Eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1) - Rat Genome Database

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Gene: Eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1) Rattus norvegicus
Analyze
Symbol: Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
RGD ID: 70883
Description: Enables eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in several processes, including HRI-mediated signaling; negative regulation of hemoglobin biosynthetic process; and response to iron ion starvation. Predicted to act upstream of or within several processes, including macrophage differentiation; multicellular organismal-level iron ion homeostasis; and regulation of protein metabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eukaryotic translation initiation factor 2-alpha kinase 1; HCR; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; hemin-sensitive initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2a kinase; Hri
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,824,431 - 15,858,266 (-)NCBIGRCr8
mRatBN7.21210,710,771 - 10,744,597 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1210,705,874 - 10,744,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,518,738 - 11,551,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,142,030 - 12,175,225 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,165,859 - 11,198,988 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,749,026 - 12,782,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,748,785 - 12,782,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01214,792,379 - 14,825,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,039,139 - 11,072,708 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11210,969,549 - 11,102,636 (-)NCBI
Celera1212,508,244 - 12,541,227 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
nucleus  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression. Mellor H, etal., J Biol Chem 1994 Apr 8;269(14):10201-4.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10671563   PMID:11036079   PMID:11050009   PMID:11560503   PMID:11726526   PMID:15931390   PMID:17932563  


Genomics

Comparative Map Data
Eif2ak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,824,431 - 15,858,266 (-)NCBIGRCr8
mRatBN7.21210,710,771 - 10,744,597 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1210,705,874 - 10,744,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,518,738 - 11,551,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,142,030 - 12,175,225 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,165,859 - 11,198,988 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,749,026 - 12,782,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,748,785 - 12,782,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01214,792,379 - 14,825,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,039,139 - 11,072,708 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11210,969,549 - 11,102,636 (-)NCBI
Celera1212,508,244 - 12,541,227 (-)NCBICelera
Cytogenetic Map12p11NCBI
EIF2AK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,022,247 - 6,059,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl76,022,247 - 6,059,175 (-)EnsemblGRCh38hg38GRCh38
GRCh3776,061,878 - 6,098,806 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,029,988 - 6,065,302 (-)NCBINCBI36Build 36hg18NCBI36
Build 3475,836,705 - 5,872,017NCBI
Celera76,637,836 - 6,674,825 (+)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef75,933,661 - 5,969,897 (-)NCBIHuRef
CHM1_176,061,585 - 6,098,572 (-)NCBICHM1_1
T2T-CHM13v2.076,140,020 - 6,176,976 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,108,223 - 6,145,211 (-)NCBI
Eif2ak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,803,586 - 143,839,535 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,803,543 - 143,841,069 (+)EnsemblGRCm39 Ensembl
GRCm385143,817,792 - 143,902,717 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,817,788 - 143,904,251 (+)EnsemblGRCm38mm10GRCm38
MGSCv375144,632,731 - 144,663,586 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365144,125,388 - 144,156,112 (+)NCBIMGSCv36mm8
Celera5140,849,644 - 140,884,939 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.67NCBI
Eif2ak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,723,777 - 13,754,150 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546013,723,674 - 13,754,545 (+)NCBIChiLan1.0ChiLan1.0
EIF2AK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2611,611,603 - 11,647,378 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1759,936,328 - 59,972,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v077,382,669 - 7,418,469 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.176,221,342 - 6,256,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl76,222,187 - 6,256,252 (-)Ensemblpanpan1.1panPan2
EIF2AK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,447,225 - 11,478,611 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl611,447,081 - 11,478,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,072,983 - 13,104,439 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0611,447,489 - 11,478,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl611,446,574 - 11,479,049 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1611,324,176 - 11,355,599 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,303,440 - 11,334,903 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,530,063 - 11,561,526 (-)NCBIUU_Cfam_GSD_1.0
Eif2ak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344139,515,266 - 139,555,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936750389,845 - 432,460 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936750389,913 - 430,783 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl35,075,054 - 5,113,622 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.135,075,026 - 5,113,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.235,136,781 - 5,170,736 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,225,768 - 15,269,692 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,233,909 - 15,269,594 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666102820,984 - 859,948 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2ak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474031,274,483 - 31,306,430 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474031,223,583 - 31,306,749 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif2ak1
132 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:101
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000001392
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat

Markers in Region
BI293383  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera20642,758 - 642,956UniSTS
RH 3.4 Map2053.73UniSTS
Cytogenetic Map20p12UniSTS
RH128540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,222,572 - 3,222,781 (+)MAPPERmRatBN7.2
Rnor_6.0203,746,676 - 3,746,884NCBIRnor6.0
Rnor_5.0205,833,418 - 5,833,626UniSTSRnor5.0
Celera20649,770 - 649,978UniSTS
RH 3.4 Map2053.23UniSTS
Cytogenetic Map20p12UniSTS
RH142857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21210,738,458 - 10,738,577 (+)MAPPERmRatBN7.2
Rnor_6.01212,776,029 - 12,776,147NCBIRnor6.0
Rnor_5.01214,819,233 - 14,819,351UniSTSRnor5.0
RGSC_v3.41211,066,659 - 11,066,777UniSTSRGSC3.4
Celera1212,535,172 - 12,535,290UniSTS
Cytogenetic Map12p11UniSTS
BI293046  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,205,800 - 3,205,961 (+)MAPPERmRatBN7.2
Rnor_6.0203,731,094 - 3,731,254NCBIRnor6.0
Rnor_5.0205,817,836 - 5,817,996UniSTSRnor5.0
Celera20632,879 - 633,039UniSTS
RH 3.4 Map2015.8UniSTS
Cytogenetic Map20p12UniSTS
BE120231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21210,723,081 - 10,723,244 (+)MAPPERmRatBN7.2
Rnor_6.01212,760,653 - 12,760,815NCBIRnor6.0
Rnor_5.01214,803,857 - 14,804,019UniSTSRnor5.0
RGSC_v3.41211,051,282 - 11,051,444UniSTSRGSC3.4
Celera1212,519,800 - 12,519,962UniSTS
RH 3.4 Map12121.6UniSTS
Cytogenetic Map12p11UniSTS
Pou5f1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,223,376 - 3,223,553 (+)MAPPERmRatBN7.2
Rnor_6.0203,747,480 - 3,747,656NCBIRnor6.0
Rnor_5.0205,834,222 - 5,834,398UniSTSRnor5.0
Celera20650,574 - 650,750UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001392   ⟹   ENSRNOP00000001392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1210,705,874 - 10,744,573 (-)Ensembl
Rnor_6.0 Ensembl1212,748,785 - 12,782,139 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079836   ⟹   ENSRNOP00000075036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1210,705,874 - 10,744,573 (-)Ensembl
Rnor_6.0 Ensembl1212,749,081 - 12,782,146 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092346   ⟹   ENSRNOP00000075792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1212,752,073 - 12,752,583 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1210,710,849 - 10,733,937 (-)Ensembl
Rnor_6.0 Ensembl1212,752,472 - 12,757,217 (-)Ensembl
RefSeq Acc Id: NM_013223   ⟹   NP_037355
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,825,113 - 15,858,164 (-)NCBI
mRatBN7.21210,711,453 - 10,744,508 (-)NCBI
Rnor_6.01212,749,026 - 12,782,078 (-)NCBI
Rnor_5.01214,792,379 - 14,825,284 (-)NCBI
RGSC_v3.41211,039,139 - 11,072,708 (-)RGD
Celera1212,508,244 - 12,541,227 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089135   ⟹   XP_038945063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,824,431 - 15,858,266 (-)NCBI
mRatBN7.21210,710,771 - 10,744,596 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037355   ⟸   NM_013223
- UniProtKB: Q63185 (UniProtKB/Swiss-Prot),   Q642C7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075792   ⟸   ENSRNOT00000092346
RefSeq Acc Id: ENSRNOP00000075036   ⟸   ENSRNOT00000079836
RefSeq Acc Id: ENSRNOP00000001392   ⟸   ENSRNOT00000001392
RefSeq Acc Id: XP_038945063   ⟸   XM_039089135
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9K9 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63185-F1-model_v2 AlphaFold Q63185 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698435
Promoter ID:EPDNEW_R8960
Type:initiation region
Name:Eif2ak1_1
Description:eukaryotic translation initiation factor 2 alpha kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01212,782,102 - 12,782,162EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70883 AgrOrtholog
BioCyc Gene G2FUF-20019 BioCyc
Ensembl Genes ENSRNOG00000001050 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001392 ENTREZGENE
  ENSRNOT00000001392.9 UniProtKB/Swiss-Prot
  ENSRNOT00000079836.2 UniProtKB/TrEMBL
  ENSRNOT00000092482.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:27137 UniProtKB/Swiss-Prot
NCBI Gene Eif2ak1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2ak1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001050 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5F3_RAT UniProtKB/TrEMBL
  E2AK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642C7 ENTREZGENE
UniProt Secondary Q642C7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Eif2ak1  eukaryotic translation initiation factor 2 alpha kinase 1      Symbol and Name updated 629477 APPROVED
2003-03-11 Eif2ak1  eukaryotic translation initiation factor 2 alpha kinase 1  Hri  hemin-sensitive initiation factor 2a kinase  Data merged from RGD:619810 628472 PROVISIONAL
2002-08-07 Hri  hemin-sensitive initiation factor 2a kinase      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Eif2ak1  eukaryotic translation initiation factor 2 alpha kinase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in all tissues studied 70728
gene_homology protein aa sequence shares 82% homology with rabbit reticulocyte HCR 70728
gene_regulation downregulated by hemin, a hemoglobin precursor 70728