Gsto1 (glutathione S-transferase omega 1)

Gene: Gsto1 (glutathione S-transferase omega 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Gsto1

Name:

glutathione S-transferase omega 1

RGD ID:

12581526

Description:

ENCODES a protein that exhibits glutathione dehydrogenase (ascorbate) activity (ortholog); INVOLVED IN L-ascorbic acid biosynthetic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); autism spectrum disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN axon (ortholog); basement membrane (ortholog); cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glutathione S-transferase omega 1, transcript variant X1; glutathione S-transferase omega 1, transcript variant X2; glutathione S-transferase omega-1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	30,328,927 - 30,339,488 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	1,930,695 - 1,943,422 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	1,932,152 - 1,943,342 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

autism spectrum disorder (ISO)

Chemical and Drug Induced Liver Injury (ISO)

COVID-19 (ISO)

disease of cellular proliferation (ISO)

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

leukemia (ISO)

lung disease (ISO)

neurodegenerative disease (ISO)

Parkinson's disease (ISO)

pre-malignant neoplasm (ISO)

Prostatic Neoplasms (ISO)

Seasonal Allergic Rhinitis (ISO)

skin disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular oxidant detoxification (IEA)

cellular response to arsenic-containing substance (IEA)

glutathione metabolic process (IEA)

L-ascorbic acid biosynthetic process (ISO)

L-ascorbic acid metabolic process (IEA)

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (IEA)

xenobiotic catabolic process (IEA)

Cellular Component

axon (ISO)

basement membrane (ISO)

cell body (ISO)

cytoplasm (IEA)

nuclear membrane (ISO)

Molecular Function

glutathione dehydrogenase (ascorbate) activity (IEA,ISO)

glutathione transferase activity (IEA)

methylarsonate reductase activity (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

transferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gsto1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	30,328,927 - 30,339,488 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	1,930,695 - 1,943,422 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	1,932,152 - 1,943,342 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GSTO1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	104,254,173 - 104,267,455 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	104,235,356 - 104,267,459 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	106,013,931 - 106,027,213 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	106,004,668 - 106,017,203 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	106,004,667 - 106,017,199	NCBI
Celera	10	99,754,787 - 99,768,056 (+)	NCBI		Celera
Cytogenetic Map	10	q25.1	NCBI
HuRef	10	99,645,735 - 99,659,002 (+)	NCBI		HuRef
CHM1_1	10	106,297,838 - 106,311,108 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	105,142,310 - 105,155,591 (+)	NCBI		T2T-CHM13v2.0

Gsto1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	47,843,412 - 47,853,229 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	47,843,409 - 47,853,229 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	47,854,973 - 47,864,790 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	47,854,970 - 47,864,790 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	47,929,479 - 47,939,280 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	47,908,300 - 47,918,101 (+)	NCBI		MGSCv36	mm8
Celera	19	48,615,471 - 48,625,281 (+)	NCBI		Celera
Cytogenetic Map	19	D1	NCBI
cM Map	19	40.41	NCBI

Gsto1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	256,662,377 - 256,672,515 (+)	NCBI		GRCr8
mRatBN7.2	1	246,721,089 - 246,731,228 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	246,721,221 - 246,731,468 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	254,848,516 - 254,858,523 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	261,541,609 - 261,551,494 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	254,191,672 - 254,201,560 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	267,607,437 - 267,617,387 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	267,607,418 - 267,617,387 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	275,040,049 - 275,050,033 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	253,228,547 - 253,238,531 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	253,493,307 - 253,503,274 (+)	NCBI
Celera	1	242,486,178 - 242,496,113 (+)	NCBI		Celera
Cytogenetic Map	1	q54	NCBI

GSTO1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	116,140,609 - 116,153,570 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	116,145,764 - 116,158,902 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	100,853,682 - 100,866,892 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	104,312,403 - 104,325,733 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	104,313,024 - 104,325,733 (+)	Ensembl	panpan1.1		panPan2

GSTO1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	16,569,421 - 16,579,239 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	16,569,066 - 16,619,880 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	16,741,837 - 16,751,645 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	17,047,667 - 17,057,466 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	17,047,318 - 17,057,465 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	16,595,211 - 16,605,015 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	16,623,890 - 16,633,711 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	16,762,582 - 16,772,417 (+)	NCBI		UU_Cfam_GSD_1.0

GSTO1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	115,206,188 - 115,216,613 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	115,206,434 - 115,216,624 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	125,175,630 - 125,185,821 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GSTO1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	97,305,094 - 97,317,892 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	58,424,657 - 58,438,025 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gsto1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624831	3,342,584 - 3,352,467 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624831	3,342,539 - 3,351,766 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013362104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000013397 ⟹ ENSSTOP00000012004

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936600	1,930,695 - 1,943,422 (-)	Ensembl

RefSeq Acc Id:

XM_005333584 ⟹ XP_005333641

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	30,328,927 - 30,339,488 (-)	NCBI
SpeTri2.0	NW_004936600	1,932,152 - 1,942,701 (-)	NCBI

Sequence:

show sequence

GCGGAGTTGGCGGCAGCCAGGGGCTGGCACTTTTGAGCTGAGAAGGAGGAGCGACCTATTTCCT
GAATCGCCTGCAAACCCCAGAGCCGAGGCGTGGGGAATTCGGCCGGCGCTGCGCCACGATGTCG
GGGGGATCAGCCAAGAGCCTGGCAAAGGGAAGCGCGCCCCCGGGGCCTGTCCCGGAAGGCTTGA
TCCGCCTCTACAGCATGAGGTTCTGTCCGTTTGCCCAGAGGACGCGGTTGGTCCTGAAGGCCAA
AGGAATCGAGCATGAAATCATCAATATCAACCTGAGAAATAAGCCTGAGTGGTACTTCAAGAAG
AATCCCCTGGGTTTAGTGCCAGTTCTGGAAAACAGTCAGGGTCAGTTGATCTCTGAATCTACCA
TCACTTGTGAGTACCTGGATGAAGCATATCCCGGGAAGAAGCTGTTGCCGGATGATCCTTATGA
AAAAGCTTGCCAAAAGATGGTCTTTGAGTTATTTTCTAAGGTACCATCTTTGATGGCAAACTTT
ATTAAAGGGCAAAATAAAGAAAACTGGTCTGGCCTAAAAGAAGAATTGAAGAAAGAATTCAGCA
AGCTAGAGGAGGTTCTGACTAATAAGGAGACAACCTTCTTTGGTGGCAATTCTGTGTCTATGAT
TGATTATCTCATCTGGCCCTGGTTTGAACGGCTGGAAGCAGTGGAGCTAAATGAGTGTGTAGCC
CACACTCCAAAACTTAAGCTCTGGATAGCAGCCATGAAGAAAGATCCCACAGTATCAGCCCTCC
TCCATGATGTGAAGACTCATCAAGGATTCTTAGGCCTCTACTTACAGAACAGCCTGGAGGCCTT
TGACTATGGGCTCTAAAGTGGGCAAAAATCAGCACTGAAGTTATGTCTAATATTTTACTTCACC
TATGTGTATAATAACATGCTTTCATTTTATCAAGTGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333641	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000012004.2
GenBank Protein	KAG3264134	(Get FASTA)	NCBI Sequence Viewer
	KAG3264135	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333641 ⟸ XM_005333584

- UniProtKB:

I3MKX6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGGSAKSLAKGSAPPGPVPEGLIRLYSMRFCPFAQRTRLVLKAKGIEHEIININLRNKPEWYF
KKNPLGLVPVLENSQGQLISESTITCEYLDEAYPGKKLLPDDPYEKACQKMVFELFSKVPSLMA
NFIKGQNKENWSGLKEELKKEFSKLEEVLTNKETTFFGGNSVSMIDYLIWPWFERLEAVELNEC
VAHTPKLKLWIAAMKKDPTVSALLHDVKTHQGFLGLYLQNSLEAFDYGL

hide sequence

RefSeq Acc Id:

ENSSTOP00000012004 ⟸ ENSSTOT00000013397

Protein Domains

GST C-terminal GST N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000013401	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000013397.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1050.10	UniProtKB/TrEMBL
	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Glutathione-S-Trfase_C-like	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	Glutathione_S-Trfase	UniProtKB/TrEMBL
	Glutathione_S-Trfase_N	UniProtKB/TrEMBL
	GST_C	UniProtKB/TrEMBL
	GST_omega	UniProtKB/TrEMBL
	Omega/Tau-like	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
NCBI Gene	Gsto1	ENTREZGENE
PANTHER	GLUTATHIONE S-TRANSFERASE OMEGA-1	UniProtKB/TrEMBL
	PTHR43968	UniProtKB/TrEMBL
Pfam	GST_C_3	UniProtKB/TrEMBL
	GST_N_3	UniProtKB/TrEMBL
PRINTS	GSTRNSFRASEO	UniProtKB/TrEMBL
PROSITE	GLUTAREDOXIN_2	UniProtKB/TrEMBL
	GST_CTER	UniProtKB/TrEMBL
	GST_NTER	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47616	UniProtKB/TrEMBL
	SSF52833	UniProtKB/TrEMBL
UniProt	I3MKX6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD