Npb (neuropeptide B) - Rat Genome Database

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Gene: Npb (neuropeptide B) Rattus norvegicus
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Symbol: Npb
Name: neuropeptide B
RGD ID: 708513
Description: Enables G protein-coupled receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and feeding behavior. Predicted to be located in extracellular region. Orthologous to human NPB (neuropeptide B); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: preproneuropeptide B; preproprotein L7; rPPL7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,382,307 - 106,385,566 (+)NCBIGRCr8
mRatBN7.210105,883,992 - 105,887,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,874,708 - 105,887,254 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,990,498 - 110,990,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,453,526 - 110,453,960 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,807,106 - 105,807,540 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,786,222 - 109,786,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,786,222 - 109,786,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,377,548 - 109,380,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,999,845 - 110,000,279 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,014,348 - 110,014,783 (+)NCBI
Celera10104,430,057 - 104,430,491 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. Fujii R, etal., J Biol Chem 2002 Sep 13;277(37):34010-6. Epub 2002 Jul 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16736466   PMID:17067739   PMID:19885618   PMID:22484289   PMID:33105700  


Genomics

Comparative Map Data
Npb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,382,307 - 106,385,566 (+)NCBIGRCr8
mRatBN7.210105,883,992 - 105,887,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,874,708 - 105,887,254 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,990,498 - 110,990,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,453,526 - 110,453,960 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,807,106 - 105,807,540 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,786,222 - 109,786,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,786,222 - 109,786,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,377,548 - 109,380,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,999,845 - 110,000,279 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,014,348 - 110,014,783 (+)NCBI
Celera10104,430,057 - 104,430,491 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
NPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,902,238 - 81,902,905 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,900,745 - 81,902,905 (+)EnsemblGRCh38hg38GRCh38
GRCh371779,860,114 - 79,860,781 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,453,446 - 77,453,916 (+)NCBINCBI36Build 36hg18NCBI36
Celera1776,464,079 - 76,464,788 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,261,752 - 75,262,461 (+)NCBIHuRef
CHM1_11779,946,276 - 79,946,985 (+)NCBICHM1_1
T2T-CHM13v2.01782,769,398 - 82,770,065 (+)NCBIT2T-CHM13v2.0
Npb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,499,303 - 120,499,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,499,303 - 120,499,919 (+)EnsemblGRCm39 Ensembl
GRCm3811120,608,477 - 120,609,100 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,608,477 - 120,609,093 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711120,469,791 - 120,470,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,424,599 - 120,425,033 (+)NCBIMGSCv36mm8
Celera11132,343,769 - 132,344,392 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.33NCBI
Npb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,268,371 - 1,268,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,268,216 - 1,268,964 (-)NCBIChiLan1.0ChiLan1.0
NPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,436,500 - 98,438,984 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,337,273 - 103,340,957 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,306,883 - 76,308,470 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19390,493 - 392,339 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9391,781 - 392,314 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha9993,780 - 994,469 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09984,997 - 985,686 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9985,098 - 985,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,010,145 - 1,010,834 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,136,741 - 1,137,430 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,215,405 - 1,216,094 (-)NCBIUU_Cfam_GSD_1.0
Npb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,001,978 - 1,002,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,409,354 - 5,409,815 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,408,560 - 5,410,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,092,653 - 1,093,202 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,092,643 - 1,093,361 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,774,767 - 73,776,311 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,775,695 - 73,776,149 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,227,843 - 45,228,334 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,744,413 - 10,744,811 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,742,517 - 10,744,972 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npb
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:100
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000054953
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 7 41 101 72 79 51 25 51 3 183 76 90 45 51 28

Sequence


Ensembl Acc Id: ENSRNOT00000054953   ⟹   ENSRNOP00000051836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10109,786,222 - 109,786,656 (+)Ensembl
RefSeq Acc Id: NM_153293   ⟹   NP_695205
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,384,978 - 106,385,566 (+)NCBI
mRatBN7.210105,886,652 - 105,887,240 (+)NCBI
Rnor_6.010109,786,222 - 109,786,656 (+)NCBI
Rnor_5.010109,377,548 - 109,380,249 (+)NCBI
RGSC_v3.410109,999,845 - 110,000,279 (+)RGD
Celera10104,430,057 - 104,430,491 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085299   ⟹   XP_038941227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,382,307 - 106,385,564 (+)NCBI
mRatBN7.210105,883,992 - 105,887,689 (+)NCBI
Protein Sequences
Protein RefSeqs NP_695205 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941227 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC07177 (Get FASTA)   NCBI Sequence Viewer  
  EDM06867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051837.3
  ENSRNOP00055047027
  ENSRNOP00060029215
  ENSRNOP00065004208
GenBank Protein Q8K4P2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_695205   ⟸   NM_153293
- Peptide Label: precursor
- UniProtKB: Q8K4P2 (UniProtKB/Swiss-Prot),   A6HLG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051836   ⟸   ENSRNOT00000054953
RefSeq Acc Id: XP_038941227   ⟸   XM_039085299
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4P2-F1-model_v2 AlphaFold Q8K4P2 1-119 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697968
Promoter ID:EPDNEW_R8492
Type:single initiation site
Name:Npb_1
Description:neuropeptide B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,786,184 - 109,786,244EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708513 AgrOrtholog
BioCyc Gene G2FUF-22404 BioCyc
Ensembl Genes ENSRNOG00000036685 Ensembl
  ENSRNOG00000036686 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055032912 UniProtKB/Swiss-Prot
  ENSRNOG00060020500 UniProtKB/Swiss-Prot
  ENSRNOG00065004018 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054954.5 UniProtKB/Swiss-Prot
  ENSRNOT00055056930 UniProtKB/Swiss-Prot
  ENSRNOT00060035542 UniProtKB/Swiss-Prot
  ENSRNOT00065005853 UniProtKB/Swiss-Prot
InterPro Neuropept_B_pre UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuropept_BW_pre UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:259222 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 259222 ENTREZGENE
PANTHER NEUROPEPTIDE B UniProtKB/Swiss-Prot
  NEUROPEPTIDE B UniProtKB/TrEMBL
  NEUROPEPTIDE B UniProtKB/TrEMBL
  PTHR28553 UniProtKB/Swiss-Prot
Pfam NPBW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npb PhenoGen
PRINTS NROPEPTIDEBW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPNRPEPTIDEB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036685 RatGTEx
  ENSRNOG00000036686 RatGTEx
  ENSRNOG00055032912 RatGTEx
  ENSRNOG00060020500 RatGTEx
  ENSRNOG00065004018 RatGTEx
UniProt A6HLG2 ENTREZGENE, UniProtKB/TrEMBL
  NPB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Npb  neuropeptide B    preproneuropeptide B  Name updated 1299863 APPROVED