Septin9 (septin 9) - Rat Genome Database

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Gene: Septin9 (septin 9) Rattus norvegicus
Analyze
Symbol: Septin9
Name: septin 9
RGD ID: 708523
Description: Predicted to enable GTPase activity and molecular adaptor activity. Involved in anterograde dendritic transport of neurotransmitter receptor complex. Is active in presynapse. Human ortholog(s) of this gene implicated in brachial plexus neuritis and colorectal cancer. Orthologous to human SEPTIN9 (septin 9); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E-septin; eighth septin; Eseptin; LOC103693480; MLL septin-like fusion; MLL septin-like fusion gene; Msf; Sept9; septin 9-like 1; septin-9; septin-9-like; septin-like protein; Septin9l1; SLP; Slpa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,908,557 - 103,077,789 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10102,908,560 - 103,077,788 (+)EnsemblGRCr8
mRatBN7.210102,409,798 - 102,579,056 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,409,711 - 102,579,055 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10107,547,582 - 107,681,629 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,010,686 - 107,144,737 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,365,460 - 102,499,848 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,208,308 - 106,340,747 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,264,434 - 106,348,490 (+)Ensemblrn6Rnor6.0
Rnor_5.010105,841,829 - 105,987,909 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410107,343,672 - 107,479,964 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10101,009,659 - 101,144,045 (+)NCBICelera
RGSC_v3.110107,358,175 - 107,494,457 (+)NCBI
Cytogenetic Map10q32.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dopamine  (ISO)
enzyme inhibitor  (ISO)
finasteride  (EXP)
flutamide  (EXP)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP,ISO)
methoxyacetic acid  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
propylparaben  (ISO)
rotenone  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Detection of colorectal cancer in urine using DNA methylation analysis. Bach S, etal., Sci Rep. 2021 Jan 27;11(1):2363. doi: 10.1038/s41598-021-81900-6.
2. Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport. Bai X, etal., Mol Biol Cell. 2016 Mar 15;27(6):897-906. doi: 10.1091/mbc.E15-07-0493. Epub 2016 Jan 28.
3. Identification of a novel alternatively spliced septin. Fung ET and Scheller RH, FEBS Lett 1999 May 21;451(2):203-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Alternative exon usage of rat septins. Jackisch BO, etal., Biochem Biophys Res Commun 2000 Aug 18;275(1):180-8.
6. Mutations in SEPT9 cause hereditary neuralgic amyotrophy. Kuhlenbaumer G, etal., Nat Genet. 2005 Oct;37(10):1044-6. Epub 2005 Sep 25.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. Surka MC, etal., Mol Biol Cell 2002 Oct;13(10):3532-45.
13. Characterization of presynaptic septin complexes in mammalian hippocampal neurons. Tsang CW, etal., Biol Chem. 2011 Aug;392(8-9):739-49. doi: 10.1515/BC.2011.077. Epub 2011 Jul 19.
14. Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions. Tänzer M, etal., PLoS One. 2010 Feb 4;5(2):e9061. doi: 10.1371/journal.pone.0009061.
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15277470   PMID:15485874   PMID:16641100   PMID:17546647   PMID:18809578   PMID:22871113   PMID:23572511   PMID:25468996   PMID:30053369   PMID:36012625  


Genomics

Comparative Map Data
Septin9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,908,557 - 103,077,789 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10102,908,560 - 103,077,788 (+)EnsemblGRCr8
mRatBN7.210102,409,798 - 102,579,056 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,409,711 - 102,579,055 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10107,547,582 - 107,681,629 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,010,686 - 107,144,737 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,365,460 - 102,499,848 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,208,308 - 106,340,747 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,264,434 - 106,348,490 (+)Ensemblrn6Rnor6.0
Rnor_5.010105,841,829 - 105,987,909 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410107,343,672 - 107,479,964 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10101,009,659 - 101,144,045 (+)NCBICelera
RGSC_v3.110107,358,175 - 107,494,457 (+)NCBI
Cytogenetic Map10q32.2NCBI
SEPTIN9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381777,281,499 - 77,500,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1777,280,569 - 77,500,596 (+)Ensemblhg38GRCh38
GRCh371775,277,581 - 75,496,678 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361772,827,197 - 73,008,273 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341772,827,743 - 73,008,269NCBI
Celera1771,879,127 - 72,091,668 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1770,908,680 - 70,922,066 (+)NCBIHuRef
HuRef1770,710,975 - 70,904,981 (+)NCBIHuRef
CHM1_11775,342,249 - 75,561,442 (+)NCBICHM1_1
T2T-CHM13v2.01778,174,746 - 78,394,627 (+)NCBIT2T-CHM13v2.0
Septin9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,090,487 - 117,253,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,090,487 - 117,253,151 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811117,199,661 - 117,362,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,199,661 - 117,362,325 (+)Ensemblmm10GRCm38
MGSCv3711117,060,975 - 117,223,639 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611117,147,810 - 117,178,397 (+)NCBIMGSCv36mm8
Celera11128,945,198 - 129,106,872 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.61NCBI
Septin9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,942,056 - 5,090,441 (-)Ensembl
ChiLan1.0NW_0049555064,943,108 - 5,033,088 (-)NCBIChiLan1.0ChiLan1.0
SEPTIN9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21993,333,491 - 93,553,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11798,162,783 - 98,382,841 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01771,361,002 - 71,580,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11776,920,236 - 77,139,586 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1776,920,236 - 77,139,586 (+)EnsemblpanPan2panpan1.1
SEPTIN9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.193,495,764 - 3,571,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl93,448,793 - 3,616,732 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha94,177,822 - 4,324,227 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.094,172,563 - 4,319,394 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,172,850 - 4,319,487 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,194,434 - 4,343,014 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.094,317,550 - 4,463,926 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.094,400,426 - 4,546,246 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Septin9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,125,375 - 4,203,819 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,142,549 - 2,285,077 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,213,459 - 2,286,582 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEPTIN9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl124,254,775 - 4,405,628 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1124,254,771 - 4,347,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,002,058 - 4,153,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SEPTIN9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11644,211,692 - 44,424,242 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1644,213,623 - 44,310,524 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607714,938,473 - 15,151,219 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Septin9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,988,904 - 7,159,072 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248016,988,914 - 7,156,469 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Septin9
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1966,705,995 - 66,809,300 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Septin9
877 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:154
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000003891, ENSRNOT00000010365, ENSRNOT00000055000
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 48 67 138 95 11 47 36 32 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_176856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF170253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF173899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF180525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF180526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW534888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI284394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF977797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK364935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO403626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY311267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003891   ⟹   ENSRNOP00000003891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,984,158 - 103,077,788 (+)Ensembl
mRatBN7.2 Ensembl10102,479,065 - 102,579,055 (+)Ensembl
Rnor_6.0 Ensembl10106,264,434 - 106,348,490 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099603   ⟹   ENSRNOP00000092999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,943,374 - 103,077,784 (+)Ensembl
mRatBN7.2 Ensembl10102,444,646 - 102,579,048 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100054   ⟹   ENSRNOP00000096445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,976,296 - 103,077,788 (+)Ensembl
mRatBN7.2 Ensembl10102,477,540 - 102,579,055 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113646   ⟹   ENSRNOP00000079555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,908,560 - 103,077,772 (+)Ensembl
mRatBN7.2 Ensembl10102,409,711 - 102,579,055 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130850   ⟹   ENSRNOP00000110507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,913,800 - 103,077,778 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159507   ⟹   ENSRNOP00000102335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,910,721 - 103,077,778 (+)Ensembl
RefSeq Acc Id: NM_001113497   ⟹   NP_001106969
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,043,293 - 103,077,789 (+)NCBI
mRatBN7.210102,544,559 - 102,579,056 (+)NCBI
Rnor_6.010106,307,033 - 106,340,747 (+)NCBI
Rnor_5.010105,841,829 - 105,987,909 (+)NCBI
RGSC_v3.410107,343,672 - 107,479,964 (+)RGD
Celera10101,109,802 - 101,144,045 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031837   ⟹   NP_114025
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,976,296 - 103,077,789 (+)NCBI
mRatBN7.210102,477,540 - 102,579,056 (+)NCBI
Rnor_6.010106,241,201 - 106,340,747 (+)NCBI
Rnor_5.010105,841,829 - 105,987,909 (+)NCBI
RGSC_v3.410107,343,672 - 107,479,964 (+)RGD
Celera10101,042,555 - 101,144,045 (+)NCBI
Sequence:
RefSeq Acc Id: NM_176856   ⟹   NP_789826
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,943,406 - 103,077,789 (+)NCBI
mRatBN7.210102,444,647 - 102,579,056 (+)NCBI
Rnor_6.010106,208,308 - 106,340,747 (+)NCBI
Rnor_5.010105,841,829 - 105,987,909 (+)NCBI
RGSC_v3.410107,343,672 - 107,479,964 (+)RGD
Celera10101,009,659 - 101,144,045 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086949   ⟹   XP_038942877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,910,928 - 103,077,781 (+)NCBI
mRatBN7.210102,412,169 - 102,579,052 (+)NCBI
RefSeq Acc Id: XM_039086950   ⟹   XP_038942878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,908,557 - 103,077,781 (+)NCBI
mRatBN7.210102,409,798 - 102,579,052 (+)NCBI
RefSeq Acc Id: XM_039086952   ⟹   XP_038942880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,995,275 - 103,077,781 (+)NCBI
mRatBN7.210102,496,530 - 102,579,052 (+)NCBI
RefSeq Acc Id: XM_039086953   ⟹   XP_038942881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,043,897 - 103,077,781 (+)NCBI
mRatBN7.210102,544,798 - 102,579,052 (+)NCBI
RefSeq Acc Id: XM_039086954   ⟹   XP_038942882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,015,639 - 103,077,781 (+)NCBI
mRatBN7.210102,520,977 - 102,579,052 (+)NCBI
RefSeq Acc Id: XM_063269973   ⟹   XP_063126043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,995,475 - 103,077,781 (+)NCBI
RefSeq Acc Id: XM_063269974   ⟹   XP_063126044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,054,260 - 103,077,781 (+)NCBI
RefSeq Acc Id: NP_789826   ⟸   NM_176856
- Peptide Label: isoform 2
- UniProtKB: A0A8I6GK23 (UniProtKB/TrEMBL),   A6HL11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_114025   ⟸   NM_031837
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GM30 (UniProtKB/TrEMBL),   A6HL12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106969   ⟸   NM_001113497
- Peptide Label: isoform 3
- UniProtKB: A6HL14 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003891   ⟸   ENSRNOT00000003891
RefSeq Acc Id: XP_038942878   ⟸   XM_039086950
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZNH9 (UniProtKB/TrEMBL),   A6HL10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942877   ⟸   XM_039086949
- Peptide Label: isoform X1
- UniProtKB: A6HL10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942880   ⟸   XM_039086952
- Peptide Label: isoform X3
- UniProtKB: A6HL13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942882   ⟸   XM_039086954
- Peptide Label: isoform X5
- UniProtKB: A6HL14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942881   ⟸   XM_039086953
- Peptide Label: isoform X5
- UniProtKB: A6HL14 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096445   ⟸   ENSRNOT00000100054
Ensembl Acc Id: ENSRNOP00000092999   ⟸   ENSRNOT00000099603
Ensembl Acc Id: ENSRNOP00000079555   ⟸   ENSRNOT00000113646
RefSeq Acc Id: XP_063126043   ⟸   XM_063269973
- Peptide Label: isoform X3
- UniProtKB: A6HL13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126044   ⟸   XM_063269974
- Peptide Label: isoform X4
- UniProtKB: A6HL14 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102335   ⟸   ENSRNOT00000159507
Ensembl Acc Id: ENSRNOP00000110507   ⟸   ENSRNOT00000130850
Protein Domains
Septin-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZR6-F1-model_v2 AlphaFold Q9QZR6 1-564 view protein structure
AF-F1LN75-F1-model_v2 AlphaFold F1LN75 1-566 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708523 AgrOrtholog
BioCyc Gene G2FUF-22567 BioCyc
Ensembl Genes ENSRNOG00000002807 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000099603 ENTREZGENE
  ENSRNOT00000100054 ENTREZGENE
  ENSRNOT00000113646 ENTREZGENE
  ENSRNOT00000130850 ENTREZGENE
  ENSRNOT00000159507 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7936841 IMAGE-MGC_LOAD
InterPro G_SEPTIN_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Septin UniProtKB/Swiss-Prot
KEGG Report rno:83788 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188379 IMAGE-MGC_LOAD
NCBI Gene 83788 ENTREZGENE
PANTHER SEPTIN UniProtKB/Swiss-Prot
Pfam Septin UniProtKB/Swiss-Prot
PhenoGen Septin9 PhenoGen
PROSITE G_SEPTIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002807 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZNH9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK23 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM30 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LMP6_RAT UniProtKB/TrEMBL
  A0ABK0LW34_RAT UniProtKB/TrEMBL
  A6HL10 ENTREZGENE, UniProtKB/TrEMBL
  A6HL11 ENTREZGENE, UniProtKB/TrEMBL
  A6HL12 ENTREZGENE, UniProtKB/TrEMBL
  A6HL13 ENTREZGENE, UniProtKB/TrEMBL
  A6HL14 ENTREZGENE, UniProtKB/TrEMBL
  F1LN75_RAT UniProtKB/TrEMBL
  Q9QZR6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9QZJ7 UniProtKB/Swiss-Prot
  Q9QZJ8 UniProtKB/Swiss-Prot
  Q9QZP9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Septin9  septin 9  LOC103693480  septin-9-like  Data merged from RGD:9295105 737654 PROVISIONAL
2020-10-02 Septin9  septin 9  Septin9l1  septin 9-like 1  Data merged from RGD:15003245 737654 PROVISIONAL
2020-10-01 Septin9l1  septin 9-like 1  Septin9  septin 9  Name and Symbol changed 629549 APPROVED
2020-04-30 Septin9  septin 9  Sept9  septin 9  Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 Sept9  septin 9      Symbol and Name status set to provisional 45752 PROVISIONAL
2019-08-05 Septin9  septin 9  Sept9  septin 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103693480  septin-9-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-12-14 Sept9  septin 9  Slpa  septin-like protein  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference