Slc1a5 (solute carrier family 1 member 5) - Rat Genome Database

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Gene: Slc1a5 (solute carrier family 1 member 5) Rattus norvegicus
Analyze
Symbol: Slc1a5
Name: solute carrier family 1 member 5
RGD ID: 708512
Description: Enables L-amino acid transmembrane transporter activity; antiporter activity; and ligand-gated channel activity. Involved in carboxylic acid transport. Predicted to be located in basal plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC1A5 (solute carrier family 1 member 5); PARTICIPATES IN argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; citrullinemia pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Asct2; ATB(0); CAZ-associated structural protein; H4-ASCT2; H4-system ASC-like transporter; insulin-activated amino acid transporter; neutral amino acid transporter B(0); Slc1a7; sodium-dependent neutral amino acid transporter ASCT2; sodium-dependent neutral amino acid transporter type 2; solute carrier family 1 (neutral amino acid transporter), member 5; solute carrier family 1, member 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,584,949 - 86,599,052 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,584,949 - 86,599,054 (+)EnsemblGRCr8
mRatBN7.2177,456,849 - 77,470,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,456,694 - 77,470,952 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx182,837,237 - 82,851,346 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,401,281 - 91,415,390 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,592,328 - 84,606,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,710,686 - 78,724,789 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,710,539 - 78,724,794 (+)Ensemblrn6Rnor6.0
Rnor_5.0179,957,648 - 79,971,751 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,111,082 - 77,125,166 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera171,941,916 - 71,956,019 (+)NCBICelera
RGSC_v3.1177,189,192 - 77,203,276 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
Bardoxolone methyl  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium silicate  (ISO)
cefaloridine  (EXP)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corosolic acid  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dithioerythritol  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
enzyme inhibitor  (ISO)
erianin  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
Lobetyolin  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N(4)-hydroxycytidine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thiazoles  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
basal plasma membrane  (ISO)
melanosome  (IEA)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. The astroglial ASCT2 amino acid transporter as a mediator of glutamine efflux. Broer A, etal., J Neurochem 1999 Nov;73(5):2184-94.
2. Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance. Bröer A, etal., Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):705-10.
3. Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma. Chen Z, etal., J Pharm Biomed Anal. 2021 Apr 15;197:113937. doi: 10.1016/j.jpba.2021.113937. Epub 2021 Feb 5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma. Honjo H, etal., J Surg Oncol. 2016 Mar;113(4):381-9. doi: 10.1002/jso.24160. Epub 2016 Mar 3.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. Piao L, etal., J Mol Med (Berl). 2013 Oct;91(10):1185-97. doi: 10.1007/s00109-013-1064-7. Epub 2013 Jun 21.
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Identification of a plasma membrane glutamine transporter from the rat hepatoma cell line H4-IIE-C3. Pollard M, etal., Biochem J 2002 Nov 15;368(Pt 1):371-5.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier. Tetsuka K, etal., J Neurochem. 2003 Nov;87(4):891-901. doi: 10.1046/j.1471-4159.2003.02063.x.
14. Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer. Toyoda M, etal., Br J Cancer. 2014 May 13;110(10):2506-13. doi: 10.1038/bjc.2014.178. Epub 2014 Apr 24.
15. Characterization of rapid and high-affinity uptake of L-serine in neurons and astrocytes in primary culture. Yamamoto T, etal., FEBS Lett. 2003 Jul 31;548(1-3):69-73.
16. Clinical significance of coexpression of L-type amino acid transporter 1 (LAT1) and ASC amino acid transporter 2 (ASCT2) in lung adenocarcinoma. Yazawa T, etal., Am J Transl Res. 2015 Jun 15;7(6):1126-39. eCollection 2015.
Additional References at PubMed
PMID:10933718   PMID:15581847   PMID:17475673   PMID:19192626   PMID:19946888   PMID:20448142   PMID:20458337   PMID:20599776   PMID:20977479   PMID:23492904   PMID:23581544   PMID:26459476  
PMID:27272177   PMID:29872227   PMID:32242892  


Genomics

Comparative Map Data
Slc1a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,584,949 - 86,599,052 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,584,949 - 86,599,054 (+)EnsemblGRCr8
mRatBN7.2177,456,849 - 77,470,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,456,694 - 77,470,952 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx182,837,237 - 82,851,346 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,401,281 - 91,415,390 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,592,328 - 84,606,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,710,686 - 78,724,789 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,710,539 - 78,724,794 (+)Ensemblrn6Rnor6.0
Rnor_5.0179,957,648 - 79,971,751 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,111,082 - 77,125,166 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera171,941,916 - 71,956,019 (+)NCBICelera
RGSC_v3.1177,189,192 - 77,203,276 (+)NCBI
Cytogenetic Map1q21NCBI
SLC1A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,774,883 - 46,788,594 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,774,883 - 46,788,617 (-)Ensemblhg38GRCh38
GRCh371947,278,140 - 47,291,851 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,969,980 - 51,983,653 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341951,969,981 - 51,983,653NCBI
Celera1944,082,395 - 44,096,097 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,702,915 - 43,716,958 (-)NCBIHuRef
CHM1_11947,280,017 - 47,293,715 (-)NCBICHM1_1
T2T-CHM13v2.01949,600,712 - 49,614,415 (-)NCBIT2T-CHM13v2.0
Slc1a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,515,259 - 16,532,199 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,515,265 - 16,532,199 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38716,781,334 - 16,798,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,781,340 - 16,798,274 (+)Ensemblmm10GRCm38
MGSCv37717,366,695 - 17,383,623 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36715,939,929 - 15,956,765 (+)NCBIMGSCv36mm8
Celera713,979,416 - 13,996,329 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Slc1a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955574798,004 - 806,631 (-)NCBIChiLan1.0ChiLan1.0
SLC1A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,922,399 - 52,939,392 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,793,572 - 54,807,596 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,765,001 - 43,778,981 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,294,052 - 52,308,159 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,294,655 - 52,307,529 (-)EnsemblpanPan2panpan1.1
SLC1A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,150,205 - 109,161,375 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,150,205 - 109,161,141 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1108,630,028 - 108,640,938 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01109,676,678 - 109,687,827 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,676,206 - 109,688,731 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,353,817 - 109,364,724 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,988,004 - 108,998,931 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,856,686 - 109,867,593 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc1a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934918,980,757 - 18,992,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664598,468 - 610,698 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936664599,012 - 610,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC1A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,647,438 - 52,661,459 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1652,647,432 - 52,661,464 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,026,660 - 48,032,162 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC1A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,139,417 - 40,150,312 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607319,833,875 - 19,850,399 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc1a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,831,368 - 6,838,593 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248326,830,799 - 6,839,118 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc1a5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12172,292,506 - 172,307,122 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc1a5
132 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:71
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000021455, ENSRNOT00000064332
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
D1Wox77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,470,700 - 77,470,898 (+)MAPPERmRatBN7.2
Rnor_6.0178,724,538 - 78,724,735NCBIRnor6.0
Rnor_5.0179,971,500 - 79,971,697UniSTSRnor5.0
RGSC_v3.4177,124,915 - 77,125,112UniSTSRGSC3.4
Celera171,955,768 - 71,955,965UniSTS
Cytogenetic Map1q21UniSTS
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021455   ⟹   ENSRNOP00000021455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,584,949 - 86,599,051 (+)Ensembl
mRatBN7.2 Ensembl177,456,694 - 77,470,952 (+)Ensembl
Rnor_6.0 Ensembl178,710,539 - 78,724,794 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064332   ⟹   ENSRNOP00000060053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,584,949 - 86,599,051 (+)Ensembl
mRatBN7.2 Ensembl177,456,694 - 77,470,952 (+)Ensembl
Rnor_6.0 Ensembl178,711,077 - 78,724,259 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111666   ⟹   ENSRNOP00000084829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,584,949 - 86,599,051 (+)Ensembl
mRatBN7.2 Ensembl177,456,694 - 77,470,952 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124330   ⟹   ENSRNOP00000109193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,585,340 - 86,599,054 (+)Ensembl
RefSeq Acc Id: NM_175758   ⟹   NP_786934
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,584,949 - 86,599,052 (+)NCBI
mRatBN7.2177,456,849 - 77,470,952 (+)NCBI
Rnor_6.0178,710,686 - 78,724,789 (+)NCBI
Rnor_5.0179,957,648 - 79,971,751 (+)NCBI
RGSC_v3.4177,111,082 - 77,125,166 (+)RGD
Celera171,941,916 - 71,956,019 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103908   ⟹   XP_038959836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,586,005 - 86,599,052 (+)NCBI
mRatBN7.2177,457,908 - 77,470,938 (+)NCBI
RefSeq Acc Id: NP_786934   ⟸   NM_175758
- UniProtKB: D3ZJ25 (UniProtKB/Swiss-Prot),   Q9Z1J7 (UniProtKB/TrEMBL),   F7F8V1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021455   ⟸   ENSRNOT00000021455
Ensembl Acc Id: ENSRNOP00000060053   ⟸   ENSRNOT00000064332
RefSeq Acc Id: XP_038959836   ⟸   XM_039103908
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000084829   ⟸   ENSRNOT00000111666
Ensembl Acc Id: ENSRNOP00000109193   ⟸   ENSRNOT00000124330

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJ25-F1-model_v2 AlphaFold D3ZJ25 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689738
Promoter ID:EPDNEW_R262
Type:multiple initiation site
Name:Slc1a5_1
Description:solute carrier family 1 member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,710,534 - 78,710,594EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708512 AgrOrtholog
BioCyc Gene G2FUF-60595 BioCyc
Ensembl Genes ENSRNOG00000015948 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021455 ENTREZGENE
  ENSRNOT00000064332.4 UniProtKB/Swiss-Prot
Gene3D-CATH Sodium:dicarboxylate symporter UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100054 IMAGE-MGC_LOAD
InterPro DAACS UniProtKB/Swiss-Prot
  Na-dicarboxylate_symporter UniProtKB/Swiss-Prot
  Na-dicarboxylate_symporter_CS UniProtKB/Swiss-Prot
  Na:dicarbo_symporter_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:91449 IMAGE-MGC_LOAD
NCBI Gene 292657 ENTREZGENE
PANTHER NEUTRAL AMINO ACID TRANSPORTER B(0) UniProtKB/Swiss-Prot
  SODIUM/DICARBOXYLATE SYMPORTER-RELATED UniProtKB/Swiss-Prot
Pfam SDF UniProtKB/Swiss-Prot
PhenoGen Slc1a5 PhenoGen
PRINTS EDTRNSPORT UniProtKB/Swiss-Prot
PROSITE NA_DICARBOXYL_SYMP_1 UniProtKB/Swiss-Prot
  NA_DICARBOXYL_SYMP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015948 RatGTEx
Superfamily-SCOP Proton glutamate symport protein UniProtKB/Swiss-Prot
UniProt A0A8I6GC77_RAT UniProtKB/TrEMBL
  A0ABK0LT41_RAT UniProtKB/TrEMBL
  AAAT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  F7F8V1 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1J7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc1a5  solute carrier family 1 member 5  Slc1a5  solute carrier family 1 (neutral amino acid transporter), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Slc1a5  solute carrier family 1 (neutral amino acid transporter), member 5  Slc1a7  solute carrier family 1, member 7  Data merged from RGD:628679 737654 APPROVED
2006-03-30 Slc1a5  solute carrier family 1 (neutral amino acid transporter), member 5    sodium-dependent neutral amino acid transporter ASCT2  Name updated 1299863 APPROVED
2004-09-10 Slc1a5  sodium-dependent neutral amino acid transporter ASCT2  Asct2    Symbol and Name updated 1299863 APPROVED
2003-02-27 Slc1a7  solute carrier family 1, member 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the hepatoma cell line H4-IIE-C3 628314
gene_function catalyses Na+-dependent glutamine uptake 628314
gene_homology loop region between transmembrane helices 3 and 4 shares less than 60% sequence similarity with region from ASCT2 in rat liver 628314
gene_homology nucleotide sequence is 86.4% identical to the rat ASCT2 gene (GenBank AJ132846) 628314
gene_product member of the ASCT/B0 family of transporters 628314
gene_protein 551 amino acid protein 628314