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Gene: Slc27a5 (solute carrier family 27 member 5) Rattus norvegicus

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Symbol:

Slc27a5

Name:

solute carrier family 27 member 5

RGD ID:

708535

Description:

Enables cholate-CoA ligase activity. Involved in bile acid metabolic process. Part of protein-containing complex. Orthologous to human SLC27A5 (solute carrier family 27 member 5); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

BA-CoA ligase; BACS; BAL; bile acid CoA ligase; bile acid-CoA ligase; bile acyl-CoA synthetase; cholate--CoA ligase; FATP-5; fatty acid transport protein 5; LOC79111; long-chain fatty acid transport protein 5; long-chain-fatty-acid--CoA ligase; rBAL-1; solute carrier family 27 (fatty acid transporter), member 5; very long-chain acyl-CoA synthetase-related protein; VLACS-related; VLACSR

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC27A5 (solute carrier family 27 member 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc27a5 (solute carrier family 27 (fatty acid transporter), member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc27a5 (solute carrier family 27 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC27A5 (solute carrier family 27 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC27A5 (solute carrier family 27 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc27a5 (solute carrier family 27 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC27A5 (solute carrier family 27 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC27A5 (solute carrier family 27 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc27a5 (solute carrier family 27 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slc27a5 (solute carrier family 27 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CDIP1 (cell death inducing p53 target 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Slc27a5 (solute carrier family 27 (fatty acid transporter), member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SLC27A5 (solute carrier family 27 member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc27a2b (solute carrier family 27 member 2b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	zgc:158482	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	zgc:101540	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	FAT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FAT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	acs-20	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	slc27a2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Allele / Splice:

Slc27a5^m1Mcwi ; Slc27a5^m2Mcwi

Genetic Models:

FHH-Slc27a5^m1Mcwi ; BN-Slc27a5^m2Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	82,688,742 - 82,699,335 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	82,688,750 - 82,699,358 (-)	Ensembl				GRCr8
mRatBN7.2	1	73,616,556 - 73,627,149 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	73,616,564 - 73,627,172 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	78,996,966 - 79,007,611 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	87,561,304 - 87,571,949 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	80,752,046 - 80,762,691 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	65,576,599 - 65,587,192 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	65,576,535 - 65,587,186 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	66,387,832 - 66,398,425 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	72,924,630 - 72,935,223 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	60,212,177 - 60,222,770 (+)	NCBI		Celera
RGSC_v3.1	1	73,002,740 - 73,013,332 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

myoepithelioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

berberine (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

chenodeoxycholic acid (ISO)

cholic acid (ISO)

choline (ISO)

cisplatin (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

deoxycholic acid (ISO)

dicrotophos (ISO)

dioxygen (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fluoxetine (EXP)

flutamide (EXP)

formaldehyde (ISO)

fumonisin B1 (ISO)

furan (EXP)

glafenine (EXP)

glycidol (EXP)

GW 4064 (ISO)

imipenem hydrate (ISO)

L-methionine (ISO)

Lasiocarpine (ISO)

lead diacetate (ISO)

LY294002 (ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

mifepristone (ISO)

N-nitrosodiethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nimesulide (EXP)

O-methyleugenol (ISO)

obeticholic acid (ISO)

okadaic acid (ISO)

olanzapine (ISO)

oxycodone (EXP)

p-toluidine (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

rifampicin (ISO)

rotenone (EXP)

sodium arsenite (ISO)

streptozocin (ISO)

T-2 toxin (EXP)

tert-butyl ethyl ether (EXP)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thioacetamide (EXP)

Torularhodin (ISO)

triphenyl phosphate (EXP)

ursodeoxycholic acid (ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

zinc atom (EXP,ISO)

zinc(0) (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid biosynthetic process (IEA,ISO)

bile acid metabolic process (IBA,IMP,ISO)

fatty acid metabolic process (IEA)

fatty acid transport (ISO)

ketone body biosynthetic process (ISO)

lipid metabolic process (IEA)

lipid transport (IEA)

long-chain fatty acid import across plasma membrane (ISO)

long-chain fatty acid import into cell (IBA)

long-chain fatty acid metabolic process (IBA)

monocarboxylic acid metabolic process (IEA)

triglyceride mobilization (ISO)

very long-chain fatty acid metabolic process (IEA,ISO)

Cellular Component

basal plasma membrane (IEA,ISO)

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IBA,IEA,ISO)

plasma membrane (IBA,IEA)

protein-containing complex (IDA)

Molecular Function

acid-thiol ligase activity (IEA)

ATP binding (IEA)

cholate-CoA ligase activity (IDA,IEA,ISO)

CoA-ligase activity (IEA)

fatty acid transmembrane transporter activity (IEA,ISO)

ligase activity (IEA)

long-chain fatty acid transmembrane transporter activity (IBA,IEA,ISO,ISS)

long-chain fatty acid-CoA ligase activity (IBA,IEA)

nucleotide binding (IEA)

protein-containing complex binding (IDA)

very long-chain fatty acid-CoA ligase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid biosynthetic pathway (IEA,ISO)

bile acid transport pathway (IEA)

cerebrotendinous xanthomatosis pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

familial hypercholanemia pathway (ISO)

primary bile acid biosynthetic pathway (IEA)

Zellweger syndrome pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning and expression of rat liver bile acid CoA ligase.	Falany CN, etal., J Lipid Res 2002 Dec;43(12):2062-71.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization.	He D, etal., J Lipid Res. 2003 Dec;44(12):2242-9. Epub 2003 Sep 1.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes.	Wheeler JB, etal., Arch Biochem Biophys. 1997 Dec 1;348(1):15-24.

Additional References at PubMed

PMID:9671728	PMID:10479480	PMID:10749848	PMID:11980911	PMID:12477932	PMID:15489334	PMID:16618416	PMID:16618417	PMID:20530735

Genomics

Comparative Map Data

Slc27a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	82,688,742 - 82,699,335 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	82,688,750 - 82,699,358 (-)	Ensembl				GRCr8
mRatBN7.2	1	73,616,556 - 73,627,149 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	73,616,564 - 73,627,172 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	78,996,966 - 79,007,611 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	87,561,304 - 87,571,949 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	80,752,046 - 80,762,691 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	65,576,599 - 65,587,192 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	65,576,535 - 65,587,186 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	66,387,832 - 66,398,425 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	72,924,630 - 72,935,223 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	60,212,177 - 60,222,770 (+)	NCBI		Celera
RGSC_v3.1	1	73,002,740 - 73,013,332 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

SLC27A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	58,498,333 - 58,511,992 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	58,479,512 - 58,512,413 (-)	Ensembl			hg38	GRCh38
GRCh37	19	59,009,700 - 59,023,359 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	63,701,517 - 63,715,161 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	63,701,517 - 63,715,157	NCBI
Celera	19	56,053,816 - 56,067,542 (-)	NCBI		Celera
Cytogenetic Map	19	q13.43	NCBI
HuRef	19	55,319,377 - 55,333,864 (-)	NCBI		HuRef
CHM1_1	19	59,003,732 - 59,017,394 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	61,594,402 - 61,607,985 (-)	NCBI		T2T-CHM13v2.0

Slc27a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	12,722,273 - 12,732,119 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	12,722,273 - 12,732,119 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	12,988,346 - 12,998,192 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	12,988,346 - 12,998,192 (-)	Ensembl			mm10	GRCm38
MGSCv37	7	13,573,695 - 13,583,541 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	11,888,532 - 11,898,329 (-)	NCBI		MGSCv36	mm8
Celera	7	10,613,981 - 10,626,137 (-)	NCBI		Celera
Cytogenetic Map	7	A1	NCBI
cM Map	7	7.71	NCBI

Slc27a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955584	1,112,117 - 1,121,323 (-)	Ensembl
ChiLan1.0	NW_004955584	1,112,387 - 1,121,500 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC27A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	64,768,032 - 64,788,131 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	66,555,906 - 66,576,003 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	55,507,455 - 55,520,448 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	64,329,567 - 64,342,630 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	64,329,567 - 64,342,630 (-)	Ensembl			panPan2	panpan1.1

SLC27A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	99,435,140 - 99,438,388 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	99,833,542 - 99,842,039 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	100,048,410 - 100,056,905 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	100,041,887 - 100,056,901 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	99,693,751 - 99,702,249 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	99,406,581 - 99,415,077 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	100,161,220 - 100,169,717 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc27a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	218,019,774 - 218,029,145 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937062	89,664 - 98,113 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004937062	90,217 - 98,562 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC27A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	63,065,830 - 63,075,202 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	63,068,880 - 63,075,246 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLC27A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	50,782,713 - 50,793,816 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	50,781,544 - 50,792,515 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	4,088,423 - 4,092,128 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc27a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	84,552 - 92,556 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624832	84,456 - 92,706 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc27a5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	174,187,193 - 174,197,238 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc27a5
84 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	24
Interacting mature miRNAs:	25
Transcripts:	ENSRNOT00000026575
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	43457837	87558729	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	43457837	87558729	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	42122968	87122968	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	43457837	87558729	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	51909206	91302615	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	43509952	88509952	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	42122968	87122968	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat

Markers in Region

BE107935

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	73,616,603 - 73,616,779 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	65,586,969 - 65,587,144	NCBI	Rnor6.0
Rnor_5.0	1	66,398,202 - 66,398,377	UniSTS	Rnor5.0
RGSC_v3.4	1	72,935,000 - 72,935,175	UniSTS	RGSC3.4
Celera	1	60,222,547 - 60,222,722	UniSTS
RH 3.4 Map	1	765.69	UniSTS
Cytogenetic Map	1	q21	UniSTS

Genetic Models

This gene Slc27a5 is modified in the following models/strains:

FHH-Slc27a5^m1Mcwi BN-Slc27a5^m2Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	11	22	109	91	89	59	34	59	6	210	82	4	87	54	61	30	3	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_024143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF242189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026575 ⟹ ENSRNOP00000026574

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	82,688,750 - 82,699,358 (-)	Ensembl
mRatBN7.2 Ensembl	1	73,616,564 - 73,627,172 (-)	Ensembl
Rnor_6.0 Ensembl	1	65,576,535 - 65,587,186 (+)	Ensembl

RefSeq Acc Id:

NM_024143 ⟹ NP_077057

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	82,688,742 - 82,699,335 (-)	NCBI
mRatBN7.2	1	73,616,556 - 73,627,149 (-)	NCBI
Rnor_6.0	1	65,576,599 - 65,587,192 (+)	NCBI
Rnor_5.0	1	66,387,832 - 66,398,425 (+)	NCBI
RGSC_v3.4	1	72,924,630 - 72,935,223 (+)	RGD
Celera	1	60,212,177 - 60,222,770 (+)	RGD

Sequence:

show sequence

CTCAGAGCTGAGACTACCCGCTCTCAGCTACTTCACAAAGAGCCAGTGCCATGGGTGTTTGGAA
GAAACTAACCTTCTTGCTGCTGTCGCTGCTTCTCCTGGTTGGCCTGGGGCAGCCCCTGTGGCCA
GCAGCTACGGCTCTGGCCCTGCGTTGGTTCCTGGGAGACCCCACGTGCTTTGTGCTGCTTGGCT
TGGCATTCCTGGGCAGACCCTGGATCAGCTCCTGGATACCCCACTGGCTGAGCCTGGCAGCAGC
AGCTCTCACATTATCCCTATTGCCTCCACGGCCACCCCCAGAACTTCGCTGGCTGCACAAAGAT
GTGGCCTTCGCCTTCAAGTTGCTTTTCTATGGCCTGAACCTCAGGCGACGCCTTAACAGACATC
CTCCAGAACTCTTTGTGGATGCTTTAGAGCAGCAAGCACAGGCCCGGCCTGACCAGGTGGCCTT
GGTGTGTACTGGGTCTGAGGGCTGCTCAATCACAAATAGGGAGCTGAATGCCAAGGCCTGTCAA
GCAGCATGGGCCCTGAAAGCAAAGCTGAAGGAAGCCACAATCCAGGAGGACAAAGGCGCTACTG
CTATTTTAGTACTCCCGTCCAAGTCCATTTCTGCTCTGAGTGTGTTTCTGGGTTTGGCCAAGTT
GGGCTGCCCTGTGGCCTGGATCAATCCACACAGTCGAGGAATGCCCTTGCTACACTCTGTGCAG
AGCTCTGGGGCTAGTGTGCTGATTGTGGATCCAGACCTCCAGGAGAACCTGGAAGAAGTCCTTC
CCAAGCTGCTAGCTGAGAACATTCGATGCTTCTACCTTGGCCACAGCTCACCCACTCCGGGCGT
AGAGGCTCTAGGAGCTGCCCTGGACGCTGCACCTTCTGACCCAGTGCCTGCCAAGCTTCGTGCT
AATATAAAGTGGAAATCCCCAGCCATATTCATCTATACTTCAGGGACCACTGGACTTCCAAAGC
CAGCCATCCTATCACATGAGCGGGTCATACAAATGAGTAACGTGCTGTCCTTTTGTGGGAGAAC
AGCTGATGATGTGGTCTACAATGTTCTACCTCTGTACCATTCGATGGGGCTTGTCCTTGGAGTC
CTCGGCTGCTTACAACTTGGAGCCACCTGTGTCCTGGCCCCCAAGTTCTCTGCTTCCCGATACT
GGGCTGAGTGCCGGCAGTACAGTGTGACAGTGGTCCTGTATGTGGGTGAAGTCCTGCGATACTT
GTGTAATGTCCCAGGGCAACCAGAAGACAAGAAACATACAGTGCGGTTCGCATTGGGCAATGGA
CTTCGGGCAGACGTGTGGGAAAACTTCCAGCAACGATTTGGTCCCATTCAGATCTGGGAACTCT
ACGGCTCCACAGAGGGCAACGTGGGCTTAATGAACTATGTGGGGCACTGCGGGGCTGTGGGCAA
GACCAGCTGCTTCATTCGAATGCTGACTCCCCTTGAGCTTGTACAGTTTGACATAGAGACGGCA
GAGCCTGTGAGGGACAAACAGGGTTTTTGCATCCCTGTGGAGACAGGAAAGCCAGGACTTCTTT
TGACCAAGATTCGAAAGAACCAACCCTTCCTGGGCTACCGTGGTTCCCAGGATGAAACCAAGCG
GAAACTGGTTGCGAACGTACGGCAAGTAGGAGACCTCTACTACAACACAGGGGATGTGCTGGCC
TTGGACCAGGAAGGCTTCTTCTACTTCCGAGACCGCCTTGGTGACACCTTCCGGTGGAAGGGTG
AAAATGTATCCACTCGAGAGGTGGAGGGTGTGTTGTCTATCCTAGACTTCCTAGAGGAAGTCAA
TGTCTATGGTGTGACTGTGCCAGGGTGTGAGGGTAAGGTTGGCATGGCTGCTGTGAAACTGGCT
CCTGGGAAGACTTTTGATGGGCAGAAGCTCTACCAGCATGTCCGCTCCTGGCTCCCTGCCTATG
CCACACCTCATTTCATCCGTATCCAGGACTCCCTGGAGATCACAAACACCTACAAGCTAGTGAA
GTCACAACTGGCGCGTGAGGGTTTTGATGTGGGGGTCATTGCTGACCCTCTCTACATACTGGAC
AACAAGGCCGAAACCTTCCGGAGTCTGATGCCAGATGTGTACCAGGCTGTGTGTGAAGGAACCT
GGAAGCTCTGATCACCTAGCCAAGTGGAAGGCTATCCAAAAGTGTGGAAATCGGAAATCGACAC
TAGTCAGCTTCACAAAGTGGTCAGGGTTCCAGATGTCCATGGCCCAGTAGTACTTAGAGAATAA
ACTTGAATGTGTATATAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_077057	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG09770	(Get FASTA)	NCBI Sequence Viewer
	AAH91147	(Get FASTA)	NCBI Sequence Viewer
	EDL75770	(Get FASTA)	NCBI Sequence Viewer
	EDL75771	(Get FASTA)	NCBI Sequence Viewer
	EDL75772	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026574
	ENSRNOP00000026574.2
GenBank Protein	Q9ES38	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_077057 ⟸ NM_024143

- UniProtKB:

Q9ES38 (UniProtKB/Swiss-Prot), A6KQM0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGVWKKLTFLLLSLLLLVGLGQPLWPAATALALRWFLGDPTCFVLLGLAFLGRPWISSWIPHWL
SLAAAALTLSLLPPRPPPELRWLHKDVAFAFKLLFYGLNLRRRLNRHPPELFVDALEQQAQARP
DQVALVCTGSEGCSITNRELNAKACQAAWALKAKLKEATIQEDKGATAILVLPSKSISALSVFL
GLAKLGCPVAWINPHSRGMPLLHSVQSSGASVLIVDPDLQENLEEVLPKLLAENIRCFYLGHSS
PTPGVEALGAALDAAPSDPVPAKLRANIKWKSPAIFIYTSGTTGLPKPAILSHERVIQMSNVLS
FCGRTADDVVYNVLPLYHSMGLVLGVLGCLQLGATCVLAPKFSASRYWAECRQYSVTVVLYVGE
VLRYLCNVPGQPEDKKHTVRFALGNGLRADVWENFQQRFGPIQIWELYGSTEGNVGLMNYVGHC
GAVGKTSCFIRMLTPLELVQFDIETAEPVRDKQGFCIPVETGKPGLLLTKIRKNQPFLGYRGSQ
DETKRKLVANVRQVGDLYYNTGDVLALDQEGFFYFRDRLGDTFRWKGENVSTREVEGVLSILDF
LEEVNVYGVTVPGCEGKVGMAAVKLAPGKTFDGQKLYQHVRSWLPAYATPHFIRIQDSLEITNT
YKLVKSQLAREGFDVGVIADPLYILDNKAETFRSLMPDVYQAVCEGTWKL

hide sequence

Ensembl Acc Id:

ENSRNOP00000026574 ⟸ ENSRNOT00000026575

Protein Domains

AMP-binding enzyme C-terminal AMP-dependent synthetase/ligase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ES38-F1-model_v2	AlphaFold	Q9ES38	1-690	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689674

Promoter ID:

EPDNEW_R199

Type:

initiation region

Name:

Slc27a5_1

Description:

solute carrier family 27 member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	65,576,595 - 65,576,655	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708535	AgrOrtholog
BioCyc Gene	G2FUF-60701	BioCyc
BioCyc Pathway	PWY-6061 [bile acid biosynthesis, neutral pathway]	BioCyc
BioCyc Pathway Image	PWY-6061	BioCyc
Ensembl Genes	ENSRNOG00000019626	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000026575	ENTREZGENE
	ENSRNOT00000026575.5	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.300.30	UniProtKB/Swiss-Prot
	3.40.50.12780	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7370589	IMAGE-MGC_LOAD
InterPro	AMP-bd_C	UniProtKB/Swiss-Prot
	AMP-bd_C_sf	UniProtKB/Swiss-Prot
	AMP-binding_CS	UniProtKB/Swiss-Prot
	AMP-dep_Synth/Lig	UniProtKB/Swiss-Prot
	AMP-dep_Synthh-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:79111	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108681	IMAGE-MGC_LOAD
NCBI Gene	79111	ENTREZGENE
PANTHER	LONG-CHAIN FATTY ACID TRANSPORT PROTEIN	UniProtKB/Swiss-Prot
	LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 5	UniProtKB/Swiss-Prot
Pfam	AMP-binding	UniProtKB/Swiss-Prot
	AMP-binding_C	UniProtKB/Swiss-Prot
PhenoGen	Slc27a5	PhenoGen
PROSITE	AMP_BINDING	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019626	RatGTEx
Superfamily-SCOP	Acetyl-CoA synthetase-like	UniProtKB/Swiss-Prot
UniProt	A6KQM0	ENTREZGENE, UniProtKB/TrEMBL
	A6KQM1_RAT	UniProtKB/TrEMBL
	A6KQM2_RAT	UniProtKB/TrEMBL
	Q9ES38	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc27a5	solute carrier family 27 member 5	Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Slc27a5	solute carrier family 27 (fatty acid transporter), member 5		bile acid CoA ligase	Name updated	1299863	APPROVED
2004-09-10	Slc27a5	bile acid CoA ligase	LOC79111		Symbol and Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways