Gsto1 (glutathione S-transferase omega 1) - Rat Genome Database

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Gene: Gsto1 (glutathione S-transferase omega 1) Rattus norvegicus
Analyze
Symbol: Gsto1
Name: glutathione S-transferase omega 1
RGD ID: 70952
Description: Enables glutathione dehydrogenase (ascorbate) activity. Involved in L-ascorbic acid biosynthetic process. Located in several cellular components, including basement membrane; cell body; and nuclear membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human GSTO1 (glutathione S-transferase omega 1); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase omega 1-1; glutathione S-transferase omega-1; glutathione-dependent dehydroascorbate reductase; GSTO 1-1; GSTO-1; MGC94845; MMA(V) reductase; monomethylarsonic acid reductase; S-(Phenacyl)glutathione reductase; SPG-R
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,662,377 - 256,672,515 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1256,662,531 - 256,676,167 (+)EnsemblGRCr8
mRatBN7.21246,721,089 - 246,731,228 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,721,221 - 246,731,468 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1254,848,516 - 254,858,523 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01261,541,609 - 261,551,494 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01254,191,672 - 254,201,560 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,607,437 - 267,617,387 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,607,418 - 267,617,387 (+)Ensemblrn6Rnor6.0
Rnor_5.01275,040,049 - 275,050,033 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41253,228,547 - 253,238,531 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1242,486,178 - 242,496,113 (+)NCBICelera
RGSC_v3.11253,493,307 - 253,503,274 (+)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
brequinar  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibric acid  (EXP)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
DDT  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-tocopherol  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
hemin  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
Mesaconitine  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
microcystin  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
NCX-4040  (ISO)
nickel atom  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
basement membrane  (IDA)
cell body  (IDA)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA)
nuclear membrane  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Toward protein biomarkers for allergy: CD4+ T cell proteomics in allergic and nonallergic subjects sampled in and out of pollen season. Bluggel M, etal., J Proteome Res. 2011 Apr 1;10(4):1558-70. Epub 2011 Mar 16.
2. Expression of CYP and GST in human normal and colon tumor tissues. Bulus H, etal., Biotech Histochem. 2019 Jan;94(1):1-9. doi: 10.1080/10520295.2018.1493220. Epub 2018 Aug 9.
3. Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer disease. Capurso C, etal., Rejuvenation Res. 2010 Dec;13(6):645-52. Epub 2010 Sep 6.
4. Subcellular localization of a glutathione-dependent dehydroascorbate reductase within specific rat brain regions. Fornai F, etal., Neuroscience. 2001;104(1):15-31.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
8. Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase. Ishikawa T, etal., J Biol Chem 1998 Oct 30;273(44):28708-12.
9. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Li YJ, etal., Hum Mol Genet 2003 Dec 15;12(24):3259-67. Epub 2003 Oct 21.
10. Purification and characterization of glutathione-dependent dehydroascorbate reductase from rat liver. Maellaro E, etal., Biochem J 1994 Jul 15;301 ( Pt 2):471-6.
11. Gene Data Set MGD Curation, June 12, 2002
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. Ozturk A, etal., Neurobiol Aging. 2005 Aug-Sep;26(8):1161-5. Epub 2004 Dec 18.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
19. Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. Wahner AD, etal., Neurosci Lett. 2007 Feb 21;413(3):274-8. Epub 2006 Dec 27.
Additional References at PubMed
PMID:11035031   PMID:11511179   PMID:12477932   PMID:12928150   PMID:19056867   PMID:20458337   PMID:23376485   PMID:23533145   PMID:31505169   PMID:32057363  


Genomics

Comparative Map Data
Gsto1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,662,377 - 256,672,515 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1256,662,531 - 256,676,167 (+)EnsemblGRCr8
mRatBN7.21246,721,089 - 246,731,228 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,721,221 - 246,731,468 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1254,848,516 - 254,858,523 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01261,541,609 - 261,551,494 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01254,191,672 - 254,201,560 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,607,437 - 267,617,387 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,607,418 - 267,617,387 (+)Ensemblrn6Rnor6.0
Rnor_5.01275,040,049 - 275,050,033 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41253,228,547 - 253,238,531 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1242,486,178 - 242,496,113 (+)NCBICelera
RGSC_v3.11253,493,307 - 253,503,274 (+)NCBI
Cytogenetic Map1q54NCBI
GSTO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810104,254,173 - 104,267,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10104,235,356 - 104,267,461 (+)Ensemblhg38GRCh38
GRCh3710106,013,931 - 106,027,213 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610106,004,668 - 106,017,203 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410106,004,667 - 106,017,199NCBI
Celera1099,754,787 - 99,768,056 (+)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef1099,645,735 - 99,659,002 (+)NCBIHuRef
CHM1_110106,297,838 - 106,311,108 (+)NCBICHM1_1
T2T-CHM13v2.010105,142,310 - 105,155,591 (+)NCBIT2T-CHM13v2.0
Gsto1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391947,843,412 - 47,853,229 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1947,843,409 - 47,853,229 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381947,854,973 - 47,864,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1947,854,970 - 47,864,790 (+)Ensemblmm10GRCm38
MGSCv371947,929,479 - 47,939,280 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361947,908,300 - 47,918,101 (+)NCBIMGSCv36mm8
Celera1948,615,471 - 48,625,281 (+)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1940.41NCBI
GSTO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28116,140,609 - 116,153,570 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110116,145,764 - 116,158,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010100,853,682 - 100,866,892 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110104,312,403 - 104,325,733 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10104,313,024 - 104,325,733 (+)EnsemblpanPan2panpan1.1
GSTO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12816,569,421 - 16,579,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2816,569,066 - 16,619,880 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2816,741,837 - 16,751,645 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02817,047,667 - 17,057,466 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2817,047,318 - 17,057,465 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12816,595,211 - 16,605,015 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02816,623,890 - 16,633,711 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02816,762,582 - 16,772,417 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gsto1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721330,328,927 - 30,339,488 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366001,930,695 - 1,943,422 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366001,932,152 - 1,943,342 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14115,206,188 - 115,216,613 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114115,206,434 - 115,216,624 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214125,175,630 - 125,185,821 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSTO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1997,305,094 - 97,317,892 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604858,424,657 - 58,438,025 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsto1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248313,342,584 - 3,352,467 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248313,342,539 - 3,351,766 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gsto1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1247,362,784 - 47,372,699 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gsto1
112 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000016851
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016851   ⟹   ENSRNOP00000016851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,721,298 - 246,731,468 (+)Ensembl
Rnor_6.0 Ensembl1267,607,437 - 267,617,387 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076367   ⟹   ENSRNOP00000067943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1267,607,418 - 267,617,367 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1256,662,531 - 256,664,136 (+)Ensembl
mRatBN7.2 Ensembl1246,721,221 - 246,722,689 (+)Ensembl
Rnor_6.0 Ensembl1267,607,483 - 267,608,950 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097867   ⟹   ENSRNOP00000095479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,721,255 - 246,731,468 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128454   ⟹   ENSRNOP00000107772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1256,662,547 - 256,676,167 (+)Ensembl
RefSeq Acc Id: NM_001007602   ⟹   NP_001007603
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,662,531 - 256,672,515 (+)NCBI
mRatBN7.21246,721,243 - 246,731,228 (+)NCBI
Rnor_6.01267,607,437 - 267,617,387 (+)NCBI
Rnor_5.01275,040,049 - 275,050,033 (+)NCBI
RGSC_v3.41253,228,547 - 253,238,531 (+)RGD
Celera1242,486,178 - 242,496,113 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108850   ⟹   XP_038964778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,662,377 - 256,672,515 (+)NCBI
mRatBN7.21246,721,089 - 246,731,221 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001007603 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964778 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79363 (Get FASTA)   NCBI Sequence Viewer  
  ACI32122 (Get FASTA)   NCBI Sequence Viewer  
  EDL94392 (Get FASTA)   NCBI Sequence Viewer  
  EDL94393 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000107772
GenBank Protein Q9Z339 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007603   ⟸   NM_001007602
- UniProtKB: Q9Z339 (UniProtKB/Swiss-Prot),   Q6AXR6 (UniProtKB/TrEMBL),   A6JHR8 (UniProtKB/TrEMBL),   B6DYQ5 (UniProtKB/TrEMBL),   F7F9Z0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016851   ⟸   ENSRNOT00000016851
Ensembl Acc Id: ENSRNOP00000067943   ⟸   ENSRNOT00000076367
RefSeq Acc Id: XP_038964778   ⟸   XM_039108850
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000095479   ⟸   ENSRNOT00000097867
Ensembl Acc Id: ENSRNOP00000107772   ⟸   ENSRNOT00000128454
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z339-F1-model_v2 AlphaFold Q9Z339 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690981
Promoter ID:EPDNEW_R1506
Type:initiation region
Name:Gsto1_1
Description:glutathione S-transferase omega 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01267,607,462 - 267,607,522EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70952 AgrOrtholog
BioCyc Gene G2FUF-55463 BioCyc
Ensembl Genes ENSRNOG00000028746 Ensembl
  ENSRNOG00000071889 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000128454 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109248 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_omega UniProtKB/Swiss-Prot
  GST_Omega/HSP26 UniProtKB/Swiss-Prot
  Omega/Tau-like UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:94845 IMAGE-MGC_LOAD
NCBI Gene 114846 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE OMEGA-1 UniProtKB/Swiss-Prot
  PTHR43968 UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N_2 UniProtKB/Swiss-Prot
PhenoGen Gsto1 PhenoGen
PRINTS GSTRNSFRASEO UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028746 RatGTEx
  ENSRNOG00000071889 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8I5ZZS8_RAT UniProtKB/TrEMBL
  A6JHR8 ENTREZGENE, UniProtKB/TrEMBL
  A6JHR9_RAT UniProtKB/TrEMBL
  B6DYQ5 ENTREZGENE, UniProtKB/TrEMBL
  F7F9Z0 ENTREZGENE, UniProtKB/TrEMBL
  GSTO1_RAT UniProtKB/Swiss-Prot
  Q6AXR6 ENTREZGENE
  Q9Z339 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Gsto1  glutathione S-transferase omega 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased 1.5 fold in SHR compared with WKY rats 1357414
gene_protein 213 amino acids with a molecular weight of 24,929 70644