structure and function of glutamate receptor ion channels. Madden DR Nat Rev Neurosci. 2002 Feb;3(2):91-101.
15. Gene Data Set MGD Curation, June 12, 2002
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus. Moga DE, etal., J Comp Neurol. 2003 Jul 14;462(1):15-28. doi: 10.1002/cne.10710.
18. A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties. Nakanishi N, etal., Neuron 1990 Nov;5(5):569-81.
19. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Nakatsu Y, etal., Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8. Epub 2009 Jul 7.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. NSF binding to GluR2 regulates synaptic transmission. Nishimune A, etal., Neuron. 1998 Jul;21(1):87-97.
22. The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. Nishizaki T and Matsumura T, Brain Res Mol Brain Res 2002 Jan 31;98(1-2):130-4.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines. Radley JJ, etal., Brain Res. 2007 Feb 23;1134(1):87-94. Epub 2007 Jan 17.
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, etal., Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.
29. Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Shi S, etal., Cell. 2001 May 4;105(3):331-43.
30. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Sommer B, etal., Science 1990 Sep 28;249(4976):1580-5.
31. Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Sutton MA, etal., Nature 2003 Jan 2;421(6918):70-5.
32. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Xia J, etal., Neuron 1999 Jan;22(1):179-87.
33. Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. Zhao WQ, etal., J Biol Chem. 2010 Mar 5;285(10):7619-32. doi: 10.1074/jbc.M109.057182. Epub 2009 Dec 23.
34. Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM. Zhao Y, etal., Science. 2019 Apr 26;364(6438):355-362. doi: 10.1126/science.aaw8250. Epub 2019 Apr 11.
Additional References at PubMed
PMID:2168579   PMID:7992055   PMID:8889548   PMID:9069286   PMID:10414981   PMID:10688364   PMID:12477932   PMID:12507773   PMID:12665613   PMID:14706873   PMID:14969735   PMID:15260958  
PMID:15610164   PMID:16436610   PMID:17093100   PMID:17256974   PMID:17873364   PMID:19020286   PMID:19063943   PMID:19200070   PMID:20869354   PMID:21141507   PMID:21172611   PMID:22044924  
PMID:22632720   PMID:22871113   PMID:23212166   PMID:23296627   PMID:23375774   PMID:23884930   PMID:25524891   PMID:27641494   PMID:28103481   PMID:28951554  


Genomics

Comparative Map Data
Gria3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X125,103,975 - 125,369,690 (+)NCBIGRCr8
mRatBN7.2X120,238,515 - 120,504,106 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX120,238,534 - 120,504,096 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX122,364,427 - 122,627,112 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X125,885,906 - 126,148,553 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X123,482,751 - 123,745,405 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X127,561,843 - 127,829,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX127,562,660 - 127,829,753 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X127,655,758 - 127,922,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,452,523 - 3,718,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X3,460,084 - 3,724,042 (-)NCBI
CeleraX119,369,614 - 119,631,774 (+)NCBICelera
Cytogenetic MapXq35NCBI
GRIA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X123,184,278 - 123,490,915 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX123,184,153 - 123,490,915 (+)EnsemblGRCh38hg38GRCh38
GRCh37X122,318,131 - 122,624,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X122,145,777 - 122,452,447 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X122,043,692 - 122,064,066NCBI
CeleraX122,704,041 - 123,010,712 (+)NCBICelera
Cytogenetic MapXq25NCBI
HuRefX111,704,466 - 112,009,621 (+)NCBIHuRef
CHM1_1X122,228,980 - 122,535,894 (+)NCBICHM1_1
T2T-CHM13v2.0X121,492,985 - 121,799,656 (+)NCBIT2T-CHM13v2.0
Gria3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X40,489,351 - 40,767,478 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX40,489,731 - 40,767,478 (+)EnsemblGRCm39 Ensembl
GRCm38X41,400,819 - 41,678,601 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX41,400,854 - 41,678,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X38,754,481 - 39,031,778 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X37,646,141 - 37,923,227 (+)NCBIMGSCv36mm8
CeleraX28,988,899 - 29,264,344 (+)NCBICelera
Cytogenetic MapXA4NCBI
cM MapX23.19NCBI
Gria3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547311,281,379 - 11,574,907 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547311,283,642 - 11,574,836 (-)NCBIChiLan1.0ChiLan1.0
GRIA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X122,656,097 - 122,963,692 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X122,659,758 - 122,967,298 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X112,380,229 - 112,687,740 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X122,562,571 - 122,870,130 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX122,562,330 - 122,870,130 (+)Ensemblpanpan1.1panPan2
GRIA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X94,729,828 - 95,006,244 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX94,730,943 - 95,004,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX80,782,519 - 81,064,503 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X96,499,224 - 96,776,045 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX96,499,201 - 96,776,041 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X93,943,627 - 94,219,547 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X95,702,771 - 95,978,497 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X95,485,249 - 95,767,174 (+)NCBIUU_Cfam_GSD_1.0
Gria3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X93,664,315 - 93,937,477 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364797,050,016 - 7,323,196 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364797,050,018 - 7,323,047 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX100,827,461 - 101,109,207 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X100,827,293 - 101,109,213 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X115,591,526 - 115,873,477 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606535,883,967 - 36,191,270 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gria3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247971,775,071 - 2,169,286 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247971,775,105 - 2,167,651 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gria3
684 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1672
Count of miRNA genes:341
Interacting mature miRNAs:487
Transcripts:ENSRNOT00000010367, ENSRNOT00000029031
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat

Markers in Region
DXGot55  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X127,612,051 - 127,612,247NCBIRnor6.0
Rnor_5.0X127,705,805 - 127,706,001UniSTSRnor5.0
RGSC_v3.4X3,668,948 - 3,669,157RGDRGSC3.4
RGSC_v3.4X3,668,949 - 3,669,157UniSTSRGSC3.4
RGSC_v3.1X3,674,504 - 3,674,713RGD
CeleraX119,418,712 - 119,418,919UniSTS
Cytogenetic MapXq11UniSTS
RH143176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X120,436,857 - 120,436,970 (+)MAPPERmRatBN7.2
Rnor_6.0X127,761,592 - 127,761,704NCBIRnor6.0
Rnor_5.0X127,854,198 - 127,854,310UniSTSRnor5.0
RGSC_v3.4X3,521,277 - 3,521,389UniSTSRGSC3.4
CeleraX119,564,585 - 119,564,697UniSTS
RH 3.4 Map5717.3UniSTS
Cytogenetic MapXq11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 15 9 60 28 11
Low 3 19 28 27 10 27 7 7 14 34 13 7
Below cutoff 12 12 12 1 4 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001112742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF201350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF559208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ205510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB713194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV723256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV762496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M85036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000010367   ⟹   ENSRNOP00000010367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX120,238,988 - 120,504,096 (+)Ensembl
Rnor_6.0 EnsemblX127,562,660 - 127,829,753 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000029031   ⟹   ENSRNOP00000031170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX120,238,534 - 120,502,023 (+)Ensembl
Rnor_6.0 EnsemblX127,562,660 - 127,829,753 (+)Ensembl
RefSeq Acc Id: NM_001112742   ⟹   NP_001106213
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,104,605 - 125,369,690 (+)NCBI
mRatBN7.2X120,238,988 - 120,504,106 (+)NCBI
Rnor_6.0X127,562,660 - 127,829,763 (+)NCBI
Rnor_5.0X127,655,758 - 127,922,244 (+)NCBI
RGSC_v3.4X3,452,523 - 3,718,486 (-)RGD
CeleraX119,369,614 - 119,631,774 (+)RGD
Sequence:
RefSeq Acc Id: NM_032990   ⟹   NP_116785
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,104,605 - 125,369,690 (+)NCBI
mRatBN7.2X120,238,988 - 120,504,106 (+)NCBI
Rnor_6.0X127,562,660 - 127,829,763 (+)NCBI
Rnor_5.0X127,655,758 - 127,922,244 (+)NCBI
RGSC_v3.4X3,452,523 - 3,718,486 (-)RGD
CeleraX119,369,614 - 119,631,774 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257496   ⟹   XP_006257558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,104,141 - 125,369,690 (+)NCBI
mRatBN7.2X120,238,524 - 120,504,106 (+)NCBI
Rnor_6.0X127,561,874 - 127,829,763 (+)NCBI
Rnor_5.0X127,655,758 - 127,922,244 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257501   ⟹   XP_006257563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,103,977 - 125,369,690 (+)NCBI
mRatBN7.2X120,238,517 - 120,504,106 (+)NCBI
Rnor_6.0X127,561,852 - 127,829,763 (+)NCBI
Rnor_5.0X127,655,758 - 127,922,244 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601950   ⟹   XP_017457439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,104,433 - 125,369,690 (+)NCBI
mRatBN7.2X120,238,833 - 120,504,106 (+)NCBI
Rnor_6.0X127,562,531 - 127,829,763 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601951   ⟹   XP_017457440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,103,975 - 125,369,690 (+)NCBI
mRatBN7.2X120,238,515 - 120,504,106 (+)NCBI
Rnor_6.0X127,561,852 - 127,829,763 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005497951
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,104,433 - 125,362,408 (+)NCBI
mRatBN7.2X120,238,831 - 120,496,821 (+)NCBI
RefSeq Acc Id: NP_116785   ⟸   NM_032990
- Peptide Label: isoform 1 precursor
- UniProtKB: P19492 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001106213   ⟸   NM_001112742
- Peptide Label: isoform 2 precursor
- UniProtKB: P19492 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257563   ⟸   XM_006257501
- Peptide Label: isoform X1
- UniProtKB: P19492 (UniProtKB/Swiss-Prot),   G3V6Z5 (UniProtKB/TrEMBL),   A6JML7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257558   ⟸   XM_006257496
- Peptide Label: isoform X1
- UniProtKB: P19492 (UniProtKB/Swiss-Prot),   G3V6Z5 (UniProtKB/TrEMBL),   A6JML7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457440   ⟸   XM_017601951
- Peptide Label: isoform X2
- UniProtKB: P19492 (UniProtKB/Swiss-Prot),   G3V8Y9 (UniProtKB/TrEMBL),   A6JML6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457439   ⟸   XM_017601950
- Peptide Label: isoform X1
- UniProtKB: P19492 (UniProtKB/Swiss-Prot),   G3V6Z5 (UniProtKB/TrEMBL),   A6JML7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031170   ⟸   ENSRNOT00000029031
RefSeq Acc Id: ENSRNOP00000010367   ⟸   ENSRNOT00000010367
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19492-F1-model_v2 AlphaFold P19492 1-888 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70958 AgrOrtholog
BIND 144355
BioCyc Gene G2FUF-1237 BioCyc
Ensembl Genes ENSRNOG00000007682 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010367 ENTREZGENE
  ENSRNOT00000010367.7 UniProtKB/TrEMBL
  ENSRNOT00000029031.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Solute-binding_3/MltF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29628 UniProtKB/Swiss-Prot
NCBI Gene 29628 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SBP_bac_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GRIA3 RGD
PhenoGen Gria3 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007682 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JML6 ENTREZGENE, UniProtKB/TrEMBL
  A6JML7 ENTREZGENE, UniProtKB/TrEMBL
  G3V6Z5 ENTREZGENE, UniProtKB/TrEMBL
  G3V8Y9 ENTREZGENE, UniProtKB/TrEMBL
  GRIA3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Gria3  glutamate ionotropic receptor AMPA type subunit 3  Gria3  glutamate receptor, ionotropic, AMPA 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Gria3  glutamate receptor, ionotropic, AMPA 3  Gria3  glutamate receptor, ionotrophic, AMPA 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Gria3  glutamate receptor, ionotrophic, AMPA 3  Gria3  glutamate receptor, ionotropic, AMPA3 (alpha 3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Gria3  glutamate receptor, ionotropic, AMPA3 (alpha 3)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation 2-pyrrolidinone potentiation of AMPA receptor activity may occur via inhibition of calcium/calmodulin-dependent protein kinase (CaMKII) 728843