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Gene: Cdc5l (cell division cycle 5-like) Rattus norvegicus

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Symbol:

Cdc5l

Name:

cell division cycle 5-like

RGD ID:

70892

Description:

Enables enzyme binding activity; leucine zipper domain binding activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to interleukin-2; cellular response to prolactin; and cellular response to wortmannin. Located in nuclear speck and perinuclear region of cytoplasm. Part of protein-DNA complex. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 3-chloropropane-1,2-diol; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CDC5 (cell division cycle 5 S. pombe homolog)-like; CDC5 (cell division cycle 5, S. pombe, homolog)-like; CDC5 cell division cycle 5-like; CDC5 cell division cycle 5-like (S. pombe); cdc5-like protein; cell division cycle 5-like (S. pombe); cell division cycle 5-like protein; cell division cycle 5-related protein; pombe Cdc5-related protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CDC5L (cell division cycle 5 like)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cdc5l (cell division cycle 5-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cdc5l (cell division cycle 5 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CDC5L (cell division cycle 5 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CDC5L (cell division cycle 5 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdc5l (cell division cycle 5 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CDC5L (cell division cycle 5 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CDC5L (cell division cycle 5 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cdc5l (cell division cycle 5 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cdc5l (cell division cycle 5 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CDC5L (cell division cycle 5 like)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cdc5l (cell division cycle 5-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cdc5lrt9 (cell division cycle 5 like, retrotransposed 9)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Cdc5lrt8 (cell division cycle 5 like, retrotransposed 8)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Cdc5lrt7 (cell division cycle 5 like, retrotransposed 7)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Cdc5lrt6 (cell division cycle 5 like, retrotransposed 6)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Cdc5lrt10 (cell division cycle 5 like, retrotransposed 10)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Cdc5lrt5 (cell division cycle 5 like, retrotransposed 5)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Cdc5lrt4 (cell division cycle 5 like, retrotransposed 4)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Cdc5lrt1 (cell division cycle 5 like, retrotransposed 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	cdc5l (CDC5 cell division cycle 5-like (S. pombe))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CEF1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Cdc5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cdc-5L	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cdc5l	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cdc5l	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	23,062,397 - 23,100,901 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	23,062,205 - 23,100,899 (+)	Ensembl				GRCr8
mRatBN7.2	9	15,564,949 - 15,603,453 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	15,564,767 - 15,603,450 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	24,151,506 - 24,189,633 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	29,214,190 - 29,252,317 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	27,514,951 - 27,553,079 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	17,949,764 - 17,988,514 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	17,949,764 - 17,988,509 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	16,838,171 - 16,876,921 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	11,165,631 - 11,204,135 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	13,308,462 - 13,346,957 (+)	NCBI		Celera
RGSC_v3.1	9	11,162,952 - 11,201,455 (+)	NCBI
Cytogenetic Map	9	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

CAKUT (ISO)

esophagus adenocarcinoma (ISO)

Lung Neoplasms (ISO)

osteosarcoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (EXP)

caffeine (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

deoxynivalenol (ISO)

dicrotophos (ISO)

dimethylarsinic acid (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

flavonoids (EXP)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

glafenine (EXP)

hydrogen peroxide (ISO)

inulin (ISO)

ivermectin (ISO)

methyl methanesulfonate (ISO)

motexafin gadolinium (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nimesulide (EXP)

nitrates (ISO)

paclitaxel (ISO)

paracetamol (ISO)

parathion (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thiram (ISO)

trichostatin A (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

wortmannin (EXP)

zinc acetate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to fibroblast growth factor stimulus (IEP)

cellular response to interleukin-2 (IEP)

cellular response to nerve growth factor stimulus (IDA)

cellular response to prolactin (IEP)

cellular response to wortmannin (IDA)

DNA damage checkpoint signaling (IEA,ISO,ISS)

DNA damage response (IEA)

DNA repair (IEA)

G2/M transition of mitotic cell cycle (TAS)

mRNA processing (IEA)

mRNA splicing, via spliceosome (IBA,IEA,ISO,ISS)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA,TAS)

regulation of transcription by RNA polymerase II (IBA)

RNA splicing (IEA)

Cellular Component

catalytic step 2 spliceosome (IEA,ISO)

cytoplasm (IEA,ISO)

DNA replication factor A complex (IEA,ISO,ISS)

nuclear speck (IDA,IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

perinuclear region of cytoplasm (IDA)

post-mRNA release spliceosomal complex (IEA,ISO)

post-spliceosomal complex (IEA,ISO)

protein-DNA complex (IDA)

Prp19 complex (IBA,IEA,ISO,ISS)

spliceosomal complex (IBA,IEA,ISO)

U12-type catalytic step 2 spliceosome (IEA,ISO)

U2-type catalytic step 1 spliceosome (IEA,ISO)

U2-type catalytic step 2 spliceosome (IEA,ISO,ISS)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

identical protein binding (IEA,ISO)

leucine zipper domain binding (IPI)

protein binding (IPI,ISO)

protein domain specific binding (IEA)

protein kinase binding (IPI)

protein phosphatase 1 binding (IPI)

RNA binding (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

transcription corepressor binding (IPI)

WD40-repeat domain binding (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas.	Bonner AE, etal., Oncogene. 2004 Feb 5;23(5):1166-76.
2.	NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry.	Boudrez A, etal., J Biol Chem. 2000 Aug 18;275(33):25411-7.
3.	Splicing and beyond: the many faces of the Prp19 complex.	Chanarat S and Strasser K, Biochim Biophys Acta. 2013 Oct;1833(10):2126-34. doi: 10.1016/j.bbamcr.2013.05.023. Epub 2013 Jun 3.
4.	DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition.	Engemann H, etal., Nucleic Acids Res 2002 Mar 15;30(6):1408-17.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target.	Hansel DE, etal., Am J Surg Pathol. 2005 Mar;29(3):390-9.
7.	Prolactin, interleukin-2 and FGF-2 stimulate expression, nuclear distribution and DNA-binding of rat homolog of pombe Cdc5 in Nb2 T lymphoma cells.	Johnson LM and Too CK, Mol Cell Endocrinol. 2001 Nov 26;184(1-2):151-61.
8.	Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma.	Lu XY, etal., Mol Cancer Res. 2008 Jun;6(6):937-46. doi: 10.1158/1541-7786.MCR-07-2115.
9.	Gene Data Set	MGD Curation, June 12, 2002
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Differential expression of elongation factor-2, alpha4 phosphoprotein and Cdc5-like protein in prolactin-dependent/independent rat lymphoid cells.	Too CK Mol Cell Endocrinol 1997 Aug 8;131(2):221-32.
17.	Involvement of the mouse Prp19 gene in neuronal/astroglial cell fate decisions.	Urano Y, etal., J Biol Chem. 2006 Mar 17;281(11):7498-514. Epub 2005 Dec 13.
18.	Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation.	Urano-Tashiro Y, etal., J Neurosci Res. 2010 Oct;88(13):2787-97. doi: 10.1002/jnr.22455.

Additional References at PubMed

PMID:9038199	PMID:11082045	PMID:11991638	PMID:12477932	PMID:16332694	PMID:19946888	PMID:20176811	PMID:22681889	PMID:24332808	PMID:28076346	PMID:28131823

Genomics

Comparative Map Data

Cdc5l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	23,062,397 - 23,100,901 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	23,062,205 - 23,100,899 (+)	Ensembl				GRCr8
mRatBN7.2	9	15,564,949 - 15,603,453 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	15,564,767 - 15,603,450 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	24,151,506 - 24,189,633 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	29,214,190 - 29,252,317 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	27,514,951 - 27,553,079 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	17,949,764 - 17,988,514 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	17,949,764 - 17,988,509 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	16,838,171 - 16,876,921 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	11,165,631 - 11,204,135 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	13,308,462 - 13,346,957 (+)	NCBI		Celera
RGSC_v3.1	9	11,162,952 - 11,201,455 (+)	NCBI
Cytogenetic Map	9	q12	NCBI

CDC5L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	44,387,706 - 44,450,425 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	44,387,565 - 44,450,425 (+)	Ensembl			hg38	GRCh38
GRCh37	6	44,355,443 - 44,418,162 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	44,463,280 - 44,522,758 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	44,463,279 - 44,522,757	NCBI
Celera	6	45,908,480 - 45,967,835 (+)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	44,077,869 - 44,140,670 (+)	NCBI		HuRef
CHM1_1	6	44,358,890 - 44,421,686 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	44,222,452 - 44,285,059 (+)	NCBI		T2T-CHM13v2.0

Cdc5l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	45,702,809 - 45,744,633 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	45,702,810 - 45,744,663 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	45,391,887 - 45,433,707 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	45,391,884 - 45,433,737 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	45,528,836 - 45,570,656 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	44,855,468 - 44,897,288 (-)	NCBI		MGSCv36	mm8
Celera	17	48,822,530 - 48,866,019 (-)	NCBI		Celera
Cytogenetic Map	17	B3	NCBI
cM Map	17	22.36	NCBI

Cdc5l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	9,990,613 - 10,032,034 (+)	Ensembl
ChiLan1.0	NW_004955437	9,990,613 - 10,032,034 (+)	NCBI	ChiLan1.0	ChiLan1.0

CDC5L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	58,891,113 - 58,955,556 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	54,761,126 - 54,821,533 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	43,983,840 - 44,043,029 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	45,265,845 - 45,326,392 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	45,265,845 - 45,326,383 (+)	Ensembl			panPan2	panpan1.1

CDC5L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	12,779,936 - 12,822,978 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	12,780,010 - 12,822,801 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	12,807,973 - 12,851,031 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	13,266,108 - 13,309,161 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	13,266,132 - 13,309,158 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	12,791,651 - 12,835,010 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	12,879,429 - 12,922,495 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	12,973,455 - 13,016,504 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cdc5l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	48,262,000 - 48,311,662 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	15,648,678 - 15,698,106 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	15,647,470 - 15,698,095 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDC5L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	39,384,556 - 39,431,248 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	39,384,397 - 39,427,729 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	45,306,065 - 45,349,669 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDC5L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	27,727,185 - 27,785,233 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	27,722,819 - 27,785,268 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	44,437,105 - 44,495,930 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdc5l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	15,477,193 - 15,517,636 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624754	15,477,188 - 15,517,656 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cdc5l
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	84,454,349 - 84,491,979 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cdc5l
346 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	54
Count of miRNA genes:	45
Interacting mature miRNAs:	53
Transcripts:	ENSRNOT00000027264
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5346479	50346479	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	8750492	53750492	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	1	31250552	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	496645	45496645	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	6214995	51214995	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	8750492	53750492	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	41763315	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5346479	50416711	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	6714888	29567695	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	496645	45496645	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	21031430	49025574	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	496645	45496645	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	6214995	51214995	Rat

Markers in Region

RH125755

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	15,603,111 - 15,603,365 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	17,988,173 - 17,988,426	NCBI	Rnor6.0
Rnor_5.0	9	16,876,580 - 16,876,833	UniSTS	Rnor5.0
RGSC_v3.4	9	11,203,794 - 11,204,047	UniSTS	RGSC3.4
Celera	9	13,346,616 - 13,346,869	UniSTS
Cytogenetic Map	9	q12	UniSTS

RH131317

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	15,603,052 - 15,603,233 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	17,988,114 - 17,988,294	NCBI	Rnor6.0
Rnor_5.0	9	16,876,521 - 16,876,701	UniSTS	Rnor5.0
RGSC_v3.4	9	11,203,735 - 11,203,915	UniSTS	RGSC3.4
Celera	9	13,346,557 - 13,346,737	UniSTS
RH 3.4 Map	9	78.6	UniSTS
Cytogenetic Map	9	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF000578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC111403	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027264 ⟹ ENSRNOP00000027264

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	23,062,205 - 23,100,894 (+)	Ensembl
mRatBN7.2 Ensembl	9	15,564,767 - 15,603,450 (+)	Ensembl
Rnor_6.0 Ensembl	9	17,949,764 - 17,988,509 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112966 ⟹ ENSRNOP00000079717

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	15,564,767 - 15,591,798 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000120250 ⟹ ENSRNOP00000087958

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	23,064,232 - 23,100,899 (+)	Ensembl
mRatBN7.2 Ensembl	9	15,566,784 - 15,603,450 (+)	Ensembl

RefSeq Acc Id:

NM_053527 ⟹ NP_445979

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	23,062,397 - 23,100,899 (+)	NCBI
mRatBN7.2	9	15,564,949 - 15,603,453 (+)	NCBI
Rnor_6.0	9	17,949,764 - 17,988,514 (+)	NCBI
Rnor_5.0	9	16,838,171 - 16,876,921 (+)	NCBI
RGSC_v3.4	9	11,165,631 - 11,204,135 (+)	RGD
Celera	9	13,308,462 - 13,346,957 (+)	RGD

Sequence:

show sequence

GGTCGCTCTTGGAGGAAGTGGCCTCTTTGCGTCCCGTGACCGAAGCGCCGTTACTACTTTCTCG
AAGCTCCACTCGGCCGCTTGCCGGACACTCCGCCGCCAAGATGCCCCGGATTATGATCAAAGGG
GGCGTGTGGAGGAATACGGAGGATGAAATTCTTAAAGCAGCGGTAATGAAATATGGGAAAAACC
AGTGGTCTAGGATTGCCTCATTGCTGCATAGGAAATCGGCAAAGCAGTGCAAAGCCAGATGGTA
CGAATGGCTGGACCCAAGTATTAAGAAAACTGAATGGTCCAGAGAAGAGGAAGAAAAGCTCTTG
CACTTGGCCAAGCTGATGCCAACGCAGTGGAGGACCATTGCTCCAATCATAGGAAGGACAGCAG
CCCAGTGCTTGGAGCACTATGAATTCCTCCTGGACAAAACTGCCCAAAGGGACAATGAAGAGGA
AACAACAGATGACCCCCGAAAACTTAAGCCTGGAGAGATAGATCCAAATCCAGAAACCAAACCA
GCCCGGCCTGATCCAATTGACATGGATGAGGATGAACTTGAGATGCTTTCTGAGGCTCGAGCCC
GTTTGGCCAATACTCAAGGAAAGAAGGCTAAGAGGAAAGCAAGAGAAAAGCAGTTGGAAGAAGC
AAGGCGCCTTGCTGCCCTCCAGAAAAGACGGGAACTTCGAGCAGCTGGCATAGAGATTCAGAAG
AAAAGGAAAAAGAAGAGAGGAGTTGATTATAATGCTGAAATCCCATTTGAAAAAAAGCCTGCTC
TTGGTTTTTATGATACTTCTGAGGAGAATTACCAGGCCCTTGATGCTGATTTCAGGAAATTACG
ACAGCAGGATCTTGACGGGGAGCTAAGATCTGAAAAAGAAGGAAGAGATAGAAAAAAAGACAAA
CAGCATTTAAAAAGGAAAAAAGAATCTGATTTACCATCTGCTATCCTTCAAACTAGTGGTGTCT
CTGAGTTTACTAAAAAGAGAAGCAAACTTGTGCTGCCTGCCCCTCAGATTTCAGATGCTGAACT
CCAGGAAGTTGTCAAGGTAGGCCAGGCCAGTGAAGTTGCACGGCAGACTGCGGAGGAGTCTGGG
ATCACAAACTCTGCTTCTAGCACTCTCCTGTCTGAGTACAATGTCACAAACAACAGCATTGCTC
TGAGAACACCACGGACTCCAGCCTCCCAAGACAGGATTCTACAGGAAGCTCAGAACCTCATGGC
CTTGACCAATGTGGACACTCCACTGAAAGGTGGGCTTAACACCCCACTGCACGAGAGTGACTTC
TCTGGTGTGACGCCACAGCGGCAGGTTGTGCAGACTCCAAATACGGTTCTGTCTACCCCTTTCA
GGACTCCTTCTAATGGAGCTGAAGGGCTGACTCCCCGGAGTGGAACAACCCCGAAACCAGTCAC
TAACGCCACCCCAGGTAGAACACCACTTAGAGACAAATTAAACATTAATCCAGAGGATGGAATG
GCAGACTACAGTGACCCCTCTTACGTGAAGCAGATGGAAAGAGAATCTCGTGAACATCTCCGTC
TAGGGTTGTTAGGCCTCCCTGCACCGAAGAATGATTTTGAAATTGTTCTGCCAGAAAATGCGGA
GAAGGAACTGGAAGAACGTGAAATGGATGACACGTACATCGAGGATGCTGCTGATGTGGATGCT
CGAAAGCAGGCCATACGAGATGCTGAGCGTGTAAAGGAAATGAAACGAATGCACAAAGCTGTTC
AGAAGGATCTACCCAGACCGTCTGAAGTAAATGAAACTATTTTAAGACCTTTAAATGTAGAACC
ACCTCTAACAGATTTGCAGAAAAGTGAGGAACTGATCAAAAAAGAGATGATTACGATGCTTCAT
TATGACCTGCTGCATCACCCCTACGAGCCGTCTGGGAATAAGAAAGGGAAAAACGTCGGGTTTG
CTACCAACAATTCAGAGCACATTACCTATCTTGAGCATAGCCCTTATGAGAAGTTCTCCAAAGA
GGATCTAAAAAAGGCCCAGGATGTTCTGGTGCAAGAGATGGAAGTGGTAAAACAAGGAATGAGC
CACGGAGAACTCTCCAGTGAAGCTTACAACCAGGTGTGGGAGGAATGCTACAGTCAAGTCCTCT
ATCTTCCTGCTCAGAGCCGCTACACACGGGCTAATCTTGCTAGCAAAAAGGACAGAATTGAATC
ACTTGAAAAGAGACTTGAGATAAACAGGGGTCACATGACAACAGAAGCCAAGAGAGCTGCAAAG
ATGGAAAAAAAGATGAAGATTTTGCTGGGTGGTTACCAGTCCCGCGCCATGGGGCTCCTGAAGC
AGCTGAACGACCTGTGGGACCAAATCGAGCAGGCGCACCTGGAGCTGCGCACCTTTGAGGAACT
CAAGAAACACGAAGACTCTGCTATTCCCCGTAGGCTAGAGTGTCTAAAGGAAGATGTGCAGCGG
CAACAGGAAAGAGAGAAAGAGCTTCAGCAAAGATATGCGGATTTGCTGATGGAGAAAGAGACTT
TACAGGCAAAGTTCTGAAGCACAGAGGACGCTCTGCCTCAGAAGAACTAGTTGCTGGTTTCGTA
CTCAGCAAGGCCGAGACTGACCTTTCTCCTCATTGACAAAGTCACCCAGCACCTGTGGGCTCTC
GGTTGCTTGTTTTGAATGATACTGATCTTGCGTGTTCTGTGTTACAAACTTGGACTCCAGGATA
ATAAGGGTTTAAATTATCCAGATGCTCATTCTTTGCCAGTGTCATATTTACAAAATTTCGTAGT
TTAGGCCTTTAATTTAAAAAGCCTGATTTTAAATACTGCCTGCAAGTAAACCCTTGAATAAAAA
GAACATGTGAAGAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063267788 ⟹ XP_063123858

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	23,080,080 - 23,100,901 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_445979	(Get FASTA)	NCBI Sequence Viewer
	XP_063123858	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD05365	(Get FASTA)	NCBI Sequence Viewer
	AAI61839	(Get FASTA)	NCBI Sequence Viewer
	EDM18727	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027264
	ENSRNOP00000027264.4
GenBank Protein	O08837	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445979 ⟸ NM_053527

- UniProtKB:

O08837 (UniProtKB/Swiss-Prot), B1WBQ0 (UniProtKB/TrEMBL), A0A8I6A562 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWS
REEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEI
DPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELR
AAGIEIQKKRKKKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKE
GRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVA
RQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLN
TPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKL
NINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREMDDTYI
EDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIK
KEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHITYLEHSPYEKFSKEDLKKAQDVLVQEM
EVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINRGHMT
TEAKRAAKMEKKMKILLGGYQSRAMGLLKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLE
CLKEDVQRQQEREKELQQRYADLLMEKETLQAKF

hide sequence

Ensembl Acc Id:

ENSRNOP00000027264 ⟸ ENSRNOT00000027264

Ensembl Acc Id:

ENSRNOP00000079717 ⟸ ENSRNOT00000112966

Ensembl Acc Id:

ENSRNOP00000087958 ⟸ ENSRNOT00000120250

RefSeq Acc Id:	XP_063123858 ⟸ XM_063267788
- Peptide Label:	isoform X1

Protein Domains

HTH myb-type Myb-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O08837-F1-model_v2	AlphaFold	O08837	1-802	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696548

Promoter ID:

EPDNEW_R7072

Type:

multiple initiation site

Name:

Cdc5l_1

Description:

cell division cycle 5-like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	17,949,752 - 17,949,812	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70892	AgrOrtholog
BioCyc Gene	G2FUF-28161	BioCyc
Ensembl Genes	ENSRNOG00000019975	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000027264	ENTREZGENE
	ENSRNOT00000027264.5	UniProtKB/Swiss-Prot
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7125496	IMAGE-MGC_LOAD
	IMAGE:9101355	IMAGE-MGC_LOAD
InterPro	CDC5L/Cef1	UniProtKB/Swiss-Prot
	Cdc5p/Cef1	UniProtKB/Swiss-Prot
	Homeobox-like_sf	UniProtKB/Swiss-Prot
	Myb_dom	UniProtKB/Swiss-Prot
	SANT/Myb	UniProtKB/Swiss-Prot
	SANT_CDC5L_II	UniProtKB/Swiss-Prot
KEGG Report	rno:85434	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:187349	IMAGE-MGC_LOAD
	MGC:93301	IMAGE-MGC_LOAD
NCBI Gene	85434	ENTREZGENE
PANTHER	CELL DIVISION CYCLE 5-LIKE PROTEIN	UniProtKB/Swiss-Prot
	CELL DIVISION CYCLE 5-LIKE PROTEIN	UniProtKB/Swiss-Prot
Pfam	Myb_Cef	UniProtKB/Swiss-Prot
	Myb_DNA-bind_6	UniProtKB/Swiss-Prot
PhenoGen	Cdc5l	PhenoGen
PROSITE	HTH_MYB	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019975	RatGTEx
SMART	SANT	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot
UniProt	A0A8I6A562	ENTREZGENE, UniProtKB/TrEMBL
	B1WBQ0	ENTREZGENE, UniProtKB/TrEMBL
	CDC5L_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-01-23	Cdc5l	cell division cycle 5-like	Cdc5l	CDC5 cell division cycle 5-like (S. pombe)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Cdc5l	CDC5 cell division cycle 5-like (S. pombe)	Cdc5l	cell division cycle 5-like (S. pombe)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Cdc5l	cell division cycle 5-like (S. pombe)			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	binds the leucine zipper domain of DAP-like kinase (Dlk), binding occurs via the Cdc5l C-terminal region between residues 500 and 802	619664
gene_regulation	differential display shows transcription upregulated by prolactin	61637

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)